Metabolic effects of time-released garlic powder tablets in type 2 diabetes mellitus: The results of double-blinded placebo-controlled study
Abstract
Late complications in type 2 diabetic patients are commonly associated with accelerated development of atherosclerosis. In type 2 diabetes mellitus, non-enzymatic glycosylation of apo-B that is a function of hyperglycaemia is an efficient biochemical way of low-density lipoprotein atherogenic modification. So, proper metabolic control is needed to prevent late complications of diabetes. The study was performed to estimate the effects of time-released garlic powder tablet Allicor on the parameters of metabolic control and plasma lipids in type 2 diabetes mellitus. The metabolic action of Allicor was investigated in the 4-week double-blinded placebo-controlled study in 60 type 2 diabetic patients. Fasting blood glucose was measured daily, and serum fructosamine as well as cholesterol and triglyceride levels were determined at the baseline, after 1, 2, 3 and 4 weeks. It has been demonstrated that treatment with Allicor resulted in better metabolic control due to the lowering of fasting blood glucose, serum fructosamine and serum triglyceride levels. The results of this study may allow recommending garlic powder tablets Allicor for the treatment of type 2 diabetes mellitus along with dietary treatment and/or sulfonylurea derivatives to achieve better metabolic control. The benefits from garlic preparations may lead to the reduction of cardiovascular risk in diabetic patients.
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Garlic administration at a dose of 300 and 60 mg/day for 12 months and 12 weeks, respectively, decreased total cholesterol, triglyceride, and LDL while increased HDL in patients.
“Sobenin et al. [110,111] revealed that garlic administration at a dose of 300 and 60 mg/day for 12 months and 12 weeks, respectively decreased TC, TG, and LDL while increased HDL.”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [110]
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- Authors
- Sobenin, I. A., Nedosugova, L. V., Filatova, L. V., Balabolkin, M. I., Gorchakova, T. V., & Orekhov, A. N.
- Affiliations
- Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences (RU)
- Venue
- Acta Diabetologica
- Published
- 2007-09-06
- Volume
- 45
- Issue
- 1
- Pages
- 1-6
- ISSN
- 0940-5429 (ISSN-L)
- 1432-5233
- OpenAlex
- W2097385227
- Cited by
- 119
- References
- 51
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 3 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 4 · 2013: 12 · 2012: 6
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Diabetologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 2 diabetes, metabolic control, fasting blood glucose, serum fructosamine, serum triglycerides, serum cholesterol, glycation, atherosclerosis, cardiovascular risk, sulfonylurea derivatives
- MeSH terms
- Adult, Blood Glucose, Cholesterol, Diabetes Mellitus, Type 2, Double-Blind Method, Female, Garlic, Humans, Lipids, Male, Middle Aged, Placebos, Powders, Tablets, Fructosamine
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