Metabolic endotoxemia with obesity: Is it real and is it relevant?

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(2000) · PubMed · Cited by 13,173 · see citing works

Inflammation and metabolic disorders

Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works

Human gut microbes associated with obesity

Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works

Prevalence of Overweight and Obesity in the United States, 1999-2004

Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., & Flegal, K. M. (2006) · JAMA · doi:10.1001/jama.295.13.1549 · Cited by 8,720 · see citing works

A core gut microbiome in obese and lean twins

Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works

Metabolic Endotoxemia Initiates Obesity and Insulin Resistance

Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works

Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association

Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797 · see citing works

Insulin signalling and the regulation of glucose and lipid metabolism

Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works

Lipopolysaccharide endotoxins

Raetz, C. R. H., & Whitfield, C. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135414 · Cited by 4,404 · see citing works

Inflammatory Mechanisms in Obesity

Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works

LPS/TLR4 signal transduction pathway

Lu, Y.-C., Yeh, W.-C., & Ohashi, P. S. (2008) · Cytokine · doi:10.1016/j.cyto.2008.01.006 · Cited by 3,301 · see citing works

Mechanisms linking obesity with cardiovascular disease

Van Gaal, L. F., Mertens, I. L., & De Block, C. E. (2006) · Nature · doi:10.1038/nature05487 · Cited by 2,814 · see citing works

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518 · see citing works

Microbiota and SCFA in lean and overweight healthy subjects

Schwiertz, A., Taras, D., Schäfer, K., Beijer, S., Bos, N. A., Donus, C., & Hardt, P. D. (2010) · Obesity · doi:10.1038/oby.2009.167 · Cited by 2,457 · see citing works

Inflammation: the link between insulin resistance, obesity and diabetes

Dandona, P. (2004) · Trends in Immunology · doi:10.1016/j.it.2003.10.013 · Cited by 2,170 · see citing works

Human gut microbiota in obesity and after gastric bypass

Zhang, H., DiBaise, J. K., Zuccolo, A., Kudrna, D., Braidotti, M., Yu, Y., Parameswaran, P., Crowell, M. D., Wing, R., Rittmann, B. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812600106 · Cited by 1,880 · see citing works

NF-κB activation by reactive oxygen species: Fifteen years later

Gloire, G., Legrand-Poels, S., & Piette, J. G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.04.011 · Cited by 1,540 · see citing works

Mechanism of free fatty acid-induced insulin resistance in humans.

Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539 · see citing works

Gut Microbiota and Metabolic Endotoxemia in Young Obese Mexican Subjects

Radilla-Vázquez, R. B., Parra‐Rojas, I., Martínez-Hernández, N. E., Márquez‐Sandoval, F., Illades‐Aguiar, B., & Castro-Alarcón, N. (2016) · Obesity Facts · doi:10.1159/000442479 · Cited by 1,197 · see citing works

Differential Adaptation of Human Gut Microbiota to Bariatric Surgery–Induced Weight Loss

Furet, J.-P., Kong, L.-C., Tap, J., Poitou, C., Basdevant, A., Bouillot, J.-L., Mariat, D., Corthier, G., Doré, J., Henegar, C., et al. (2010) · Diabetes · doi:10.2337/db10-0253 · Cited by 1,173 · see citing works

Early differences in fecal microbiota composition in children may predict overweight

Kalliomäki, M. A., Collado, M. C., Salminen, S., & Isolauri, E. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.3.534 · Cited by 1,056 · see citing works

Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes

Creely, S. J., McTernan, P. G., Kusminski, C. M., Fisher, F. M., Da Silva, N. F., Khanolkar, M., Evans, M., Harte, A. L., & Kumar, S. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00302.2006 · Cited by 1,043 · see citing works

Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women

Santacruz, A., Collado, M. C., García-Valdés, L., Segura, M. T., Martín-Lagos, J. A., Anjos, T., Martí-Romero, M., Lopez, R. M., Florido, J., Campoy, C., et al. (2010) · British Journal of Nutrition · doi:10.1017/s0007114510000176 · Cited by 868 · see citing works

Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women

Dewulf, E. M., Cani, P. D., Claus, S. P., Fuentes, S., Puylaert, P. G., Neyrinck, A. M., Bindels, L. B., de Vos, W. M., Gibson, G. R., Thissen, J.-P., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303304 · Cited by 825 · see citing works

The homeostasis model in the San Antonio Heart Study.

