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Cited by 272Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment ResearchNeurological disorders and treatments

Magnetic resonance imaging for the diagnosis of Parkinson’s disease

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Heim, Beatrice, Krismer, Florian, De Marzi, Roberto, Seppi, Klaus·2017·Journal of Neural Transmission
DOI 10.1007/s00702-017-1717-8PMC PMC5514207
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Abstract

The differential diagnosis of parkinsonian syndromes is considered one of the most challenging in neurology and error rates in the clinical diagnosis can be high even at specialized centres. Despite several limitations, magnetic resonance imaging (MRI) has undoubtedly enhanced the diagnostic accuracy in the differential diagnosis of neurodegenerative parkinsonism over the last three decades. This review aims to summarize research findings regarding the value of the different MRI techniques, including advanced sequences at high- and ultra-high-field MRI and modern image analysis algorithms, in the diagnostic work-up of Parkinson's disease. This includes not only the exclusion of alternative diagnoses for Parkinson's disease such as symptomatic parkinsonism and atypical parkinsonism, but also the diagnosis of early, new onset, and even prodromal Parkinson's disease.

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  • Deep learning applications to CT and radiomics improve possibilities for automated diagnostics.

    “Deep learning applications to CT and radiomics improve their possibilities for automated diagnostics even more [76].”

    From Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease (2025) · cites this paper as [76]

    The Conclusion and future development section (page unavailable) says machine-learning analysis of MRI may enable automated differentiation of parkinsonian syndromes, pending larger studies. That supports the general prospect of automated diagnosis, but not the claim’s specific attribution to deep learning applied to CT and radiomics. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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  1. Adler CH Beach TG Hentz JG Shill HA Caviness JN Driver-Dunckley E Low clinical diagnostic accuracy of early vs. advanced Parkinson disease: clinicopathologic study Neurology 2014 83 5 406 412 24975862 PMC4132570
  2. Agosta F Kostic VS Galantucci S Mesaros S Svetel M Pagani E The in vivo distribution of brain tissue loss in Richardson’s syndrome and PSP-parkinsonism: a VBM-DARTEL study Eur J Neurosci 2010 32 4 640 647 20597976
  3. Agosta F Canu E Stojkovic T Pievani M Tomic A Sarro L The topography of brain damage at different stages of Parkinson’s disease Hum Brain Mapp 2013 34 11 2798 2807 22528144 PMC6870174
  4. Agosta F Caso F Stankovic I Inuggi A Petrovic I Svetel M Cortico-striatal-thalamic network functional connectivity in hemiparkinsonism Neurobiol Aging 2014 35 11 2592 2602 25004890
  5. Anik Y Iseri P Demirci A Komsuoglu S Inan N Magnetization transfer ratio in early period of Parkinson disease Acad Radiol 2007 14 2 189 192 17236991
  6. Aquino D Contarino V Albanese A Minati L Farina L Grisoli M Substantia nigra in Parkinson’s disease: a multimodal MRI comparison between early and advanced stages of the disease Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol 2014 35 5 753 758 24337946
  7. Arabia G Morelli M Paglionico S Novellino F Salsone M Giofre L An magnetic resonance imaging T2*-weighted sequence at short echo time to detect putaminal hypointensity in Parkinsonisms Mov Disord Off J Mov Disord Soc 2010 25 16 2728 2734 20925073
  8. Ashburner J Friston KJ Voxel-based morphometry—the methods Neuroimage 2000 11 6 Pt 1 805 821 10860804
  9. Azuma M Hirai T Yamada K Yamashita S Ando Y Tateishi M Lateral asymmetry and spatial difference of iron deposition in the substantia nigra of patients with parkinson disease measured with quantitative susceptibility mapping AJNR Am J Neuroradiol 2016 37 5 782 788 26822728 PMC4867267
  10. Bae YJ Kim JM Kim E Lee KM Kang SY Park HS Loss of nigral hyperintensity on 3 Tesla MRI of Parkinsonism: comparison with (123) I-FP-CIT SPECT Mov Disord Off J Mov Disord Soc 2016 31 5 684 692 26990970
  11. Barbagallo G Sierra-Pena M Nemmi F Traon AP Meissner WG Rascol O Multimodal MRI assessment of nigro-striatal pathway in multiple system atrophy and Parkinson disease Mov Disord Off J Mov Disord Soc 2016 31 3 325 334 26676922
  12. Barbosa JH Santos AC Tumas V Liu M Zheng W Haacke EM Quantifying brain iron deposition in patients with Parkinson’s disease using quantitative susceptibility mapping, R2 and R2 Magn Reson Imaging 2015 33 5 559 565 25721997
  13. Barsottini OG Ferraz HB Maia AC Jr Silva CJ Rocha AJ Differentiation of Parkinson’s disease and progressive supranuclear palsy with magnetic resonance imaging: the first Brazilian experience Parkinsonism Relat Disord 2007 13 7 389 393 17275393
