Ultrastructural and lanthanum tracer examination of rapidly resorbing rat alveolar bone suggests that osteoclasts internalize dying bone cells
Abstract
Glutaraldehyde-formaldehyde fixed undecalcified alveolar bone from 7-day-old rats was prepared for light and electron microscopy. Colloidal lanthanum was used as an ultrastructural tracer, and both random and semi-serial sections were examined. Lanthanum penetrated the infoldings of the ruffled border and some nearby vacuoles and vesicles. The majority of vacuoles and vesicles were lanthanum-free. Some osteoclast profiles contained a large vacuole with a cell enclosed in its interior. The enclosed cell exhibited an irregular nucleus containing condensed peripheral chromatin, intact cytoplasmic organelles, conspicuous rough endoplasmic reticulum and large blebs on the cell surface. These features are characteristic of osteoblasts or bone-lining cells or immature osteocytes which may be undergoing apoptosis or necrosis. The observation of remnants of cellular structures within internalized osteoclast vacuoles, together with the above results, suggests that osteoclasts engulf and probably degrade dying osteoblasts/bone-lining cells or immature osteocytes.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Osteoclasts are able to remove dying osteocytes and/or osteoblasts from a remodeling site.
“Accordingly, it has been reported that osteoclasts engulf apoptotic osteocytes [74, 75, 192], suggesting that osteoclasts are able to remove dying osteocytes and/or osteoblasts from a remodeling site (Figures 4(c) and 4(d)).”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [192]
Osteoclasts engulf apoptotic osteocytes.
“Accordingly, it has been reported that osteoclasts engulf apoptotic osteocytes [74, 75, 192], suggesting that osteoclasts are able to remove dying osteocytes and/or osteoblasts from a remodeling site (Figures 4(c) and 4(d)).”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [192]
Cites
Apoptosis, oncosis, and necrosis. An overview of cell death.
Majno, G., & Joris, I. (1995) · PubMed · Cited by 3,328 · see citing works
Professional and non-professional phagocytes: an introduction
Rabinovitch, M. (1995) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)88955-2 · Cited by 548 · see citing works
The pathobiology of the osteoclast.
Chambers, T. J. (1985) · Journal of Clinical Pathology · doi:10.1136/jcp.38.3.241 · Cited by 275 · see citing works
Athanasou, N. A., & Quinn, J. (1990) · Journal of Clinical Pathology · doi:10.1136/jcp.43.12.997 · Cited by 182 · see citing works
Electron microscopic localization of hydrolytic enzymes in osteoclasts
Doty, S. B., & Schofield, B. (1972) · The Histochemical Journal · doi:10.1007/bf01890996 · Cited by 118 · see citing works
Some morphological observations on osteoclasts
Jones, S. J., & BOYDE, A. (1977) · Cell and Tissue Research · doi:10.1007/bf00220298 · Cited by 90 · see citing works
Elmardi, A. S., Katchburian, M., & Katchburian, E. (1990) · Calcified Tissue International · doi:10.1007/bf02555002 · Cited by 69 · see citing works
Self-citationStudies on the development of ameloblasts: I. fine structure
Katchburian, E., & Holt, S. J. (1972) · Journal of Cell Science · doi:10.1242/jcs.11.2.415 · Cited by 66 · see citing works
Self-citationCytoplasmic vacuoles and bodies of the osteoclast
Lucht, U. (1972) · Cell and Tissue Research · doi:10.1007/bf00315128 · Cited by 60 · see citing works
Cellular and Molecular Mechanisms in the Regulation and Function of Osteoclasts
Chambers, T. J., & Hall, T. J. (1991) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60682-2 · Cited by 57 · see citing works
Absorption of peroxidase by osteoclasts as studied by electron microscope histochemistry
Lucht, U. (1972) · Histochemie · doi:10.1007/bf00279810 · Cited by 56 · see citing works
Nijweide, P. J., Vrijheid-Lammers, T., Mulder, R. J. P., & Blok, J. (1985) · Histochemistry · doi:10.1007/bf00684377 · Cited by 56 · see citing works
Effects of parathyroid hormone on osteoclasts in vivo
Lucht, U., & Maunsbach, A. B. (1973) · Cell and Tissue Research · doi:10.1007/bf00307123 · Cited by 40 · see citing works
Lack of Fc receptors on osteoclasts
Hogg, N., Shapiro, I. M., Jones, S. J., Slusarenko, M., & BOYDE, A. (1980) · Cell and Tissue Research · doi:10.1007/bf00236514 · Cited by 38 · see citing works
Endocytosis in Odontoclasts and Osteoclasts Using Microperoxidase as a Tracer
