Oxytocin increases thresholds of colonic visceral perception in patients with irritable bowel syndrome.
Open accessAbstract
AIM: The effects of oxytocin on colonic perception of intraluminal distension were evaluated in 26 patients with irritable bowel syndrome (IBS), using a flaccid bag placed in the descending colon and connected to a computerised barostat. METHOD: Symptomatic responses (first sensation and pain) were evaluated during isobaric distensions (4 mm Hg increments, five minute duration, five minute interval with return to zero pressure between each step), performed automatically by the barostat, during a continuous infusion of placebo or various doses of oxytocin (10, 20, 30, and 50 mU/min). RESULTS: The distension pressure (mean (SD)) required to induce a first abdominal sensation was 17.3 (5.5) mm Hg on placebo, 19.9 (5.8) on oxytocin 10 mU/min (NS), 22.3 (6.0) mm Hg on oxytocin 20 mU/min (p < 0.01), 23.1 (6.6) mm Hg on oxytocin 30 mU/min (p < 0.01), and 24.0 (7.1) mm Hg on oxytocin 50 mU/min (p < 0.01). The distension pressure required to induce pain was 24.8 (6.3) mm Hg on placebo, 26.0 (5.8) on oxytocin 10 mU/min (NS), 33.3 (7.8) mm Hg on oxytocin 20 mU/min (p < 0.01), 34.2 (7.6) mm Hg on oxytocin 30 mU/min (p < 0.01), and 34.3 (7.9) mm Hg on oxytocin 50 mU/ min (p < 0.01). Compliance curves were not different after placebo and oxytocin injection at the different doses. Naloxone did not inhibit the effect of oxytocin. Oxytocin also did not alter somatic perception, characterised by the RIII reflex at the level of the biceps femori. CONCLUSIONS: Oxytocin significantly increases thresholds for visceral perception in IBS patients at doses equal or to greater than 20 mU/min, possibly by acting at the level of visceral afferents.
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An i.v. oxytocin infusion decreased colonic visceral perception in patients with irritable bowel syndrome.
“and that an i.v. oxytocin infusion decreased colonic visceral perception in patients with irritable bowel syndrome 20.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [20]
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- Authors
- Louvel, D., Delvaux, M., Felez, A., Fioramonti, J., Bueno, L., Lazorthes, Y., & Frexinos, J.
- Affiliations
- Hôpital Rangueil (FR)
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1996-11-01
- Volume
- 39
- Issue
- 5
- Pages
- 741-747
- ISSN
- 0017-5749 (ISSN-L)
- PMC
- PMC1383401
- OpenAlex
- W2165039155
- Cited by
- 113
- References
- 41
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 9 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 10 · 2017: 8 · 2016: 4 · 2015: 3 · 2014: 9 · 2013: 2 · 2012: 1
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, irritable bowel syndrome, descending colon, barostat, naloxone, RIII reflex, somatic sensation, visceral hypersensitivity, smooth muscle relaxation, gastrointestinal motility, visceral afferents, descending pain modulation, dose-response relationship, intravenous infusion
- MeSH terms
- Adult, Colon, Colonic Diseases, Functional, Dose-Response Relationship, Drug, Electric Stimulation, Female, Humans, Infusions, Intravenous, Male, Middle Aged, Naloxone, Narcotic Antagonists, Oxytocin, Perception, Pressure, Reflex, Pain Threshold
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