  14. Baudrexel S Nurnberger L Rub U Seifried C Klein JC Deller T Quantitative mapping of T1 and T2* discloses nigral and brainstem pathology in early Parkinson’s disease Neuroimage 2010 51 2 512 520 20211271
  15. Baudrexel S Seifried C Penndorf B Klein JC Middendorp M Steinmetz H The value of putaminal diffusion imaging vs. 18-fluorodeoxyglucose positron emission tomography for the differential diagnosis of the Parkinson variant of multiple system atrophy Mov Disord Off J Mov Disord Soc 2014 29 3 380 387 24243813
  16. Beyer MK Janvin CC Larsen JP Aarsland D A magnetic resonance imaging study of patients with Parkinson’s disease with mild cognitive impairment and dementia using voxel-based morphometry J Neurol Neurosurg Psychiatry 2007 78 3 254 259 17028119 PMC2117633
  17. Bhattacharya K Saadia D Eisenkraft B Yahr M Olanow W Drayer B Brain magnetic resonance imaging in multiple-system atrophy and Parkinson disease: a diagnostic algorithm Arch Neurol 2002 59 5 835 842 12020268
  18. Biswal BB Resting state fMRI: a personal history Neuroimage 2012 62 2 938 944 22326802 PMC12911935
  19. Blain CR Barker GJ Jarosz JM Coyle NA Landau S Brown RG Measuring brain stem and cerebellar damage in parkinsonian syndromes using diffusion tensor MRI Neurology 2006 67 12 2199 2205 17190944
  20. Blazejewska AI Schwarz ST Pitiot A Stephenson MC Lowe J Bajaj N Visualization of nigrosome 1 and its loss in PD: pathoanatomical correlation and in vivo 7 T MRI Neurology 2013 81 6 534 540 23843466 PMC3775686
  21. Boelmans K Bodammer NC Suchorska B Kaufmann J Ebersbach G Heinze HJ Diffusion tensor imaging of the corpus callosum differentiates corticobasal syndrome from Parkinson’s disease Parkinsonism Relat Disord 2010 16 8 498 502 20573537
  22. Boesch SM Wolf C Seppi K Felber S Wenning GK Schocke M Differentiation of SCA2 from MSA-C using proton magnetic resonance spectroscopic imaging J Magn Reson Imaging JMRI 2007 25 3 564 569 17326083
  23. Bowen BC Block RE Sanchez-Ramos J Pattany PM Lampman DA Murdoch JB Proton MR spectroscopy of the brain in 14 patients with Parkinson disease AJNR Am J Neuroradiol 1995 16 1 61 68 7900603 PMC8337695
  24. Boxer AL Geschwind MD Belfor N Gorno-Tempini ML Schauer GF Miller BL Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsy Arch Neurol 2006 63 1 81 86 16401739
  25. Brant-Zawadzki M Gillan GD Nitz WR MP RAGE: a three-dimensional, T1-weighted, gradient-echo sequence–initial experience in the brain Radiology 1992 182 3 769 775 1535892
  26. Brenneis C Seppi K Schocke M Benke T Wenning GK Poewe W Voxel based morphometry reveals a distinct pattern of frontal atrophy in progressive supranuclear palsy J Neurol Neurosurg Psychiatry 2004 75 2 246 249 14742598 PMC1738933
  27. Brenneis C Egger K Scherfler C Seppi K Schocke M Poewe W Progression of brain atrophy in multiple system atrophy. A longitudinal VBM study J Neurol 2007 254 2 191 196 17334661
  28. Brockmann K Hilker R Pilatus U Baudrexel S Srulijes K Magerkurth J GBA-associated PD. Neurodegeneration, altered membrane metabolism, and lack of energy failure Neurology 2012 79 3 213 220 22722629
  29. Buckner RL Krienen FM Yeo BT Opportunities and limitations of intrinsic functional connectivity MRI Nat Neurosci 2013 16 7 832 837 23799476
  30. Burton EJ McKeith IG Burn DJ Williams ED O’Brien JT Cerebral atrophy in Parkinson’s disease with and without dementia: a comparison with Alzheimer’s disease, dementia with Lewy bodies and controls Brain J Neurol 2004 127 Pt 4 791 800 14749292
  31. Camicioli R Gee M Bouchard TP Fisher NJ Hanstock CC Emery DJ Voxel-based morphometry reveals extra-nigral atrophy patterns associated with dopamine refractory cognitive and motor impairment in parkinsonism Parkinsonism Relat Disord 2009 15 3 187 195 18573676
  32. Canu E Agosta F Sarasso E Volonte MA Basaia S Stojkovic T Brain structural and functional connectivity in Parkinson’s disease with freezing of gait Hum Brain Mapp 2015 36 12 5064 5078 26359798 PMC6869160
  33. Castellanos G Fernandez-Seara MA Lorenzo-Betancor O Ortega-Cubero S Puigvert M Uranga J Automated neuromelanin imaging as a diagnostic biomarker for Parkinson’s disease Mov Disord Off J Mov Disord Soc 2015 30 7 945 952 25772492
  34. Cerasa A Messina D Pugliese P Morelli M Lanza P Salsone M Increased prefrontal volume in PD with levodopa-induced dyskinesias: a voxel-based morphometry study Mov Disord Off J Mov Disord Soc 2011 26 5 807 812 21384430
  35. Ceravolo R Antonini A Frosini D De Iuliis A Weis L Cecchin D Nigral anatomy and striatal denervation in genetic Parkinsonism: a family report Mov Disord Off J Mov Disord Soc 2015 30 8 1148 1149 26095323
  36. Chang CC Chang YY Chang WN Lee YC Wang YL Lui CC Cognitive deficits in multiple system atrophy correlate with frontal atrophy and disease duration Eur J Neurol 2009 16 10 1144 1150 19486137
  37. Chaudhuri KR Lemmens GM Williams SC Ellis C Lloyd CM Dawson J Proton magnetic resonance spectroscopy of the striatum in Parkinson’s disease patients with motor response fluctuations Parkinsonism Relat Disord 1996 2 2 63 67 18591020
