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Resistance exercise-induced increase in muscle mass correlates with p70S6 kinase phosphorylation in human subjects
Abstract
The purpose of the present study was to investigate the possible relationship between a change in Thr(389) phosphorylation of p70S6 kinase (p70(S6k)) after a single resistance training session and an increase in skeletal muscle mass following short-term resistance training. Eight male subjects performed an initial resistance training session in leg press, six sets of 6RM with 2 min between sets. Muscle biopsies were obtained from the vastus lateralis before (T1) and 30 min after the initial training session (T2). Six of these subjects completed a 14-week resistance-training programme, three times per week (nine exercises, six sets, 6RM). A third muscle biopsy was obtained at the end of the 14-week training period (T3). One repetition maximum (1RM) squat, bench press and leg press strength as well as fat-free mass (FFM, with dual energy X-ray absorptiometry) were determined at T1 and T3. The results show that the increase in Thr(389) phosphorylation of p70(S6k) after the initial training session was closely correlated with the percentage increase in whole body FFM (r = 0.89, P < 0.01), FFM(leg) (r = 0.81, P < 0.05), 1RM squat (r = 0.84, P < 0.05), and type IIA muscle fibre cross sectional area (r = 0.82, P < 0.05) after 14 weeks of resistance training. These results may suggest that p70(S6k) phosphorylation is involved in the signalling events leading to an increase in protein accretion in human skeletal muscle following resistance training, at least during the initial training period.
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“acute increases in mTOR signaling markers following one bout of resistance exercise are associated with muscle hypertrophy following weeks of resistance training (Terzis et al., 2008; Hulmi et al., 2009; Mayhew et al., 2009; Mitchell et al., 2013)”
From Skeletal Muscle Ribosome and Mitochondrial Biogenesis in Response to Different Exercise Training Modalities (2021) · cites this paper as Terzis et al., 2008
In the citing paper
“This finding in rats has since been demonstrated in humans [10], suggesting that activation of mTORC1 is key to increasing muscle mass and strength.”
From Using Molecular Biology to Maximize Concurrent Training (2014) · cites this paper as [10]
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Cited by
Sorted by citations
Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation
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“Due to the importance of protein synthesis exceeding breakdown over an extended period of time, the degree of muscle hypertrophy induced by resistance exercise is strongly associated with the degree of p70S6K phosphorylation (Baar and Esser, 1999; Terzis et al., 2008).”
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“The extent of p70s6K phosphorylation reportedly predicts the extent of accretion of muscle in rats (Baar & Esser, 1999) and in weight lifters (Terzis et al. 2008), but no direct correlation between p70s6K phosphorylation and increases in muscle synthesis have been reported and certainly not in…”
BackgroundResistance exercise load does not determine training-mediated hypertrophic gains in young men
Mitchell, C. J., Churchward-Venne, T. A., West, D. W. D., Burd, N. A., Breen, L., Baker, S. K., & Phillips, S. M. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00307.2012 · Cited by 627
“Previously, a significant correlation between early (1 h postexercise) phosphorylation of p70S6K and muscle hypertrophy was observed (39); our results, which include a larger sample size than the previous investigation, failed to support a similar relationship (Fig.”
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“Therefore, in an effort to contextualize the results of our planned measurements of protein synthesis we also sought to measure phosphorylation of signalling proteins of the Akt–mTOR–p70S6K (Nautilus, Vancouver, USA) pathway shown by others to be responsive to resistance exercise (Karlsson et al. 2004; Coffey et al. 2…”
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Metadata
- Authors
- Terzis, G., Georgiadis, G., Stratakos, G., Vogiatzis, I., Kavouras, S., Manta, P., Mascher, H., & Blomstrand, E.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Harokopio University of Athens (GR)
- Swedish School of Sport and Health Sciences (SE)
- Corresponding author
- Terzis, Gerasimos
- Venue
- European Journal of Applied Physiology
- Published
- 2007-09-14
- Volume
- 102
- Issue
- 2
- Pages
- 145-152
- ISSN
- 0020-9376 (ISSN-L)
- 1439-6319
- 1439-6327
- OpenAlex
- W1964076858
- Cited by
- 242
- References
- 35
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 5 · 2020: 11 · 2019: 11 · 2018: 19 · 2017: 16 · 2016: 20 · 2015: 16 · 2014: 17 · 2013: 24 · 2012: 18
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National and Kapodistrian University of Athens
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- resistance training, p70 S6 kinase, skeletal muscle hypertrophy, fat-free mass, muscle strength, protein accretion, mTOR signaling, vastus lateralis
- MeSH terms
- Exercise Test, Physical Exertion, Humans, Male, Muscle Contraction, Phosphorylation, Statistics as Topic, Exercise, Muscle, Skeletal, Ribosomal Protein S6 Kinases, 70-kDa, Young Adult
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