Oxytocin is expressed by both intrinsic sensory and secretomotor neurons in the enteric nervous system of guinea pig
Abstract
Single- and double-immunostaining techniques were used systematically to study the distribution pattern and neurochemical density of oxytocin-immunoreactive (-ir) neurons in the digestive tract of the guinea pig. Oxytocin immunoreactivity was distributed widely in the guinea pig gastrointestinal tract; 3%, 13%, 17%, 15%, and 10% of ganglion neurons were immunoreactive for oxytocin in the myenteric plexuses of the gastric corpus, jejunum, ileum, proximal colon, and distal colon, respectively, and 36%, 40%, 52%, and 56% of ganglion neurons were immunoreactive for oxytocin in the submucosal plexuses of the jejunum, ileum, proximal colon, and distal colon, respectively. In the myenteric plexus, oxytocin was expressed exclusively in the intrinsic enteric afferent neurons, as identified by calbindin 28 K. In the submucosal plexuses, oxytocin was expressed in non-cholinergic secretomotor neurons, as identified by vasoactive intestinal polypeptide. Oxytocin-ir nerve fibers in the inner circular muscle layer possibly arose from the myenteric oxytocin-ir neurons, and oxytocin-ir nerve fibers in the mucosa possibly arose from both the myenteric and submucosal oxytocin-ir neurons. Thus, oxytocin in the digestive tract might be involved in gastrointestinal tract motility mainly via the regulation of the inner circular muscle and the balance of the absorption and secretion of water and electrolytes.
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One potential pathway involves the effects of alterations in brain oxytocin on visceral functioning, particularly the vagus, leading to an increase in peripheral oxytocin levels.
“One potential pathway involves the effects of alterations in brain OT on visceral functioning, particularly the vagus, which lead to an increase in peripheral OT levels (57).”
From Oxytocin administration to parent enhances infant physiological and behavioral readiness for social engagement (2012) · cites this paper as [57]
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- Authors
- Yu, Q., Ji, R., Gao, X., Fu, J., Guo, W., Song, X., Zhao, X., Burnstock, G., Shi, X., He, C., & Xiang, Z.
- Affiliations
- Second Military Medical University (CN)
- The Royal Free Hospital (GB)
- Corresponding author
- Xiang, Zhenghua
- ORCID
- Venue
- Cell and Tissue Research
- Published
- 2011-03-26
- Volume
- 344
- Issue
- 2
- Pages
- 227-237
- ISSN
- 0302-766X (ISSN-L)
- 1432-0878
- OpenAlex
- W1998064393
- Cited by
- 24
- References
- 18
- Citations by year
- 2026: 2 · 2024: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell and Tissue Research (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- oxytocin, enteric nervous system, secretomotor neurons, myenteric plexus, submucosal plexus, vasoactive intestinal peptide, gastrointestinal motility
- MeSH terms
- Animals, Guinea Pigs, Humans, Immunohistochemistry, Motor Neurons, Oxytocin, Sensory Receptor Cells, Enteric Nervous System, Gastrointestinal Tract, Mice, Rats
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