Neuronal apoptosis at the G1/S cell cycle checkpoint
Abstract
Apoptosis is a fundamental and essential process in development and tissue homeostasis of multicellular organisms. Roughly half of all the neurons produced during neurogenesis die apoptotically before the nervous system matures. Apoptosis is also involved in various neurodegenerative disorders such as Alzheimer's disease and neuronal trauma. Investigation of the mechanisms underlying neuronal apoptosis led to an unexpected discovery that in many cases revival of the quiescent and dormant cell cycle machinery is a common theme. Recent data suggest that uncoordinated expression of cell cycle molecules and the consequent breach of cell cycle checkpoints could be one of the primary mechanisms by which postmitotic neurons undergo apoptotic death. Evidence indicates that upregulation of cyclin-D-CDK4/6 activity and deregulation of E2F transcription factors mark key events in early stages of neuronal apoptosis. Active E2F repression by Rb family members is required for the survival of neurons. Apoptotic signals promote successive phosphorylation and dysfunction of Rb family members, resulting in sequential E2F derepression and expression of selective E2F-responsive genes. Thus, expression of derepressed E2F-responsive genes may be instrumental in propagating and amplifying the apoptotic signals instructing neuronal cells to carry out the apoptotic program.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A cell cycle regulatory failure occurs in lymphocytes as it was observed in neurons.
“Nevertheless, despite these several defence mechanisms, authors showed a cell cycle regulatory failure in lymphocytes as it was observed in neurons [130–132, 168, 169].”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [130]
Cites
The Cellular Effects of E2F Overexpression
Adams, P. D., & Kaelin, W. G. (1996) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-79910-5_4 · Cited by 113 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works
Effect of single wall carbon nanotubes on human HEK293 cells
Cui, D., Tian, F., Ozkan, C. S., Wang, M., & Gao, H. (2004) · Toxicology Letters · doi:10.1016/j.toxlet.2004.08.015 · Cited by 825 · see citing works
Taupin, P. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.08.002 · Cited by 645 · see citing works
Giovanni, S. D., Movsesyan, V. A., Ahmed, F. A. K. M., Černak, I., Schinelli, S., Stoica, B. A., & Faden, A. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500989102 · Cited by 380 · see citing works
Staropoli, J. F., McDermott, C., Martinat, C., Schulman, B. A., Demireva, E. Y., & Abeliovich, A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00084-9 · Cited by 378 · see citing works
Cell Cycle Activation Linked to Neuronal Cell Death Initiated by DNA Damage
Kruman, I. I., Wersto, R. P., Cardozo‐Pelaez, F., Smilenov, L. B., Chan, S. L., Chrest, F. J., Emokpae, R., Gorospe, M., & Mattson, M. P. (2004) · Neuron · doi:10.1016/s0896-6273(04)00017-0 · Cited by 365 · see citing works
Cell cycle regulation of neuronal apoptosis in development and disease
Becker, E. B. E., & Bonni, A. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.12.005 · Cited by 300 · see citing works
Cdc2 Phosphorylation of BAD Links the Cell Cycle to the Cell Death Machinery
Konishi, Y., Lehtinen, M. K., Donovan, N., & Bonni, A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00524-5 · Cited by 288 · see citing works
Complement: a novel factor in basal and ischemia‐induced neurogenesis
Bogestål, Y. R., Hietala, M. A., Wilhelmsson, U., Fotheringham, A. P., Davies, I., Nilsson, A.-K., Zwirner, J., Wetsel, R. A., Gerard, C. J., Pekny, M., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601004 · Cited by 279 · see citing works