Haffner, S. M., Miettinen, H., & Stern, M. P. (1997) · Diabetes Care · doi:10.2337/diacare.20.7.1087 · Cited by 788 · see citing works

Toxic Shock Syndrome and Bacterial Superantigens: An Update

McCormick, J. K., Yarwood, J. M., & Schlievert, P. M. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.77 · Cited by 788 · see citing works

A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation.

Erridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776 · see citing works

The randle cycle revisited: a new head for an old hat.

Hue, L., & Taegtmeyer, H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00093.2009 · Cited by 743 · see citing works

The endocannabinoid system links gut microbiota to adipogenesis

Muccioli, G. G., Naslain, D., Bäckhed, F., Reigstad, C. S., Lambert, D. M., Delzenne, N. M., & Cani, P. D. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.46 · Cited by 691 · see citing works

Chylomicrons promote intestinal absorption of lipopolysaccharides

Ghoshal, S., Witta, J., Zhong, J., de Villiers, W., & Eckhardt, E. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800156-jlr200 · Cited by 662 · see citing works

Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-κB

Park, H. S., Jung, H. Y., Park, E. Y., Kim, J., Lee, W. J., & Bae, Y. S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.3589 · Cited by 635 · see citing works

Relationship between Plasma Levels of Lipopolysaccharide (LPS) and LPS‐Binding Protein in Patients with Severe Sepsis and Septic Shock

Opal, S. M., Scannon, P. J., Vincent, J., White, M., Carroll, S. F., Palardy, J. E., Parejo, N. A., Pribble, J. P., & Lemke, J. H. (1999) · The Journal of Infectious Diseases · doi:10.1086/315093 · Cited by 609 · see citing works

Energy intake is associated with endotoxemia in apparently healthy men

Amar, J., Burcelin, R., Ruidavets, J. B., Cani, P. D., Fauvel, J., Alessi, M., Chamontin, B., & Ferrières, J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1219 · Cited by 594 · see citing works

Involvement of Reactive Oxygen Species in Toll-Like Receptor 4-Dependent Activation of NF-κB

Asehnoune, K., Strassheim, D., Mitra, S., Kim, J. Y., & Abraham, E. H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2522 · Cited by 564 · see citing works

A high-fat diet is associated with endotoxemia that originates from the gut

Pendyala, S., Walker, J. M., & Holt, P. R. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.01.034 · Cited by 546 · see citing works

Bifidobacterium longum with Fructo-Oligosaccharides in Patients with Non Alcoholic Steatohepatitis

Malaguarnera, M., Vacante, M., Antic, T., Giordano, M., Chisari, G., Acquaviva, R., Mastrojeni, S., Malaguarnera, G., Mistretta, A., Volti, G. L., et al. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1887-4 · Cited by 456 · see citing works

Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes

Song, M. J., Kim, K. H., Yoon, J. M., & Kim, J. B. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.170 · Cited by 454 · see citing works

Endotoxemia Is Associated With an Increased Risk of Incident Diabetes

Pussinen, P. J., Havulinna, A. S., Lehto, M. J., Sundvall, J., & Salomaa, V. V. (2011) · Diabetes Care · doi:10.2337/dc10-1676 · Cited by 407 · see citing works

Bacterial Endotoxin Activity in Human Serum Is Associated With Dyslipidemia, Insulin Resistance, Obesity, and Chronic Inflammation

Lassenius, M., Pietiläinen, K., Kaartinen, K., Pussinen, P., Syrjänen, J., Forsblom, C., Pörsti, I., Rissanen, A., Kaprio, J., Mustonen, J., et al. (2011) · Diabetes Care · doi:10.2337/dc10-2197 · Cited by 404 · see citing works

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

Reyna, S. M., Ghosh, S., Tantiwong, P., Meka, C. S. R., Eagan, P. A., Jenkinson, C. P., Cersósimo, E., DeFronzo, R. A., Coletta, D. K., Sriwijitkamol, A., et al. (2008) · Diabetes · doi:10.2337/db08-0038 · Cited by 381 · see citing works

