Natural products as novel anti-obesity agents: insights into mechanisms of action and potential for therapeutic management

The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481 · see citing works

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works

Adipose Tissue as an Endocrine Organ

Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522 · see citing works

Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856 · see citing works

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works

Understanding Adipocyte Differentiation

Gregoire, F. M., Smas, C. M., & Sul, H. S. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.3.783 · Cited by 2,357 · see citing works

Brown and beige fat: Development, function and therapeutic potential

Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328 · see citing works

Ginseng pharmacology

Attele, A. S., Wu, J. A., & Yuan, C. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00212-9 · Cited by 1,870 · see citing works

Unexpected evidence for active brown adipose tissue in adult humans

Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2006 · Cited by 1,824 · see citing works

Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe)

Mao, Q.-Q., Xu, X.-Y., Cao, S.-Y., Gan, R.-Y., Corke, H., Beta, T., & Li, H.-B. (2019) · Foods · doi:10.3390/foods8060185 · Cited by 1,418 · see citing works

Obesity: Epidemiology, Pathophysiology, and Therapeutics

Lin, X., & Li, H. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.706978 · Cited by 1,404 · see citing works

Adipogenesis and metabolic health

Ghaben, A. L., & Scherer, P. E. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0093-z · Cited by 1,395 · see citing works

Insulin resistance and cardiovascular disease

Ginsberg, H. N. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10762 · Cited by 1,358 · see citing works

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

Seale, P., Conroe, H. M., Estall, J. L., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S., & Spiegelman, B. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44271 · Cited by 1,241 · see citing works

Adipose tissue browning and metabolic health

Bartelt, A., & Heeren, J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.204 · Cited by 1,177 · see citing works

Cross-Regulation of C/EBPα and PPARγ Controls the Transcriptional Pathway of Adipogenesis and Insulin Sensitivity

Wu, Z., Rosen, E. D., Brun, R. P., Hauser, S., Adelmant, G., Troy, A. E., McKeon, C., Darlington, G., & Spiegelman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80306-8 · Cited by 1,015 · see citing works

The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation

Frühbeck, G., Gómez‐Ambrosi, J., Muruzábal, F., & Burrell, M. A. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.6.e827 · Cited by 964 · see citing works

Effect of Sibutramine on Cardiovascular Outcomes in Overweight and Obese Subjects

James, W. P. T., Caterson, I. D., Coutinho, W., Finer, N., Van Gaal, L. F., Maggioni, A. P., Torp-Pedersen, C., Sharma, A. M., Shepherd, G. M., Rode, R. A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1003114 · Cited by 943 · see citing works

Adenosine receptors as drug targets — what are the challenges?

Chen, J., Eltzschig, H. K., & Fredholm, B. B. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3955 · Cited by 895 · see citing works

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

Cohen, P., Levy, J. D., Zhang, Y., Frontini, A., Kolodin, D., Svensson, K. J., Lo, J. C., Zeng, X., Ye, L., Khandekar, M. J., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.021 · Cited by 878 · see citing works

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

Qiang, L., Wang, L., Kon, N., Zhao, W., Lee, S., Zhang, Y., ROSENBAUM, M. S., Zhao, Y., Gu, W. J., Farmer, S. R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.027 · Cited by 802 · see citing works

Flavan‐3‐ols: Nature, occurrence and biological activity

Aron, P. M., & Kennedy, J. A. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700137 · Cited by 770 · see citing works

Adipose tissue in control of metabolism

Luo, L., & Liu, M. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0211 · Cited by 708 · see citing works

Mechanisms of insulin resistance in obesity

Ye, J. (2013) · Frontiers of Medicine · doi:10.1007/s11684-013-0262-6 · Cited by 699 · see citing works

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

Shabalina, I. G., Petrovič, N., de Jong, J. M. A., Kalinovich, A., Cannon, B., & Nedergaard, J. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.044 · Cited by 637 · see citing works

Induction of Peroxisome Proliferator-Activated Receptor γ during the Conversion of 3T3 Fibroblasts into Adipocytes Is Mediated by C/EBPβ, C/EBPδ, and Glucocorticoids

Wu, Z., Bucher, N. L. R., & Farmer, S. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4128 · Cited by 605 · see citing works

The Cannabinoid CB1 Receptor Antagonist SR141716 Increases Acrp30 mRNA Expression in Adipose Tissue of Obese fa/fa Rats and in Cultured Adipocyte Cells

Bensaïd, M., Gary‐Bobo, M., Esclangon, A., Maffrand, J., Fur, G. L., Oury-Donat, F., & Soubrié, P. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.4.908 · Cited by 593 · see citing works

The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance

Goossens, G. H. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.10.010 · Cited by 591 · see citing works

Anatomical, Physiological, and Functional Diversity of Adipose Tissue

Zwick, R. K., Guerrero‐Juarez, C. F., Horsley, V., & Plikus, M. V. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.12.002 · Cited by 526 · see citing works

Coffee, Caffeine, and Health

van Dam, R. M., Hu, F. B., & Willett, W. C. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1816604 · Cited by 508 · see citing works

An Update Review of Saffron and its Active Constituents

Rı́os, J. L., Recio, M. C., Giner, R. M., & Máñez, S. (1996) · Phytotherapy Research · doi:10.1002/(sici)1099-1573(199605)10:3 · Cited by 504 · see citing works

The Browning of White Adipose Tissue: Some Burning Issues

Nedergaard, J., & Cannon, B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.005 · Cited by 500 · see citing works

Therapeutic applications of fenugreek.

Basch, E., Ulbricht, C. E., Kuo, G. M., Szapary, P. O., & Smith, M. A. (2003) · PubMed · Cited by 496 · see citing works

A Peripheral Mechanism for CB1 Cannabinoid Receptor-Dependent Modulation of Feeding

Gómez, R., Navarro, M., Ferrer, B., Trigo, J. M., Bilbao, A., del Arco, I., Cippitelli, A., Nava, F. A., Piomelli, D., & de Fonseca, F. R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09612.2002 · Cited by 486 · see citing works

Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus

Bhatt, J. K., Thomas, S., & Nanjan, M. J. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.06.003 · Cited by 475 · see citing works

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

Kajimura, S., Seale, P., Tomaru, T., Erdjument-Bromage, H., Cooper, M. P., Ruas, J. L., Chin, S., Tempst, P., Lazar, M. A., & Spiegelman, B. M. (2008) · Genes & Development · doi:10.1101/gad.1666108 · Cited by 468 · see citing works

Brown versus White Adipose Tissue: A Mini-Review

Saely, C. H., Geiger, K. D., & Drexel, H. (2010) · Gerontology · doi:10.1159/000321319 · Cited by 461 · see citing works

Phytochemicals and regulation of the adipocyte life cycle

Rayalam, S., Della‐Fera, M. A., & Baile, C. A. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.12.007 · Cited by 450 · see citing works

Fenugreek: A review on its nutraceutical properties and utilization in various food products

Wani, S. A., & Kumar, P. (2016) · Journal of the Saudi Society of Agricultural Sciences · doi:10.1016/j.jssas.2016.01.007 · Cited by 447 · see citing works

Berberine activates thermogenesis in white and brown adipose tissue

Zhang, Z., Zhang, H., Li, B., Meng, X.-J., Wang, J., Zhang, Y., Yao, S., Ma, Q., Jin, L., Yang, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms6493 · Cited by 439 · see citing works

Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity

Dulloo, A. G., Seydoux, J., Girardier, L., Chantre, P., & Vandermander, J. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801101 · Cited by 436 · see citing works

Natural Cinnamic Acids, Synthetic Derivatives and Hybrids with Antimicrobial Activity

Guzman, J. D. (2014) · Molecules · doi:10.3390/molecules191219292 · Cited by 419 · see citing works

Ursolic acid: An anti‐ and pro‐inflammatory triterpenoid

Ikeda, Y., Murakami, A., & Ohigashi, H. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700389 · Cited by 417 · see citing works

Lipase Inhibitors for Obesity: A Review

Liu, T., Liu, X., Chen, Q., & Shi, Y. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110314 · Cited by 409 · see citing works

The efficacy of ginseng. A systematic review of randomised clinical trials

Vogler, B., Pittler, M. H., & Ernst, E. (1999) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050674 · Cited by 364 · see citing works

American Ginseng (Panax quinquefolius L) Reduces Postprandial Glycemia in Nondiabetic Subjects and Subjects With Type 2 Diabetes Mellitus

Vuksan, V. V. V., Sievenpiper, J. L., Koo, V. Y. Y., Francis, T., Beljan‐Zdravkovic, U., Xu, Z., & Vidgen, E. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.7.1009 · Cited by 355 · see citing works

AGA Clinical Practice Guideline on Pharmacological Interventions for Adults With Obesity

Grunvald, E., Shah, R., Hernaez, R., Chandar, A. K., Pickett-Blakely, O., Teigen, L. M., Harindhanavudhi, T., Sultan, S., Singh, S., & Davitkov, P. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.08.045 · Cited by 347 · see citing works

Is there a role for serotonin (5-hydroxytryptamine) in feeding?

