Aging of skeletal muscle: a 12-yr longitudinal study
Abstract
The present study examines age-related changes in skeletal muscle size and function after 12 yr. Twelve healthy sedentary men were studied in 1985–86 (T1) and nine (initial mean age 65.4 ± 4.2 yr) were reevaluated in 1997–98 (T2). Isokinetic muscle strength of the knee and elbow extensors and flexors showed losses ( P < 0.05) ranging from 20 to 30% at slow and fast angular velocities. Computerized tomography ( n = 7) showed reductions ( P < 0.05) in the cross-sectional area (CSA) of the thigh (12.5%), all thigh muscles (14.7%), quadriceps femoris muscle (16.1%), and flexor muscles (14.9%). Analysis of covariance showed that strength at T1 and changes in CSA were independent predictors of strength at T2. Muscle biopsies taken from vastus lateralis muscles ( n = 6) showed a reduction in percentage of type I fibers (T1 = 60% vs. T2 = 42%) with no change in mean area in either fiber type. The capillary-to-fiber ratio was significantly lower at T2 (1.39 vs. 1.08; P = 0.043). Our observations suggest that a quantitative loss in muscle CSA is a major contributor to the decrease in muscle strength seen with advancing age and, together with muscle strength at T1, accounts for 90% of the variability in strength at T2.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Aging is associated with alterations in myosin heavy chain (MHC) distribution.
“aging has been associated with alterations in myosin heavy chain (MHC) distribution [90].”
From Gut Microbiota Contribute to Age-Related Changes in Skeletal Muscle Size, Composition, and Function: Biological Basis for a Gut-Muscle Axis (2018) · cites this paper as [90]
Cites
What is the cause of the ageing atrophy?
Lexell, J. E., Taylor, C. C., & Sjöstróm, M. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90132-3 · Cited by 2,080 · see citing works
Muscle biopsy: A modern approach
(1975) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(75)90022-2 · Cited by 1,387 · see citing works
Strength conditioning in older men: skeletal muscle hypertrophy and improved function
Frontera, W. R., Meredith, C. N., O'Reilly, K. P., Knuttgen, H. G., & Evans, W. J. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.64.3.1038 · Cited by 1,386 · see citing works
Self-citationTHE SPECIFICITY OF THE HISTOCHEMICAL METHOD FOR ADENOSINE TRIPHOSPHATAS
Padykula, H. A., & Herman, E. (1955) · Journal of Histochemistry & Cytochemistry · doi:10.1177/3.3.170 · Cited by 1,219 · see citing works
A cross-sectional study of muscle strength and mass in 45- to 78-yr-old men and women
Frontera, W. R., HUGHES, V. A., Lutz, K. J., & Evans, W. J. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.71.2.644 · Cited by 1,011 · see citing works
Self-citationPadykula, H. A., & Herman, E. (1955) · Journal of Histochemistry & Cytochemistry · doi:10.1177/3.3.161 · Cited by 654 · see citing works
Muscle quality. I. Age-associated differences between arm and leg muscle groups
Lynch, N. A., Metter, E. J., Lindle, R. S., Fozard, J. L., Tobin, J. D., Roy, T. A., Fleg, J. L., & Hurley, B. F. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.1.188 · Cited by 596 · see citing works
Age-Associated Loss of Power and Strength in the Upper Extremities in Women and Men
Metter, E. J., Conwit, R., Tobin, J., & Fozard, J. L. (1997) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/52a.5.b267 · Cited by 592 · see citing works
Aging of human muscle: structure, function and adaptability
Porter, M. M., Vandervoort, A. A., & Lexell, J. E. (1995) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.1995.tb00026.x · Cited by 555 · see citing works
Suction applied to a muscle biopsy maximizes sample size
Evans, W. J., Phinney, S. D., & Young, V. R. (1982) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198201000-00018 · Cited by 520 · see citing works