Tanaka, T., Morioka, T., AYASAKA, N., Jima, T., & Kondo, T. (1990) · Journal of Dental Research · doi:10.1177/00220345900690031101 · Cited by 35 · see citing works
Phagocytosis of osteocytes by osteoclasts in femora of two week-old rabbits
Soskolne, W. A. (1978) · Cell and Tissue Research · doi:10.1007/bf00233897 · Cited by 17 · see citing works
Tanaka, T., & Tanaka, M. (1988) · Calcified Tissue International · doi:10.1007/bf02553754 · Cited by 15 · see citing works
Uptake of peroxidase by calcitonin inhibited osteoclasts
Lucht, U., & N�rgaard, J. O. R. (1977) · Histochemistry and Cell Biology · doi:10.1007/bf00489672 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044 · see citing works
Osteoclast Ruffled Border Has Distinct Subdomains for Secretion and Degraded Matrix Uptake
Mulari, M. T. K., Zhao, H., Lakkakorpi, P. T., & Väänänen, H. K. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.40206.x · Cited by 140 · see citing works
Ahmadzadeh, K., Vanoppen, M., Rosé, C. D., Matthys, P., & Wouters, C. H. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.873226 · Cited by 119 · see citing works
Xu, J., Feng, H. T., Wang, C., Yip, K. H. M., Pavlos, N. J., Papadimitriou, J. M., Wood, D., & Zheng, M. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10477 · Cited by 97 · see citing works
Cerri, P. S., Boabaid, F., & Katchburian, E. (2003) · Journal of Periodontal Research · doi:10.1034/j.1600-0765.2003.02006.x · Cited by 57 · see citing works
Self-citationApoptotic bone cells may be engulfed by osteoclasts during alveolar bone resorption in young rats
Boabaid, F., Cerri, P. S., & Katchburian, E. (2001) · Tissue and Cell · doi:10.1054/tice.2001.0179 · Cited by 53 · see citing works
Self-citationOsteoblasts engulf apoptotic bodies during alveolar bone formation in the rat maxilla
Cerri, P. S. (2005) · The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology · doi:10.1002/ar.a.20220 · Cited by 45 · see citing works
Decrease in the number and apoptosis of alveolar bone osteoclasts in estrogen‐treated rats
Faloni, A. P. S., Sasso‐Cerri, E., Katchburian, E., & Cerri, P. S. (2007) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2006.00932.x · Cited by 40 · see citing works
Self-citationAnalysis of three separate probes suggests the absence of endocytosis in Neurospora crassa hyphae
Torralba, S., & Heath, I. B. (2002) · Fungal Genetics and Biology · doi:10.1016/s1087-1845(02)00513-3 · Cited by 38 · see citing works
Suzuki, R., Domon, T., & Wakita, M. (2000) · Anatomy and Embryology · doi:10.1007/s004290000101 · Cited by 25 · see citing works
Suzuki, R., Domon, T., Wakita, M., & Akisaka, T. (2003) · Tissue and Cell · doi:10.1016/s0040-8166(03)00020-x · Cited by 13 · see citing works
Apoptosis in the regenerate produced by mandibular osteodistraction in the mature rat*
Liu, Z., Anderson, M., Gu, G., & King, G. (2005) · Orthodontics and Craniofacial Research · doi:10.1111/j.1601-6343.2004.00310.x · Cited by 10 · see citing works
Suzuki, R. (2005) · Journal of Oral Biosciences · doi:10.1016/s1349-0079(05)80026-x · Cited by 1 · see citing works
Adams, C. S., & Horton, W. E. (2001) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(01)06010-2
Modelação matemática para avaliar o risco de fratura por desmineralização óssea
Teixeira, D. J. S. (2014) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Phagocytic osteoclasts in the alveolar bone of diabetic rats with periodontitis
Bak, E., Kim, A. R., Kim, J., & Yoo, Y. (2020) · International Journal of Oral Biology · doi:10.11620/ijob.2020.45.3.92
- Authors
- Taniwaki, N. N., & Katchburian, E.
- Affiliations
- Instituto Adolfo Lutz (BR)
- Universidade Federal de São Paulo (BR)
- ORCID
- Taniwaki, N. N.
- Venue
- Cell and Tissue Research
- Published
- 1998-06-24
- Volume
- 293
- Issue
- 1
- Pages
- 173-176
- ISSN
- 0302-766X (ISSN-L)
- 1432-0878
- OpenAlex
- W2095402053
- Cited by
- 17
- References
- 18
- Citations by year
- 2022: 1 · 2020: 1 · 2019: 1 · 2015: 1 · 2014: 1
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell and Tissue Research (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
- Keywords
- osteoclasts, alveolar bone loss, lanthanum tracer, ruffled border, apoptosis, necrosis, osteoblasts, bone lining cells, ultrastructure, rats
- MeSH terms
- Animals, Bone Resorption, Colloids, Endocytosis, Lanthanum, Microscopy, Electron, Osteoclasts, Phagocytosis, Cell Death, Rats, Wistar, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
