Influence of muscle glycogen availability on ERK1/2 and Akt signaling after resistance exercise in human skeletal muscle

Creer, Andrew; Gallagher, Philip; Slivka, Dustin; Jemiolo, Bozena; Fink, William; Trappe, Scott

doi:10.1152/japplphysiol.00110.2005

Cited by 150Muscle metabolism and nutritionMetabolism, Diabetes, and CancerMuscle Physiology and Disorders

Influence of muscle glycogen availability on ERK1/2 and Akt signaling after resistance exercise in human skeletal muscle

Creer, Andrew, Gallagher, Philip, Slivka, Dustin, Jemiolo, Bozena, Fink, William, Trappe, Scott·2005·Journal of Applied Physiology

DOI 10.1152/japplphysiol.00110.2005

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Abstract

Two pathways that have been implicated for cellular growth and development in response to muscle contraction are the extracellular signal-regulated kinase (ERK1/2) and Akt signaling pathways. Although these pathways are readily stimulated after exercise, little is known about how nutritional status may affect stimulation of these pathways in response to resistance exercise in human skeletal muscle. To investigate this, experienced cyclists performed 30 repetitions of knee extension exercise at 70% of one repetition maximum after a low (2%) or high (77%) carbohydrate (LCHO or HCHO) diet, which resulted in low or high (approximately 174 or approximately 591 mmol/kg dry wt) preexercise muscle glycogen content. Muscle biopsies were taken from the vastus lateralis before, approximately 20 s after, and 10 min after exercise. ERK1/2 and p90 ribosomal S6 kinase phosphorylation increased (P < or = 0.05) 10 min after exercise, regardless of muscle glycogen availability. Akt phosphorylation was elevated (P < 0.05) 10 min after exercise in the HCHO trial but was unaffected after exercise in the LCHO trial. Mammalian target of rapamycin phosphorylation was similar to that of Akt during each trial; however, change or lack of change was not significant. In conclusion, the ERK1/2 pathway appears to be unaffected by muscle glycogen content. However, muscle glycogen availability appears to contribute to regulation of the Akt pathway, which may influence cellular growth and adaptation in response to resistance exercise in a low-glycogen state.

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MAZZETTI, S. A. (2003) · Cardinal Scholar (Ball State University)
Title from approval sheet: Effects of different resistance exercise protocols on Akt and ERK activation in human skeletal muscle
Mazzetti, S. A. (2003) · Cardinal Scholar (Ball State University)
The Effect of Carbohydrate Ingestion Following Eccentric Resistance Exercise on AKT/mTOR and ERK Pathways: A Randomized, Double-Blinded, Crossover Study
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Effect Of Muscle Glycogen Status And Nutrition On Cell Signaling Following Resistance Exercise
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Resistance exercise with low glycogen increases p53 phosphorylation and PGC-1à mRNA in skeletal muscle
CAMERA, D. M., Hawley, J., & Coffey, V. (2015) · QUT ePrints (Queensland University of Technology)

Authors: Creer, A., Gallagher, P., Slivka, D., Jemiolo, B., Fink, W., & Trappe, S.
Affiliations: Ball State University (US)
ORCID: Creer, Andrew
Gallagher, Philip
Slivka, Dustin
Trappe, Scott
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 2005-09
Volume: 99
Issue: 3
Pages: 950-956
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/japplphysiol.00110.2005
OpenAlex: W2166195206
Cited by: 150
References: 47
Citations by year: 2025: 1 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 8 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 18 · 2013: 10 · 2012: 9
FWCI: 3.52
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG 18409, R01AG018409)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: muscle glycogen, resistance training, ERK signaling, Akt signaling, p90 ribosomal S6 kinase, mTOR, skeletal muscle, dietary carbohydrates, muscle hypertrophy, vastus lateralis, exercise adaptation
MeSH terms: Adult, Dietary Carbohydrates, Glycogen, Humans, Knee Joint, Male, Muscle Contraction, Physical Endurance, Proto-Oncogene Proteins, Signal Transduction, Protein Serine-Threonine Kinases, Muscle, Skeletal, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Proto-Oncogene Proteins c-akt

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Influence of muscle glycogen availability on ERK1/2 and Akt signaling after resistance exercise in human skeletal muscle

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