Environmental exposure and mitochondrial epigenetics: study design and analytical challenges
Open accessAbstract
The environment can influence human health and disease in many harmful ways. Many epidemiological studies have been conducted with the aim of elucidating the association between environmental exposure and human disease at the molecular and pathological levels, and such associations can often be through induced epigenetic changes. One such mechanism for this is through environmental factors increasing oxidative stress in the cell, and this stress can subsequently lead to alterations in DNA molecules. The two cellular organelles that contain DNA are the nucleus and mitochondria, and the latter are particularly sensitive to oxidative stress, with mitochondrial functions often disrupted by increased stress. There has been a substantial increase over the past decade in the number of epigenetic studies investigating the impact of environmental exposures upon genomic DNA, but to date there has been insufficient attention paid to the impact upon mitochondrial epigenetics in studying human disease with exposure to environment. Here, in this review, we will discuss mitochondrial epigenetics with regard to epidemiological studies, with particular consideration given to study design and analytical challenges. Furthermore, we suggest future directions and perspectives in the field of mitochondrial epigenetic epidemiological studies.
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- Authors
- Byun, H.-M., & Baccarelli, A. A.
- Affiliations
- Harvard University (US)
- Corresponding author
- Byun, Hyang-Min
- Venue
- Human Genetics
- Published
- 2014-01-09
- Volume
- 133
- Issue
- 3
- Pages
- 247-257
- ISSN
- 0018-7348 (ISSN-L)
- 0340-6717
- 1432-1203
- PMC
- PMC4351743
- OpenAlex
- W2093726653
- Cited by
- 68
- References
- 86
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 2
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- National Institute of Environmental Health Sciences (R21ES022694, R01ES021733)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- mitochondrial epigenetics, environmental exposure, oxidative stress, DNA methylation, mitochondrial DNA, research design, analytical challenges, environmental epidemiology, human disease
- MeSH terms
- Cell Nucleus, DNA, Mitochondrial, Environmental Exposure, Humans, Mitochondria, Genome, Human, Epidemiologic Studies, DNA Methylation, Epigenesis, Genetic, Gene-Environment Interaction
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