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Alternative splicing in aging and longevity
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“Likewise, the observed decline in transcriptional and posttranscriptional efficiency and fidelity in the course of aging, and its negative consequences on the proteome health may also open new opportunities for prolongevity strategies 76 .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [76]
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“Aging causes an increase of the transcriptional noise and an aberrant production and maturation of many mRNAs 75,76 .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [76]
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Alternative isoform regulation in human tissue transcriptomes
Wang, E. T., Sandberg, R., Luo, S., Khrebtukova, I., Zhang, L., Mayr, C., Kingsmore, S. F., Schroth, G. P., & Burge, C. B. (2008) · Nature · doi:10.1038/nature07509 · Cited by 5,181
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Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.039 · Cited by 2,764
Context-dependent control of alternative splicing by RNA-binding proteins
Fu, X.-D., & Ares, M. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3778 · Cited by 1,044
p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
Fujita, K., Mondal, A. M., Horikawa, I., Nguyen, G. H., Kumamoto, K., Sohn, J. J., Bowman, E. D., Mathe, E. A., Schetter, A. J., Pine, S. R., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1928 · Cited by 336
Analysis of alternative splicing associated with aging and neurodegeneration in the human brain
Tollervey, J. R., Wang, Z., Hortobágyi, T., Witten, J. T., Zarnack, K., Kayikci, M., Clark, T. A., Schweitzer, A. C., Rot, G., Curk, T., et al. (2011) · Genome Research · doi:10.1101/gr.122226.111 · Cited by 252
Widespread splicing changes in human brain development and aging
Mazin, P., Xiong, J., Liu, X., Yan, Z., Zhang, X., Li, M., He, L., Somel, M., Yuan, Y., Phoebe Chen, Y., et al. (2013) · Molecular Systems Biology · doi:10.1038/msb.2012.67 · Cited by 216
Swindell, W. R. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-585 · Cited by 171
Tang, Y., Horikawa, I., Ajiro, M., Robles, A. I., Fujita, K., Mondal, A. M., Stauffer, J. K., Zheng, Z.-M., & Harris, C. C. (2013) · Oncogene · doi:10.1038/onc.2012.288 · Cited by 165
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Cited by
Sorted by citations
Hallmarks of aging: An expanding universe
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549
Proteomics in aging research: A roadmap to clinical, translational research
Moaddel, R., Ubaida‐Mohien, C., Tanaka, T., Lyashkov, A., Basisty, N., Schilling, B., Semba, R. D., Franceschi, C., Gorospe, M., & Ferrucci, L. (2021) · Aging Cell · doi:10.1111/acel.13325 · Cited by 139
Metadata
- Authors
- Bhadra, M., Howell, P., Dutta, S., Heintz, C., & Mair, W. B.
- ORCID
- Mair, William B.
- Venue
- Human Genetics
- Published
- 2019-12-13
- Volume
- 139
- Issue
- 3
- Pages
- 357-369
- ISSN
- 0340-6717
- 1432-1203
- PMC
- PMC8176884
- Cited by
- 205
- References
- 9
- Language
- en
- Funders
- National Institute on Aging (R01AG051954)
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