Systemic low-grade inflammation is related to both circulating and adipose tissue TNFα, leptin and IL-6 levels in obese women

Maachi, M., Piéroni, L., Bruckert, É., Jardel, C., Fellahi, S., Hainque, B., Capeau, J., & Jp, B. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802718 · Cited by 379 · see citing works

A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome

Xiao, S., Fei, N., Pang, X., Shen, J., Wang, L., Zhang, B., Zhang, M. H., Zhang, X., Zhang, C., Li, M., et al. (2013) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12228 · Cited by 378 · see citing works

Endotoxemia: Methods of detection and clinical correlates

Hurley, J. C. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.2.268 · Cited by 318 · see citing works

Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression

Ghanim, H., Sia, C. L., Upadhyay, M., Korzeniewski, K., Viswanathan, P., Abuaysheh, S., Mohanty, P., & Dandona, P. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28584 · Cited by 299 · see citing works

Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation

Laugerette, F., Vors, C., Géloën, A., Chauvin, M., Soulage, C. O., Lambert-Porcheron, S., Peretti, N., Alligier, M., Burcelin, R., Laville, M., et al. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.11.011 · Cited by 291 · see citing works

Xylo-oligosaccharide (XOS) in combination with inulin modulates both the intestinal environment and immune status in healthy subjects, while XOS alone only shows prebiotic properties

Lecerf, J.-M., Dépeint, F., Clerc, E., Dugenet, Y., Niamba, C. N., Rhazi, L., Cayzeele, A., Abdelnour, G., Jaruga, A., Younes, H., et al. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511007252 · Cited by 262 · see citing works

Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species

Wei, Y., Chen, K., Whaley‐Connell, A. T., Stump, C. S., Ibdah, J. A., & Sowers, J. R. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00561.2007 · Cited by 258 · see citing works

Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle

Frost, R. A., Nystrom, G. J., & Lang, C. H. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00039.2002 · Cited by 253 · see citing works

Pregravid Obesity Associates With Increased Maternal Endotoxemia and Metabolic Inflammation

Basu, S., Haghiac, M., Surace, P., Challier, J.-C., Guerre-Millo, M., Singh, K., Waters, T. P., Minium, J., Presley, L. H., Catalano, P. M., et al. (2010) · Obesity · doi:10.1038/oby.2010.215 · Cited by 246 · see citing works

Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll-Like Receptor-4 and Suppressor of Cytokine Signaling-3

Deopurkar, R., Ghanim, H., Friedman, J., Abuaysheh, S., Sia, C. L., Mohanty, P., Viswanathan, P., Chaudhuri, A., & Dandona, P. (2010) · Diabetes Care · doi:10.2337/dc09-1630 · Cited by 246 · see citing works

Differential liver sensitization to Toll-like receptor pathways in mice with alcoholic fatty liver

Gustot, T., Lemmers, A., Moreno, C., Nagy, N., Quertinmont, E., Nicaise, C., Franchimont, D. P., Louis, H., Deviere, J. M., & Moine, O. L. (2006) · Hepatology · doi:10.1002/hep.21138 · Cited by 244 · see citing works

High Fat Intake Leads to Acute Postprandial Exposure to Circulating Endotoxin in Type 2 Diabetic Subjects

Harte, A. L., Varma, M. C., Tripathi, G., McGee, K. C., Al‐Daghri, N. M., Al-Attas, O. S., Sabico, S., O’Hare, J. P., Ceriello, A., Saravanan, P., et al. (2011) · Diabetes Care · doi:10.2337/dc11-1593 · Cited by 236 · see citing works

Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: A randomized controlled clinical trial

Dehghan, P., Pourghassem Gargari, B., & Asghari Jafar-abadi, M. (2014) · Nutrition · doi:10.1016/j.nut.2013.09.005 · Cited by 207 · see citing works

Reactive Oxygen and Nitrogen Species Differentially Regulate Toll-Like Receptor 4-Mediated Activation of NF-κB and Interleukin-8 Expression

Ryan, K. A., Smith, M. F., Sanders, M. K., & Ernst, P. B. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.2123-2130.2004 · Cited by 198 · see citing works

In Vivo Effects of Bifidobacteria and Lactoferrin on Gut Endotoxin Concentration and Mucosal Immunity in Balb/c Mice