Kuan, C.-Y., Schloemer, A. J., Lu, A., Burns, K. A., Weng, W.-L., Williams, M. T., Strauss, K. I., Vorhees, C. V., Flavell, R. A., Davis, R. J., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3883-04.2004 · Cited by 279 · see citing works
Gene profiling in spinal cord injury shows role of cell cycle in neuronal death
Giovanni, S. D., Knoblach, S. M., Brandoli, C., Aden, S. A., Hoffman, E. P., & Faden, A. I. (2003) · Annals of Neurology · doi:10.1002/ana.10472 · Cited by 274 · see citing works
Gong, X., Tang, X., Wiedmann, M. W., Xuemin, W., Peng, J., Zheng, D., Blair, L. A. C., Marshall, J. J., & Mao, Z. (2003) · Neuron · doi:10.1016/s0896-6273(03)00191-0 · Cited by 260 · see citing works
Neuronal cell cycle: the neuron itself and its circumstances
Frade, J. M., & Ovejero-Benito, M. C. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1004937 · Cited by 245 · see citing works
Ferraiuolo, L., Heath, P. R., Holden, H. M., Kasher, P. R., Kirby, J., & Shaw, P. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1470-07.2007 · Cited by 198 · see citing works
Arendt, T. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.007 · Cited by 188 · see citing works
Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death
Tian, B., Yang, Q., & Mao, Z. (2009) · Nature Cell Biology · doi:10.1038/ncb1829 · Cited by 184 · see citing works
Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d
Chen, P., Zindy, F., Abdala, C., Liu, F., Li, X., Roussel, M. F., & Segil, N. (2003) · Nature Cell Biology · doi:10.1038/ncb976 · Cited by 169 · see citing works
In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS
Lossi, L., & Merighi, A. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00051-0 · Cited by 169 · see citing works
Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology
Hoozemans, J. J. M., Veerhuis, R., Rozemüller, A. J. M., & Eikelenboom, P. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.11.001 · Cited by 168 · see citing works
Complete Loss of Ndel1 Results in Neuronal Migration Defects and Early Embryonic Lethality
Sasaki, S., Mori, D., Toyo‐oka, K., Chen, A. Y.-C., Garrett-Beal, L. J., Muramatsu, M., Miyagawa, S., Hiraiwa, N., Yoshiki, A., Wynshaw-Boris, A. J., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7812-7827.2005 · Cited by 164 · see citing works
Tanaka, A. (2004) · Blood · doi:10.1182/blood-2004-08-3247 · Cited by 162 · see citing works
Neural cell cycle dysregulation and central nervous system diseases
Wang, W., Bu, B., Xie, M., Zhang, M., Yu, Z., & Tao, D. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.01.007 · Cited by 160 · see citing works
Nguyen, M. D., Boudreau, M., Križ, J., Couillard‐Després, S., Kaplan, D. R., & Julien, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02131.2003 · Cited by 159 · see citing works
Cycling at the interface between neurodevelopment and neurodegeneration
Nguyen, M. D., Mushynski, W. E., & Julien, J. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401108 · Cited by 149 · see citing works
Cyclin‐dependent kinase‐5 in neurodegeneration
Shelton, S. B., & Johnson, G. V. W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2003.02328.x · Cited by 144 · see citing works
The role of the DNA damage response in neuronal development, organization and maintenance
Barzilai, A., Biton, S., & Shiloh, Y. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.005 · Cited by 135 · see citing works
Regulation of Neuronal Survival and Death by E2F-Dependent Gene Repression and Derepression
Liu, D. X., & Greene, L. A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00495-0 · Cited by 132 · see citing works
Self-citationChalazonitis, A., D’Autréaux, F., Guha, U., Pham, T. D., Faure, C. C., Chen, J. J., Roman, D., Kan, L., Rothman, T. P., Kessler, J. A., et al. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3688-03.2004 · Cited by 131 · see citing works