  38. Chen Y Yang W Long J Zhang Y Feng J Li Y Discriminative analysis of Parkinson’s disease based on whole-brain functional connectivity PLoS One 2015 10 4 e0124153 25885059 PMC4401568
  39. Cho ZH Oh SH Kim JM Park SY Kwon DH Jeong HJ Direct visualization of Parkinson’s disease by in vivo human brain imaging using 7.0 T magnetic resonance imaging Mov Disord Off J Mov Disord Soc 2011 26 4 713 718 21506148
  40. Chung EJ Kim EG Bae JS Eun CK Lee KS Oh M Usefulness of diffusion-weighted MRI for differentiation between Parkinson’s disease and Parkinson variant of multiple system atrophy J Mov Disord 2009 2 2 64 68 24868359 PMC4027714
  41. Clarke CE Lowry M Systematic review of proton magnetic resonance spectroscopy of the striatum in parkinsonian syndromes Eur J Neurol 2001 8 6 573 577 11784341
  42. Cochrane CJ Ebmeier KP Diffusion tensor imaging in parkinsonian syndromes: a systematic review and meta-analysis Neurology 2013 80 9 857 864 23439701 PMC3598454
  43. Compta Y Ibarretxe-Bilbao N Pereira JB Junque C Bargallo N Tolosa E Grey matter volume correlates of cerebrospinal markers of Alzheimer-pathology in Parkinson’s disease and related dementia Parkinsonism Relat Disord 2012 18 8 941 947 22595621
  44. Cordato NJ Pantelis C Halliday GM Velakoulis D Wood SJ Stuart GW Frontal atrophy correlates with behavioural changes in progressive supranuclear palsy Brain J Neurol 2002 125 Pt 4 789 800 11912112
  45. Cordato NJ Duggins AJ Halliday GM Morris JG Pantelis C Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy Brain J Neurol 2005 128 Pt 6 1259 1266 15843423
  46. Cosottini M Ceravolo R Faggioni L Lazzarotti G Michelassi MC Bonuccelli U Assessment of midbrain atrophy in patients with progressive supranuclear palsy with routine magnetic resonance imaging Acta Neurol Scand 2007 116 1 37 42 17587253
  47. da Rocha AJ Maia AC Jr da Silva CJ Braga FT Ferreira NP Barsottini OG Pyramidal tract degeneration in multiple system atrophy: the relevance of magnetization transfer imaging Mov Disord Off J Mov Disord Soc 2007 22 2 238 244 17133514
  48. Dalaker TO Zivadinov R Larsen JP Beyer MK Cox JL Alves G Gray matter correlations of cognition in incident Parkinson’s disease Mov Disord Off J Mov Disord Soc 2010 25 5 629 633 20213820
  49. Dashtipour K Liu M Kani C Dalaie P Obenaus A Simmons D Iron accumulation is not homogenous among patients with Parkinson’s disease Parkinsons Dis 2015 2015 324843 25945281 PMC4402185
  50. Davie CA Wenning GK Barker GJ Tofts PS Kendall BE Quinn N Differentiation of multiple system atrophy from idiopathic Parkinson’s disease using proton magnetic resonance spectroscopy Ann Neurol 1995 37 2 204 210 7847862
  51. De Marzi R Seppi K Hogl B Muller C Scherfler C Stefani A Loss of dorsolateral nigral hyperintensity on 3.0 T susceptibility-weighted imaging in idiopathic rapid eye movement sleep behavior disorder Ann Neurol 2016 79 6 1026 1030 27016314
  52. Dell’Acqua F Catani M Structural human brain networks: hot topics in diffusion tractography Curr Opin Neurol 2012 25 4 375 383 22766720
  53. Drayer BP Olanow W Burger P Johnson GA Herfkens R Riederer S Parkinson plus syndrome: diagnosis using high field MR imaging of brain iron Radiol 1986 159 2 493 498 3961182
  54. Du G Lewis MM Styner M Shaffer ML Sen S Yang QX Combined R2* and diffusion tensor imaging changes in the substantia nigra in Parkinson’s disease Mov Disord Off J Mov Disord Soc 2011 26 9 1627 1632 PMC3154471 21618607
  55. Du G Lewis MM Sen S Wang J Shaffer ML Styner M Imaging nigral pathology and clinical progression in Parkinson’s disease Mov Disord Off J Mov Disord Soc 2012 27 13 1636 1643 PMC3510346 23008179
  56. Du G Liu T Lewis MM Kong L Wang Y Connor J Quantitative susceptibility mapping of the midbrain in Parkinson’s disease Mov Disord Off J Mov Disord Soc 2016 31 3 317 324 PMC5315570 26362242
  57. Eckert T Sailer M Kaufmann J Schrader C Peschel T Bodammer N Differentiation of idiopathic Parkinson’s disease, multiple system atrophy, progressive supranuclear palsy, and healthy controls using magnetization transfer imaging Neuroimage 2004 21 1 229 235 14741660
  58. Eckert T Tang C Eidelberg D Assessment of the progression of Parkinson’s disease: a metabolic network approach Lancet Neurol 2007 6 10 926 932 17884682 PMC2870718
  59. Ellfolk U Joutsa J Rinne JO Parkkola R Jokinen P Karrasch M Striatal volume is related to phonemic verbal fluency but not to semantic or alternating verbal fluency in early Parkinson’s disease J Neural Transm (Vienna) 2014 121 1 33 40 23913130 PMC3889690
  60. Emir UE Tuite PJ Oz G Elevated pontine and putaminal GABA levels in mild-moderate Parkinson disease detected by 7 T proton MRS PloS One 2012 7 1 e30918 22295119 PMC3266292
  61. Esterhammer R Schocke M Seppi K Basal ganglia cellular pathology in multiple system atrophy, progressive supranuclear palsy and Parkinson disease. Can quantitative magnetic resonance spectroscopic imaging make the difference? Eur J Neurol 2010 17 9 1111 1112 20561041