Griffiths, E. A., Duffy, L. C., Schanbacher, F. L., Qiao, H., Dryja, D., Leavens, A., Rossman, J., Rich, G. A., DiRienzo, D. B., & Ogra, P. L. O. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000026302.92898.ae · Cited by 197 · see citing works

The Role of Bifidobacteria in Gut Barrier Function After Thermal Injury in Rats

Wang, Z., Xiao, G., Yao, Y.-M., Guo, S., Lu, K., & Sheng, Z. (2006) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000196574.70614.27 · Cited by 193 · see citing works

Metabolic syndrome and oxidative stress

Ando, K., & Fujita, T. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.04.030 · Cited by 164 · see citing works

THE SEPSIS SYNDROME

Bone, R. C. (1996) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(05)70307-5 · Cited by 158 · see citing works

Toll-like receptor 4 modulates skeletal muscle substrate metabolism

Frisard, M. I., McMillan, R. P., Marchand, J., Wahlberg, K. A., Wu, Y., Voelker, K. A., Heilbronn, L. K., Haynie, K. R., Muoio, B. M., Li, L., et al. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00307.2009 · Cited by 157 · see citing works

Recent advances in biosensor based endotoxin detection

Das, A. P., Kumar, P., & Swain, S. K. (2013) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.07.020 · Cited by 155 · see citing works

Development of endotoxin tolerance in humans in vivo

Draisma, A., Pickkers, P., Bouw, M. P. W. J. M., et al. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e31819c3c67 · Cited by 152 · see citing works

Direct effects of endotoxin on the endothelium: barrier function and injury.

Bannerman, D. D., & Goldblum, S. E. (1999) · PubMed · Cited by 150 · see citing works

Detoxifying endotoxin: time, place and person

Munford, R. S. (2005) · Journal of Endotoxin Research · doi:10.1179/096805105x35161 · Cited by 150 · see citing works

Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies

Al-Attas, O. S., Al‐Daghri, N. M., Al-Rubeaan, K. A., da Silva, N. F., Sabico, S., Kumar, S., McTernan, P. G., & Harte, A. L. (2009) · Cardiovascular Diabetology · doi:10.1186/1475-2840-8-20 · Cited by 145 · see citing works

Reduction in endotoxemia, oxidative and inflammatory stress, and insulin resistance after Roux-en-Y gastric bypass surgery in patients with morbid obesity and type 2 diabetes mellitus

Monte, S. V., Caruana, J. A., Ghanim, H., Sia, C. L., Korzeniewski, K., Schentag, J. J., & Dandona, P. (2012) · Surgery · doi:10.1016/j.surg.2011.09.038 · Cited by 143 · see citing works

A single intravenous dose of endotoxin rapidly alters serum lipoproteins and lipid transfer proteins in normal volunteers

Hudgins, L. C., Parker, T. S., Levine, D. M., Gordon, B. R., Saal, S. D., Jiang, X., Seidman, C. E., Tremaroli, J. D., Lai, J., & Rubin, A. L. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200440-jlr200 · Cited by 141 · see citing works

Continuous infusion chemotherapy: a critical review.

Vogelzang, N. J. (1984) · Journal of Clinical Oncology · doi:10.1200/jco.1984.2.11.1289 · Cited by 136 · see citing works

Probiotic supplementation prevents high-fat, overfeeding-induced insulin resistance in human subjects

Hulston, C. J., Churnside, A. A., & Venables, M. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114514004097 · Cited by 133 · see citing works

Overfeeding increases postprandial endotoxemia in men: Inflammatory outcome may depend on LPS transporters LBP and sCD14

Laugerette, F., Alligier, M., Bastard, J., Drai, J., Chanséaume, E., Lambert-Porcheron, S., Laville, M., Morio, B., Vidal, H., & Michalski, M. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400044 · Cited by 132 · see citing works

Endotoxemia, nutrition, and cardiometabolic disorders

Kallio, K. A. E., Hätönen, K. A., Lehto, M., Salomaa, V., Männistö, S., & Pussinen, P. J. (2015) · Acta Diabetologica · doi:10.1007/s00592-014-0662-3 · Cited by 125 · see citing works