Hussain, M. S., Baig, S. M., Neumann, S., Peche, V. S., Szczepanski, S., Nürnberg, G., Tariq, M., Jameel, M., Khan, T. N., Fatima, A., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt374 · Cited by 126 · see citing works
Role of cyclin D1 cytoplasmic sequestration in the survival of postmitotic neurons
Sumrejkanchanakij, P., Tamamori-Adachi, M., Matsunaga, Y., Eto, K., & Ikeda, M.-A. (2003) · Oncogene · doi:10.1038/sj.onc.1206870 · Cited by 107 · see citing works
Bieberich, E., MacKinnon, S. E., Silva, J., Noggle, S., & Condie, B. G. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212067 · Cited by 118 · see citing works
To die or grow: Parkinson's disease and cancer
WEST, A., DAWSON, V, & DAWSON, T. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.05.002 · Cited by 106 · see citing works
Cell fate determination during G1 phase progression
Blomen, V. A., & Boonstra, J. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7271-z · Cited by 116 · see citing works
Hoozemans, J. J. M., Brückner, M. K., Rozemüller, A. J. M., Veerhuis, R., Eikelenboom, P., & Arendt, T. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.8.678 · Cited by 116 · see citing works
Cell cycle molecules define a pathway required for neuron death in development and disease
Greene, L. A., Liu, D. X., Troy, C. M., & Biswas, S. C. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.12.003 · Cited by 115 · see citing works
Self-citationDu, F., Lou, J., Jiang, R., Fang, Z., Zhao, X., Niu, Y., Zou, S., Zhang, M., Gong, A., & Wu, C. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s130455 · Cited by 108 · see citing works
DUAL SPECIFICITY PROTEIN PHOSPHATASES: Therapeutic Targets for Cancer and Alzheimer's Disease
Ducruet, A. P., Vogt, A., Wipf, P., & Lazo, J. S. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.100040 · Cited by 108 · see citing works
Cell cycle molecules and vertebrate neuron death: E2F at the hub
Greene, L. A., Biswas, S. C., & Liu, D. X. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401341 · Cited by 108 · see citing works
Self-citationThe anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions
Manchado, E., Eguren, M., & Malumbres, M. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380065 · Cited by 107 · see citing works
Tse, K., & Herrup, K. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14079 · Cited by 104 · see citing works
Alzheimer’s Disease and Cancer: When Two Monsters Cannot Be Together
Majd, S., Power, J., & Majd, Z. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00155 · Cited by 102 · see citing works
NGF deprivation-induced gene expression: after ten years, where do we stand?
Freeman, R. S., Burch, R. L., Crowder, R. J., Lomb, D. J., Schoell, M. C., Straub, J. A., & Xie, L. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)46008-1 · Cited by 100 · see citing works
Bim Is a Direct Target of a Neuronal E2F-Dependent Apoptotic Pathway
Biswas, S. C., Liu, D. X., & Greene, L. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1570-05.2005 · Cited by 98 · see citing works
Self-citationJoseph, C., Mangani, A. S., Gupta, V. B., Chitranshi, N., Shen, T., Dheer, Y., Devaraj, K. B., Mirzaei, M., You, Y., Graham, S. L., et al. (2020) · Aging and Disease · doi:10.14336/ad.2019.0923 · Cited by 97 · see citing works
Konishi, Y., & Bonni, A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01649.2003 · Cited by 97 · see citing works
Chin, P. C., Liu, L., Morrison, B. E., Siddiq, A., Ratan, R. R., Bottiglieri, T., & D’Mello, S. R. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02530.x · Cited by 93 · see citing works
p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death
Hamdane, M., Bretteville, A., Sambo, A., Schindowski, K., Bégard, S., Delacourte, A., Bertrand, P., & Buée, L. (2005) · Journal of Cell Science · doi:10.1242/jcs.01724 · Cited by 93 · see citing works