Self-citationCoggan, A. R., Spina, R. J., King, D. S., Rogers, M. A., Rogers, M. A., Brown, M., Nemeth, P. M., & Holloszy, J. O. (1992) · Journal of Gerontology · doi:10.1093/geronj/47.3.b71 · Cited by 456 · see citing works
Capillary Density in Skeletal Muscle of Man
Andersen, P. (1975) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1975.tb10043.x · Cited by 448 · see citing works
Rantanen, T., Guralnik, J. M., Sakari‐Rantala, R., Leveille, S. G., Simonsick, E. M., Ling, S. M., & Fried, L. P. (1999) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/s0003-9993(99)90109-0 · Cited by 390 · see citing works
Grip strength changes over 27 yr in Japanese-American men
Rantanen, T., Masaki, K., Foley, D., Izmirlian, G., White, L. R., & Guralnik, J. M. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.6.2047 · Cited by 364 · see citing works
The Ether Soluble Porphyrins Found in the Urine of Normal Man and Rabbit
Eriksen, L., Eriksen, N., & Haavaldsen, S. (1962) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365516209075148 · Cited by 358 · see citing works
Bassey, E. J., & Harries, U. (1993) · Clinical Science · doi:10.1042/cs0840331 · Cited by 318 · see citing works
Muscle morphology, enzymatic activity, and muscle strength in elderly men: A follow‐up study
ANIANSSON, A., Hedberg, M., Henning, G., & Grimby, G. (1986) · Muscle & Nerve · doi:10.1002/mus.880090702 · Cited by 314 · see citing works
Rantanen, T., Era, P. A., & Heikkinen, E. M. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb03193.x · Cited by 278 · see citing works
Decline in isokinetic force with age: muscle cross-sectional area and specific force
Jubrias, S. A., Odderson, I. R., Esselman, P. C., & Conley, K. E. (1997) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s004240050392 · Cited by 222 · see citing works
Lexell, J. E., & Downham, D. Y. (1991) · Acta Neuropathologica · doi:10.1007/bf00293457 · Cited by 188 · see citing works
Variability in muscle fibre areas in whole human quadriceps muscle: effects of increasing age.
Lexell, J. E., & Taylor, C. C. (1991) · Europe PMC (PubMed Central) · Cited by 185 · see citing works
The Ether Soluble Porphyrins Found in the Urine of Normal Man and Rabbit
Eriksen, L., Eriksen, N., & Haavaldsen, S. (1962) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365516209075148 · Cited by 146 · see citing works
Heart involvement in muscular dystrophies due to sarcoglycan gene mutations
Melacini, P., Fanin, M., Duggan, D. J., Freda, M. P., Berardinelli, A. L., Danieli, G. A., Barchitta, A., Hoffman, E. P., Volta, S. D., & Angelini, C. I. (1999) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(199904)22:4 · Cited by 136 · see citing works
Time Trends in Physical Activity among College Alumni, 1962–1988
Lee, I., Paffenbarger, R. S., & Hsieh, C. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116387 · Cited by 136 · see citing works
A 12-Year Follow-up Study of Ankle Muscle Function in Older Adults
Winegard, K. J., Hicks, A. L., SALE, D. G., & Vandervoort, A. A. (1996) · The Journals of Gerontology Series A · doi:10.1093/gerona/51a.3.b202 · Cited by 135 · see citing works
Muscle function in 75-year-old men and women. A longitudinal study.
ANIANSSON, A., Sperling, L., Rundgren, Å., & Lehnberg, E. (1983) · PubMed · Cited by 132 · see citing works
Compensatory muscle fiber hypertrophy in elderly men
ANIANSSON, A., Grimby, G., & Hedberg, M. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.3.812 · Cited by 112 · see citing works
Clement, F. J. (1974) · Journal of Gerontology · doi:10.1093/geronj/29.4.423 · Cited by 96 · see citing works
Muscle capillarization, O2diffusion distance, and V˙ o 2kinetics in old and young individuals
Chilibeck, P. D., Paterson, D. H., Cunningham, D. A., Taylor, A. W., & Noble, E. G. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.1.63 · Cited by 96 · see citing works
