Formation of GABAA receptor complexes containing α1 and α5 subunits is paralleling a multiple T-maze learning task in mice

Ghafari, Maryam; Falsafi, Soheil Keihan; Szodorai, Edit; Kim, Eun-Jung; Li, Lin; Höger, Harald; Berger, Johannes; Fuchs, Karoline; Sieghart, Werner; Lubec, Gert

doi:10.1007/s00429-016-1233-x

Cited by 19Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNicotinic Acetylcholine Receptors Study

Formation of GABAA receptor complexes containing α1 and α5 subunits is paralleling a multiple T-maze learning task in mice

Ghafari, Maryam, Falsafi, Soheil Keihan, Szodorai, Edit, Kim, Eun-Jung, Li, Lin, Höger, Harald, Berger, Johannes, Fuchs, Karoline +2 more·2017·Brain Structure and Function

DOI 10.1007/s00429-016-1233-x

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Abstract

There is limited information on the role of GABA type A receptors (GABA A Rs) containing α1, α5 and γ2 subunits in learning and memory. Here, we assessed the possible role of such receptors in spatial learning using the multiple T-maze (MTM) paradigm. C57BL/6J mice were trained in the MTM which induced elevated levels of α1 and α5 subunit-containing hippocampal GABA A R complexes. Moreover, spatial learning evoked a significant increase in the colocalization of α1 and α5 subunits in both, CA1 and dentate gyrus regions of the hippocampus suggesting the formation of complexes containing both subunits. Additionally, the presence of α1, α5 and γ2 subunits in high molecular weight GABA A Rs was detected and significant correlation in the level of α1-containing complexes with those containing α5 and γ2 subunits was demonstrated. Accordingly, α1 deficiency led to decreased levels of γ2 subunit-containing complexes, however, had no effect on α5-containing ones. On the other hand, α1 knockout mice showed impaired performance in the MTM correlating with increased levels of α5 subunit-containing GABA A Rs in comparison to trained floxed control animals which quickly learned the task. Taken together, these results suggest that α1, α5 and γ2-containing hippocampal GABA A R complexes play an essential role in spatial learning and memory in which targeted disruption of the α1 subunit produces profound deficits.

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Training in a spatial memory task leads to increased expression of α5GABAARs in hippocampus.
“Another study showed that training in a spatial memory task leads to increased expression of α5GABAARs in the hippocampus [79]”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [79]

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Authors: Ghafari, M., Falsafi, S. K., Szodorai, E., Kim, E.-J., Li, L., Höger, H., Berger, J., Fuchs, K., Sieghart, W., & Lubec, G.
Affiliations: Medical University of Vienna (AT)
ORCID: Szodorai, Edit
Li, Lin
Berger, Johannes
Sieghart, Werner
Venue: Brain Structure and Function
Publisher: Springer Science and Business Media LLC
Published: 2016-05-07
Volume: 222
Issue: 1
Pages: 549-561
ISSN: 1863-2653 (ISSN-L)
1863-2661
DOI: 10.1007/s00429-016-1233-x
OpenAlex: W2346887701
Cited by: 19
References: 37
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 1
FWCI: 1.69
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Brain Structure and Function (publishedVersion)
PubMed (publishedVersion)
Funders: McLean Hospital
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: GABAA receptor, alpha1 subunit, alpha5 subunit, gamma2 subunit, spatial learning, memory, hippocampus, CA1, dentate gyrus, learning deficits
MeSH terms: Animals, Hippocampus, Male, Mice, Inbred C57BL, Receptors, GABA-A, Mice, Knockout, Maze Learning, Protein Subunits, Mice

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Formation of GABAA receptor complexes containing α1 and α5 subunits is paralleling a multiple T-maze learning task in mice

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