  62. Esterhammer R Seppi K Reiter E Pinter B Mueller C Kremser C Potential of diffusion tensor imaging and relaxometry for the detection of specific pathological alterations in Parkinson’s disease (PD) PloS One 2015 10 12 e0145493 26713760 PMC4705111
  63. Federico F Simone IL Lucivero V Iliceto G De Mari M Giannini P Proton magnetic resonance spectroscopy in Parkinson’s disease and atypical parkinsonian disorders Mov Disord Off J Mov Disord Soc 1997 12 6 903 909 9399213
  64. Federico F Simone IL Lucivero V Mezzapesa DM de Mari M Lamberti P Usefulness of proton magnetic resonance spectroscopy in differentiating parkinsonian syndromes Ital J Neurol Sci 1999 20 4 223 229 10551908
  65. Feng JY Huang B Yang WQ Zhang YH Wang LM Wang LJ The putaminal abnormalities on 3.0 T magnetic resonance imaging: can they separate parkinsonism-predominant multiple system atrophy from Parkinson’s disease? Acta Radiol 2015 56 3 322 328 24619850
  66. Fernandez-Seara MA Mengual E Vidorreta M Aznarez-Sanado M Loayza FR Villagra F Cortical hypoperfusion in Parkinson’s disease assessed using arterial spin labeled perfusion MRI Neuroimage 2012 59 3 2743 2750 22032942
  67. Fiorenzato E Weis L Seppi K Onofrj M Cortelli P Zanigni S Brain structural profile of multiple system atrophy patients with cognitive impairment J Neural Transm 2017 124 3 293 302 27778099
  68. Firbank MJ Harrison RM O’Brien JT A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson’s disease Dement Geriatr Cogn Disord 2002 14 2 64 76 12145453
  69. Fischl B Dale AM Measuring the thickness of the human cerebral cortex from magnetic resonance images Proc Natl Acad Sci USA 2000 97 20 11050 11055 10984517 PMC27146
  70. Focke NK Helms G Pantel PM Scheewe S Knauth M Bachmann CG Differentiation of typical and atypical Parkinson syndromes by quantitative MR imaging AJNR Am J Neuroradiol 2011 32 11 2087 2092 21998102 PMC7964420
  71. Focke NK Helms G Scheewe S Pantel PM Bachmann CG Dechent P Individual voxel-based subtype prediction can differentiate progressive supranuclear palsy from idiopathic Parkinson syndrome and healthy controls Hum Brain Mapp 2011 32 11 1905 1915 21246668 PMC6870106
  72. Gama RL Tavora DF Bomfim RC Silva CE Bruin VM Bruin PF Morphometry MRI in the differential diagnosis of parkinsonian syndromes Arquivos de neuro-psiquiatria 2010 68 3 333 338 20602031
  73. Gardner RC Boxer AL Trujillo A Mirsky JB Guo CC Gennatas ED Intrinsic connectivity network disruption in progressive supranuclear palsy Ann Neurol 2013 73 5 603 616 23536287 PMC3732833
  74. Ghosh BC Calder AJ Peers PV Lawrence AD Acosta-Cabronero J Pereira JM Social cognitive deficits and their neural correlates in progressive supranuclear palsy Brain J Neurol 2012 135 Pt 7 2089 2102 PMC3381722 22637582
  75. Giordano A Tessitore A Corbo D Cirillo G de Micco R Russo A Clinical and cognitive correlations of regional gray matter atrophy in progressive supranuclear palsy Parkinsonism Relat Disord 2013 19 6 590 594 23477861
  76. Groger A Bender B Wurster I Chadzynski GL Klose U Berg D Differentiation between idiopathic and atypical parkinsonian syndromes using three-dimensional magnetic resonance spectroscopic imaging J Neurol Neurosurg Psychiatry 2013 84 6 644 649 23334525
  77. Groschel K Hauser TK Luft A Patronas N Dichgans J Litvan I Magnetic resonance imaging-based volumetry differentiates progressive supranuclear palsy from corticobasal degeneration Neuroimage 2004 21 2 714 724 14980574
  78. Guevara CA Blain CR Stahl D Lythgoe DJ Leigh PN Barker GJ Quantitative magnetic resonance spectroscopic imaging in Parkinson’s disease, progressive supranuclear palsy and multiple system atrophy Eur J Neurol 2010 17 9 1193 1202 20402762
  79. Gupta D Saini J Kesavadas C Sarma PS Kishore A Utility of susceptibility-weighted MRI in differentiating Parkinson’s disease and atypical parkinsonism Neuroradiology 2010 52 12 1087 1094 20358367
  80. Hagmann P Jonasson L Maeder P Thiran JP Wedeen VJ Meuli R Understanding diffusion MR imaging techniques: from scalar diffusion-weighted imaging to diffusion tensor imaging and beyond Radiogr Rev Publ Radiol Soc N Am Inc 2006 26 Suppl 1 S205 S223 17050517
  81. Haller S Badoud S Nguyen D Garibotto V Lovblad KO Burkhard PR Individual detection of patients with Parkinson disease using support vector machine analysis of diffusion tensor imaging data: initial results AJNR Am J Neuroradiol 2012 33 11 2123 2128 22653326 PMC7965604
  82. Haller S Badoud S Nguyen D Barnaure I Montandon ML Lovblad KO Differentiation between Parkinson disease and other forms of Parkinsonism using support vector machine analysis of susceptibility-weighted imaging (SWI): initial results Eur Radiol 2013 23 1 12 19 22797981
  83. Han YH Lee JH Kang BM Mun CW Baik SK Shin YI Topographical differences of brain iron deposition between progressive supranuclear palsy and parkinsonian variant multiple system atrophy J Neurol Sci 2013 325 1–2 29 35 23260321