Skeletal muscle characteristics among distance runners: a 20-yr follow-up study
Trappe, S. W., COSTILL, D. L., Fink, W. J., et al. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.78.3.823 · Cited by 96 · see citing works
Analysis of sampling errors in biopsy techniques using data from whole muscle cross sections
Lexell, J. E., Taylor, C. C., & Sjöstróm, M. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.59.4.1228 · Cited by 84 · see citing works
The quadriceps strength of healthy elderly people remeasured after eight years
Greig, C. A., Botella, J., & Young, A. (1993) · Muscle & Nerve · doi:10.1002/mus.880160103 · Cited by 73 · see citing works
Schroll, M., Avlund, K., & Davidsen, M. (1997) · Aging Clinical and Experimental Research · doi:10.1007/bf03340140 · Cited by 66 · see citing works
Era, P. A., & Rantanen, T. (1997) · PubMed · Cited by 52 · see citing works
Racial Differences in Muscle Strength in Disabled Older Women
Rantanen, T., Guralnik, J. M., Leveille, S. G., Izmirlian, G., Hirsch, R., Simonsick, E. M., Ling, S. M., & Fried, L. P. (1998) · The Journals of Gerontology Series A · doi:10.1093/gerona/53a.5.b355 · Cited by 47 · see citing works
Madsen, O. R., Lauridsen, U. B., Hartkopp, A., & S�rensen, O. H. (1997) · European Journal of Applied Physiology · doi:10.1007/s004210050154 · Cited by 46 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Sarcopenia in Asia: Consensus Report of the Asian Working Group for Sarcopenia
Chen, L.-K., Liu, L.-K., Woo, J., Assantachai, P., Auyeung, T.-W., Bahyah, K. S., Chou, M.-Y., Chen, L.-Y., Hsu, P.-S., Krairit, O., et al. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.11.025 · Cited by 4,051 · see citing works
Fielding, R. A., Vellas, B., Evans, W. J., Bhasin, S., Morley, J. E., Newman, A. B., Abellan van Kan, G., Andrieu, S., Bauer, J., Breuille, D., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.01.003 · Cited by 3,256 · see citing works
“Over the age span from 20 to 80 years of age, there is approximately a 30% reduction in muscle mass and a decline in cross-sectional area of about 20% (14).”
BackgroundSelf-citationGoodpaster, B. H., Park, S. W., Harris, T. B., Kritchevsky, S. B., Nevitt, M., Schwartz, A. V., Simonsick, E. M., Tylavsky, F. A., Visser, M., Newman, A. B., et al. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.10.1059 · Cited by 3,083 · see citing works
Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797 · see citing works
Skeletal muscle: A brief review of structure and function
Frontera, W. R., & Ochala, J. (2015) · Calcified Tissue International · doi:10.1007/s00223-014-9915-y · Cited by 1,758 · see citing works
Self-citationInvited Review: Aging and sarcopenia
Doherty, T. J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00347.2003 · Cited by 1,764 · see citing works
The healthcare costs of sarcopenia in the United States
Janssen, I., Shepard, D. S., Katzmarzyk, P. T., & Roubenoff, R. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52014.x · Cited by 1,546 · see citing works
Self-citationLongitudinal study of muscle strength, quality, and adipose tissue infiltration
Delmonico, M. J., Harris, T. B., Visser, M., Park, S. W., Conroy, M. B., Velasquez-Mieyer, P., Boudreau, R., Manini, T. M., Nevitt, M., Newman, A. B., et al. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28047 · Cited by 1,446 · see citing works
Visser, M., Goodpaster, B. H., Kritchevsky, S. B., Newman, A. B., Nevitt, M., Rubin, S. M., Simonsick, E. M., Harris, T. B., & Study, F. T. H. A. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.3.324 · Cited by 1,403 · see citing works
Mitchell, W. K., Williams, J., Atherton, P., Larvin, M., Lund, J., & Narici, M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00260 · Cited by 1,377 · see citing works
