Efficacy and Safety of Emodepside 2.1 %/Praziquantel 8.6% Spot-on Formulation in the Treatment of Feline Aelurostrongylosis
Abstract
The objective of the present study was to evaluate the efficacy and safety of the antiparasitic spot-on formulation containing emodepside 2.1%/praziquantel 8.6% (Profender, Bayer) in the treatment of natural feline infection with the lungworm Aelurostrongylus abstrusus (Nematoda, Strongylida). Efficacy of Profender given once at the licensed dose was tested in comparison to a control oral formulation containing fenbendazole 18.75% (Panacur, Intervet) given over three consecutive days at the licensed dose. Efficacy assessment was based on larvae per gramme of faeces (LPG) counts, measured on days 28 +/- 2 following treatment and compared to counts on days -6 to -2. In total 24 cats treated either with Profender (n = 12) or with Panacur (n = 12) were included in the assessment of efficacy and safety. Mean LPG post-baseline counts (days 28 +/- 2) were 1.3 LPG for both Profender and Panacur, demonstrating similar efficacy of 99.38% for Profender and 99.29% for the control product. No treated animals showed adverse events. This trial demonstrated that both Profender spot-on formulation and oral paste Panacur are safe and effective in the treatment of aelurotrongylosis in cats. Future practical perspectives in feline medicine and the major advantages of the spot-on product compared to the oral paste are discussed.
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Indocile or feral cats refusing oral formulations can be easily treated with the spot-on containing moxidectin or emodepside.
“indocile or feral cats refusing oral formulations can be easily treated with the spot-on containing moxidectin or emodepside [171,172]”
From Pet roundworms and hookworms: A continuing need for global worming (2012) · cites this paper as [172]
Cites
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BackgroundCyclooctadepsipeptides – a new class of anthelmintically active compounds
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Canine and feline cardiopulmonary parasitic nematodes in Europe: emerging and underestimated
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Self-citationPet roundworms and hookworms: A continuing need for global worming
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Self-citation
- Authors
- Traversa, D., Milillo, P., Di Cesare, A., Lohr, B., Iorio, R., Pampurini, F., Schaper, R., Bartolini, R., & Heine, J.
- Affiliations
- University of Teramo (IT)
- Bayer (Italy) (IT)
- Elanco Animal Health (Germany) (DE)
- Corresponding author
- Traversa, Donato
- Venue
- Parasitology Research
- Published
- 2009-06-28
- Volume
- 105
- Issue
- S1
- Pages
- 83-90
- ISSN
- 0044-3255 (ISSN-L)
- 0932-0113
- 1432-1955
- OpenAlex
- W2073515950
- Semantic Scholar
- d86a9aa745e194db7eb651c4e02eb625fea5ea03
- Cited by
- 53
- References
- 15
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2021: 7 · 2020: 2 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 8 · 2014: 4 · 2013: 2 · 2012: 5
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Parasitology Research (publishedVersion)
- PubMed (publishedVersion)
- UniTERAMO Research Catalog (University of Teramo) (submittedVersion)
- Funders
- Bayer Animal Health
- Topics
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Health Sciences › Veterinary › Small Animals › Veterinary Pharmacology and Anesthesia
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Mollusks and Parasites Studies
- Keywords
- emodepside, praziquantel, spot-on formulation, Aelurostrongylus abstrusus, fenbendazole, antiparasitic drug efficacy, drug safety, fecal egg count
- MeSH terms
- Animals, Anthelmintics, Cat Diseases, Cats, Double-Blind Method, Drug Combinations, Feces, Fenbendazole, Larva, Metastrongyloidea, Praziquantel, Treatment Outcome, Strongylida Infections, Depsipeptides
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