  84. Hauser RA Murtaugh FR Akhter K Gold M Olanow CW Magnetic resonance imaging of corticobasal degeneration J Neuroimaging Off J Am Soc Neuroimaging 1996 6 4 222 226 8903073
  85. Hirata FC Sato JR Vieira G Lucato LT Leite CC Bor-Seng-Shu E Substantia nigra fractional anisotropy is not a diagnostic biomarker of Parkinson’s disease: a diagnostic performance study and meta-analysis Eur Radiol 2016 27709279
  86. Holtbernd F Eidelberg D The utility of neuroimaging in the differential diagnosis of parkinsonian syndromes Semin Neurol 2014 34 2 202 209 24963679 PMC4556352
  87. Hong JY Lee JE Sohn YH Lee PH Neurocognitive and atrophic patterns in Parkinson’s disease based on subjective memory complaints J Neurol 2012 259 8 1706 1712 22289965
  88. Hopes L Grolez G Moreau C Lopes R Ryckewaert G Carriere N magnetic resonance imaging features of the nigrostriatal system: biomarkers of Parkinson’s disease stages? PloS One 2016 11 4 e0147947 27035571 PMC4818028
  89. Hotter A Esterhammer R Schocke MF Seppi K Potential of advanced MR imaging techniques in the differential diagnosis of parkinsonism Mov Disord Off J Mov Disord Soc 2009 24 Suppl 2 S711 S720 19877241
  90. Hu MT White SJ Herlihy AH Chaudhuri KR Hajnal JV Brooks DJ A comparison of (18)F-dopa PET and inversion recovery MRI in the diagnosis of Parkinson’s disease Neurology 2001 56 9 1195 1200 11342685
  91. Hughes AJ Daniel SE Ben-Shlomo Y Lees AJ The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service Brain J Neurol 2002 125 Pt 4 861 870 11912118
  92. Huppertz HJ Moller L Sudmeyer M Hilker R Hattingen E Egger K Differentiation of neurodegenerative parkinsonian syndromes by volumetric magnetic resonance imaging analysis and support vector machine classification Mov Disord Off J Mov Disord Soc 2016 31 10 1506 1517 27452874
  93. Hussl A Mahlknecht P Scherfler C Esterhammer R Schocke M Poewe W Diagnostic accuracy of the magnetic resonance Parkinsonism index and the midbrain-to-pontine area ratio to differentiate progressive supranuclear palsy from Parkinson’s disease and the Parkinson variant of multiple system atrophy Mov Disord Off J Mov Disord Soc 2010 25 14 2444 2449 20878992
  94. Hutchinson M Raff U Parkinson’s disease: a novel MRI method for determining structural changes in the substantia nigra J Neurol Neurosurg Psychiatry 1999 67 6 815 818 10567508 PMC1736694
  95. Hutchinson M Raff U Detection of Parkinson’s disease by MRI: spin-lattice distribution imaging Mov Disord Off J Mov Disord Soc 2008 23 14 1991 1997 18759364
  96. Hutchinson M Raff U Lebedev S MRI correlates of pathology in parkinsonism: segmented inversion recovery ratio imaging (SIRRIM) Neuroimage 2003 20 3 1899 1902 14642500
  97. Ibarretxe-Bilbao N Junque C Segura B Baggio HC Marti MJ Valldeoriola F Progression of cortical thinning in early Parkinson’s disease Mov Disord Off J Mov Disord Soc 2012 27 14 1746 1753 23124622
  98. Ito M Watanabe H Kawai Y Atsuta N Tanaka F Naganawa S Usefulness of combined fractional anisotropy and apparent diffusion coefficient values for detection of involvement in multiple system atrophy J Neurol Neurosurg Psychiatry 2007 78 7 722 728 17353258 PMC2117692
  99. Jankovic J Rajput AH McDermott MP Perl DP The evolution of diagnosis in early Parkinson disease. Parkinson Study Group Arch Neurol 2000 57 3 369 372 10714663
  100. Jesse S Kassubek J Muller HP Ludolph AC Unrath A Signal alterations of the basal ganglia in the differential diagnosis of Parkinson’s disease: a retrospective case-controlled MRI data bank analysis BMC Neurol 2012 12 163 23273141 PMC3543204
  101. Josephs KA Tang-Wai DF Edland SD Knopman DS Dickson DW Parisi JE Correlation between antemortem magnetic resonance imaging findings and pathologically confirmed corticobasal degeneration Arch Neurol 2004 61 12 1881 1884 15596608
  102. Jubault T Brambati SM Degroot C Kullmann B Strafella AP Lafontaine AL Regional brain stem atrophy in idiopathic Parkinson’s disease detected by anatomical MRI PloS One 2009 4 12 e8247 20011063 PMC2784293
  103. Kalia LV Lang AE Parkinson’s disease Lancet 2015 386 9996 896 912 25904081
  104. Kamagata K Motoi Y Hori M Suzuki M Nakanishi A Shimoji K Posterior hypoperfusion in Parkinson’s disease with and without dementia measured with arterial spin labeling MRI J Magn Reson Imaging JMRI 2011 33 4 803 807 21448943
  105. Kamagata K Hatano T Okuzumi A Motoi Y Abe O Shimoji K Neurite orientation dispersion and density imaging in the substantia nigra in idiopathic Parkinson disease Eur Radiol 2016 26 8 2567 2577 26515546
  106. Kanazawa M Shimohata T Terajima K Onodera O Tanaka K Tsuji S Quantitative evaluation of brainstem involvement in multiple system atrophy by diffusion-weighted MR imaging J Neurol 2004 251 9 1121 1124 15372256
  107. Karagulle Kendi AT Lehericy S Luciana M Ugurbil K Tuite P Altered diffusion in the frontal lobe in Parkinson disease. AJNR Am J Neuroradiol 2008 29 3 501 505 18202242 PMC8118887
  108. Kashihara K Shinya T Higaki F Reduction of neuromelanin-positive nigral volume in patients with MSA, PSP and CBD Internal Med 2011 50 16 1683 1687 21841326