Fragala, M. S., Cadore, E. L., Dorgo, S., Izquierdo, M., Kraemer, W. J., Peterson, M. D., & Ryan, E. D. (2019) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003230 · Cited by 1,290 · see citing works
Skeletal Muscle Cutpoints Associated with Elevated Physical Disability Risk in Older Men and Women
Janssen, I. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh058 · Cited by 1,190 · see citing works
Sarcopenia with limited mobility: an international consensus
Morley, J. E., Abbatecola, A. M., Argiles, J. M., Baracos, V., Bauer, J., Bhasin, S., Cederholm, T., Stewart Coats, A. J., Cummings, S. R., Evans, W. J., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.04.014 · Cited by 1,125 · see citing works
Self-citationSarcopenic obesity: definition, cause and consequences
Stenholm, S., Harris, T. B., Rantanen, T., Visser, M., Kritchevsky, S. B., & Ferrucci, L. (2008) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e328312c37d · Cited by 1,070 · see citing works
Visser, M., Kritchevsky, S. B., Goodpaster, B. H., Newman, A. B., Nevitt, M., Stamm, E., & Harris, T. B. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50217.x · Cited by 845 · see citing works
Sarcopenia: characteristics, mechanisms and functional significance
Narici, M. V., & Maffulli, N. (2010) · British Medical Bulletin · doi:10.1093/bmb/ldq008 · Cited by 827 · see citing works
Hughes, V. A., Frontera, W. R., Roubenoff, R., Evans, W. J., & Singh, M. A. F. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.2.473 · Cited by 804 · see citing works
Self-citationResistance exercise for muscular strength in older adults: a meta-analysis
Peterson, M. D., Rhea, M. R., Sen, A., & Gordon, P. M. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.03.004 · Cited by 808 · see citing works
Resistance Training is Medicine: Effects of Strength Training on Health
Westcott, W. L. (2012) · Current Sports Medicine Reports · doi:10.1249/jsr.0b013e31825dabb8 · Cited by 778 · see citing works
Accelerated Loss of Skeletal Muscle Strength in Older Adults With Type 2 Diabetes
Park, S. W., Goodpaster, B. H., Strotmeyer, E. S., Kuller, L. H., Broudeau, R., Kammerer, C., de Rekeneire, N., Harris, T. B., Schwartz, A. V., Tylavsky, F. A., et al. (2007) · Diabetes Care · doi:10.2337/dc06-2537 · Cited by 766 · see citing works
Borde, R., Hortobágyi, T., & Granacher, U. (2015) · Sports Medicine · doi:10.1007/s40279-015-0385-9 · Cited by 737 · see citing works
Physical activity and exercise: Strategies to manage frailty
Angulo, J., El Assar, M., Álvarez-Bustos, A., & Rodríguez-Mañas, L. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101513 · Cited by 771 · see citing works
Kumar, V., Selby, A., Rankin, D., Patel, R., Atherton, P., Hildebrandt, W., Williams, J., Smith, K., Seynnes, O., Hiscock, N., et al. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.164483 · Cited by 740 · see citing works
Decreased Muscle Strength and Quality in Older Adults With Type 2 Diabetes
Park, S. W., Goodpaster, B. H., Strotmeyer, E. S., de Rekeneire, N., Harris, T. B., Schwartz, A. V., Tylavsky, F. A., & Newman, A. B. (2006) · Diabetes · doi:10.2337/db05-1183 · Cited by 751 · see citing works
Wang, D. X. M., Yao, J., Zirek, Y., Reijnierse, E. M., & Maier, A. B. (2020) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12502 · Cited by 655 · see citing works
Effects of Aging on Muscle Fibre Type and Size
Deschenes, M. R. (2004) · Sports Medicine · doi:10.2165/00007256-200434120-00002 · Cited by 671 · see citing works
García-Hermoso, A., Cavero-Redondo, I., Ramírez-Vélez, R., Ruiz, J. R., Ortega, F. B., Lee, D.-C., & Martínez-Vizcaíno, V. (2018) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2018.01.008 · Cited by 609 · see citing works
Lean Tissue Imaging: A New Era for Nutritional Assessment and Intervention
Prado, C. M. M., & Heymsfield, S. B. (2014) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607114550189 · Cited by 550 · see citing works
