The DOI matches its Crossref record; 126 of the 127 references it cites were found in a registry or an index.
Genetics of human aggressive behaviour
Abstract
A consideration of the evolutionary, physiological and anthropological aspects of aggression suggests that individual differences in such behaviour will have important genetic as well as environmental underpinning. Surveys of the likely pathways controlling the physiological and neuronal processes involved highlight, as obvious targets to investigate, genes implicated in sexual differentiation, anxiety, stress response and the serotonin neurotransmitter pathway. To date, however, association studies on single candidates have provided little evidence for any such loci with a major effect size. This may be because genes do not operate independently, but function against a background in which other genetic and environmental factors are crucial. Indeed, a series of recent studies, particularly concentrating on the serotonin and norepinephrine metabolising enzyme, monoamine oxidase A, has emphasised the necessity of examining gene by environmental interactions if the contributions of individual loci are to be understood. These findings will have major significance for the interpretation and analysis of data from detailed whole genome association studies. Functional imaging studies of genetic variants affecting serotonin pathways have also provided valuable insights into potential links between genes, brain and aggressive behaviour.
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“This includes a polymorphism in the promoter of the monoamine oxidase A (MAOA) gene, an important locus widely associated with pathological forms of aggression which, in humans, manifests in a broad spectrum of psychiatric conditions, such as manic and bipolar disorders and schizophrenia, among others [17, 18].”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [17]
In the citing paper
“The PFC role in aggression has been studied in different species, e.g. PFC lesions result in impulsive and antisocial behaviors in humans [23] and offensive aggression in rodents [17].”
From Gene expression profiles underlying aggressive behavior in the prefrontal cortex of cattle (2021) · cites this paper as [17]
Citations
Cites
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Role of genotype in the cycle of violence in maltreated children
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1 of the 127 references couldn’t be matched to a known paper.
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- Turner (1994) Genetic and hormonal influence on male violence. In: Archer J (ed) Male violence. Routledge, New York, pp 233–252
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Items 201–213 of 213
Aggressive Verhaltensstörungen
Schmeck, K., & Stadler, C. (2012) · PSYCH up2date · doi:10.1055/s-0032-1327239
Benefits for Aggression in Humans
Rook, S. M., & Iyer‐Eimerbrink, P. A. (2022) · Springer eBooks · doi:10.1007/978-3-319-55065-7_2115
Downes, S. M., & Tabery, J. G. (2021) · Springer eBooks · doi:10.1007/978-3-319-19650-3_1668
Genetics of Brain Structure and Function
Fountoulakis, K. N. (2022) · Springer eBooks · doi:10.1007/978-3-031-10351-3_18
โมเดลเชงสาเหตของความกาวราวและการศกษาคลนสมองของผทกระทำผดซำและคนปกต
อินทหมื่น, น., ไชยวุฒิกรณ์วานิช, อ., & ศิริพรพาณิชย์, ว. (2019) · doi:10.58837/chula.the.2019.766
de Antioquia, U., Valencia, M., Delgado, L. C., Universidad, C. E. S., Noriega, I., Al‐Khalil, K., Trejos‐Castillo, E., O’Boyle, M. W., Villanueva-Bonilla, C., Surcolombiana, U., et al. (2023) · Editorial Universidad Santiago de Cali eBooks · doi:10.35985/9786287604421 · Cited by 6
Javeriana, P. U., Mejía, Ó. M. A., Rodríguez, D. A. L., Javeriana, P. U., Martínez, A. M. M., & Javeriana, P. U. (2023) · Editorial Universidad Santiago de Cali eBooks · doi:10.35985/9786287604421.8
Behavioral variation changes across an urbanization gradient in a population of great titsPreprint
Gervais, L., Thompson, M., de Villemereuil, P., Burkhard, T. T., Teplitsky, C., Class, B., Réale, D. J. F., & Charmantier, A. (2024) · doi:10.32942/x2kw4c
The Impact of OXTR, HTR2A, and AR Gene Polymorphisms on Aggressive Behavior in Armenian Students
Proshakov, P. A., Куликов, А. М., Mkrtchyan, R., Revyakinaa, L. A., Butovskaya, M., & Lazebny, O. E. (2025) · Adaptive Human Behavior and Physiology · doi:10.1007/s40750-025-00262-9
Eusebi, P. G., Sevane, N., ́Rourke, T. O., Pizarro, M., Boeckx, C. A., & Dunner, S. (2021) · Figshare · doi:10.6084/m9.figshare.14385600
Ehrenhofer‐Murray, A. E. (2025) · Springer eBooks · doi:10.1007/978-3-662-70328-1_15
Aggression aus psychologischer Sicht
Altenmüller, M. S., Fischer, M. V., & Gollwitzer, M. (2026) · Springer eBooks · doi:10.1007/978-3-658-48132-2_16
Metadata
- Authors
- Craig, I. W., & Halton, K. E.
- Affiliations
- King's College London (GB)
- Corresponding author
- Craig, Ian W.
- Halton, Kelly E.
- ORCID
- Craig, Ian W.
- Venue
- Human Genetics
- Published
- 2009-06-09
- Volume
- 126
- Issue
- 1
- Pages
- 101-113
- ISSN
- 0018-7348 (ISSN-L)
- 0340-6717
- 1432-1203
- OpenAlex
- W2158647822
- Cited by
- 213
- References
- 127
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 14 · 2020: 29 · 2019: 8 · 2018: 16 · 2017: 9 · 2016: 8 · 2015: 25 · 2014: 17 · 2013: 14 · 2012: 31
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- aggression, sexual differentiation, anxiety, stress response, serotonin pathway, monoamine oxidase A, norepinephrine, gene-environment interaction, individual differences, whole-genome association studies
- MeSH terms
- Adolescent, Aggression, Alleles, Catechol O-Methyltransferase, Child, Dopamine beta-Hydroxylase, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Monoamine Oxidase, Pituitary-Adrenal System, Polymorphism, Genetic, Receptors, Androgen, Serotonin, Sex Factors, Stress, Psychological, Testosterone, Genetic Variation, Meta-Analysis as Topic, Tandem Repeat Sequences, Chromosomes, Human, Y, Epigenesis, Genetic, Serotonin Plasma Membrane Transport Proteins, Nitric Oxide Synthase Type I, Genome-Wide Association Study, Young Adult
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