Efficacy of Procox® Oral Suspension for Dogs (0.1% Emodepside and 2% Toltrazuril) against Experimental Nematode (Toxocara cati and Ancylostoma tubaeforme) Infections in Cats
Open accessAbstract
Two exploratory studies were performed to determine the optimum therapeutic dose of Procox(®) for the removal of experimental infection with mature adult Toxocara (T.) cati and Ancylostoma (A.) tubaeforme in kittens. Procox(®) is a new oral suspension containing a combination of the nematocidal and coccidiocidal active principles emodepside (0.1 %) and toltrazuril (2 %).In the first study, 18 eight-weeks-old kittens were inoculated with 450 L3 larvae of T. cati. 56 days after infection, the kittens were allocated to three treatment groups and were treated with 0.5 mg emodepside/kg body weight (group 1), 0.25 mg emodepside/kg body weight (group 2) and 0.1 mg emodepside/kg body weight (group 3), respectively. In the second study, 10 eight-weeks-old kittens were inoculated with 350 L3 larvae of A. tubaeforme. Four weeks after infection, the kittens were allocated to two treatment groups and were treated with 0.1 mg emodepside/kg body weight (group 1) or 0.25 mg emodepside/kg body weight (group 2). In both studies, all kittens received a reference treatment with Drontal(®) (230 mg pyrantel embonate and 20 mg praziquantel per tablet) at the recommended dose of one tablet/4 kg body weight 5 days after treatment with Procox(®). Anthelmintic efficacy was calculated by reduction in worm numbers expelled with the faeces following treatment with Procox(®) as compared with faecal worm numbers after reference treatment with Drontal(®), by thus avoiding necropsy of the animals.In the T. cati study, emodepside was at 99.9 %, 100 % and 96.5 % effective at a dosage of 0.5 mg, 0.25 mg and 0.1 mg per kg body weight, respectively. Against A. tubaeforme emodepside was at 95.7 % and 100 % effective at a dosage of 0.1 mg and 0.25 mg per kg body weight. No adverse events were seen during either study.It can be concluded that Procox(®) is efficacious for the control of mature adult T. cati and A. tubaeforme infections in cats at a single-dose rate of 0.25 mg emodepside/kg body weight.
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The oral suspension containing emodepside and toltrazuril has high palatability when administered in cats.
“and high palatability when administered in cats [144]”
From Pet roundworms and hookworms: A continuing need for global worming (2012) · cites this paper as [144]
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Pet roundworms and hookworms: A continuing need for global worming
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- Authors
- Petry, G., Kruedewagen, E., Bach, T., Gasda, N., & Krieger, K. J.
- Affiliations
- Elanco Animal Health (Germany) (DE)
- Corresponding author
- Petry, Gabriele
- Venue
- Parasitology Research
- Published
- 2011-07-08
- Volume
- 109
- Issue
- S1
- Pages
- 37-43
- ISSN
- 0044-3255 (ISSN-L)
- 0932-0113
- 1432-1955
- OpenAlex
- W2079467226
- Cited by
- 14
- References
- 19
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2017: 1 · 2016: 2 · 2013: 3 · 2012: 4
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Parasitology Research (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Health Sciences › Medicine › Pathology and Forensic Medicine › Parasitic infections in humans and animals
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Keywords
- emodepside, toltrazuril, Toxocara cati, Ancylostoma tubaeforme, anthelmintic efficacy, dose optimization, kittens, pyrantel embonate, praziquantel, fecal egg count, experimental infection, coccidiosis
- MeSH terms
- Administration, Oral, Ancylostoma, Ancylostomiasis, Animals, Antinematodal Agents, Cat Diseases, Cats, Drug Combinations, Drug Evaluation, Larva, Parasite Egg Count, Toxocara, Toxocariasis, Triazines, Depsipeptides
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