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Cited by 338Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolNeuroscience and Neuropharmacology Research

Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intake

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MICZEK, K, YAP, J, COVINGTONIII, H·2008·Pharmacology & Therapeutics
DOI 10.1016/j.pharmthera.2008.07.006PMC PMC2713609
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Abstract

The impact of ostensibly aversive social stresses on triggering, amplifying and prolonging intensely rewarding drug taking is an apparent contradiction in need of resolution. Social stress encompasses various types of significant life events ranging from maternal separation stress, brief episodes of social confrontations in adolescence and adulthood, to continuous subordination stress, each with its own behavioral and physiological profile. The neural circuit comprising the VTA-accumbens-PFC-amygdala is activated by brief episodes of social stress, which is critical for the DA-mediated behavioral sensitization and increased stimulant consumption. A second neural circuit comprising the raphe-PFC-hippocampus is activated by continuous subordination stress and other types of uncontrollable stress. In terms of the development of therapeutics, brief maternal separation stress has proven useful in characterizing compounds acting on subtypes of GABA, glutamate, serotonin and opioid receptors with anxiolytic potential. While large increases in alcohol and cocaine intake during adulthood have been seen after prolonged maternal separation experiences during the first two weeks of rodent life, these effects may be modulated by additional yet to be identified factors. Brief episodes of defeat stress can engender behavioral sensitization that is relevant to escalated and prolonged self-administration of stimulants and possibly opioids, whereas continuous subordination stress leads to anhedonia-like effects. Understanding the intracellular cascade of events for the transition from episodic to continuous social stress in infancy and adulthood may provide insight into the modulation of basic reward processes that are critical for addictive and affective disorders.

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  • Social defeat stress in mice has excellent etiological, predictive, discriminative and face validity.

    “When considering experimental approaches for studying depression, social defeat stress, in particular, has been shown to have excellent etiological, predictive, discriminative and face validity.”

    From A standardized protocol for repeated social defeat stress in mice (2011) · cites this paper as [11]

    Section 3.3.2.1 (Antidepressants; page unavailable) says social defeat can model some features of affective disorders, including anhedonia in mice, and discusses antidepressant effects. But it notes that anhedonia does not occur in all animals, while section 3.3.2 (Therapeutics; page unavailable) cautions that defeat-related responses may reflect anxiety or affective disorders. The paper does not establish excellent etiological, predictive, discriminative and face validity as a set. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Individual responses to social stressors within experimental preparations have become increasingly useful in modeling aspects of depression-like behavior with high construct, face, discriminative and predictive validity.

    “Individual responses to social stressors within experimental preparations have thus become increasingly useful in modeling aspects of depression-like behavior with high construct, face, discriminative and predictive validity3,7–11.”

    From A standardized protocol for repeated social defeat stress in mice (2011) · cites this paper as [11]

    Section 3.3.2.1 (Antidepressants; page unavailable) describes social-defeat procedures as modeling some features of affective disorders, including anhedonia, and reports that antidepressants can reverse some stress-related changes. But sections 3.3.2 and 4 caution that these behaviors can also resemble anxiety and are difficult to map onto clinical diagnoses. The paper therefore supports their usefulness for modeling aspects of depression-like behavior, not the unqualified claim of high construct, face, discriminative, and predictive validity. (LLM, conf=0.86)

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Authors
MICZEK, K., YAP, J., & COVINGTONIII, H.
Affiliations
Tufts University (US)
Corresponding author
MICZEK, K
ORCID
MICZEK, K
Venue
Pharmacology & Therapeutics
Publisher
Elsevier BV
Published
2008-11
Volume
120
Issue
2
Pages
102-128
ISSN
0163-7258 (ISSN-L)
DOI
10.1016/j.pharmthera.2008.07.006
PMC
PMC2713609
OpenAlex
W1974322969
Cited by
338
References
27
Citations by year
2026: 8 · 2025: 13 · 2024: 9 · 2023: 10 · 2022: 10 · 2021: 21 · 2020: 17 · 2019: 7 · 2018: 26 · 2017: 24 · 2016: 19 · 2015: 25 · 2014: 24 · 2013: 25 · 2012: 21
FWCI
10.83
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (R01AA013983)
  • National Institute on Drug Abuse (R01DA002632)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
social stress, drug abuse, maternal separation stress, behavioral sensitization, dopamine, anxiolytics, alcohol self-administration, cocaine self-administration, anhedonia, opioid self-administration, preclinical models
MeSH terms
Adolescent, Adult, Animals, Dopamine, Humans, Maternal Deprivation, Models, Biological, Reward, Self Administration, Stress, Psychological, Substance-Related Disorders, Models, Animal

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