A new era in pyrogen testing

Ding, J. L., & Ho, B. (2001) · Trends in biotechnology · doi:10.1016/s0167-7799(01)01694-8 · Cited by 115 · see citing works

Observations on the Measurement and Evaluation of Endotoxemia by a Quantitative Limulus Lysate Microassay

Cohen, J., & McConnell, J. (1984) · The Journal of Infectious Diseases · doi:10.1093/infdis/150.6.916 · Cited by 96 · see citing works

The impairment of glucogenesis by gram negative infection

LaNoue, K. F., Mason, A. D., & Daniels, J. P. (1968) · Metabolism · doi:10.1016/0026-0495(68)90019-x · Cited by 90 · see citing works

Endotoxin Detection – from Limulus Amebocyte Lysate to Recombinant Factor C

Ding, J. L., & Ho, B. (2010) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-90-481-9078-2_9 · Cited by 89 · see citing works

Lipopolysaccharide binding protein, obesity status and incidence of metabolic syndrome: a prospective study among middle-aged and older Chinese

Liu, X., Lu, L., Yao, P., Ma, Y., Wang, F., Jin, Q., Ye, X., Li, H., Hu, F. B., Sun, L., et al. (2014) · Diabetologia · doi:10.1007/s00125-014-3288-7 · Cited by 78 · see citing works

Limulus amebocyte lysate (LAL) detection of endotoxin in human blood

Novitsky, T. J. (1994) · Journal of Endotoxin Research · doi:10.1177/096805199400100407 · Cited by 76 · see citing works

EFFECTS OF BACTERIAL ENDOTOXINS ON METABOLISM

Berry, L. J., & Smythe, D. S. (1964) · The Journal of Experimental Medicine · doi:10.1084/jem.120.5.721 · Cited by 73 · see citing works

Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll-Like Receptor-4 and Suppressor of Cytokine Signaling-3.

Deopurkar, R., Ghanim, G., Friedman, & Abuaysheh (2010) · Diabetes Care · Cited by 71 · see citing works

Limitations of the Limulus Amebocyte Lysate Test in Demonstrating Circulating Lipopolysaccharides

Novitsky, T. J. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09018.x · Cited by 65 · see citing works

Plasma endotoxin level of healthy donors

Nádházi, Z., Takáts, A., Offenmüller, K., & Bertók, L. (2002) · Acta Microbiologica et Immunologica Hungarica · doi:10.1556/amicr.49.2002.1.15 · Cited by 60 · see citing works

Alterations of mitochondrial metabolism and protein concentrations in subacute septicemia

Tavakoli, H., & Mela, L. (1982) · Infection and Immunity · doi:10.1128/iai.38.2.536-541.1982 · Cited by 60 · see citing works

Human Experimental Endotoxemia in Modeling the Pathophysiology, Genomics, and Therapeutics of Innate Immunity in Complex Cardiometabolic Diseases

Patel, P. N., Shah, R. Y., Ferguson, J. F., & Reilly, M. P. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304455 · Cited by 58 · see citing works

Cytokine Abnormalities in the Etiology of the Cardiometabolic Syndrome

DeMarco, V. G., Johnson, M. S., Whaley‐Connell, A. T., & Sowers, J. R. (2010) · Current Hypertension Reports · doi:10.1007/s11906-010-0095-5 · Cited by 54 · see citing works

Low Levels of Lipopolysaccharide Modulate Mitochondrial Oxygen Consumption in Skeletal Muscle

Frisard, M. I., Wu, Y., McMillan, R. P., Voelker, K. A., Wahlberg, K. A., Anderson, A. S., Boutagy, N. E., Resendes, K., Ravussin, É., & Hulver, M. W. (2014) · Metabolism · doi:10.1016/j.metabol.2014.11.007 · Cited by 50 · see citing works

Insulin Sensitivity, Glucose Effectiveness, and Free Fatty Acid Dynamics after Human Islet Transplantation for Type 1 Diabetes

Rickels, M. R., Naji, A., & Teff, K. L. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2519 · Cited by 45 · see citing works

Prognostic value of endotoxin activity assay in patients with severe sepsis after cardiac surgery

Yaroustovsky, M., Plyushch, M., Попов, Д. А., et al. (2013) · Journal of Inflammation · doi:10.1186/1476-9255-10-8 · Cited by 45 · see citing works