  109. Kassubek J Muller HP Computer-based magnetic resonance imaging as a tool in clinical diagnosis in neurodegenerative diseases Expert Rev Neurother 2016 16 3 295 306 26807776
  110. Kim YH Ma HI Kim YJ Utility of the midbrain tegmentum diameter in the differential diagnosis of progressive supranuclear palsy from idiopathic Parkinson’s disease J Clin Neurol 2015 11 3 268 274 26174787 PMC4507382
  111. Kim JM Jeong HJ Bae YJ Park SY Kim E Kang SY Loss of substantia nigra hyperintensity on 7 T MRI of Parkinson’s disease, multiple system atrophy, and progressive supranuclear palsy Parkinsonism Relat Disord 2016 26 47 54 26951846
  112. Lehericy S Vaillancourt DE Seppi K Monchi O Rektorova I Antonini A McKeown MJ Masellis M Berg D Rowe JB Lewis SJG Williams-Gray CH Tessitore A Siebner HR The role of high-field magnetic resonance imaging in parkinsonian disorders: Pushing the boundaries forward Mov Disord 2017 28370449
  113. Kollensperger M Seppi K Liener C Boesch S Heute D Mair KJ Diffusion weighted imaging best discriminates PD from MSA-P: a comparison with tilt table testing and heart MIBG scintigraphy Mov Disord Off J Mov Disord Soc 2007 22 12 1771 1776 17579357
  114. Kostic VS Agosta F Petrovic I Galantucci S Spica V Jecmenica-Lukic M Regional patterns of brain tissue loss associated with depression in Parkinson disease Neurology 2010 75 10 857 863 20686125
  115. Kraft E Trenkwalder C Auer DP T2*-weighted MRI differentiates multiple system atrophy from Parkinson’s disease Neurology 2002 59 8 1265 1267 12391363
  116. Kwon DH Kim JM Oh SH Jeong HJ Park SY Oh ES Seven-Tesla magnetic resonance images of the substantia nigra in Parkinson disease Ann Neurol 2012 71 2 267 277 22367998
  117. Lagarde J Valabregue R Corvol JC Pineau F Le Ber I Vidailhet M Are frontal cognitive and atrophy patterns different in PSP and bvFTD? A comparative neuropsychological and VBM study PloS One 2013 8 11 e80353 24278277 PMC3835584
  118. Langkammer C Pirpamer L Seiler S Deistung A Schweser F Franthal S Quantitative susceptibility mapping in Parkinson’s disease PloS One 2016 11 9 e0162460 27598250 PMC5012676
  119. Langley J Huddleston DE Sedlacik J Boelmans K Hu XP Parkinson’s disease-related increase of T2*-weighted hypointensity in substantia nigra pars compacta Mov Disord Off J Mov Disord Soc 2016 32 3 441 449 28004859
  120. Le Bihan D Looking into the functional architecture of the brain with diffusion MRI Nat Rev Neurosci 2003 4 6 469 480 12778119
  121. Lee JH Baik SK Putaminal hypointensity in the parkinsonian variant of multiple system atrophy: simple visual assessment using susceptibility-weighted imaging J Mov Disord 2011 4 2 60 63 24868396 PMC4027686
  122. Lee WH Lee CC Shyu WC Chong PN Lin SZ Hyperintense putaminal rim sign is not a hallmark of multiple system atrophy at 3 T AJNR Am J Neuroradiol 2005 26 9 2238 2242 16219828 PMC7976126
  123. Lee YC Liu CS Wu HM Wang PS Chang MH Soong BW The ‘hot cross bun’ sign in the patients with spinocerebellar ataxia Eur J Neurol 2009 16 4 513 516 19187260
  124. Lee SE Rabinovici GD Mayo MC Wilson SM Seeley WW DeArmond SJ Clinicopathological correlations in corticobasal degeneration Ann Neurol 2011 70 2 327 340 21823158 PMC3154081
  125. Lee EY Sen S Eslinger PJ Wagner D Shaffer ML Kong L Early cortical gray matter loss and cognitive correlates in non-demented Parkinson’s patients Parkinsonism Relat Disord 2013 19 12 1088 1093 23932064 PMC3858507
  126. Lee JH Han YH Kang BM Mun CW Lee SJ Baik SK Quantitative assessment of subcortical atrophy and iron content in progressive supranuclear palsy and parkinsonian variant of multiple system atrophy J Neurol 2013 260 8 2094 2101 23670309
  127. Levin BE Katzen HL Maudsley A Post J Myerson C Govind V Whole-brain proton MR spectroscopic imaging in Parkinson’s disease J Neuroimaging Off J Am Soc Neuroimaging 2014 24 1 39 44 PMC4593470 23228009
  128. Long D Wang J Xuan M Gu Q Xu X Kong D Automatic classification of early Parkinson’s disease with multi-modal MR imaging PloS One 2012 7 11 e47714 23152757 PMC3494697
  129. Longoni G Agosta F Kostic VS Stojkovic T Pagani E Stosic-Opincal T MRI measurements of brainstem structures in patients with Richardson’s syndrome, progressive supranuclear palsy-parkinsonism, and Parkinson’s disease Mov Disord Off J Mov Disord Soc 2011 26 2 247 255 21412831
  130. Madhyastha TM Askren MK Boord P Zhang J Leverenz JB Grabowski TJ Cerebral perfusion and cortical thickness indicate cortical involvement in mild Parkinson’s disease Mov Disord Off J Mov Disord Soc 2015 30 14 1893 1900 PMC4567553 25759166
  131. Mahlknecht P Hotter A Hussl A Esterhammer R Schocke M Seppi K Significance of MRI in diagnosis and differential diagnosis of Parkinson’s disease Neuro Degener Dis 2010 7 5 300 318 20616565
  132. Mahlknecht P Seppi K Poewe W The concept of prodromal Parkinson’s disease J Parkinson’s Dis 2015 5 4 681 697 26485429 PMC4927924