Blundell, J. E. (1977) · PubMed · Cited by 345 · see citing works

Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity

Tan, D. ‐., Manchester, L. C., Fuentes‐Broto, L., Paredes, S. D., & Reiter, R. J. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00756.x · Cited by 343 · see citing works

The FDA's Assessment of Two Drugs for Chronic Weight Management

Colman, E., Golden, J., Roberts, M., Egan, A., Weaver, J., & Rosebraugh, C. (2012) · New England Journal of Medicine · doi:10.1056/nejmp1211277 · Cited by 342 · see citing works

Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea

Diepvens, K., Westerterp, K. R., & Westerterp‐Plantenga, M. S. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00832.2005 · Cited by 341 · see citing works

Anti-obesity effect of Nelumbo nucifera leaves extract in mice and rats

Ono, Y., 服部, 英., Fukaya, Y., Imai, S., & Ohizumi, Y. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.12.036 · Cited by 337 · see citing works

Peroxisome Proliferator-activated Receptor α Activates Transcription of the Brown Fat Uncoupling Protein-1 Gene

Barberà, M. J., Schlüter, A., Pedraza, N., Iglesias, R., Villarroya, F., & Giralt, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006246200 · Cited by 337 · see citing works

Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel‐dependent mechanisms

Baskaran, P., Krishnan, V., Ren, J. T., & Thyagarajan, B. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13514 · Cited by 325 · see citing works

Cinnamic Acid and Its Derivatives: Mechanisms for Prevention and Management of Diabetes and Its Complications

Adisakwattana, S. (2017) · Nutrients · doi:10.3390/nu9020163 · Cited by 314 · see citing works

Liraglutide for weight management: a critical review of the evidence

Mehta, A., Marso, S. P., & Neeland, I. J. (2017) · Obesity Science & Practice · doi:10.1002/osp4.84 · Cited by 311 · see citing works

The sacred lotus (Nelumbo nucifera)– phytochemical and therapeutic profile

Mukherjee, P. K., Mukherjee, D., Maji, A. K., Rai, S., & Heinrich, M. (2009) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.61.04.0001 · Cited by 309 · see citing works

Chemistry, Biogenesis, and Biological Activities ofCinnamomum zeylanicum

Jayaprakasha, G. K., & Rao, L. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408391003699550 · Cited by 299 · see citing works

Management of overweight and obesity in primary care—A systematic overview of international evidence‐based guidelines

Semlitsch, T., Stigler, F. L., Jeitler, K., Horvath, K., & Siebenhofer, A. (2019) · Obesity Reviews · doi:10.1111/obr.12889 · Cited by 298 · see citing works

The Effects of Capsaicin and Capsiate on Energy Balance: Critical Review and Meta-analyses of Studies in Humans

Ludy, M., Moore, G. E., & Mattes, R. D. (2011) · Chemical Senses · doi:10.1093/chemse/bjr100 · Cited by 297 · see citing works

Orlistat: its current status as an anti-obesity drug

Ballinger, A., & Peikin, S. R. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01422-x · Cited by 296 · see citing works

Peroxisome Proliferator-activated Receptor α (PPARα) Induces PPARγ Coactivator 1α (PGC-1α) Gene Expression and Contributes to Thermogenic Activation of Brown Fat

Hondares, E., Rosell, M., Díaz-Delfín, J., Olmos, Y., Monsalve, M., Iglesias, R., Villarroya, F., & Giralt, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.252775 · Cited by 295 · see citing works

Role of Peroxisome Proliferator-Activated Receptor-γ in Maintenance of the Characteristics of Mature 3T3-L1 Adipocytes

Tamori, Y., Masugi, J., Nishino, N., & Kasuga, M. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2045 · Cited by 294 · see citing works

Analgesic and antioxidant activity of mangiferin and its derivatives: The structure activity relationship

Dar, A., Faizi, S., Naqvi, S., Roome, T., Zikr-ur-Rehman, S., Ali, M., Firdous, S., & Moin, S. T. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.596 · Cited by 289 · see citing works

Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: Results of a randomized, double-blind, placebo-controlled study of efficacy and safety

Vuksan, V. V. V., Sung, M., Sievenpiper, J. L., Stavro, P. M., Jenkins, A. L., Buono, M. D., Lee, K.-S., Leiter, L. A., Nam, K. Y., Arnason, J. T., et al. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.04.003 · Cited by 287 · see citing works

Melatonin in <i>Glycyrrhiza uralensis</i>: response of plant roots to spectral quality of light and UV‐B radiation

Afreen, F., Zobayed, S. M. A., & Kozai, T. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00337.x · Cited by 283 · see citing works

Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study.

Gupta, A., Gupta, R., & Lal, B. (2001) · PubMed · Cited by 278 · see citing works

Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARγ pathway

Huang, C., Zhang, Y., Gong, Z., Sheng, X., Li, Z., Zhang, W., & Qin, Y. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.07.095 · Cited by 277 · see citing works

UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes

Ikeda, K., & Yamada, T. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00498 · Cited by 276 · see citing works

Molecular Mechanism of Insulin Resistance in Obesity and Type 2 Diabetes

Choi, K., & Kim, Y. (2010) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2010.25.2.119 · Cited by 271 · see citing works

Medical aspects of the chewing of khat leaves.

Halbach, H. (1972) · PubMed · Cited by 268 · see citing works

Soluble dietary fibre fraction ofTrigonella foenum-graecum(fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action

Hannan, J. M. A., Ali, L., Rokeya, B., Khaleque, J., Akhter, M., Flatt, P. R., & Abdel‐Wahab, Y. H. A. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507657869 · Cited by 263 · see citing works

Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers

Dulloo, A. G., Geissler, C. A., Horton, T., Collins, A. L., & Miller, D. S. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/49.1.44 · Cited by 258 · see citing works

Mitochondrial Transcription Factor A Induction by Redox Activation of Nuclear Respiratory Factor 1

Piantadosi, C. A., & Suliman, H. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508805200 · Cited by 254 · see citing works

Procyanidins: a comprehensive review encompassing structure elucidation via mass spectrometry

Rue, E. A., Rush, M. D., & van Breemen, R. B. (2017) · Phytochemistry Reviews · doi:10.1007/s11101-017-9507-3 · Cited by 251 · see citing works

Heterogeneity of white adipose tissue: molecular basis and clinical implications

Kwok, K. H. M., Lam, K. S. L., & Xu, A. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.5 · Cited by 250 · see citing works

Genistein: Its role in metabolic diseases and cancer

Mukund, V., Mukund, D., Sharma, V., Mannarapu, M., & Alam, A. (2017) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.09.004 · Cited by 248 · see citing works

Effectiveness of Cinnamon for Lowering Hemoglobin A1C in Patients with Type 2 Diabetes: A Randomized, Controlled Trial

Crawford, P. F. (2009) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2009.05.080093 · Cited by 247 · see citing works

Worldwide epidemic of obesity

Haththotuwa, R. N., Wijeyaratne, C. N., & Senarath, U. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817921-5.00001-1 · Cited by 242 · see citing works

Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/β-catenin signaling

Ahn, J., Lee, H., Kim, S., & Ha, T. Y. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00369.2009 · Cited by 240 · see citing works

Saponins from Platycodi Radix Ameliorate High Fat Diet–Induced Obesity in Mice

Han, L.-K., Zheng, Y., Okuda, H., Xu, B., & Kimura, Y. (2002) · Journal of Nutrition · doi:10.1093/jn/132.8.2241 · Cited by 235 · see citing works

Green Tea Polyphenol Epigallocatechin Gallate Inhibits Adipogenesis and Induces Apoptosis in 3T3‐L1 Adipocytes

Lin, J., Della‐Fera, M. A., & Baile, C. A. (2005) · Obesity Research · doi:10.1038/oby.2005.115 · Cited by 234 · see citing works

Health Care–Associated Bloodstream Infections

Kaye, K. S., Friedman, N. D., & Sexton, D. J. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-3-200308050-00018 · Cited by 232 · see citing works

Tumour necrosis factor-α inhibits adipogenesis via a β-catenin/TCF4(TCF7L2)-dependent pathway

Cawthorn, W. P., Heyd, F., Hegyi, K., & Sethi, J. K. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402127 · Cited by 230 · see citing works

Behavioral Satiety Sequence (BSS) for the Diagnosis of Drug Action on Food Intake

Halford, J. C. G., Wanninayake, S. C. D., & Blundell, J. E. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00032-x · Cited by 230 · see citing works

Skeletal muscle thermogenesis and its role in whole body energy metabolism

Periasamy, M., Herrera, J. L., & Reis, F. C. G. (2017) · Diabetes &amp; Metabolism Journal · doi:10.4093/dmj.2017.41.5.327 · Cited by 230 · see citing works

Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without pre-diabetes

Rosenstock, J., Klaff, L. J., Schwartz, S., Northrup, J., Holcombe, J. H., Wilhelm, K., & Trautmann, M. (2010) · Diabetes Care · doi:10.2337/dc09-1203 · Cited by 229 · see citing works

The effect and safety of an ephedrine/caffeine compound compared to ephedrine, caffeine and placebo in obese subjects on an energy restricted diet. A double blind trial.

Astrup, A. V., Breum, L., Toubro, S., Hein, P., & QUAADE, F. (1992) · PubMed · Cited by 227 · see citing works

A systematic review of anti-obesity medicinal plants - an update

Hasani‐Ranjbar, S., Jouyandeh, Z., & Abdollahi, M. R. (2013) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/2251-6581-12-28 · Cited by 226 · see citing works

Garlic (<i>Allium sativum </i>L.): Adverse effects and drug interactions in humans

Borrelli, F., Capasso, R., & Izzo, A. A. (2007) · Molecular Nutrition &amp; Food Research · doi:10.1002/mnfr.200700072 · Cited by 223 · see citing works

Induction of Adipose Tissue Browning as a Strategy to Combat Obesity

Kuryłowicz, A., & Puzianowska-Kuźnicka, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176241 · Cited by 219 · see citing works

Common dietary supplements for weight loss.

Saper, R. B., Eisenberg, D. M., & Phillips, R. S. (2004) · PubMed · Cited by 218 · see citing works

Serotonin (5-HT) Drugs: Effects on Appetite Expression and Use for the Treatment of Obesity

Halford, J. C. G., Harrold, J. A., Lawton, C. L., & Blundell, J. E. (2005) · Current Drug Targets · doi:10.2174/1389450053174550 · Cited by 215 · see citing works

Capsaicin-Induced -Adrenergic Action on Energy Metabolism in Rats: Influence of Capsaicin on Oxygen Consumption, the Respiratory Quotient, and Substrate Utilization

Kawada, T., Watanabe, T., Takaishi, T., Tanaka, T., & Iwai, K. (1986) · Experimental Biology and Medicine · doi:10.3181/00379727-183-42414 · Cited by 214 · see citing works

Natural Dietary and Herbal Products in Anti-Obesity Treatment

Sun, N.-N., Wu, T.-Y., & Chau, C. (2016) · Molecules · doi:10.3390/molecules21101351 · Cited by 213 · see citing works

Amorfrutins are potent antidiabetic dietary natural products

Weidner, C., de Groot, J. C., Prasad, A., Freiwald, A., Quedenau, C., Kliem, M., Plauth, A., Kodelja, V., Han, T., Giegold, S., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116971109 · Cited by 212 · see citing works

Browning of White Fat: Novel Insight Into Factors, Mechanisms, and Therapeutics: FAT BROWNING AND THEIR POTENTIAL AS THERAPEUTICS

Jeremic, N., Chaturvedi, P., & Tyagi, S. C. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25450 · Cited by 211 · see citing works