A human model of inflammatory cardio-metabolic dysfunction; a double blind placebo-controlled crossover trial

Mehta, N. N., Heffron, S. P., Patel, P. N., Ferguson, J. F., Shah, R. D., Hinkle, C. C., Krishnamoorthy, P. M., Shah, R., Tabita‐Martinez, J., Terembula, K., et al. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-124 · Cited by 44 · see citing works

Temporal Metabolic Profiling of Plasma During Endotoxemia in Humans

Kamisoglu, K., Sleight, K. E., Calvano, S. E., Coyle, S. M., Corbett, S., & Androulakis, I. P. (2013) · Shock · doi:10.1097/shk.0000000000000063 · Cited by 42 · see citing works

Bacterial DNA Translocation Holds Increased Insulin Resistance and Systemic Inflammatory Levels in Morbid Obese Patients

Ortiz, S., Zapater, P., Estrada, J. L., Enriquez, P., Rey, M., Abad, Á. L., Such, J. M., Lluı́s, F., & Francés, R. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4483 · Cited by 37 · see citing works

Altered control of carbohydrate metabolism in endotoxemia.

Jj, S., Gj, B., Mészáros, K., et al. (1989) · PubMed · Cited by 36 · see citing works

Early skeletal muscle adaptations to short‐term high‐fat diet in humans before changes in insulin sensitivity

Anderson, A. S., Haynie, K. R., McMillan, R. P., Osterberg, K. L., Boutagy, N. E., Frisard, M. I., Davy, B. M., Davy, K. P., & Hulver, M. W. (2015) · Obesity · doi:10.1002/oby.21031 · Cited by 35 · see citing works

Effect of the orlistat on serum endotoxin lipopolysaccharide and adipocytokines in South Asian individuals with impaired glucose tolerance

Dixon, A., Valsamakis, G., Hanif, M. W., Field, A., Boutsiadis, A., Harte, A. L., McTernan, P. G., Barnett, A. H., & Kumar, S. (2008) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2008.01800.x · Cited by 32 · see citing works

Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents

Lira, F. S., Neto, J. C. R., Pimentel, G. D., dos Santos, R. V. T., Carnier, J., Sanches, P. D. L., de Piano, A., de Souza, C. T., Tock, L., Tufik, S., et al. (2012) · Nutrition Journal · doi:10.1186/1475-2891-11-74 · Cited by 30 · see citing works

Detection of endotoxin in blood and other specimens by evaluation of photometrically registered LAL-reaction-kinetics in microtiter plates.

Ditter, B., Becker, K. P., URBASCHEK, R., & Urbaschek, B. (1982) · PubMed · Cited by 25 · see citing works

Direct Effects of Locally Administered Lipopolysaccharide on Glucose, Lipid, and Protein Metabolism in the Placebo-Controlled, Bilaterally Infused Human Leg

Buhl, M. R., Bosnjak, E., Vendelbo, M. H., Gjedsted, J., Nielsen, R. R., Krusenstjerna-Hafstrøm, T., Vestergaard, E. T., Jessen, N., Tønnesen, E., Møller, A. B., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3836 · Cited by 21 · see citing works

Interference with the LAL Test and How to Address It

Dawson, M. E., & Lal, D. (2005) · Cited by 21 · see citing works

Inhibitory Effect of Heparin on the Limulus Test for Endotoxin

Sullivan, J. D., & Watson, S. W. (1975) · Journal of Clinical Microbiology · doi:10.1128/jcm.2.2.151-151.1975 · Cited by 20 · see citing works

Quantification of endotoxin inhibition in serum and plasma using a turbidimetric LAL assay.

Novitsky, T. J., & Roslansky, P. F. (1985) · PubMed · Cited by 17 · see citing works

A comparison of the changes in the blood sugar and blood phosphorus in rabbits following the injection of suspensions of different dead bacteria

Delafield, M. E. (1932) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700350108 · Cited by 14 · see citing works

BLOOD SUGAR STUDIES

Zeckwer, I. T., & Goodell, H. (1925) · The Journal of Experimental Medicine · doi:10.1084/jem.42.1.57 · Cited by 13 · see citing works

Biochemical characterization of Limulus clotting factors and inhibitors which interact with bacterial endotoxins.

