Cited by 242Muscle metabolism and nutritionMuscle Physiology and DisordersSports Performance and Training

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Resistance exercise-induced increase in muscle mass correlates with p70S6 kinase phosphorylation in human subjects

Terzis, Gerasimos, Georgiadis, Giorgos, Stratakos, Grigoris, Vogiatzis, Ioannis, Kavouras, Stavros, Manta, Panagiota, Mascher, Henrik, Blomstrand, Eva·2007·European Journal of Applied Physiology

DOI 10.1007/s00421-007-0564-y

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Abstract

The purpose of the present study was to investigate the possible relationship between a change in Thr(389) phosphorylation of p70S6 kinase (p70(S6k)) after a single resistance training session and an increase in skeletal muscle mass following short-term resistance training. Eight male subjects performed an initial resistance training session in leg press, six sets of 6RM with 2 min between sets. Muscle biopsies were obtained from the vastus lateralis before (T1) and 30 min after the initial training session (T2). Six of these subjects completed a 14-week resistance-training programme, three times per week (nine exercises, six sets, 6RM). A third muscle biopsy was obtained at the end of the 14-week training period (T3). One repetition maximum (1RM) squat, bench press and leg press strength as well as fat-free mass (FFM, with dual energy X-ray absorptiometry) were determined at T1 and T3. The results show that the increase in Thr(389) phosphorylation of p70(S6k) after the initial training session was closely correlated with the percentage increase in whole body FFM (r = 0.89, P < 0.01), FFM(leg) (r = 0.81, P < 0.05), 1RM squat (r = 0.84, P < 0.05), and type IIA muscle fibre cross sectional area (r = 0.82, P < 0.05) after 14 weeks of resistance training. These results may suggest that p70(S6k) phosphorylation is involved in the signalling events leading to an increase in protein accretion in human skeletal muscle following resistance training, at least during the initial training period.

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Molecular predictors of resistance training outcomes in young untrained female adults
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BackgroundInfluential
TLR2 and TLR4 activation induces p38 MAPK‐dependent phosphorylation of S6 kinase 1 in C2C12 myotubes
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Ingestion of 10 grams of whey protein prior to a single bout of resistance exercise does not augment Akt/mTOR pathway signaling compared to carbohydrate
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Electromyostimulation with blood flow restriction enhances activation of mTOR and MAPK signaling pathways in rat gastrocnemius muscles
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Moderate-Intensity Strength Exercise to Exhaustion Results in More Pronounced Signaling Changes in Skeletal Muscles of Strength-Trained Compared With Untrained Individuals
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muscle hypertrophy nor strength of the elbow flexors resistance exercise enhance neither training-induced Elevations in ostensibly anabolic hormones with
Holwerda, A. M., Baker, S. K., Phillips, S. M., West, D. W. D., Burd, N. A., Tang, J. E., Moore, D. R., Atherton, P. J., Stout, J. R., Beyer, K. S., et al. (2011) · Cited by 6
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Effect of eccentric action velocity on expression of genes related to myostatin signaling pathway in human skeletal muscle
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Authors: Terzis, G., Georgiadis, G., Stratakos, G., Vogiatzis, I., Kavouras, S., Manta, P., Mascher, H., & Blomstrand, E.
Affiliations: National and Kapodistrian University of Athens (GR)
Harokopio University of Athens (GR)
Swedish School of Sport and Health Sciences (SE)
Corresponding author: Terzis, Gerasimos
ORCID: Terzis, Gerasimos
Stratakos, Grigoris
Vogiatzis, Ioannis
Kavouras, Stavros
Blomstrand, Eva
Venue: European Journal of Applied Physiology
Publisher: Springer Science and Business Media LLC
Published: 2007-09-14
Volume: 102
Issue: 2
Pages: 145-152
ISSN: 0020-9376 (ISSN-L)
1439-6319
1439-6327
DOI: 10.1007/s00421-007-0564-y
OpenAlex: W1964076858
Cited by: 242
References: 35
Citations by year: 2026: 4 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 5 · 2020: 11 · 2019: 11 · 2018: 19 · 2017: 16 · 2016: 20 · 2015: 16 · 2014: 17 · 2013: 24 · 2012: 18
FWCI: 6.21
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: European Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National and Kapodistrian University of Athens
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords: resistance training, p70 S6 kinase, skeletal muscle hypertrophy, fat-free mass, muscle strength, protein accretion, mTOR signaling, vastus lateralis
MeSH terms: Exercise Test, Physical Exertion, Humans, Male, Muscle Contraction, Phosphorylation, Statistics as Topic, Exercise, Muscle, Skeletal, Ribosomal Protein S6 Kinases, 70-kDa, Young Adult

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Resistance exercise-induced increase in muscle mass correlates with p70S6 kinase phosphorylation in human subjects

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