Effects of Capsaicin on Induction of Apoptosis and Inhibition of Adipogenesis in 3T3-L1 Cells

Hsu, C., & Yen, G. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf062912b · Cited by 210 · see citing works

PPARs in the Control of Uncoupling Proteins Gene Expression

Villarroya, F., Iglesias, R., & Giralt, M. (2007) · PPAR Research · doi:10.1155/2007/74364 · Cited by 207 · see citing works

Natural Products with Anti-obesity Effects and Different Mechanisms of Action

Fu, C., Jiang, Y., Guo, J., & Su, Z. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04468 · Cited by 207 · see citing works

Antidiabetic activity of a xanthone compound, mangiferin

Miura, T., Ichiki, H., Hashimoto, I., Iwamoto, N., Kao, M., Kubo, M., Ishihara, E., Komatsu, Y., Okada, M., Ishida, T., et al. (2001) · Phytomedicine · doi:10.1078/0944-7113-00009 · Cited by 206 · see citing works

Curcumin Exerts Antidifferentiation Effect through AMPKα-PPAR-γ in 3T3-L1 Adipocytes and Antiproliferatory Effect through AMPKα-COX-2 in Cancer Cells

Lee, Y. K., Lee, W. S., Hwang, J. T., Kwon, D. Y., Surh, Y. J., & Park, O. J. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf802737z · Cited by 204 · see citing works

Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications

Gómez‐Hernández, A., Beneit, N., Díaz-Castroverde, S., & Escribano, Ó. (2016) · International Journal of Endocrinology · doi:10.1155/2016/1216783 · Cited by 204 · see citing works

Browning of white adipose tissue: lessons from experimental models

Bargut, T. C. L., Souza‐Mello, V., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0051 · Cited by 204 · see citing works

Polyphenols and their effects on diabetes management: A review

Aryaeian, N., Sedehi, S. K., & Arablou, T. (2017) · Medical Journal of the Islamic Republic of Iran · doi:10.14196/mjiri.31.134 · Cited by 202 · see citing works

Chronic Ingestion of Flavan-3-ols and Isoflavones Improves Insulin Sensitivity and Lipoprotein Status and Attenuates Estimated 10-Year CVD Risk in Medicated Postmenopausal Women With Type 2 Diabetes

Curtis, P. J., Sampson, M., Potter, J., Dhatariya, K., Kroon, P. A., & Cassidy, A. (2012) · Diabetes Care · doi:10.2337/dc11-1443 · Cited by 200 · see citing works

C/EBPα and the Corepressors CtBP1 and CtBP2 Regulate Repression of Select Visceral White Adipose Genes during Induction of the Brown Phenotype in White Adipocytes by Peroxisome Proliferator-Activated Receptor γ Agonists

Vernochet, C., Peres, S. B., Davis, K. E., McDonald, M. E., Qiang, L., Wang, H., Scherer, P. E., & Farmer, S. R. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01899-08 · Cited by 199 · see citing works

Anti-obesity Effect ofDioscorea nipponicaMakino with Lipase-inhibitory Activity in Rodents

Kwon, C.-S., Sohn, H. Y., Kim, S. H., Kim, J. H., Son, K. H., Lee, J. S., Lim, J., & Kim, J. (2003) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.67.1451 · Cited by 197 · see citing works

Synthetic Cathinone and Cannabinoid Designer Drugs Pose a Major Risk for Public Health

Weinstein, A. M., Rosca, P., Fattore, L., & London, E. D. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00156 · Cited by 194 · see citing works

Phytochemicals of garlic: Promising candidates for cancer therapy

Zhang, Y., Liu, X., Ruan, J., Zhuang, X., Zhang, X., & Li, Z. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109730 · Cited by 186 · see citing works

The physiological regulation of uncoupling proteins

Nicholls, D. G. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.02.005 · Cited by 183 · see citing works

Effect of Fenugreek Seeds on Blood Glucose and Lipid Profiles in Type 2 Diabetic Patients

Kassaian, N., Azadbakht, L., Forghani, B. A. M., & Amini, M. (2009) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.79.1.34 · Cited by 180 · see citing works

Regulatory circuits controlling white versus brown adipocyte differentiation

Hansen, J. B., & Kristiansen, K. (2006) · Biochemical Journal · doi:10.1042/bj20060402 · Cited by 178 · see citing works

Anti-obesity effects in rodents of dietary teasaponin, a lipase inhibitor

Han, L.-K., Kimura, Y., Kawashima, M., Takaku, T., Taniyama, T., Hayashi, T., Zheng, Y.-N., & Okuda, H. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801747 · Cited by 176 · see citing works

Liraglutide: short‐lived effect on gastric emptying—long lasting effects on body weight

Jelsing, J., Vrang, N., Hansen, G., Raun, K., Tang‐Christensen, M., & Knudsen, L. B. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01557.x · Cited by 174 · see citing works

Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans)

Cannon, B., & Nedergaard, J. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.177 · Cited by 174 · see citing works

The thermogenic effect of thyroid hormone and its clinical implications

Silva, J. E. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-3-200308050-00010 · Cited by 173 · see citing works

Green tea catechins, caffeine and body-weight regulation

Westerterp‐Plantenga, M. S. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.02.005 · Cited by 171 · see citing works

Post-marketing withdrawal of anti-obesity medicinal products because of adverse drug reactions: a systematic review

Onakpoya, I. J., Heneghan, C. J., & Aronson, J. K. (2016) · BMC Medicine · doi:10.1186/s12916-016-0735-y · Cited by 171 · see citing works

Capsaicin in Metabolic Syndrome

Panchal, S. K., Bliss, E., & Brown, L. (2018) · Nutrients · doi:10.3390/nu10050630 · Cited by 169 · see citing works

Ursolic acid enhances the cellular immune system and pancreatic β-cell function in streptozotocin-induced diabetic mice fed a high-fat diet

Jang, S.-M., Yee, S., Choi, J., Choi, M., Do, G., Jeon, S.-M., Yeo, J., Kim, M., Seo, K., & Lee, M. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.10.013 · Cited by 167 · see citing works

Identification and Mechanism of 10-Carbon Fatty Acid as Modulating Ligand of Peroxisome Proliferator-activated Receptors

Malapaka, R. R. V., Khoo, S. K., Zhang, J., Choi, J. H., Zhou, X. E., Xu, Y., Gong, Y., Li, J., Yong, E., Chalmers, M. J., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.294785 · Cited by 163 · see citing works

Measurement and prediction of peak shivering intensity in humans

Eyolfson, D. A., Tikuisis, P., Xu, X., Weseen, G. L., & Giesbrecht, G. G. (2001) · European Journal of Applied Physiology · doi:10.1007/s004210000329 · Cited by 161 · see citing works

Resveratrol Suppresses Oxidative Stress and Inflammatory Response in Diethylnitrosamine-Initiated Rat Hepatocarcinogenesis

Bishayee, A., Barnes, K. F., Bhatia, D., Darvesh, A. S., & Carroll, R. T. (2010) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-09-0171 · Cited by 161 · see citing works

The sacred lotus (Nelumbo nucifera) - phytochemical and therapeutic profile

Mukherjee, P. K., Mukherjee, D., Maji, A. K., Rai, S., & Heinrich, M. (2009) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp/61.04.0001 · Cited by 161 · see citing works

Comparative Effects of Dietary Ginger (Zingiber officinale) and Garlic (Allium sativum) Investigated in a Type 2 Diabetes Model of Rats

Islam, M., & Choi, H. (2008) · Journal of Medicinal Food · doi:10.1089/jmf.2007.634 · Cited by 160 · see citing works

Medial hypothalamic nuclei mediate serotonin's inhibitory effect on feeding behavior

LEIBOWITZ, S. F., Weiss, G. F., & Suh, J. S. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90556-w · Cited by 160 · see citing works

Use and abuse of khat(Catha edulis): a review of the distribution, pharmacology, side effects and a description of psychosis attributed to khat chewing

Pantelis, C., Hindler, C., & Taylor, J. C. (1989) · Psychological Medicine · doi:10.1017/s0033291700024259 · Cited by 153 · see citing works

Effects of garlic oil and diallyl trisulfide on glycemic control in diabetic rats

Liu, C., Hse, H., Lii, C., Chen, P.-S., & Sheen, L. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.04.031 · Cited by 151 · see citing works

Fat burners: nutrition supplements that increase fat metabolism

Jeukendrup, A. E., & Randell, R. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00908.x · Cited by 150 · see citing works

The effects of hedonically acceptable red pepper doses on thermogenesis and appetite

Ludy, M., & Mattes, R. D. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.11.018 · Cited by 149 · see citing works

Curcumin promotes browning of white adipose tissue in a norepinephrine-dependent way

Wang, S., Wang, X., Ye, Z., Xu, C., Zhang, M., Ruan, B., Wei, M., Jiang, Y., Zhang, Y., Wang, L., et al. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.09.018 · Cited by 148 · see citing works

Cinnamon Polyphenol Extract Affects Immune Responses by Regulating Anti- and Proinflammatory and Glucose Transporter Gene Expression in Mouse Macrophages , ,3

Cao, H., Urban, J. F., & Anderson, R. A. (2008) · Journal of Nutrition · doi:10.1093/jn/138.5.833 · Cited by 147 · see citing works

The effect of Korean pine nut oil on in vitro CCK release, on appetite sensations and on gut hormones in post-menopausal overweight women

Pasman, W. J., Heimerikx, J., Rubingh, C. M., van den Berg, R., O’Shea, M., Gambelli, L., Hendriks, H., Einerhand, A. W. C., Scott, C. E., Keizer, H. G., et al. (2008) · Lipids in Health and Disease · doi:10.1186/1476-511x-7-10 · Cited by 146 · see citing works

Forskolin as an activator of cyclic AMP accumulation and lipolysis in rat adipocytes.

Litosch, I., Hudson, T. H., Mills, I., Li, S. Y., & Fain, J. N. (1982) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)14977-8 · Cited by 145 · see citing works

Fatty acids stimulate cholecystokinin secretion via an acyl chain length‐specific, Ca2+‐dependent mechanism in the enteroendocrine cell line STC‐1

McLaughlin, J. T., Lomax, R. B., Hall, L., Dockray, G. J., Thompson, D. G., & Warhurst, G. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.011by.x · Cited by 142 · see citing works

Effects of Red-Pepper Diet on the Energy Metabolism in Men.