Granule cell number, cell death and cell proliferation in the dentate gyrus of wild‐living rodents
Amrein, I., Slomianka, L., & Lipp, H. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03795.x · Cited by 92 · see citing works
Tian, D., Yu, Z., Xie, M., Bu, B., Witte, O. W., & Wang, W. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20999 · Cited by 91 · see citing works
Nestin-CreER Mice Reveal DNA Synthesis by Nonapoptotic Neurons following Cerebral Ischemia–Hypoxia
Burns, K. A., Ayoub, A. E., Breunig, J. J., Adhami, F., Weng, W.-L., Colbert, M. C., RAKIC, P. T., & Kuan, C.-Y. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl164 · Cited by 87 · see citing works
Kawano, H., Nakatani, T., Mori, T., Ueno, S., Fukaya, M., Abe, A., Kobayashi, M., Toda, F., Watanabe, M., & Matsuoka, I. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.04.001 · Cited by 86 · see citing works
Kainic acid-induced apoptosis in cerebellar granule neurons: an attempt at cell cycle re-entry
Verdaguer, E., Jordà, E. G., Canudas, A. M., Domínguez, E., Jiménez, A., Pubill, D., Escubedo, E., Camarasa, J., & Camins, A. (2002) · Neuroreport · doi:10.1097/00001756-200203250-00010 · Cited by 86 · see citing works
Alzheimer’s disease: as it was in the beginning
Kozlov, S. O., Afonin, A. М., Evsyukov, I., & Бондаренко, А. Б. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0006 · Cited by 84 · see citing works
D'Mello, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115911 · Cited by 71 · see citing works
Regulation of neuron survival and death by p130 and associated chromatin modifiersPreprint
Liu, D. X., Nath, N., Chellappan, S., & Greene, L. A. (2005) · Genes & Development · doi:10.1101/gad.1296405 · Cited by 77 · see citing works
Self-citationKendall, S. E., Battelli, C., Irwin, S., Mitchell, J., Glackin, C. A., & Verdi, J. M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7711-7724.2005 · Cited by 76 · see citing works
Neuronal expression of cell cycle-related proteins after brain ischaemia in man
Love, S. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.09.004 · Cited by 72 · see citing works
Mitochondrial dynamics in the regulation of neuronal cell death
Cheung, E. C., McBride, H. M., & Slack, R. S. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0745-5 · Cited by 70 · see citing works
Liu, D. X., Biswas, S. C., & Greene, L. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1821-04.2004 · Cited by 68 · see citing works
Self-citationOxidative stress‐induced death in the nervous system: Cell cycle dependent or independent?
Langley, B. C., & Ratan, R. R. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20210 · Cited by 68 · see citing works
Pietersen, C. Y., Mauney, S. A., Kim, S. S., Passeri, E., Lim, M. P., Rooney, R. J., Goldstein, J. M., Petryshen, T. L., Seidman, L. J., Shenton, M. E., et al. (2014) · Journal of Neurogenetics · doi:10.3109/01677063.2013.878339 · Cited by 67 · see citing works
Barrio-Alonso, E., Hernández‐Vivanco, A., Walton, C. C., Perea, G., & Frade, J. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-32708-4 · Cited by 65 · see citing works
Exploring the molecular approach of COX and LOX in Alzheimer’s and Parkinson’s disorder
Kumar, A., Behl, T., Jamwal, S., Kaur, I., Sood, A., & Kumar, P. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-06033-x · Cited by 61 · see citing works
N-myc Regulates Parkin Expression
West, A. B., Kapatos, G., O’Farrell, C., de Chavez, F. G., Chiu, K., Farrer, M. J., & Maidment, N. T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400126200 · Cited by 61 · see citing works
Cyclin-Dependent Kinase 5 in Amyotrophic Lateral Sclerosis
Nguyen, M. D., & Julien, J. (2003) · Neurosignals · doi:10.1159/000074623 · Cited by 61 · see citing works
Hoozemans, J. J. M., Veerhuis, R., Rozemüller, A. J. M., Arendt, T., & Eikelenboom, P. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.11.028 · Cited by 60 · see citing works
