The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Decline in isokinetic force with age: muscle cross-sectional area and specific force
Abstract
Humans produce less muscle force (F) as they age. However, the relationship between decreased force and muscle cross-sectional area (CSA) in older humans is not well documented. We examined changes in F and CSA to determine the relative contributions of muscle atrophy and specific force (F/CSA) to declining force production in aging humans. The proportions of myosin heavy chain (MHC) isoforms were characterized to assess whether this was related to changes in specific force with age. We measured the peak force of isokinetic knee extension in 57 males and females aged 23-80 years, and used magnetic resonance imaging to determine the contractile area of the quadriceps muscle. Analysis of MHC isoforms taken from biopsies of the vastus lateralis muscle showed no relation to specific force. F, CSA, and F/CSA decreased with age. Smaller CSA accounted for only about half of the 39% drop in force that occurred between ages 65-80 years. Specific force dropped about 1.5% per year in this age range, for a total decrease of 21%. Thus, quantitative changes in muscle (atrophy) are not sufficient to explain the strength loss associated with aging.
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“Age-associated skeletal muscle dysfunction has been well characterized and includes a reduction of muscle mass, strength and, according to several studies, endurance capacity (5, 6).”
From Discovering pathways of sarcopenia in older adults: a role for insulin resistance on mitochondria dysfunction (2011) · cites this paper as [6]
Citations
Cites
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Talmadge, R. J., & Roy, R. R. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.5.2337 · Cited by 804
Strength and cross‐sectional area of human skeletal muscle.
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Physiological changes in ageing muscles
Campbell, M. J., McComas, A. J., & Petito, F. (1973) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.36.2.174 · Cited by 738
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Aging of skeletal muscle: a 12-yr longitudinal study
Frontera, W. R., Hughes, V. A., Fielding, R. A., Fiatarone, M. A., Evans, W. J., & Roubenoff, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1321 · Cited by 1,443
Attenuation of skeletal muscle and strength in the elderly: the Health ABC Study
Goodpaster, B. H., Carlson, C. L., Visser, M., Kelley, D. E., Scherzinger, A., Harris, T. B., Stamm, E., & Newman, A. B. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2157 · Cited by 1,226
A Framework for the in Vivo Pathomechanics of Osteoarthritis at the Knee
Andriacchi, T. P., Mündermann, A., Smith, R. L., Alexander, E. J., Dyrby, C. O., & Koo, S. (2004) · Annals of Biomedical Engineering · doi:10.1023/b:abme.0000017541.82498.37 · Cited by 1,068
Wilkinson, D. J., Piasecki, M., & Atherton, P. J. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.005 · Cited by 947
Sarcopenia: characteristics, mechanisms and functional significance
Narici, M. V., & Maffulli, N. (2010) · British Medical Bulletin · doi:10.1093/bmb/ldq008 · Cited by 827
Metadata
- Authors
- Jubrias, S. A., Odderson, I. R., Esselman, P. C., & Conley, K. E.
- Affiliations
- University of Washington Medical Center (US)
- Venue
- Pfl�gers Archiv European Journal of Physiology
- Published
- 1997-06-16
- Volume
- 434
- Issue
- 3
- Pages
- 246-253
- ISSN
- 0031-6768 (ISSN-L)
- 1432-2013
- OpenAlex
- W2063035273
- Cited by
- 222
- References
- 35
- Citations by year
- 2025: 7 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 7 · 2020: 9 · 2019: 3 · 2018: 11 · 2017: 13 · 2016: 9 · 2015: 8 · 2014: 12 · 2013: 9 · 2012: 8
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pflügers Archiv - European Journal of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5t32hl007503-03, 5r01ag010853-05)
- National Institute on Aging (AG-10853)
- National Heart, Lung, and Blood Institute (HL-7503)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR41928, R01AR041928)
- NIH Clinical Center
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- muscle aging, muscle cross-sectional area, specific force, muscle atrophy, myosin heavy chain isoforms, quadriceps, vastus lateralis, knee extension, strength degradation, sarcopenia
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Female, Humans, Knee Joint, Magnetic Resonance Imaging, Male, Middle Aged, Muscle Contraction, Muscular Atrophy, Muscle, Skeletal, Muscle Fibers, Skeletal, Myosin Heavy Chains
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