Yoshioka, M., Lim, K., KIKUZATO, S., Kiyonaga, A., Tanaka, H., Shindo, M., & Suzuki, M. (1995) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.41.647 · Cited by 141 · see citing works

Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside

MacLean, D. B., & Luo, L. (2004) · Brain Research · doi:10.1016/j.brainres.2004.04.041 · Cited by 140 · see citing works

Catechol O-methyltransferase. 5. Structure-activity relations for inhibition by flavonoids

Borchardt, R. T., & Huber, J. A. (1975) · Journal of Medicinal Chemistry · doi:10.1021/jm00235a030 · Cited by 137 · see citing works

Brown Adipose Tissue Activation Is Inversely Related to Central Obesity and Metabolic Parameters in Adult Human

Wang, Q., Zhang, M., Xu, M., Gu, W., Xi, Y., Qi, L., Li, B., & Wang, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123795 · Cited by 137 · see citing works

Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX)

Ohia, S. E., Opere, C. A., LeDay, A. M., Bagchi, M., Bagchi, D., & STOHS, S. J. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1019911205672 · Cited by 135 · see citing works

Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator

Jung, S. H., Ha, Y. J., Shim, E. K., Choi, S. Y., Jin, J., Yun‐Choi, H. S., & Lee, J. R. (2007) · Biochemical Journal · doi:10.1042/bj20061123 · Cited by 135 · see citing works

Effect of Caralluma fimbriata extract on appetite, food intake and anthropometry in adult Indian men and women.

Kuriyan, R., Raj, T., Srinivas, S., Vaz, M., Rajendran, R., & Kurpad, A. (2007) · Appetite · doi:10.1016/j.appet.2006.09.013 · Cited by 134 · see citing works

Body Composition and Hormonal Adaptations Associated with Forskolin Consumption in Overweight and Obese Men

Godard, M. P., Johnson, B. A., & Richmond, S. R. (2005) · Obesity Research · doi:10.1038/oby.2005.162 · Cited by 134 · see citing works

Thermogenesis in Adipose Tissue Activated by Thyroid Hormone

Yau, W. W. Y., & Yen, P. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21083020 · Cited by 133 · see citing works

Traditional Chinese Medicines in Treatment of Patients with Type 2 Diabetes Mellitus

Xie, W., Zhao, Y., & Zhang, Y. (2011) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2011/726723 · Cited by 132 · see citing works

Neuroprotection by caffeine and more specific A2Areceptor antagonists in animal models of Parkinson’s disease

Schwarzschild, M. A., Xu, K., Öztaş, E., Petzer, J. P., Castagnoli, K., Castagnoli, N. J., & Chen, J. (2003) · Neurology · doi:10.1212/01.wnl.0000095214.53646.72 · Cited by 130 · see citing works

Banting Lecture 2012

Spiegelman, B. M. (2013) · Diabetes · doi:10.2337/db12-1665 · Cited by 129 · see citing works

Reduction of Hypothalamic Protein Tyrosine Phosphatase Improves Insulin and Leptin Resistance in Diet-Induced Obese Rats

Picardi, P. K., Calegari, V. C., Prada, P. O., Moraes, J. C., ARAUJO, E. P. D., Gomes‐Marcondes, M. C. C., Ueno, M., Carvalheira, J. B. C., Velloso, L. A., & Saad, M. J. A. (2008) · Endocrinology · doi:10.1210/en.2007-1506 · Cited by 127 · see citing works

Effects of garlic on dyslipidemia in patients with type 2 diabetes mellitus.

Ashraf, R., Aamir, K., Shaikh, A. R., & Ahmed, T. (2005) · PubMed · Cited by 127 · see citing works

Ginger nanoparticles mediated induction of Foxa2 prevents high-fat diet-induced insulin resistance

Kumar, A., Sundaram, K., Teng, Y., Mu, J., Sriwastva, M. K., Zhang, L., Hood, J. L., Yan, J., Zhang, X., Park, J. W., et al. (2022) · Theranostics · doi:10.7150/thno.62514 · Cited by 127 · see citing works

Postingestive Modulation of Food Seeking Depends on Vagus-Mediated Dopamine Neuron Activity

Fernandes, A. B., da Silva, J. A., Almeida, J., Cui, G., Gerfen, C. R., Costa, R. M., & Oliveira-Maia, A. J. (2020) · Neuron · doi:10.1016/j.neuron.2020.03.009 · Cited by 126 · see citing works

The effects of ginger on fasting blood sugar, hemoglobin a1c, apolipoprotein B, apolipoprotein a-I and malondialdehyde in type 2 diabetic patients.

Khandouzi, N., Shidfar, F., Rajab, A., Rahideh, S. T., Hosseini, P., & Taheri, M. M. (2015) · Europe PMC (PubMed Central) · Cited by 123 · see citing works

Non-Pungent Capsaicin Analogs (Capsinoids) Increase Metabolic Rate and Enhance ThermogenesisviaGastrointestinal TRPV1 in Mice

Kawabata, F., INOUE, N., MASAMOTO, Y., Matsumura, S., KIMURA, W., Kadowaki, M., Higashi, T., Tominaga, M., Inoue, K., & Fushiki, T. (2009) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.90555 · Cited by 123 · see citing works

Selective Activation of Mitogen-Activated Protein (MAP) Kinase Kinase 3 and p38α MAP Kinase Is Essential for Cyclic AMP-Dependent UCP1 Expression in Adipocytes

Robidoux, J., Cao, W., Quan, H. Y., Daniel, K. W., Moukdar, F., Bai, X., Floering, L. M., & Collins, S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5466-5479.2005 · Cited by 122 · see citing works

PPARα and Sirt1 Mediate Erythropoietin Action in Increasing Metabolic Activity and Browning of White Adipocytes to Protect Against Obesity and Metabolic Disorders

Wang, L., Teng, R., Di, L., Rogers, H. M., Wu, H., Kopp, J. B., & Noguchi, C. T. (2013) · Diabetes · doi:10.2337/db13-0518 · Cited by 122 · see citing works

A Review of Natural Stimulant and Non‐stimulant Thermogenic Agents

Stohs, S. J., & Badmaev, V. (2016) · Phytotherapy Research · doi:10.1002/ptr.5583 · Cited by 122 · see citing works

Human white adipocytes express the cold receptor TRPM8 which activation induces UCP1 expression, mitochondrial activation and heat production

Rossato, M., Granzotto, M., Macchi, V., Porzionato, A., Petrelli, L., Calcagno, A., Vencato, J., Stefani, D. D., Silvestrin, V., Rizzuto, R., et al. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.12.005 · Cited by 120 · see citing works

Saffron (Crocus sativus L.) increases glucose uptake and insulin sensitivity in muscle cells via multipathway mechanisms

Kang, C., Lee, H., Jung, E.-S., Seyedian, R., Jo, M., Kim, J.-H., Kim, J.-S., & Kim, E. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.06.092 · Cited by 119 · see citing works

Metabolic effects of time-released garlic powder tablets in type 2 diabetes mellitus: The results of double-blinded placebo-controlled study

Sobenin, I. A., Nedosugova, L. V., Filatova, L. V., Balabolkin, M. I., Gorchakova, T. V., & Orekhov, A. N. (2008) · Acta Diabetologica · doi:10.1007/s00592-007-0011-x · Cited by 119 · see citing works

Gene expression of PPARγ and PGC-1α in human omental and subcutaneous adipose tissues is related to insulin resistance markers and mediates beneficial effects of physical training

Ruschke, K., Fishbein, L. M., Dietrich, A., Klöting, N., Tönjes, A., Oberbach, A., Faßhauer, M., Jenkner, J., Schön, M. R., Stümvoll, M., et al. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0767 · Cited by 116 · see citing works

Potential of Natural Products in the Inhibition of Adipogenesis through Regulation of PPARγ Expression and/or Its Transcriptional Activity

Feng, S., Reuss, L. E., & Wang, Y. (2016) · Molecules · doi:10.3390/molecules21101278 · Cited by 116 · see citing works

Catechin Safely Improved Higher Levels of Fatness, Blood Pressure, and Cholesterol in Children

Matsuyama, T., Tanaka, Y., Kamimaki, I., Nagao, T., & Tokimitsu, I. (2008) · Obesity · doi:10.1038/oby.2008.60 · Cited by 115 · see citing works

Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus

Lu, F., Shen, L., Qin, Y., Gao, L., Li, H., & Dai, Y. (2008) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-007-9005-3 · Cited by 115 · see citing works

Regulation of white adipogenesis and its relation to ectopic fat accumulation and cardiovascular risk

Gustafson, B., & Smith, U. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.04.812 · Cited by 112 · see citing works

Mechanism of action of cathinone: The active ingredient of Khat ( Catha Edulis

Nb, P. (2009) · East African Medical Journal · doi:10.4314/eamj.v77i6.46651 · Cited by 112 · see citing works

Adipose tissue changes in obesity and the impact on metabolic function

Sam, S., & Mazzone, T. (2014) · Translational research · doi:10.1016/j.trsl.2014.05.008 · Cited by 111 · see citing works

Effects of Crocin on Diabetic Maculopathy: A Placebo-Controlled Randomized Clinical Trial

Sepahi, S., Mohajeri, S. A., Hosseini, S. M., Khodaverdi, E., Shoeibi, N., Namdari, M., & Tabassi, S. A. S. (2018) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2018.03.007 · Cited by 111 · see citing works

A survey on saffron in major islamic traditional medicine books.

