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Role of ursodeoxycholic acid in the prevention of gallstone formation after laparoscopic sleeve gastrectomy

Abdallah, Emad, Emile, Sameh Hany, Elfeki, Hossam, Fikry, Mohamed, Abdelshafy, Mahmoud, Elshobaky, Ayman, Elgendy, Hesham, Thabet, Waleed, Youssef, Mohamed, Elghadban, Hosam, Lotfy, Ahmed·2017·Surgery Today
DOI 10.1007/s00595-016-1446-x
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Abstract

Purpose Postoperative cholelithiasis (CL) is a latent complication of bariatric surgery. The aim of this study was to evaluate the role of ursodeoxycholic acid (UDCA) in the prevention of CL after laparoscopic sleeve gastrectomy (LSG). Methods This was a retrospective analysis of the prospectively collected data of patients with morbid obesity who underwent LSG. Patients were subdivided into two groups: Group I, which did not receive prophylactic treatment with UCDA after LSG; and Group II, which received UCDA therapy for 6 months after LSG. Patients' characteristics, operation duration, weight loss data, and incidence of CL at 6 and 12 months postoperatively were collected. Results A total of 406 patients (124 males, 282 females) with a mean age of 32.1 ± 9.4 years were included. The mean baseline body mass index (BMI) was 50.1 ± 8.3 kg/m 2 . Group I comprised 159 patients, and Group II comprised 247 patients. The two groups showed comparable demographics, % excess weight loss (EWL), and decrease in BMI at 6 and 12 months after LSG. Eight patients (5%) developed CL in Group I, whereas no patients in Group II did (P = 0.0005). Preoperative dyslipidemia and rapid loss of excess weight within the first 3 months after LSG were the risk factors that significantly predicted CL postoperatively. Conclusion The use of UCDA effectively reduced the incidence of CL after LSG in patients with morbid obesity. Dyslipidemia and rapid EWL in the first 3 months after LSG significantly predisp…

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Research works printed but not linked: 27

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Metadata

Authors
Abdallah, E., Emile, S. H., Elfeki, H., Fikry, M., Abdelshafy, M., Elshobaky, A., Elgendy, H., Thabet, W., Youssef, M., Elghadban, H., & Lotfy, A.
Venue
Surgery Today
Publisher
Springer Science and Business Media LLC
Published
2016-11-11
Volume
47
Issue
7
Pages
844-850
ISSN
  • 0941-1291
  • 1436-2813
DOI
10.1007/s00595-016-1446-x
Cited by
44
References
1
Language
en
Licence
www.springer.com/tdm (unspecified)

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CoChat. (2026). Citation check: Role of ursodeoxycholic acid in the prevention of gallstone formation after laparoscopic sleeve gastrectomy. https://app.cochat.ai/papers/10.1007/s00595-016-1446-x
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Abdallah, E., Emile, S. H., Elfeki, H., Fikry, M., Abdelshafy, M., Elshobaky, A., Elgendy, H., Thabet, W., Youssef, M., Elghadban, H., & Lotfy, A. (2017). Role of ursodeoxycholic acid in the prevention of gallstone formation after laparoscopic sleeve gastrectomy. Surgery Today. https://doi.org/10.1007/s00595-016-1446-x