Bhasin, S., Woodhouse, L., Casaburi, R., Singh, A. B., Mac, R. P., Lee, M., Yarasheski, K. E., Sinha-Hikim, I., Dzekov, C., Dzekov, J., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1184 · Cited by 544 · see citing works
McGregor, R. A., Cameron-Smith, D., & Poppitt, S. D. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-9 · Cited by 532 · see citing works
Intrinsic and extrinsic mechanisms regulating satellite cell function
Dumont, N. A., Wang, Y. X., & Rudnicki, M. A. (2015) · Development · doi:10.1242/dev.114223 · Cited by 491 · see citing works
Andropause: clinical implications of the decline in serum testosterone levels with aging in men
Matsumoto, A. M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.2.m76 · Cited by 490 · see citing works
Effect of strength training on human patella tendon mechanical properties of older individuals
Reeves, N. D., Maganaris, C. N., & Narici, M. V. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.035576 · Cited by 484 · see citing works
Sarcopenia, Cachexia and Aging: Diagnosis, Mechanisms and Therapeutic Options - A Mini-Review
Ali, S., & Garcia, J. M. (2014) · Gerontology · doi:10.1159/000356760 · Cited by 462 · see citing works
Skeletal muscle fat infiltration: impact of age, inactivity, and exercise
Marcus, R. L., Addison, O., Kidde, J. P., Dibble, L. E., & Lastayo, P. C. (2010) · The Journal of nutrition, health and aging · doi:10.1007/s12603-010-0081-2 · Cited by 449 · see citing works
Effects of aging on human skeletal muscle after immobilization and retraining
Suetta, C., Hvid, L. G., Justesen, L., Christensen, U., Neergaard, K., Simonsen, L., Ortenblad, N., Magnusson, S. P., Kjaer, M., & Aagaard, P. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00290.2009 · Cited by 400 · see citing works
Exercise Attenuates the Major Hallmarks of Aging
Garatachea, N., Pareja-Galeano, H., Sanchis-Gomar, F., Santos-Lozano, A., Fiuza-Luces, C., Morán, M., Emanuele, E., Joyner, M. J., & Lucia, A. (2015) · Rejuvenation Research · doi:10.1089/rej.2014.1623 · Cited by 413 · see citing works
Grosicki, G. J., Fielding, R. A., & Lustgarten, M. S. (2018) · Calcified Tissue International · doi:10.1007/s00223-017-0345-5 · Cited by 388 · see citing works
Self-citationVerdijk, L. B., Gleeson, B. G., Jonkers, R. A. M., Meijer, K., Savelberg, H. H. C. M., Dendale, P., & van Loon, L. J. C. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gln050 · Cited by 372 · see citing works
Hilton, T. N., Tuttle, L. J., Bohnert, K. L., Mueller, M. J., & Sinacore, D. R. (2008) · Physical Therapy · doi:10.2522/ptj.20080079 · Cited by 373 · see citing works
Herold, F., Törpel, A., Schega, L., & Müller, N. G. (2019) · European Review of Aging and Physical Activity · doi:10.1186/s11556-019-0217-2 · Cited by 349 · see citing works
Schmitz, A., Silder, A., Heiderscheit, B., Mahoney, J., & Thelen, D. G. (2009) · Journal of Electromyography and Kinesiology · doi:10.1016/j.jelekin.2008.10.008 · Cited by 347 · see citing works
Sarcopenia and increased adipose tissue infiltration of muscle in elderly African American women
Song, M.-Y., Ruts, E., Kim, J., Janumala, I., Heymsfield, S., & Gallagher, D. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.874 · Cited by 324 · see citing works
Optimal load for increasing muscle power during explosive resistance training in older adults.
de Vos, N. J., Singh, N. A., Ross, D. A., Stavrinos, T. M., Orr, R., & Fiatarone Singh, M. A. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.5.638 · Cited by 309 · see citing works
Aging of skeletal muscle fibers
Miljkovic, N., Lim, J.-Y., Miljkovic, I., & Frontera, W. R. (2015) · Annals of Rehabilitation Medicine · doi:10.5535/arm.2015.39.2.155 · Cited by 309 · see citing works
“The loss of muscle mass and strength in older people is of greater magnitude in longitudinal compared to cross-sectional studies [15].”