Javadi, B., Sahebkar, A., & Emami, S. A. (2013) · Europe PMC (PubMed Central) · Cited by 110 · see citing works

Esculetin: A review of its pharmacology and pharmacokinetics

Zhang, L., Xie, Q., & Li, X. (2021) · Phytotherapy Research · doi:10.1002/ptr.7311 · Cited by 110 · see citing works

Chemical constituents from Nelumbo nucifera leaves and their anti-obesity effects

Ahn, J. H., Kim, E. S., Lee, C., Kim, S., Cho, S., Hwang, B. Y., & Lee, M. K. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.04.013 · Cited by 109 · see citing works

Classics in Chemical Neuroscience: Fluoxetine (Prozac)

Wenthur, C. J., Bennett, M. R., & Lindsley, C. W. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400186j · Cited by 108 · see citing works

A review of clinical and experimental observations about antidepressant actions and side effects produced by Hypericum perforatum extracts

Rodríguez‐Landa, J. F., & Contreras, C. M. (2003) · Phytomedicine · doi:10.1078/0944-7113-00340 · Cited by 108 · see citing works

Cinnamon and Chronic Diseases

Hariri, M., & Ghiasvand, R. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-41342-6_1 · Cited by 107 · see citing works

Genistein inhibits CCAAT/enhancer-binding protein β (C/EBPβ) activity and 3T3-L1 adipogenesis by increasing C/EBP homologous protein expression

Harmon, A. W., Patel, Y. M., & Harp, J. B. (2002) · Biochemical Journal · doi:10.1042/bj20020300 · Cited by 106 · see citing works

Protective effect of Platycodi radix on carbon tetrachloride-induced hepatotoxicity

Lee, K. J., & Jeong, H. G. (2002) · Food and Chemical Toxicology · doi:10.1016/s0278-6915(01)00104-1 · Cited by 104 · see citing works

Intragastric administration of capsiate, a transient receptor potential channel agonist, triggers thermogenic sympathetic responses

Ono, K., Tsukamoto‐Yasui, M., Hara-Kimura, Y., Inoue, N., Nogusa, Y., Okabe, Y., Nagashima, K., & Kato, F. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00128.2010 · Cited by 104 · see citing works

Fenugreek (Trigonella foenum-graecum L.): An Overview

Snehlata, H. S., & Payal, D. (2012) · International Journal of Current Pharmaceutical Review and Research · doi:10.5281/zenodo.12698238 · Cited by 104 · see citing works

In vitro inhibitory effect of triterpenoidal saponins from platycodi radix on pancreatic lipase

Xu, B. J., Han, L., Zheng, Y. N., Lee, J. H., & Sung, C. K. (2005) · Archives of Pharmacal Research · doi:10.1007/bf02977712 · Cited by 103 · see citing works

Procyanidins and Their Healthy Protective Effects Against Type 2 Diabetes

González‐Abuín, N., Pinent, M., Casanova‐Martí, À., Arola, L., Blay, M., & Ardèvol, A. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140916115519 · Cited by 99 · see citing works

Ursolic acid: A systematic review of its pharmacology, toxicity and rethink on its pharmacokinetics based on PK-PD model

Sun, Q., He, M., Zhang, M., Zeng, S., Chen, L., Zhou, L., & Xu, H. (2020) · Fitoterapia · doi:10.1016/j.fitote.2020.104735 · Cited by 98 · see citing works

Harnessing glucagon‐like peptide‐1 receptor agonists for the pharmacological treatment of overweight and obesity

Burcelin, R., & Gourdy, P. (2016) · Obesity Reviews · doi:10.1111/obr.12465 · Cited by 97 · see citing works

Effects of phytochemicals against diabetes

Bacanli, M. G., DİLSİZ, S. A., Başaran, N., & Başaran, A. (2019) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2019.02.006 · Cited by 97 · see citing works

Postprandial glucose, insulin and glucagon-like peptide 1 responses to sucrose ingested with berries in healthy subjects

Törrönen, R., Sarkkinen, E. S., Niskanen, T. H., Tapola, N. S., Kilpi, K., & NISKANEN, L. K. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511004557 · Cited by 96 · see citing works

Mechanism of action of a hypoglycemic principle isolated from fenugreek seeds.

Puri, D., Prabhu, K. M., & Murthy, P. S. (2002) · PubMed · Cited by 95 · see citing works

Licochalcone A: A lipase inhibitor from the roots of Glycyrrhiza uralensis

Won, S., Kim, S.-K., Kim, Y.-M., Lee, P.-H., Ryu, J.-H., Kim, J.-W., & Rhee, H.-I. (2007) · Food Research International · doi:10.1016/j.foodres.2007.05.005 · Cited by 93 · see citing works

Mangiferin Improved Palmitate-Induced-Insulin Resistance by Promoting Free Fatty Acid Metabolism in HepG2 and C2C12 Cells via PPAR α : Mangiferin Improved Insulin Resistance

Zhang, Q., Kong, X., Yuan, H., Guan, H., Li, Y., & Niu, Y. (2019) · Journal of Diabetes Research · doi:10.1155/2019/2052675 · Cited by 93 · see citing works

Anti-obesity effects of capsaicin and the underlying mechanisms: a review

Li, R., Lan, Y., Chen, C., Cao, Y., Huang, Q., Ho, C., & Lu, M. (2020) · Food & Function · doi:10.1039/d0fo01467b · Cited by 93 · see citing works

Ginger: Is it Ready for Prime Time?

Stoner, G. D. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0055 · Cited by 91 · see citing works

Ephedrine, xanthines and prostaglandin-inhibitors: actions and interactions in the stimulation of thermogenesis.

Dulloo, A. G. (1993) · PubMed · Cited by 90 · see citing works

Contribution of beta 3-adrenoceptor activation to ephedrine-induced thermogenesis in humans.

Liu, Y., Toubro, S., Astrup, A. V., & Stock, M. J. (1995) · PubMed · Cited by 89 · see citing works

General characteristics of Pinus spp. Seed fatty acid compositions, and importance of Δ5‐olefinic acids in the taxonomy and phylogeny of the genus

Wolff, R. L., Pédrono, F., Pasquier, E., & Marpeau, A. M. (2000) · Lipids · doi:10.1007/s11745-000-0489-y · Cited by 89 · see citing works

Enhancement of insulin sensitivity in adipocytes by ginger

Sekiya, K., Ohtani, A., & Kusano, S. (2004) · BioFactors · doi:10.1002/biof.5520220130 · Cited by 88 · see citing works

Phytochemicals in the Control of Human Appetite and Body Weight

Tucci, S. A. (2010) · Pharmaceuticals · doi:10.3390/ph3030748 · Cited by 85 · see citing works

Esculetin Induces Apoptosis and Inhibits Adipogenesis in 3T3‐L1 Cells

Yang, J., Della‐Fera, M. A., Hartzell, D. L., Nelson‐Dooley, C., Hausman, D. B., & Baile, C. A. (2006) · Obesity · doi:10.1038/oby.2006.194 · Cited by 85 · see citing works

The effect of saffron (Crocus sativus L.) hydroalcoholic extract on metabolic control in type 2 diabetes mellitus: A triple-blinded randomized clinical trial

Djazayeri, A., Akhondzadeh, S., Milajerdi, A., Jazayeri, S., Hashemzadeh, N., Shirzadi, E., & Derakhshan, Z. (2018) · Journal of Research in Medical Sciences · doi:10.4103/jrms.jrms_286_17 · Cited by 85 · see citing works

Leptin Regulation of Peroxisome Proliferator-Activated Receptor-γ, Tumor Necrosis Factor, and Uncoupling Protein-2 Expression in Adipose Tissues

Qian, H., Hausman, G., Compton, M. M., Azain, M. J., Hartzell, D. L., & Baile, C. A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8680 · Cited by 84 · see citing works

Anorexigenic effects of two amines obtained from Catha edulis Forsk. (Khat) in rats

Zelger, J. L., & Carlini, E. A. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(80)90152-5 · Cited by 83 · see citing works

Role of pancreatic lipase inhibition in obesity treatment: mechanisms and challenges towards current insights and future directions

Subramaniyan, V., & Hanim, Y. U. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01729-1 · Cited by 94 · see citing works

Advancements and Challenges in Stem Cell Transplantation for Regenerative Medicine

Wei, L., Yan, W., Shah, W., Zhang, Z., Wang, M., Liu, B., Xue, Z., Cao, Y., Hou, X., Zhang, K., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35836 · Cited by 79 · see citing works

Chronic Use of Artificial Sweeteners: Pros and Cons

Kossiva, L., Kakleas, K., Christodouli, F., Soldatou, A., Karanasios, S., & Karavanaki, K. (2024) · Nutrients · doi:10.3390/nu16183162 · Cited by 55 · see citing works

Evaluating the Efficacy and Safety of Alpha-Hydroxy Acids in Dermatological Practice: A Comprehensive Clinical and Legal Review

Almeman, A. A. (2024) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s453243 · Cited by 45 · see citing works

Theabrownins from dark tea: formation, gut microbiota-mediated biotransformation, health benefits, and potential in functional food applications

Zhang, C., Li, M., Li, L., Wan, C. C., Xia, Y., Ma, H., & Xu, J. (2025) · Food & Function · doi:10.1039/d5fo02046h · Cited by 19 · see citing works

Plant-Derived Bioactive Compounds: One Health Perspective

Gonçalves, A. C., Pinto, A. R., Cima, A., Olo-Fontinha, E., Martins, J. C. L., Garcia, J., Lemos, A. M., Saavedra, M. J., Pintado, M., & Alves, M. J. (2025) · Applied Sciences · doi:10.3390/app16010327 · Cited by 24 · see citing works

Anti-obesity effects of a standardized ethanol extract of Eisenia bicyclis by regulating the AMPK signaling pathway in 3T3-L1 cells and HFD-induced mice

Yoon, Y., Chung, K., Lee, S., Heo, S.-W., Kim, Y.-R., Lee, J. K., Kim, H.-J., Park, S., Shin, Y., & Lee, K. (2024) · Food & Function · doi:10.1039/d4fo00759j · Cited by 16 · see citing works

The effect of quercetin on adipogenesis, lipolysis, and apoptosis in 3T3‐L1 adipocytes: The role of SIRT1 pathways

Maleki, M. H., Javazm, S. A., Dastghaib, S., Panji, A., Far, M. H., Mahmoodi, H., Siri, M., & Shafiee, S. M. (2024) · Obesity Science & Practice · doi:10.1002/osp4.752 · Cited by 15 · see citing works

Metabolic Syndrome and Biotherapeutic Activity of Dairy (Cow and Buffalo) Milk Proteins and Peptides: Fast Food-Induced Obesity Perspective—A Narrative Review

Abdisa, K. B., Szerdahelyi, E., Molnár, M. A., Friedrich, L. F., Lakner, Z., Koris, A. K., Tóth, A., & Nath, A. (2024) · Biomolecules · doi:10.3390/biom14040478 · Cited by 15 · see citing works

Exploiting Spinach‐Derived Extracellular Vesicles for Anti‐Obesity Therapy Through Lipid Accumulation Inhibition

