Cited by 213Neurotransmitter Receptor Influence on BehaviorPsychopathy, Forensic Psychiatry, Sexual OffendingGenetic Associations and Epidemiology

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Genetics of human aggressive behaviour

Craig, Ian W., Halton, Kelly E.·2009·Human Genetics

DOI 10.1007/s00439-009-0695-9

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Abstract

A consideration of the evolutionary, physiological and anthropological aspects of aggression suggests that individual differences in such behaviour will have important genetic as well as environmental underpinning. Surveys of the likely pathways controlling the physiological and neuronal processes involved highlight, as obvious targets to investigate, genes implicated in sexual differentiation, anxiety, stress response and the serotonin neurotransmitter pathway. To date, however, association studies on single candidates have provided little evidence for any such loci with a major effect size. This may be because genes do not operate independently, but function against a background in which other genetic and environmental factors are crucial. Indeed, a series of recent studies, particularly concentrating on the serotonin and norepinephrine metabolising enzyme, monoamine oxidase A, has emphasised the necessity of examining gene by environmental interactions if the contributions of individual loci are to be understood. These findings will have major significance for the interpretation and analysis of data from detailed whole genome association studies. Functional imaging studies of genetic variants affecting serotonin pathways have also provided valuable insights into potential links between genes, brain and aggressive behaviour.

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Authors: Craig, I. W., & Halton, K. E.
Affiliations: King's College London (GB)
Corresponding author: Craig, Ian W.
Halton, Kelly E.
ORCID: Craig, Ian W.
Venue: Human Genetics
Publisher: Springer Science and Business Media LLC
Published: 2009-06-09
Volume: 126
Issue: 1
Pages: 101-113
ISSN: 0018-7348 (ISSN-L)
0340-6717
1432-1203
DOI: 10.1007/s00439-009-0695-9
OpenAlex: W2158647822
Cited by: 213
References: 127
Citations by year: 2026: 1 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 14 · 2020: 29 · 2019: 8 · 2018: 16 · 2017: 9 · 2016: 8 · 2015: 25 · 2014: 17 · 2013: 14 · 2012: 31
FWCI: 1.58
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Human Genetics (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: aggression, sexual differentiation, anxiety, stress response, serotonin pathway, monoamine oxidase A, norepinephrine, gene-environment interaction, individual differences, whole-genome association studies
MeSH terms: Adolescent, Aggression, Alleles, Catechol O-Methyltransferase, Child, Dopamine beta-Hydroxylase, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Monoamine Oxidase, Pituitary-Adrenal System, Polymorphism, Genetic, Receptors, Androgen, Serotonin, Sex Factors, Stress, Psychological, Testosterone, Genetic Variation, Meta-Analysis as Topic, Tandem Repeat Sequences, Chromosomes, Human, Y, Epigenesis, Genetic, Serotonin Plasma Membrane Transport Proteins, Nitric Oxide Synthase Type I, Genome-Wide Association Study, Young Adult

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