Morita, T., Nakamura, T., Miyata, T., et al. (1985) · PubMed · Cited by 11 · see citing works

Cellular Metabolic Regulators

Haimovich, B., Zhang, Z., Calvano, J. E., Calvano, S. E., Kumar, A., Macor, M., Corbett, S., Coyle, S. M., & Lowry, S. F. (2013) · Annals of Surgery · doi:10.1097/sla.0b013e31829a4352 · Cited by 8 · see citing works

Commentary on: Increase in visceral fat per se does not induce insulin resistance in the canine model

Galgani, J. E., & Moro, C. (2014) · Obesity · doi:10.1002/oby.20933 · Cited by 1 · see citing works

Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System

Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876 · see citing works

Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions

Mohammad, S., & Thiemermann, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594150 · Cited by 585 · see citing works

Endotoxemia—menace, marker, or mistake?

Munford, R. S. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ru0316-151r · Cited by 219 · see citing works

New insights into the role of adipose tissue in thrombosis

Vilahur, G., Ben-Aicha, S., & Badimon, L. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx086 · Cited by 216 · see citing works

The initiation of metabolic inflammation in childhood obesity

Singer, K., & Lumeng, C. N. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88882 · Cited by 194 · see citing works

Endotoxin-initiated inflammation reduces testosterone production in men of reproductive age

Tremellen, K., McPhee, N., Pearce, K., Benson, S., Schedlowski, M., & Engler, H. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00279.2017 · Cited by 98 · see citing works

Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation

Wang, Y., Yang, J., Wang, W., Sanidad, K. Z., Cinelli, M. A., Wan, D., Hwang, S. H., Kim, D., Lee, K. S. S., Xiao, H., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916189117 · Cited by 59 · see citing works

Increased butyrate priming in the gut stalls microbiome associated-gastrointestinal inflammation and hepatic metabolic reprogramming in a mouse model of Gulf War Illness

Seth, R. K., Kimono, D., Alhasson, F., Sarkar, S., Albadrani, M., Lasley, S. K., Horner, R., Janulewicz, P., Nagarkatti, M., Nagarkatti, P., et al. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.05.006 · Cited by 55 · see citing works

Exposure to bacterial products lipopolysaccharide and flagellin and hepatocellular carcinoma: a nested case-control study

Fedirko, V., Tran, H. Q., Gewirtz, A. T., Stepien, M., Trichopoulou, A., Aleksandrova, K., Olsen, A., Tjønneland, A., Overvad, K., Carbonnel, F., et al. (2017) · BMC Medicine · doi:10.1186/s12916-017-0830-8 · Cited by 50 · see citing works

Metabolic endotoxaemia related inflammation is associated with hypogonadism in overweight men

Tremellen, K., McPhee, N., & Pearce, K. (2017) · Basic and Clinical Andrology · doi:10.1186/s12610-017-0049-8 · Cited by 45 · see citing works

Lemon flavonoids nutraceutical (Eriomin®) attenuates prediabetes intestinal dysbiosis: A double-blind randomized controlled trial

Ramos, F. M. M., Ribeiro, C. B., Cesar, T. B., Milenkovic, D., Cabral, L., Noronha, M. F., & Sivieri, K. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3654 · Cited by 17 · see citing works

No mediator is an island: A mediator supports others, but who supports the mediator?

Keys, B. (2006) · e-publications@bond (Bond University)

Transcriptional regulation of transcriptional Mediator complexes in cardiovascular development and disease.

Zhang, Y., Zhao, Y., Zhuang, L., et al. (2022) · PubMed · doi:10.16288/j.yczz.21-411

Suppression of p53 response by targeting p53-Mediator binding with a stapled peptidePreprint

Allen, B., Quach, K., Jones, T., Levandowski, C. B., Ebmeier, C. C., Rubin, J. D., Read, T. J., Dowell, R. D., Schepartz, A., & Taatjes, D. (2019) · bioRxiv · doi:10.1101/757401 · Cited by 10 · see citing works

Mediator: Structure and Function

Jin, L. (2005) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

Mediational effects as a function of Stage 3 mediator presentation

Popp, R. J., & Voss, J. F. (1966) · Psychonomic Science · doi:10.3758/bf03328317 · Cited by 3 · see citing works