Lee, J. H., Kang, S. J., & Rhee, W. J. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202400150 · Cited by 13 · see citing works

Development of Novel N-Acylhydrazone Derivatives with High Anti-obesity Activity and Improved Safety by Exploring the Pharmaceutical Properties of Aldehyde Group

Jiang, Z., Hu, Y., Guo, S., Li, Y., Zhao, D., Wei, L., Lin, Y.-W., Xu, S., Huang, S., Li, Q., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c01242 · Cited by 13 · see citing works

Deciphering the potential of Cymbopogon citratus (DC.) Stapf as an anti-obesity agent: phytochemical profiling, in vivo evaluations and molecular docking studies

Aly, O., Mekky, R. H., Pereira, F., Diab, Y. M., Tammam, M. A., & El‐Demerdash, A. (2024) · Food & Function · doi:10.1039/d4fo04602a · Cited by 13 · see citing works

Zebrafish navigating the metabolic maze: insights into human disease – assets, challenges and future implications

Yashaswini, C., Kiran, N. S., & Chatterjee, A. (2024) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-024-01539-8 · Cited by 12 · see citing works

Molecular insights into herbal medicines for the treatment of metabolic associated Steatohepatitis

Addissouky, T. A. (2025) · Discover Chemistry. · doi:10.1007/s44371-025-00212-0 · Cited by 12 · see citing works

Gastrointestinal Adverse Effects of Anti-Obesity Medications in Non-Diabetic Adults: A Systematic Review

Takrori, E., Peshin, S., & Singal, S. (2025) · Medicina · doi:10.3390/medicina61111987 · Cited by 13 · see citing works

Pectolinarigenin and its derivatives: Bridging the gap between chemical properties and pharmacological applications

Patel, N. K., Kulshrestha, R., Bhat, A. A., Mishra, R., Singla, N., Gilhotra, R. M., & Gupta, G. (2024) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2024.100378 · Cited by 11 · see citing works

Natural Lipase Inhibitors in Recent Years: A Review

Bülbül, M., & Çokdinleyen, S. (2024) · ChemistrySelect · doi:10.1002/slct.202401091 · Cited by 10 · see citing works

Mechanistic insights into the anti-obesity actions of coumarins: Therapeutic potential and future directions

Mustafa, Y. F. (2025) · Obesity Medicine · doi:10.1016/j.obmed.2025.100620 · Cited by 10 · see citing works

Modulation of adiposity and adipocyte inflammation by methanol extracts of Alpinia calcarata leaf in high-fat-diet induced-obese mice: Involvement of COX-2 and PPAR-γ

Ahmad, I., Hasan, M., Bhowmik, D. R., Begum, R., Roy, S., Islam, M. M., Ripon, M. A. R., & Hossain, M. S. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e41949 · Cited by 9 · see citing works

Diverse Therapeutic Potentials of Hypericin: An In-Depth Review

Maurya, S. K., Divakar, S., Rathee, S., & Patil, U. K. (2025) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266330142250224101958 · Cited by 9 · see citing works

Current insights on the effects of medicinal plants in the management of obesity and infectious diseases: An update from 2020

Ofoezie, E. F., Ogbonna, C. A., George, E. T., Anunobi, C. J., Olisakwe, S. C., Babarinde, S., Chukwuemeka, C. G., Ogbonna, U. E., Amafili, C. C., Omaba, O. J., et al. (2025) · Aspects of Molecular Medicine · doi:10.1016/j.amolm.2025.100075 · Cited by 9 · see citing works

A Review of the Potential Health Benefits of Nigella sativa on Obesity and Its Associated Complications

Adam, S. H., Abu, I. F., Kamal, D. A. M., Febriza, A., Kashim, M. I. A. M., & Mokhtar, M. H. (2023) · Plants · doi:10.3390/plants12183210 · Cited by 14 · see citing works

Unraveling the Anti-Obesity Potential of Luteolin: Mechanistic Insights

SHARMA, A. K., Kaur, G., Kaur, A., & Devi, S. (2024) · Current Nutrition & Food Science · doi:10.2174/0115734013307906240407093309 · Cited by 8 · see citing works

The Strong Inhibition of Pancreatic Lipase by Selected Indonesian Medicinal Plants as Anti-Obesity Agents

Rahminiwati, M., Iswantini, D., Trivadila, T., Sianipar, R. N. R., Sukma, R. M., Indariani, S., & Murni, A. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47010039 · Cited by 8 · see citing works

The Impact of Coenzyme Q10 on Cognitive Dysfunction, Antioxidant Defense, Cholinergic Activity, and Hippocampal Neuronal Damage in Monosodium Glutamate-Induced Obesity

Erfanmanesh, Z., Edalatmanesh, M. A., & Mokhtari, M. (2025) · Iranian journal of pharmaceutical research · doi:10.5812/ijpr-157068 · Cited by 8 · see citing works

Lipid‐lowering effect of mangiferin through the inhibition of pancreatic lipase activity

Wang, S., Qin, Y., Liu, Y., Jiao, R., Lin, R., Yuan, Z., & He, Z. (2025) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.14301 · Cited by 8 · see citing works

Patulin Ameliorates Hypertrophied Lipid Accumulation and Lipopolysaccharide-Induced Inflammatory Response by Modulating Mitochondrial Respiration

Hong, S., Park, S. K., Lee, J., Park, S. H., Kim, Y., Park, J., Yu, S., & Lee, Y. G. (2023) · Antioxidants · doi:10.3390/antiox12091750 · Cited by 7 · see citing works

AMPK-Mediated Hypolipidemic Effects of a Salvia miltiorrhiza and Paeonia lactiflora Mixed Extract on High-Fat Diet-Induced Liver Triglyceride Accumulation: An In Vivo and In Vitro Study

Son, J., Phong, N. V., Cha, M., Oh, B., Song, S., & Yang, S. Y. (2024) · Nutrients · doi:10.3390/nu16183189 · Cited by 6 · see citing works

Nanoparticle-Delivered Rutin Prevents Metabolic and Oxidative Imbalance in Obesity Triggered by a High-Fat Diet: In Vivo and In Silico Studies

Zahran, N. H., Abu-Elsaoud, A. M., Mohamed, A. S., & Marie, O. (2025) · Biomedicines · doi:10.3390/biomedicines13092106 · Cited by 6 · see citing works

The protective effect of crawfish chitosan on the reproductive performance of obese male rats

Fol, M. F., Hamdi, S. A. H., El‐Rahman, H. A. A., Abdel-Maksoud, M. A., Hussein, A. M., & Mostafa, N. A. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103463 · Cited by 6 · see citing works

Phytoactives for Obesity Management: Integrating Nanomedicine for Its Effective Delivery

Mandal, A. K., Sahoo, A., Almalki, W. H., Almujri, S. S., Alhamyani, A., Aodah, A. H., Alruwaili, N. K., Kadir, S. Z. B. S. A., Mandal, R. K., Almalki, R. A., et al. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae136 · Cited by 5 · see citing works

Synergistic Anti-Obesity Effects of Lactiplantibacillus plantarum Q180 and Phaeodactylum tricornutum (CKDB-322) in High-Fat-Diet-Induced Obese Mice

Noh, H.-J., Eom, J.-I., Park, S.-J., Shin, C. H., Kim, S.-M., Pan, C., & Lee, J. K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167991 · Cited by 4 · see citing works

β-Sitosterol targets the gut–brain–clock axis to ameliorate circadian disruption and metabolic dysfunction: A herb–pharmacomicrobiomic perspective

Ganamurali, N., & Sabarathinam, S. (2025) · Chronobiology International · doi:10.1080/07420528.2025.2568586 · Cited by 5 · see citing works

Identifying edible plants with high anti-obesity potential: In vitro inhibitory effect against pancreatic lipase followed by bioactive compound metabolomic screening

Tsagkaris, A. S., Loučková, A., Polak, J., & Hajšlová, J. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103453 · Cited by 5 · see citing works

Alchornea cordifolia leaf-extract ameliorates bisphenol A-induced obesity in male Wistar rats

Agboola, A. R., Itam, A. H., Ekeleme, C. M., Agwupuye, E. I., Ahmed, Z. O., Igiakong, G. P., Agbor, G. B., Abubakar, A. N., Adamu, Z., David‐Oku, E., et al. (2025) · Clinical Phytoscience · doi:10.1186/s40816-024-00389-4 · Cited by 5 · see citing works

The role of plant-derived compounds in anti-obesity drug discovery: A molecular perspective

Subramaniyan, V., Ravi, R. N., Maqsood, S., Singh, S. K., Chitra, V., Dua, K., Oliver, B. G., Dhanasekaran, S., Gupta, G., & Singh, T. G. (2025) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2025.102597 · Cited by 4 · see citing works

Obesity and Natural Products: Mechanisms, Therapeutic Potential, and Future Directions

Marie, O., & Abu-Elsaoud, A. M. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71575 · Cited by 7 · see citing works

Harnessing the Potential of Helinus integrifolius in Cosmeceutical Research: Toward Sustainable Natural Cosmetics

Gwanya, H. Y., Mbuyiswa, A.-A. N., Phokwe, O. J., Gxaba, N., & Manganyi, M. C. (2024) · Cosmetics · doi:10.3390/cosmetics11040126 · Cited by 7 · see citing works

Regulatory effects of yam (Dioscorea opposita Thunb.) glycoprotein on energy metabolism in C2C12 and 3T3-L1 cells and on crosstalk between these two cells

Li, W., Shi, J. G., Wu, X., Qiu, H., & Liu, C. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.119013 · Cited by 4 · see citing works

Synergistic Fat-Reducing Effect of Deoxycholic Acid and Rhein in Lipid-Based Nanoparticles with Reduced Toxicity for Obesity Treatment

Hsu, C., Huang, T., Lin, Z., Chen, C., Hwang, E., Chen, W.-J., & Fang, J. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s494416 · Cited by 4 · see citing works

Role of Microneedles for Improved Treatment of Obesity: Progress and Challenges

Chilamakuri, S. N., Manasa, N., Thalla, M., Ravichandiran, V., Lee, Y., Cho, S. M., Jung, H., & Natesan, S. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.4c01115 · Cited by 4 · see citing works