BackgroundResultCandow, D. G., & Chilibeck, P. D. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.2.148 · Cited by 272 · see citing works
Koster, A., Ding, J., Stenholm, S., Caserotti, P., Houston, D. K., Nicklas, B. J., You, T., Lee, J. S., Visser, M., Newman, A. B., et al. (2011) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glr070 · Cited by 274 · see citing works
Csapo, R., & Alegre, L. M. (2016) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12536 · Cited by 239 · see citing works
Billot, M., Calvani, R., Urtamo, A., Sánchez-Sánchez, J. L., Ciccolari-Micaldi, C., Chang, M., Roller-Wirnsberger, R., Wirnsberger, G., Sinclair, A., Vaquero-Pinto, M. N., et al. (2020) · Clinical Interventions in Aging · doi:10.2147/cia.s253535 · Cited by 242 · see citing works
Aging does not impair the anabolic response to a protein-rich meal
Symons, T. B., Schutzler, S. E., Cocke, T. L., Chinkes, D. L., Wolfe, R. R., & Paddon-Jones, D. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.2.451 · Cited by 240 · see citing works
Age-related differences in apoptosis with disuse atrophy in soleus muscle
Leeuwenburgh, C., Gurley, C. M., Strotman, B. A., & Dupont-Versteegden, E. E. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00576.2004 · Cited by 231 · see citing works
Endocrine Aspects of Male Sexual Dysfunctions
Buvat, J., Maggi, M., Gooren, L., Guay, A. T., Kaufman, J., Morgentaler, A., Schulman, C., Tan, H. M., Torres, L. O., Yassin, A., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01780.x · Cited by 221 · see citing works
Roberts, M. D., McCarthy, J. J., Hornberger, T. A., Phillips, S. M., Mackey, A. L., Nader, G. A., Boppart, M. D., Kavazis, A. N., Reidy, P. T., Ogasawara, R., et al. (2023) · Physiological Reviews · doi:10.1152/physrev.00039.2022 · Cited by 214 · see citing works
Scott, D., Blizzard, L., Fell, J., Ding, C., Winzenberg, T., & Jones, G. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03858.x · Cited by 213 · see citing works
Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications
Pataky, M. W., Young, W. F., & Nair, K. S. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.07.033 · Cited by 207 · see citing works
Lee, D. H., Keum, N., Hu, F. B., Orav, E. J., Rimm, E. B., Sun, Q., Willett, W. C., & Giovannucci, E. L. (2017) · British Journal of Nutrition · doi:10.1017/s0007114517002665 · Cited by 191 · see citing works
Suetta, C., Andersen, J. L., Dalgas, U., Berget, J., Koskinen, S., Aagaard, P., Magnusson, S. P., & Kjaer, M. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01354.2007 · Cited by 184 · see citing works
Sarcopenic Obesity: Epidemiologic Evidence, Pathophysiology, and Therapeutic Perspectives
Koliaki, C., Liatis, S., Dalamaga, M., & Kokkinos, A. (2019) · Current Obesity Reports · doi:10.1007/s13679-019-00359-9 · Cited by 176 · see citing works
Resistance training, sarcopenia, and the mitochondrial theory of aging
Johnston, A. P. W., De Lisio, M., & Parise, G. (2008) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h07-141 · Cited by 174 · see citing works
Age-induced oxidative stress: how does it influence skeletal muscle quantity and quality?
Baumann, C. W., Kwak, D., Liu, H. M., & Thompson, L. V. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00321.2016 · Cited by 169 · see citing works
Whitman, S. A., Wacker, M. J., Richmond, S. R., & Godard, M. P. (2005) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-005-1473-8 · Cited by 156 · see citing works
Lower extremity muscle function after strength or power training in older adults.
Marsh, A. P., Miller, M. E., Rejeski, W. J., Hutton, S. L., & Kritchevsky, S. B. (2009) · Journal of Aging and Physical Activity · doi:10.1123/japa.17.4.416 · Cited by 155 · see citing works
St‐Jean‐Pelletier, F., Pion, C. H., Leduc‐Gaudet, J., Sgarioto, N., Zovilé, I., Barbat‐Artigas, S., Reynaud, O., Alkaterji, F., Lemieux, F. C., Grenon, A., et al. (2017) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12139 · Cited by 156 · see citing works
Shin, M. J., Jeon, Y. K., & Kim, I. J. (2018) · The World Journal of Men's Health · doi:10.5534/wjmh.180001 · Cited by 134 · see citing works
Gueugneau, M., Coudy-Gandilhon, C., Théron, L., Meunier, B., Barboiron, C., Combaret, L., Taillandier, D., Polge, C., Attaix, D., Picard, B., et al. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu086 · Cited by 137 · see citing works
Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention
Brioche, T., Pagano, A. F., Py, G., & Chopard, A. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.04.006 · Cited by 129 · see citing works
Tieland, M., Franssen, R., Dullemeijer, C., van Dronkelaar, C., Kim, H. K., Ispoglou, T., Zhu, K., Prince, R. L., van Loon, L. J. C., & de Groot, L. C. P. G. M. (2017) · The Journal of nutrition, health and aging · doi:10.1007/s12603-017-0896-1 · Cited by 123 · see citing works
Satellite cell senescence underlies myopathy in a mouse model of limb-girdle muscular dystrophy 2H
Kudryashova, E., Kramerova, I., & Spencer, M. J. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59581 · Cited by 119 · see citing works
Recommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia
Reginster, J.-Y., Cooper, C., Rizzoli, R., Kanis, J. A., Appelboom, G., Bautmans, I., Bischoff-Ferrari, H. A., Boers, M., Brandi, M. L., Bruyère, O., et al. (2016) · Aging Clinical and Experimental Research · doi:10.1007/s40520-015-0517-y · Cited by 112 · see citing works
Self-citationAging of human muscle: Understanding sarcopenia at the single muscle cell level
Frontera, W. R., Rodriguez Zayas, A., & Rodriguez, N. (2012) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2011.11.012 · Cited by 108 · see citing works
Self-citationCheema, N., Herbst, A., McKenzie, D., & Aiken, J. M. (2015) · Aging Cell · doi:10.1111/acel.12399 · Cited by 107 · see citing works
Reid, K. F., Doros, G., Clark, D. J., Patten, C., Carabello, R. J., Cloutier, G. J., Phillips, E. M., Krivickas, L. S., Frontera, W. R., & Fielding, R. A. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2200-0 · Cited by 100 · see citing works
Self-citationJones, M. D., Wewege, M. A., Hackett, D. A., Keogh, J. W. L., & Hagstrom, A. D. (2021) · Sports Medicine · doi:10.1007/s40279-020-01388-4 · Cited by 96 · see citing works
Ji, C., Zheng, L., Zhang, R., Wu, Q., & Zhao, Y. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0734-4 · Cited by 89 · see citing works
Assessment of lower extremity muscle power in functionally-limited elders.
Callahan, D., Phillips, E., Carabello, R., Frontera, W. R., & Fielding, R. A. (2007) · Aging Clinical and Experimental Research · doi:10.1007/bf03324689 · Cited by 94 · see citing works
Self-citationPeng, L., Lee, W., Liu, L., Lin, M., & Chen, L. (2018) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12302 · Cited by 93 · see citing works
Effects of power training on muscle thickness of older men.
Nogueira, W., Gentil, P., Mello, S., Oliveira, R., Bezerra, A., & Bottaro, M. (2009) · International Journal of Sports Medicine · doi:10.1055/s-0028-1104584 · Cited by 91 · see citing works
Comparisons of three different methods for defining sarcopenia: an aspect of cardiometabolic risk
Kim, T. N., Park, M. S., Lee, E. J., Chung, H. S., Yoo, H. J., Kang, H. J., Song, W., Baik, S. H., & Choi, K. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-06831-7 · Cited by 86 · see citing works
Masoro, E. J. (2001) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.11.s1.s218 · Cited by 81 · see citing works
Pedrero-Chamizo, R., Gómez-Cabello, A., Mélendez, A., Vila-Maldonado, S., Espino, L., Gusi, N., Villa, G., Casajús, J. A., González-Gross, M., & Ara, I. (2015) · The Journal of nutrition, health and aging · doi:10.1007/s12603-014-0530-4 · Cited by 76 · see citing works
Role of PGC-1α in sarcopenia: Etiology and potential intervention—A mini-review
Ji, L. L., & Kang, C. (2015) · Gerontology · doi:10.1159/000365947 · Cited by 77 · see citing works
Jiang, Q., Lou, K., Hou, L., Lu, Y., Sun, L., Tan, S. C., Low, T. Y., Kord-Varkaneh, H., & Pang, S. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102360 · Cited by 71 · see citing works
Prospective views for whey protein and/or resistance training against age-related sarcopenia
Liao, Y., Peng, Z., Chen, L., Zhang, Y., Cheng, Q., Nüssler, A. K., Bao, W., Liu, L., & Yang, W. (2019) · Aging and Disease · doi:10.14336/ad.2018.0325 · Cited by 68 · see citing works
Murton, A. J. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115000130 · Cited by 66 · see citing works
Adaptations to Aerobic and Resistance Exercise in the Elderly
Lambert, C. P., & Evans, W. J. (2005) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-005-6726-5 · Cited by 67 · see citing works
