Cited by 125Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesNutritional Studies and Diet

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Endotoxemia, nutrition, and cardiometabolic disorders

Kallio, K. A. Elisa, Hätönen, Katja A., Lehto, Markku, Salomaa, Veikko, Männistö, Satu, Pussinen, Pirkko J.·2015·Acta Diabetologica

DOI 10.1007/s00592-014-0662-3

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Abstract

Aims Circulating lipopolysaccharides (LPSs), associated with both infection and inflammation, may arise from the gastrointestinal tract microbiota, and the levels may be affected by daily nutrition. We investigated whether nutrient intake affects the association of serum LPS activity with prevalent obesity, metabolic syndrome (MetS), diabetes, and coronary heart disease (CHD) and with the risk of incident CHD events.Methods The nutrition cohort (n = 2,452, mean age ± SD, 52.2 ± 10.1 years) of the FINRISK 1997 Study was followed up for 10 years. Information on macronutrient intake at baseline was collected from 24-h dietary recall. Serum endotoxin activities were determined by the Limulus amebocyte lysate assay.Results LPS activity was associated directly with the total energy intake and indirectly with carbohydrate intake in lean, healthy subjects. High LPS was significantly associated with prevalent obesity, MetS, diabetes, and CHD events, independently of established risk factors, CRP, and total energy or nutrient intake. The ORs (95 % CI) were 1.49 (1.21-1.85, p < 0.001, Q2-4 vs. Q1) for obesity, 2.56 (1.97-3.32, p < 0.001, Q2-4 vs. Q1) for MetS, 1.94 (1.06-3.52, p = 0.031, Q2-4 vs. Q1) for CHD, and 1.01 (1.00-1.01, p = 0.032, LPS unit) for diabetes. In the follow-up, high LPS was significantly associated with the risk of CHD events with a hazard ratio of 1.88 (1.13-3.12, p = 0.013, Q2-4 vs. Q1). This association was independent of baseline established risk factors, diet, obesity, MetS, and diabetes.Conclusion A high serum LPS activity is strongly associated with cardiometabolic disorders, which supports the role of bacterial infections and immune response in their etiology.

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Authors: Kallio, K. A. E., Hätönen, K. A., Lehto, M., Salomaa, V., Männistö, S., & Pussinen, P. J.
Affiliations: University of Helsinki (FI)
Finnish Institute for Health and Welfare (FI)
Helsinki University Hospital (FI)
Corresponding author: Kallio, K. A. Elisa
ORCID: Hätönen, Katja A.
Lehto, Markku
Salomaa, Veikko
Männistö, Satu
Pussinen, Pirkko J.
Venue: Acta Diabetologica
Publisher: Springer Science and Business Media LLC
Published: 2014-10-19
Volume: 52
Issue: 2
Pages: 395-404
ISSN: 0940-5429 (ISSN-L)
1432-5233
DOI: 10.1007/s00592-014-0662-3
OpenAlex: W2016971083
Cited by: 125
References: 38
Citations by year: 2026: 2 · 2025: 2 · 2024: 11 · 2023: 7 · 2022: 13 · 2021: 17 · 2020: 18 · 2019: 7 · 2018: 12 · 2017: 12 · 2016: 13 · 2015: 10
FWCI: 4.78
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Acta Diabetologica (publishedVersion)
PubMed (publishedVersion)
STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Funders: Aarne Koskelon Säätiö
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: endotoxemia, lipopolysaccharide, macronutrient intake, carbohydrate intake, energy intake, obesity, metabolic syndrome, diabetes mellitus, coronary artery disease, cardiometabolic disease, gut microbiota, bacterial infection, inflammation
MeSH terms: Adult, Aged, Energy Intake, Coronary Disease, Endotoxins, Female, Follow-Up Studies, Humans, Lipopolysaccharides, Male, Middle Aged, Cohort Studies, Nutrition Assessment, Endotoxemia

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