Nutraceuticals enhanced by nanotechnology: A new frontier for obesity treatment

Balusamy, S. R., Vijayalakshmi, S., Sumathi, S., Huq, M. A., Nag, S., Mohanto, S., Sukweenadhi, J., Oh, D. H., & Perumalsamy, H. (2025) · Process Biochemistry · doi:10.1016/j.procbio.2025.05.021 · Cited by 4 · see citing works

Disulfiram-Loaded Nanoparticles Inhibit Long-Term Proliferation on Preadipocytes

Lorenzo-Anota, H. Y., Gómez-Cantú, J., Vázquez‐Garza, E., Bernal‐Ramírez, J., Chapoy‐Villanueva, H., Mayolo‐Deloisa, K., Benavides, J., Rito‐Palomares, M., & Lozano, O. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s467909 · Cited by 3 · see citing works

Nanocarrier-enabled delivery of natural antiobesity agents

Chung, Y.-K., Hsu, C., Wang, Y., Tran, T. T. P., Alalaiwe, A. S., & Fang, J. Y. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2534328 · Cited by 5 · see citing works

Anti-obesity effect of unsaponifiable matter from hemp seed in 3T3-L1 adipocytes and high-fat diet-induced obese mice

Kwon, Y., Kim, U., Han, S. B., Park, S., Lee, J. S., Heo, H., Jeon, H.-J., Lee, D., Suh, J. H., & Sung, J. (2025) · Food & Function · doi:10.1039/d5fo02231b · Cited by 3 · see citing works

Capsaicin camphor and caffeic acid reduce adipogenesis and promote lipolysis with TRPV1 involvement

Ali, U., Wasner, F., Fan, J., Wabitsch, M., & Gregureć, D. (2025) · Scientific Reports · doi:10.1038/s41598-025-31073-3 · Cited by 3 · see citing works

Randomised, double-blind, parallel group comparison of Ashitaba ( Angelica Keiskei ) chalcone effects on visceral fat areas and waist circumference of overweight persons

Watanabe, N., Inoue, K., Hara, H., Midorikawa, M., Ohta, M., & Ohkura, N. (2024) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2024.2334070 · Cited by 3 · see citing works

The unfolded features on the synchronized fashion of gut microbiota and Drynaria rhizome against obesity via integrated pharmacology

Oh, K., Yoon, S. J., Song, S. H., Park, J. H., Kim, J. S., Kim, M. J., Kim, D. J., & Suk, K. T. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140616 · Cited by 4 · see citing works

Mitigation of Insulin Resistance, Inflammation, Oxidative Stress, and Metabolic Abnormalities by Bavachalcone in High-Fat/High-Fructose Diet-Fed Rats

Yin, J. (2025) · Indian Journal of Pharmaceutical Education and Research · doi:10.5530/ijper.20257230 · Cited by 2 · see citing works

The metabolic and anti-adiposity effects of oral Copaiba-oil supplementation are influenced by sex and obesity

Guareschi, Z. M. N. D. C., Urrutia, M. A. D., Daudt, B. M., Siqueira, B. S., Ceglarek, V. M., Santos, M. E. D., & Grassiolli, S. (2025) · Nutrivisa Revista de Nutrição e Vigilância em Saúde · doi:10.52521/nutrivisa.v12i1.14328 · Cited by 3 · see citing works

Cis-vaccenic acid exhibits an anti-obesity effect by regulating food intake and lipid metabolism in mammals

Wen, Y., Zhang, R., Xie, J., Wan, A., Mei, S., Xie, J., Lei, S., Xia, Q., & Wang, G. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.106958 · Cited by 3 · see citing works

Effects of Ecklonia stolonifera Extract on Metabolic Dysregulation in High-Fat Diet-Induced Obese Mice

Cho, S. Y., Choi, J. S., & Jung, U. J. (2024) · Journal of Medicinal Food · doi:10.1089/jmf.2023.k.0252 · Cited by 3 · see citing works

Effects of NET-2201 (Capsicum chinense L. cv.) on brown adipose tissue activation and white adipose tissue browning in high-fat-diet-induced obese mice

Han, Y.-Y., Jo, H.-N., Kim, B., Lee, J. S., Kim, J. M., Ryu, D.-H., Kim, D.-H., Park, C.-S., Kang, B., & Lee, Y.-W. (2024) · Food Science and Biotechnology · doi:10.1007/s10068-024-01692-z · Cited by 3 · see citing works

Antioxidants and Obesity

Sood, P., Kaur, G., Thapa, K., Sharma, K., & Sindhu, R. K. (2024) · Antioxidants · doi:10.1002/9781394270576.ch13 · Cited by 3 · see citing works

Obesity epidemic in European countries: from an unaddressed risk factor to a medicalized disease?

Garattini, L., & Fattore, G. (2024) · The European Journal of Health Economics · doi:10.1007/s10198-024-01752-5 · Cited by 2 · see citing works

Açaí seed extract mitigates intestinal and hypothalamic alterations in obese mice

Arnoso, B. J. D. M., de Araújo, C. A., Ramundo, G. D., de Bem, G. F., Ognibene, D. T., Fontes-Dantas, F. L., Martins, B. C., Daleprane, J. B., de Souza, M. O., Resende, Â. C., et al. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112574 · Cited by 2 · see citing works

Evidence-Based Supplementation Strategies for Wrestlers: A Systematic Review

Díaz, M. C., Martínez, A. P., Zare, R., Redha, A. A., & Forbes, S. C. (2025) · Current Nutrition Reports · doi:10.1007/s13668-025-00672-x · Cited by 2 · see citing works

Emerging Nanonutraceuticals against Obesity

Ni, L., Peng, M., Liang, Y., Ye, X., Zheng, H., Guo, D., Yang, L., Li, X., & Chen, R. (2025) · Small Science · doi:10.1002/smsc.202500116 · Cited by 3 · see citing works

Dietary Intake of Phytochemicals, Gut Microbiota, and Appetite Control

Al‐Dujaili, E. A. S. (2025) · Nutrients · doi:10.3390/nu17162646 · Cited by 2 · see citing works

In Silico and In Vivo Hepatorenal Protective Effect of Chitosan-loaded Chrysin Nanoparticles in Obese Rats

Omar, T. Y., Al-mosaidyyen, S. M., Mohammed, E. N., Saied, N. A., Ayman, F. A., Khalil, J. K., Shawoush, A. M. A., & Mohamed, A. S. (2025) · Current Topics in Medicinal Chemistry · doi:10.2174/0115680266388484250807033921 · Cited by 2 · see citing works

Anti-Obesity, Lipid-Lowering, and Anti-Hyperglycemic Effects of CB-02 in High-Fat-Diet-Induced Obese Mice

Hiep, H. L., Bang, P. V., Nhan, N. D., Ngan, N. H., To, D. C., Dung, N. V., & Phu, L. H. (2025) · Molecules · doi:10.3390/molecules30183678 · Cited by 2 · see citing works

Neoshirakia japonica (Siebold & Zucc.) Esser [Euphorbiaceae] fruit suppresses obesity and obesity-induced inflammation in adipocytes, macrophages, and obese mice

Lee, E., Park, J., & Nam, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1647343 · Cited by 2 · see citing works

Gene expression profiling of KLF4 and KLF5 in visceral adipose tissue of obese women: insights into adipogenic and metabolic regulation

Muhi, D. J., Murad, M. M., Panahi, G., Mahmoudabadi, H. Z., Emamgholipour, S., & Nowrouzi, A. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02734-z · Cited by 2 · see citing works

Ailanthus excelsa’s lipid-modulating potential through PPAR and PI3K-Akt pathways: insights from system biology approach and 3T3-L1 adipocyte studies

Gudasi, S., Patil, M. B., Gharge, S., & Khatib, N. A. (2025) · Network Modeling Analysis in Health Informatics and Bioinformatics · doi:10.1007/s13721-025-00622-1 · Cited by 2 · see citing works

Recent advances in saponin-lipase-microbiota triad effect on obesity management, a comprehensive review

Abdelfattah, M. S., Fouad, M. A., El-Ahmady, S. H., & Farag, M. A. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118363 · Cited by 2 · see citing works

Protective effects of Bambusa vulgaris leaves extract on high-fat diet-induced MASLD: insights from in silico and in vivo study

Sarkar, S., Das, S., Ghosh, A., Goswami, R. C. D., & Choudhuri, D. (2026) · 3 Biotech · doi:10.1007/s13205-026-04735-w · Cited by 2 · see citing works

Phytochemicals and Obesity: A mini Review from the Dietary Phytochemical Index Perspective

Toprak, K., Yıldırım, Z., Kaplan, D. N., Şentürk, G., & Şanlıer, N. (2026) · Current Nutrition Reports · doi:10.1007/s13668-026-00763-3 · Cited by 2 · see citing works

Ovothiol-A Mitigates High-Fat Diet-Induced Non-alcoholic Fatty Liver Disease in Rats

Arafa, N. H., Shehata, M. R., & Mohamed, A. S. (2024) · Current Bioactive Compounds · doi:10.2174/0115734072272429231106090645 · Cited by 2 · see citing works

Hypoglycemic and hypolipidemic effects of unsaponifiable matter from okra seed in diabetic rats

Seo, D.-Y., Kim, N., Jeon, A., Kwon, J., Baek, I., Shin, E., Lee, J., & Kim, Y. (2024) · Nutrition Research and Practice · doi:10.4162/nrp.2024.18.3.345 · Cited by 2 · see citing works

Ascochlorin Attenuates the Early Stage of Adipogenesis via the Wnt/β-Catenin Pathway and Inhibits High-Fat-Diet-Induced Obesity in Mice

Yu, M.-H., Jeong, Y., Son, S. W., Kwon, S. Y., Song, K., Son, H.-S., Jeon, E. J., & Chang, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810226 · Cited by 2 · see citing works

Vine Tea Extract (VTE) Inhibits High-Fat Diet-Induced Adiposity: Evidence of VTE’s Anti-Obesity Effects In Vitro and In Vivo

Lim, W., Choi, S., Kim, J., Baek, K.-S., Park, M., Lee, G., & Lim, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212042 · Cited by 2 · see citing works

Crude Extract and Solvent-Partitioned Fractions of the Halophyte Atriplex gmelinii Inhibit Adipogenesis in 3T3-L1 Preadipocytes