Self-citationBeattie, K. A., MacIntyre, N. J., Ramadan, K., Inglis, D., & Maly, M. R. (2012) · Arthritis Care & Research · doi:10.1002/acr.20628 · Cited by 65 · see citing works
Martínez-Amat, A., Aibar-Almazán, A., Fábrega-Cuadros, R., Cruz-Díaz, D., Jiménez-García, J. D., Pérez-López, F. R., Achalandabaso, A., Barranco-Zafra, R., & Hita-Contreras, F. (2018) · Maturitas · doi:10.1016/j.maturitas.2018.02.005 · Cited by 65 · see citing works
Potential benefits of creatine monohydrate supplementation in the elderly
Tarnopolsky, M. A. (2000) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/00075197-200011000-00013 · Cited by 65 · see citing works
Silva Neto, L. S., Karnikowiski, M. G. O., Tavares, A. B., & Lima, R. M. (2012) · Brazilian Journal of Physical Therapy · doi:10.1590/s1413-35552012005000044 · Cited by 65 · see citing works
Marcus, R. L., Addison, O., & LaStayo, P. C. (2013) · The Journal of nutrition, health and aging · doi:10.1007/s12603-012-0377-5 · Cited by 65 · see citing works
Assessment and definition of lean body mass deficiency in the elderly
Müller, M. J., Geisler, C., Pourhassan, M., Glüer, C.-C., & Bosy-Westphal, A. (2014) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.169 · Cited by 63 · see citing works
The influence of age and aerobic fitness: effects on mitochondrial respiration in skeletal muscle
Larsen, S., Hey‐Mogensen, M., Rabøl, R., Stride, N., Helge, J. W., & Dela, F. (2012) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02408.x · Cited by 63 · see citing works
Late-Life Onset Hypogonadism: A Review
Bassil, N., & Morley, J. E. (2010) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2010.02.003 · Cited by 59 · see citing works
Moore, D. R., Kelly, R. P., Devries, M. C., Churchward‐Venne, T. A., Phillips, S. M., Parise, G., & Johnston, A. P. (2018) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12306 · Cited by 50 · see citing works
Periodization Strategies in Older Adults: Impact on Physical Function and Health
CONLON, J. A., NEWTON, R. U., TUFANO, J. J., BANYARD, H. G., HOPPER, A. J., RIDGE, A. J., & HAFF, G. G. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001053 · Cited by 49 · see citing works
Nederveen, J. P., Ibrahim, G., Fortino, S. A., Snijders, T., Kumbhare, D., & Parise, G. (2020) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0263 · Cited by 42 · see citing works
Respiratory chain deficiency in aged spinal motor neurons
Rygiel, K. A., Grady, J. P., & Turnbull, D. M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.027 · Cited by 41 · see citing works
Schroeder, E. T., He, J., Yarasheski, K. E., Binder, E. F., Castaneda-Sceppa, C., Bhasin, S., Dieli-Conwright, C. M., Kawakubo, M., Roubenoff, R., Azen, S. P., et al. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2077-y · Cited by 37 · see citing works
Self-citationAssessment of musculoskeletal system in women with jumping mechanography
Dionyssiotis, Y. (2009) · International Journal of Women's Health · doi:10.2147/ijwh.s5889 · Cited by 32 · see citing works
Drummond, M. J., Marcus, R. L., & LaStayo, P. C. (2012) · Journal of Aging Research · doi:10.1155/2012/486930 · Cited by 28 · see citing works
- Authors
- Frontera, W. R., Hughes, V. A., Fielding, R. A., Fiatarone, M. A., Evans, W. J., & Roubenoff, R.
- Affiliations
- Tufts University (US)
- Boston University (US)
- University of Arkansas for Medical Sciences (US)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2000-04-01
- Volume
- 88
- Issue
- 4
- Pages
- 1321-1326
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2184656706
- Cited by
- 1,443
- References
- 36
- Citations by year
- 2026: 30 · 2025: 44 · 2024: 46 · 2023: 71 · 2022: 59 · 2021: 83 · 2020: 83 · 2019: 88 · 2018: 81 · 2017: 57 · 2016: 70 · 2015: 71 · 2014: 80 · 2013: 71 · 2012: 67
- FWCI
- 14.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- skeletal muscle aging, sarcopenia, muscle strength decline, cross-sectional area, thigh muscle, quadriceps, vastus lateralis, muscle fiber type, type I muscle fibers, capillary-to-fiber ratio, isokinetic strength
- MeSH terms
- Aged, Aging, Capillaries, Elbow Joint, Humans, Isometric Contraction, Knee Joint, Longitudinal Studies, Male, Middle Aged, Time Factors, Tomography, X-Ray Computed, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Development
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review