Cited by 222Muscle Physiology and DisordersNutrition and Health in AgingMuscle metabolism and nutrition

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Decline in isokinetic force with age: muscle cross-sectional area and specific force

Jubrias, S. A., Odderson, I. R., Esselman, Peter C., Conley, Kevin E.·1997·Pfl�gers Archiv European Journal of Physiology

DOI 10.1007/s004240050392

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Abstract

Humans produce less muscle force (F) as they age. However, the relationship between decreased force and muscle cross-sectional area (CSA) in older humans is not well documented. We examined changes in F and CSA to determine the relative contributions of muscle atrophy and specific force (F/CSA) to declining force production in aging humans. The proportions of myosin heavy chain (MHC) isoforms were characterized to assess whether this was related to changes in specific force with age. We measured the peak force of isokinetic knee extension in 57 males and females aged 23-80 years, and used magnetic resonance imaging to determine the contractile area of the quadriceps muscle. Analysis of MHC isoforms taken from biopsies of the vastus lateralis muscle showed no relation to specific force. F, CSA, and F/CSA decreased with age. Smaller CSA accounted for only about half of the 39% drop in force that occurred between ages 65-80 years. Specific force dropped about 1.5% per year in this age range, for a total decrease of 21%. Thus, quantitative changes in muscle (atrophy) are not sufficient to explain the strength loss associated with aging.

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Authors: Jubrias, S. A., Odderson, I. R., Esselman, P. C., & Conley, K. E.
Affiliations: University of Washington Medical Center (US)
ORCID: Esselman, Peter C.
Conley, Kevin E.
Venue: Pfl�gers Archiv European Journal of Physiology
Publisher: Springer Science and Business Media LLC
Published: 1997-06-16
Volume: 434
Issue: 3
Pages: 246-253
ISSN: 0031-6768 (ISSN-L)
1432-2013
DOI: 10.1007/s004240050392
OpenAlex: W2063035273
Cited by: 222
References: 35
Citations by year: 2025: 7 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 7 · 2020: 9 · 2019: 3 · 2018: 11 · 2017: 13 · 2016: 9 · 2015: 8 · 2014: 12 · 2013: 9 · 2012: 8
FWCI: 1.31
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Pflügers Archiv - European Journal of Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5t32hl007503-03, 5r01ag010853-05)
National Institute on Aging (AG-10853)
National Heart, Lung, and Blood Institute (HL-7503)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR41928, R01AR041928)
NIH Clinical Center
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: muscle aging, muscle cross-sectional area, specific force, muscle atrophy, myosin heavy chain isoforms, quadriceps, vastus lateralis, knee extension, strength degradation, sarcopenia
MeSH terms: Adult, Aged, Aged, 80 and over, Aging, Female, Humans, Knee Joint, Magnetic Resonance Imaging, Male, Middle Aged, Muscle Contraction, Muscular Atrophy, Muscle, Skeletal, Muscle Fibers, Skeletal, Myosin Heavy Chains

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Decline in isokinetic force with age: muscle cross-sectional area and specific force

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