  133. Mahlknecht P Krismer K Poewe W Seppi K Meta-analysis of dorsolateral nigral hyperintensity on MRI as a marker for Parkinson’s disease Mov Disord Off J Mov Disord Soc 2017 28151553
  134. Martin WR Wieler M Gee M Midbrain iron content in early Parkinson disease: a potential biomarker of disease status Neurology 2008 70 16 Pt 2 1411 1417 18172063
  135. Martin WR Wieler M Gee M Camicioli R Temporal lobe changes in early, untreated Parkinson’s disease Mov Disord Off J Mov Disord Soc 2009 24 13 1949 1954 19606493
  136. Massey LA Micallef C Paviour DC O’Sullivan SS Ling H Williams DR Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy Mov Disord Off J Mov Disord Soc 2012 27 14 1754 1762 22488922
  137. Massey LA Jager HR Paviour DC O’Sullivan SS Ling H Williams DR The midbrain to pons ratio: a simple and specific MRI sign of progressive supranuclear palsy Neurology 2013 80 20 1856 1861 23616165 PMC3908351
  138. Matsuura K Maeda M Yata K Ichiba Y Yamaguchi T Kanamaru K Neuromelanin magnetic resonance imaging in Parkinson’s disease and multiple system atrophy Eur Neurol 2013 70 1–2 70 77 23796701
  139. Meara J Bhowmick BK Hobson P Accuracy of diagnosis in patients with presumed Parkinson’s disease Age Ageing 1999 28 2 99 102 10350403
  140. Meijer FJ Bloem BR Mahlknecht P Seppi K Goraj B Update on diffusion MRI in Parkinson’s disease and atypical parkinsonism J Neurol Sci 2013 332 1–2 21 29 23866820
  141. Meijer FJ van Rumund A Fasen BA Titulaer I Aerts M Esselink R Susceptibility-weighted imaging improves the diagnostic accuracy of 3 T brain MRI in the work-up of parkinsonism AJNR Am J Neuroradiol 2015 36 3 454 460 25339647 PMC8013057
  142. Meijer FJ van Rumund A Tuladhar AM Aerts MB Titulaer I Esselink RA Conventional 3 T brain MRI and diffusion tensor imaging in the diagnostic workup of early stage parkinsonism Neuroradiology 2015 57 7 655 669 25845807 PMC4495265
  143. Meles SK Teune LK de Jong BM Dierckx RA Leenders KL Metabolic imaging in Parkinson disease J Nucl Med Off Publ Soc Nucl Med 2017 58 1 23 28 27879372
  144. Melzer TR Watts R MacAskill MR Pearson JF Rueger S Pitcher TL Arterial spin labelling reveals an abnormal cerebral perfusion pattern in Parkinson’s disease Brain J Neurol 2011 134 Pt 3 845 855 PMC3105489 21310726
  145. Menke RA Scholz J Miller KL Deoni S Jbabdi S Matthews PM MRI characteristics of the substantia nigra in Parkinson’s disease: a combined quantitative T1 and DTI study Neuroimage 2009 47 2 435 441 19447183
  146. Menke RA Jbabdi S Miller KL Matthews PM Zarei M Connectivity-based segmentation of the substantia nigra in human and its implications in Parkinson’s disease Neuroimage 2010 52 4 1175 1180 20677376
  147. Menke RA Szewczyk-Krolikowski K Jbabdi S Jenkinson M Talbot K Mackay CE Comprehensive morphometry of subcortical grey matter structures in early-stage Parkinson’s disease Hum Brain Mapp 2014 35 4 1681 1690 23861334 PMC6868970
  148. Meppelink AM de Jong BM Teune LK van Laar T Regional cortical grey matter loss in Parkinson’s disease without dementia is independent from visual hallucinations Mov Disord Off J Mov Disord Soc 2011 26 1 142 147 20922809
  149. Minati L Grisoli M Carella F De Simone T Bruzzone MG Savoiardo M Imaging degeneration of the substantia nigra in Parkinson disease with inversion-recovery MR imaging AJNR Am J Neuroradiol 2007 28 2 309 313 17297002 PMC7977418
  150. Moller L Kassubek J Sudmeyer M Hilker R Hattingen E Egger K Manual MRI morphometry in Parkinsonian syndromes Mov Disord Off J Mov Disord Soc 2017 28150443
  151. Morelli M Arabia G Novellino F Salsone M Giofre L Condino F MRI measurements predict PSP in unclassifiable parkinsonisms: a cohort study Neurology 2011 77 11 1042 1047 21832222
  152. Morelli M Arabia G Salsone M Novellino F Giofre L Paletta R Accuracy of magnetic resonance parkinsonism index for differentiation of progressive supranuclear palsy from probable or possible Parkinson disease Mov Disord Off J Mov Disord Soc 2011 26 3 527 533 21287599
  153. Mori S Crain BJ Chacko VP van Zijl PC Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging Ann Neurol 1999 45 2 265 269 9989633
  154. Muqit MM Mort D Miskiel KA Shakir RA “Hot cross bun” sign in a patient with parkinsonism secondary to presumed vasculitis J Neurol Neurosurg Psychiatry 2001 71 4 565 566 11601421 PMC1763502
  155. Nagano-Saito A Washimi Y Arahata Y Kachi T Lerch JP Evans AC Cerebral atrophy and its relation to cognitive impairment in Parkinson disease Neurology 2005 64 2 224 229 15668417
  156. Nakamura K Sugaya K Neuromelanin-sensitive magnetic resonance imaging: a promising technique for depicting tissue characteristics containing neuromelanin Neural Regener Res 2014 9 7 759 760 PMC4146273 25206885
  157. Nam Y Gho SM Kim DH Kim EY Lee J Imaging of nigrosome 1 in substantia nigra at 3 T using multiecho susceptibility map-weighted imaging (SMWI) J Magn Reson Imaging JMRI 2016 27859983
  158. Nemmi F Sabatini U Rascol O Peran P Parkinson’s disease and local atrophy in subcortical nuclei: insight from shape analysis Neurobiol Aging 2015 36 1 424 433 25174648
