Cited by 31Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolNeuroscience and Neuropharmacology Research

Stress-induced cross-sensitization to amphetamine is related to changes in the dopaminergic system

Cruz, Fábio C., Marin, Marcelo Tadeu, Leão, Rodrigo Molini, Planeta, Cleopatra S.·2012·Journal of Neural Transmission

Abstract

Repeated stress engenders behavioral sensitization. The mesolimbic dopamine system is critically involved in drug-induced behavioral sensitization. In the present study we examined the differences between adolescent and adult rats in stress-induced behavioral sensitization to amphetamine and changes in dopamine (DA) and its metabolite levels in the mesolimbic system. Adolescent or adult rats were restrained for 2 h, once a day, for 7 days. Three days after the last exposure to stress, the animals were challenged with saline or amphetamine (1.0 mg/kg i.p.) and amphetamine-induced locomotion was recorded for 40 min. Immediately after the behavioral tests, rats were decapitated and the nucleus accumbens (NAcc), ventral tegmental area (VTA) and amygdala (AM) were removed to measure tissue levels of DA and its metabolites by HPLC. Exposure to repeated restraint stress promoted behavioral sensitization to amphetamine in both adult and adolescent rats. In adult rats, amphetamine administration increased DA levels in both the stress and control groups in the NAcc and VTA. In adolescent rats, amphetamine increased DA levels in the NAcc in rats exposed to stress. Furthermore, in the AM of adolescent rats in the control group, amphetamine increased the DA levels; however, amphetamine reduced this neurotransmitter in the rats that were exposed to stress. No alteration was observed in the dopamine metabolite levels. Therefore, stress promoted behavioral sensitization to amphetamine and this may be related to changes in DA levels in the mesolimbic system. These changes appear to be dependent on ontogeny.

Integrity signals

Registry

Crossref · 10.1007/s00702-011-0720-8

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Cruz, F. C., Marin, M. T., Leão, R. M., & Planeta, C. S.
Affiliations
  • Universidade Estadual Paulista (Unesp) (BR)
  • Universidade Federal de São Carlos (BR)
Corresponding author
Planeta, Cleopatra S.
Venue
Journal of Neural Transmission
Published
2011-10-18
Volume
119
Issue
4
Pages
415-424
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
OpenAlex
W2076184516
Cited by
31
References
56
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 1
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neural Transmission (publishedVersion)
  • PubMed (publishedVersion)
  • Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) (submittedVersion)
  • UNESP Institutional Repository (São Paulo State University) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
amphetamine, cross-sensitization, mesolimbic dopamine system, dopamine levels, restraint stress, adolescent rats, ontogeny, nucleus accumbens, ventral tegmental area, amygdala, dopamine metabolites, locomotor activity
MeSH terms
Age Factors, Amphetamines, Central Nervous System Stimulants, Analysis of Variance, Animals, Animals, Newborn, Brain, Disease Models, Animal, Dopamine, Homovanillic Acid, Male, Stress, Psychological, 3,4-Dihydroxyphenylacetic Acid, Rats, Wistar, Microdialysis, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review