Alzheimer’s disease and related tauopathies: disorders of disrupted neuronal identity
Frost, B. E. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.07.006 · Cited by 56 · see citing works
Hoozemans, J. J. M., Stieler, J., van Haastert, E. S., Veerhuis, R., Rozemüller, A. J. M., Baas, F., Eikelenboom, P., Arendt, T., & Scheper, W. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.01.013 · Cited by 56 · see citing works
Johnson, K., Liu, L., Majd, N., Chavez, C., Chin, P. C., Morrison, B. E., Wang, L., Park, J., Chugh, P., Chen, H., et al. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.03004.x · Cited by 56 · see citing works
Tanaka, A., Muto, S., Konno, M., Itai, A., & Matsuda, H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-0741 · Cited by 56 · see citing works
Alteration in Long Non-Coding RNA Expression after Traumatic Brain Injury in Rats
Wang, C., Zhao, C., Weng, W., Lei, J., Lin, Y., Mao, Q., Gao, G., Feng, J., & Jiang, J. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2016.4642 · Cited by 54 · see citing works
New method for the analysis of cell cycle–specific apoptosis
Tao, D., Wu, J., Feng, Y., Qin, J., Hu, J., & Gong, J. (2004) · Cytometry Part A · doi:10.1002/cyto.a.10117 · Cited by 53 · see citing works
DNA damage, neuronal and glial cell death and neurodegeneration
Barzilai, A. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0501-0 · Cited by 53 · see citing works
Katsel, P., Tan, W., Fam, P., Purohit, D. P., & Haroutunian, V. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068361 · Cited by 52 · see citing works
Development and Regeneration of the Inner Ear
Kwan, T., White, P. M., & Segil, N. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04484.x · Cited by 52 · see citing works
Ahn, J., Lee, K.-H., Shin, D., Shim, J., Lee, J., Chang, S. Y., Lee, Y.-S., Brownstein, M., Lee, S., & Lee, Y. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.09.041 · Cited by 52 · see citing works
Hsu, W., Hsieh, F., Jeng, Y., Kuo, M., Tsao, P., Lee, H., Lin, M., Lai, H., Chen, C., Lai, D., et al. (2004) · International Journal of Cancer · doi:10.1002/ijc.20693 · Cited by 51 · see citing works
Liu, Y., Wang, Y., Cheng, C., Chen, Y., Shi, S., Qin, J., Xiao, F., Zhou, D., Lu, M., Lu, Q., et al. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008.0581 · Cited by 50 · see citing works
E2F1 Works as a Cell Cycle Suppressor in Mature Neurons
Wang, L., Wang, R., & Herrup, K. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3681-07.2007 · Cited by 50 · see citing works
Gohlke, J. M., Griffith, W. C., & Faustman, E. M. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl151 · Cited by 49 · see citing works
Hyperammonaemia induces hepatic injury with alteration of gene expression profiles
Jia, B., Yu, Z., Duan, Z., Lü, X., Li, J., Liu, X., Sun, R., Gao, X., Wang, Y., Yan, J., et al. (2013) · Liver International · doi:10.1111/liv.12365 · Cited by 49 · see citing works
Gene expression profiling in the midbrain of striatal 6-hydroxydopamine-injected mice
Iwata, S., Nomoto, M., Morioka, H., & Miyata, A. (2004) · Synapse · doi:10.1002/syn.10307 · Cited by 48 · see citing works
Schmetsdorf, S., Gärtner, U., & Arendt, T. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl091 · Cited by 48 · see citing works
PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease
Morel, M., Couturier, J., Lafay‐Chebassier, C., Paccalin, M., & Page, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00849.x · Cited by 47 · see citing works
Thinking within the D box: Initial identification of Cdh1–APC substrates in the nervous system
Kim, A. H., & Bonni, A. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.11.019 · Cited by 47 · see citing works
Neurofibrillary degeneration of the Alzheimer-type: an alternate pathway to neuronal apoptosis?
