Combined TUNEL and TRAP methods suggest that apoptotic bone cells are inside vacuoles of alveolar bone osteoclasts in young rats
Abstract
Although it is generally accepted that osteoclasts breakdown and resorb bone matrix, the possibility that they may also be able to engulf apoptotic osteoblasts/lining cells and/or osteocytes remains controversial. Apoptosis of osteoblasts/ lining cells and/or osteocytes and interactions between these cells and osteoclasts are extremely rapid events that are difficult to observe in vivo. A suitable in vivo model for studying these events is the alveolar bone of young rats because it is continuously undergoing intense resorption/remodeling. Thus, sections of aldehyde fixed alveolar bone of young rats were stained by the combined terminal deoxynucleotidyl transferase‐mediated dUTP nick end labeling (TUNEL) method and the tartrate‐resistant acid phosphatase (TRAP) method for the simultaneous visualization of apoptotic cells and osteoclasts in the same section. The combined TUNEL and TRAP reactions, in the same section, greatly facilitated visualization of relationship between osteoclasts and apoptotic bone cells during alveolar bone remodeling. Our results showed that several TRAP‐positive osteoclasts exhibited large vacuoles containing TUNEL positive apoptotic structures, probably derived from osteoblasts/lining cells and/or osteocytes. These results support the idea that alveolar bone osteoclasts are able to internalize dying apoptotic bone cells.
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During bone resorption, apoptotic osteocytes are engulfed by osteoclasts.
“In agreement, it has been shown that during bone resorption, apoptotic osteocytes are engulfed by osteoclasts [74–76].”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [75]
Osteoclasts engulf apoptotic osteocytes.
“Accordingly, it has been reported that osteoclasts engulf apoptotic osteocytes [74, 75, 192], suggesting that osteoclasts are able to remove dying osteocytes and/or osteoblasts from a remodeling site (Figures 4(c) and 4(d)).”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [75]
Osteoclasts are able to remove dying osteocytes and/or osteoblasts from a remodeling site.
“Accordingly, it has been reported that osteoclasts engulf apoptotic osteocytes [74, 75, 192], suggesting that osteoclasts are able to remove dying osteocytes and/or osteoblasts from a remodeling site (Figures 4(c) and 4(d)).”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [75]
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- Authors
- Cerri, P. S., Boabaid, F., & Katchburian, E.
- Affiliations
- Universidade Estadual Paulista (Unesp) (BR)
- Universidade Federal de São Paulo (BR)
- Corresponding author
- Katchburian, E.
- ORCID
- Cerri, P. S.
- Venue
- Journal of Periodontal Research
- Publisher
- Wiley
- Published
- 2003-02-28
- Volume
- 38
- Issue
- 2
- Pages
- 223-226
- ISSN
- 0022-3484 (ISSN-L)
- 1600-0765
- OpenAlex
- W2040948512
- Cited by
- 57
- References
- 24
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 4 · 2012: 4
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Periodontal Research (publishedVersion)
- PubMed (publishedVersion)
- Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
- UNESP Institutional Repository (São Paulo State University) (submittedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- osteoclasts, apoptosis, alveolar bone, bone remodeling, osteoblasts, osteocytes, vacuoles, TUNEL, traps, bone resorption
- MeSH terms
- Tartrate-Resistant Acid Phosphatase, Acid Phosphatase, Alveolar Process, Animals, Bone Resorption, Coloring Agents, Isoenzymes, Osteoblasts, Osteoclasts, Osteocytes, Phagocytosis, Vacuoles, Biomarkers, Bone Remodeling, Rats, Wistar, Apoptosis, In Situ Nick-End Labeling, Rats
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