Lee, J. I., Oh, J. H., Kong, C., & Seo, Y. (2023) · Journal of Korean Medicine for Obesity Research · doi:10.15429/jkomor.2023.23.2.69 · Cited by 1 · see citing works

UPLC-QTOF-MS characterized, herbal medicine, pancogrit modulates NF-κB and JAK2/STAT3 signaling pathways in cell-based model of TNF-α dependent acute pancreatitis

Balkrishna, A., Dey, T., Verma, S., Dev, R., & Varshney, A. (2024) · Journal of Biologically Active Products from Nature · doi:10.1080/22311866.2024.2392640 · Cited by 1 · see citing works

Ethanolic Extract Clove-loaded Chitosan Nanoparticles Reduce Dyslipidemia, Enhance Liver and Kidney Functions, and Improve the Antioxidant System in Obese Rats

Abelsalam, Y. G. S., Mohamed, H. R. H., Baiomy, A. A. A., Abdelfattah, M. A., & Mohamed, A. S. (2024) · Drug Delivery Letters · doi:10.2174/0122103031313909240910093810 · Cited by 1 · see citing works

Protective Effects of a Standardized Water Extract from the Stem of Ipomoea batatas L. Against High-Fat Diet-Induced Obesity

Lee, C.-W., Yoon, Y. S., Yoon, Y., Chung, K., Kim, M., Park, G., Choi, M., Jang, Y. P., & Lee, K. (2025) · Nutrients · doi:10.3390/nu17101643 · Cited by 1 · see citing works

Computational insights into human UCP1 activation by wide virtual screening as new anti-obesity: a study utilizing molecular docking and molecular dynamics simulations

Karami, E., Rostamkhani, F., Abdollahi, M., & Ahmadifard, M. (2025) · Network Modeling Analysis in Health Informatics and Bioinformatics · doi:10.1007/s13721-025-00524-2 · Cited by 1 · see citing works

Hormonal Regulation in Obesity: The Dose-dependent Impact of Artocarpus altilis Extract on Ghrelin, Leptin, and Adiponectin

Wahyudin, W., Setiawati, S., Ati, V. R. B., & Pauzi, R. Y. (2025) · Journal of Natural Remedies · doi:10.18311/jnr/2025/47615 · Cited by 1 · see citing works

Regulatory effects of specialized metabolites from Dendrobium albosanguineum on lipid metabolism and adipocyte differentiation

Wuttiin, J., Nuntawong, P., Khine, H. E. E., Sungthong, R., Kitisripanya, T., Thant, M. T., Chaotham, C., Mekboonsonglarp, W., Likhitwitayawuid, K., & Sritularak, B. (2025) · Scientific Reports · doi:10.1038/s41598-025-12547-w · Cited by 1 · see citing works

Mesoporous Silica Nanoparticle as a Potential Nanocarrier to Improve the Effectiveness of Antiobesity Drugs

Aulifa, D. L., Nurulaini, S. N., Ayodduki, Z. N. S. H., Anggi, J. F., Chandra, J., & Budiman, A. (2025) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s538644 · Cited by 1 · see citing works

Paliurus ramosissimus Leaf Extract Inhibits Adipocyte Differentiation In Vitro and In Vivo High-Fat Diet-Induced Obesity Through PPARγ Suppression

Kim, S., Son, T. H., Shin, H.-L., Kim, D., Park, G. H., Seo, J. W., Kim, H.-G., & Choi, S. (2025) · Pharmaceuticals · doi:10.3390/ph18101515 · Cited by 1 · see citing works

Molecular mechanisms of propolis in adipogenesis, lipid metabolism and white adipose tissue Browning: a systematic review of preclinical studies

Megantara, I., Karisa, P., Pakpahan, W. I., Sylviana, N., & Goenawan, H. (2025) · Adipocyte · doi:10.1080/21623945.2025.2576894 · Cited by 1 · see citing works

Understanding obesity–cancer crosstalk to inform the immunomodulatory roles of anti-obesity nanotherapeutics

Zhou, F., Li, X., Jiang, J., & Zhang, L. L. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102756 · Cited by 1 · see citing works

Obesity: current developments in mechanisms, diagnosis, classification and the evolution of personalized management

Shi, L., Li, D., & Li, Y. (2026) · Medical Review · doi:10.1515/mr-2025-0048 · Cited by 1 · see citing works

Efficacy and Safety of Steamed Ginger Extract for Body Weight and Body Fat Reduction in Overweight Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Kwon, J. E., Lee, Y.-G., Kim, I., Bae, J., Kang, S.-C., & Baek, H.-I. (2026) · Nutrients · doi:10.3390/nu18020366 · Cited by 1 · see citing works

Ameliorative Effect of Policosanol on High‐Fat Diet‐Induced Testicular Dysfunction: Implications of ROS/SIRT1 and Apoptotic Signaling Pathways in Rats

Elseweidy, M. M., Elgammal, N. S., Kilany, M. S., El‐Aziz, R. M. A., & Elnagar, G. M. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.71345 · Cited by 1 · see citing works

Update of Korean Medicine Clinical Practice Guidelines for Obesity Management: An Evidence‐Based GRADE Approach

Kim, S.-D., Son, M. J., Kim, B., Ko, M. M., Jegal, K. H., Kim, H., Park, S., Kim, K., Song, M. Y., Jo, J., et al. (2026) · Obesity · doi:10.1002/oby.70242 · Cited by 1 · see citing works

Evaluation of the acute basic biological effects of herbal formulation to control obesity: a preliminary study

Kumar, M., Kaushik, D., Kaushik, R., Khan, A. U., Billeci, L., Öz, E., Proestos, C., Brennan, C. S., Ahmad, N., Elobeid, T., et al. (2023) · International Journal of Food Science & Technology · doi:10.1111/ijfs.16669 · Cited by 1 · see citing works

Phytopharmaceuticals for Management of Disorders

Baveja, M. (2024) · Springer eBooks · doi:10.1007/978-3-031-63677-6_2 · Cited by 1 · see citing works

Therapeutic potential of Garcinia cambogia and Emblica officinalis in the management of obesity and lipid profiles in a rat model of diet induced obesity

Yadav, R., Bindra, H. K., & Chaurasia, R. C. (2024) · International Journal of Basic & Clinical Pharmacology · doi:10.18203/2319-2003.ijbcp20242423 · Cited by 1 · see citing works

Anti-Obesity Effects of Raphanus sativus Water Extract on High-Fat Diet-Induced Obese Mice and 3T3-L1 Adipocytes

Park, S. K., Choi, S. Y., & Lee, Y. G. (2024) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2024.53.9.904 · Cited by 1 · see citing works

The Physiological Effects of Orlistat and Efficiency Extract of Cinnamon on Renal Functions in Obese Male Rats

Abed, B. A., Jasim, W. K., & Rahi, T. S. (2025) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/1449/1/012024 · Cited by 1 · see citing works

Therapeutic Potential of Santa Herba Extract in Obesity: Impact on Lipid Metabolism and Hormonal Balance

Jo, Y., Hong, E., Kim, S., Kim, J. G., Lee, S., Son, W., Ma, M., Kim, S., Choi, J., & Seo, M. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70479 · Cited by 1 · see citing works

Impact of a Food Rebalancing Program Associated with Plant-Derived Food Supplements on the Biometric, Behavioral, and Biological Parameters of Obese Subjects

Houben, J., Carpentier, Y., Paulissen, G., Snick, G. V., & Soetewey, A. (2023) · Nutrients · doi:10.3390/nu15224780

Results from an Obesity Model in White Male Wistar Rats After Administration of Telang Flower (Clitoria Ternatea) Extract on Pancreatic Function and Histopathological Characteristics

Rini, W. Y., Tanjung, F. A., & Wilvia, W. (2024) · International Journal of Health and Pharmaceutical (IJHP) · doi:10.51601/ijhp.v4i2.323

Effect of Moringa Flower Extract (Moringa Oleifera) on Collagenization and Histopathology of Skin Tissue in the Healing of Dermapen Scars in Obese Male Wistar White Rats

Tanjung, D. S., Kurniawati, R., & Mylano, T. A. (2024) · International Journal of Health and Pharmaceutical (IJHP) · doi:10.51601/ijhp.v4i2.318

A Comparative Study on Anti-Obesity Efficacy of Cydonia oblonga Miller Fruit Extract in Diet-Induced Obesity Animal Models

Hwang, J. S., Hwang, M. O., Kwon, K., & Kim, E. J. (2024) · Journal of Korean Medicine for Obesity Research · doi:10.15429/jkomor.2024.24.1.13

Obesity in Europe: Less impact on chronic diseases thanks to internists?

Garattini, L., & Mazzone, A. (2025) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2025.01.011

The Therapeutic Promise of Isorhamnetin in Breaking the Obesity-Cancer Link

Fatima, R., Hussain, M. S., Bisht, A. S., & Gupta, G. (2025) · Current Nutrition & Food Science · doi:10.2174/0115734013363088250128075409

Lipolytic and Anti-Adipogenic Effect of Capsaicin, Camphor, and Caffeic acid on Human SGBS AdipocytesPreprint

Ali, U., Wabitsch, M., & Gregureć, D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.05.652232

Natural Products with Anti-obesity Effects and Different Mechanisms of Action

Fu, C., Jiang, Y., Guo, J., & Su, Z. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04468 · Cited by 207 · see citing works

Adipogenesis as a Potential Anti-Obesity Target: A Review of Pharmacological Treatment and Natural Products

Jakab, J., Miškić, B., Mikšić, Š., Juranić, B., Ćosić, V., Schwarz, D., & Včev, A. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s281186 · Cited by 256 · see citing works

Recent developments in natural products for white adipose tissue browning

Ma, P., He, P., Xu, C., Hou, B., Qiang, G., & Du, G. (2020) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(20)60021-8 · Cited by 13 · see citing works

Obesity and Natural Products: Mechanisms, Therapeutic Potential, and Future Directions

Marie, O., & Abu-Elsaoud, A. M. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71575 · Cited by 7 · see citing works

Natural products in the management of obesity: Fundamental mechanisms and pharmacotherapy

Chan, Y., Ng, S. W., Tan, J. Z. X., Gupta, G., Negi, P., Thangavelu, L. P., Balusamy, S. R., Perumalsamy, H., Yap, W. H., Singh, S. K., et al. (2021) · South African Journal of Botany · doi:10.1016/j.sajb.2021.07.026 · Cited by 26 · see citing works