Hamdane, M., Delobel, P., Sambo, A., Smet‐Nocca, C., Bégard, S., Violleau, A., Landrieu, I., Delacourte, A., Lippens, G. M., Flament, S., et al. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00533-1 · Cited by 47 · see citing works
Delston, R. B., Matatall, K. A., Sun, Y., Onken, M. D., & Harbour, J. W. (2010) · Oncogene · doi:10.1038/onc.2010.442 · Cited by 46 · see citing works
To die or not to die: DNA repair in neurons
McMurray, C. T. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.03.006 · Cited by 46 · see citing works
Cyclin D1 degradation enhances endothelial cell survival upon oxidative stress
Fasanaro, P., Magenta, A., Zaccagnini, G., Cicchillitti, L., Fucile, S., Eusebi, F., Biglioli, P., Capogrossi, M. C., & Martelli, F. (2006) · The FASEB Journal · doi:10.1096/fj.05-4695fje · Cited by 45 · see citing works
The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate
Vanderluit, J. L., Wylie, C. A., McClellan, K. A., Ghanem, N., Fortin, A., Callaghan, S. M., MacLaurin, J. G., Park, D. S., & Slack, R. S. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200703176 · Cited by 45 · see citing works
Caspases and p53 modulate FOXO3A/Id1 signaling during mouse neural stem cell differentiation
Aranha, M. M., Solá, S., Low, W. C., Steer, C. J., & Rodrigues, C. M. P. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22172 · Cited by 44 · see citing works
Exploring and exploiting the systemic effects of deregulated replication licensing
Petrakis, T. G., Komseli, E.-S., Papaioannou, M. D., Vougas, K., Polyzos, A., Myrianthopoulos, V., Mikros, E., Trougakos, I. P., Thanos, D., Branzei, D., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.12.002 · Cited by 44 · see citing works
Wang, H., Dharmalingam, P., Vasquez, V., Mitra, J., Boldogh, I. R., Rao, K. S. J., Kent, T. A., MITRA, S. P., & Hegde, M. L. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.005 · Cited by 44 · see citing works
Jordà, E. G., Verdaguer, E., Canudas, A. M., Jiménez, A., Bruna, A., Caelles, C., Bravo, R., Escubedo, E., Pubill, D., Camarasa, J., et al. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00204-1 · Cited by 43 · see citing works
RNA knockdown as a potential therapeutic strategy in Parkinson's disease
Manfredsson, F. P., Lewin, A. S., & Mandel, R. J. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302669 · Cited by 43 · see citing works
Xie, Y., Liu, Y., Ma, C., Yuan, Z., Wang, W., Zhu, Z., Gao, G., Liu, X., Yuan, H., Chen, R., et al. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.06.044 · Cited by 43 · see citing works
Pin1 : A Therapeutic Target in Alzheimer Neurodegeneration
Hamdane, M., Smet‐Nocca, C., Sambo, A., Leroy, A., Wieruszeski, J., Delobel, P., Maurage, C., Ghestem, A., Wintjens, R. T., Bégard, S., et al. (2002) · Journal of Molecular Neuroscience · doi:10.1385/jmn:19:3:275 · Cited by 43 · see citing works
Tau and DNA Damage in Neurodegeneration
Colnaghi, L., Rondelli, D., Muzi-Falconi, M., & Sertic, S. (2020) · Brain Sciences · doi:10.3390/brainsci10120946 · Cited by 42 · see citing works
Protocols for Studying Adult Neurogenesis: Insights and Recent Developments
Taupin, P. (2006) · Regenerative Medicine · doi:10.2217/17460751.2.1.51 · Cited by 42 · see citing works
Cyclin C expression is involved in the pathogenesis of Alzheimer's disease
Ueberham, U. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00132-x · Cited by 40 · see citing works
- Authors
- Liu, D. X., & Greene, L. A.
- Affiliations
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- Corresponding author
- Liu, David X.
- Venue
- Cell and Tissue Research
- Published
- 2001-05-17
- Volume
- 305
- Issue
- 2
- Pages
- 217-228
- ISSN
- 0302-766X (ISSN-L)
- 1432-0878
- OpenAlex
- W2031825480
- Cited by
- 234
- References
- 1
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 9 · 2015: 8 · 2014: 4 · 2013: 9 · 2012: 7
- FWCI
- 6.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell and Tissue Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- neuronal apoptosis, G1/S cell cycle checkpoint, postmitotic neurons, cyclin D1, CDK4/6, E2F transcription factors, retinoblastoma protein, neurogenesis, neurodegeneration, Alzheimer's disease, cell cycle re-entry
- MeSH terms
- Animals, Cell Cycle, DNA-Binding Proteins, Humans, Neurons, Nuclear Proteins, Phosphoproteins, Proteins, Proto-Oncogene Proteins, Transcription Factors, Signal Transduction, Retinoblastoma Protein, G1 Phase, S Phase, Cyclins, Apoptosis, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Cyclin-Dependent Kinases, E2F Transcription Factors, Retinoblastoma-Like Protein p130, Retinoblastoma-Like Protein p107, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Cyclin D
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