  159. Nicoletti G Fera F Condino F Auteri W Gallo O Pugliese P MR imaging of middle cerebellar peduncle width: differentiation of multiple system atrophy from Parkinson disease Radiology 2006 239 3 825 830 16714464
  160. Nicoletti G Lodi R Condino F Tonon C Fera F Malucelli E Apparent diffusion coefficient measurements of the middle cerebellar peduncle differentiate the Parkinson variant of MSA from Parkinson’s disease and progressive supranuclear palsy Brain J Neurol 2006 129 Pt 10 2679 2687 16815875
  161. Nicoletti G Rizzo G Barbagallo G Tonon C Condino F Manners D Diffusivity of cerebellar hemispheres enables discrimination of cerebellar or parkinsonian multiple system atrophy from progressive supranuclear palsy-Richardson syndrome and Parkinson disease Radiology 2013 267 3 843 850 23329659
  162. Nicoletti G Tonon C Lodi R Condino F Manners D Malucelli E Morelli M Novellino F Paglionico S Lanza P Messina D Barone P Morgante L Zappia M Barbiroli B Quattrone A Apparent diffusion coefficient of the superior cerebellar peduncle differentiates progressive supranuclear palsy from Parkinson's disease Mov Disord 2008 23 16 2370 2376 18816803
  163. Nigro S Arabia G Antonini A Weis L Marcante A Tessitore A Magnetic Resonance Parkinsonism Index: diagnostic accuracy of a fully automated algorithm in comparison with the manual measurement in a large Italian multicentre study in patients with progressive supranuclear palsy Eur Radiol 2016 27761709
  164. Nishio Y Hirayama K Takeda A Hosokai Y Ishioka T Suzuki K Corticolimbic gray matter loss in Parkinson’s disease without dementia Eur J Neurol 2010 17 8 1090 1097 20298422
  165. Oba H Yagishita A Terada H Barkovich AJ Kutomi K Yamauchi T New and reliable MRI diagnosis for progressive supranuclear palsy Neurology 2005 64 12 2050 2055 15985570
  166. O’Callaghan C Naismith SL Hodges JR Lewis SJ Hornberger M Fronto-striatal atrophy correlates of inhibitory dysfunction in Parkinson’s disease vs. behavioural variant frontotemporal dementia Cortex J Devoted Study Nerv Syst Behav 2013 49 7 1833 1843 23306064
  167. Ofori E Pasternak O Planetta PJ Burciu R Snyder A Febo M Increased free water in the substantia nigra of Parkinson’s disease: a single-site and multi-site study Neurobiol Aging 2015 36 2 1097 1104 25467638 PMC4315708
  168. Ofori E Pasternak O Planetta PJ Li H Burciu RG Snyder AF Longitudinal changes in free-water within the substantia nigra of Parkinson’s disease Brain J Neurol 2015 138 Pt 8 2322 2331 PMC4840947 25981960
  169. Ohtsuka C Sasaki M Konno K Kato K Takahashi J Yamashita F Differentiation of early-stage parkinsonisms using neuromelanin-sensitive magnetic resonance imaging Parkinsonism Relat Disord 2014 20 7 755 760 24768616
  170. O’Neill J Schuff N Marks WJ Jr Feiwell R Aminoff MJ Weiner MW Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson’s disease Mov Disord Off J Mov Disord Soc 2002 17 5 917 927 12360540
  171. Padovani A Borroni B Brambati SM Agosti C Broli M Alonso R Diffusion tensor imaging and voxel based morphometry study in early progressive supranuclear palsy J Neurol Neurosurg Psychiatry 2006 77 4 457 463 16306152 PMC2077489
  172. Pan P Zhan H Xia M Zhang Y Guan D Xu Y Aberrant regional homogeneity in Parkinson’s disease: a voxel-wise meta-analysis of resting-state functional magnetic resonance imaging studies Neurosci biobehav Rev 2017 72 223 231 27916710
  173. Pastakia B Polinsky R Di Chiro G Simmons JT Brown R Wener L Multiple system atrophy (Shy-Drager syndrome): MR imaging Radiology 1986 159 2 499 502 3961183
  174. Pasternak O Sochen N Gur Y Intrator N Assaf Y Free water elimination and mapping from diffusion MRI Magn Reson Med 2009 62 3 717 730 19623619
  175. Paviour DC Price SL Stevens JM Lees AJ Fox NC Quantitative MRI measurement of superior cerebellar peduncle in progressive supranuclear palsy Neurology 2005 64 4 675 679 15728291
  176. Paviour DC Price SL Jahanshahi M Lees AJ Fox NC Longitudinal MRI in progressive supranuclear palsy and multiple system atrophy: rates and regions of atrophy Brain J Neurol 2006 129 Pt 4 1040 1049 16455792
  177. Paviour DC Price SL Jahanshahi M Lees AJ Fox NC Regional brain volumes distinguish PSP, MSA-P, and PD: MRI-based clinico-radiological correlations Mov Disord Off J Mov Disord Soc 2006 21 7 989 996 16602104
  178. Paviour DC Thornton JS Lees AJ Jager HR Diffusion-weighted magnetic resonance imaging differentiates Parkinsonian variant of multiple-system atrophy from progressive supranuclear palsy Mov Disord Off J Mov Disord Soc 2007 22 1 68 74 17089396
  179. Pellecchia MT Barone P Mollica C Salvatore E Ianniciello M Longo K Diffusion-weighted imaging in multiple system atrophy: a comparison between clinical subtypes Mov Disord Off J Mov Disord Soc 2009 24 5 689 696 19117367
  180. Peran P Cherubini A Assogna F Piras F Quattrocchi C Peppe A Magnetic resonance imaging markers of Parkinson’s disease nigrostriatal signature Brain J Neurol 2010 133 11 3423 3433 20736190
  181. Pereira JB Junque C Marti MJ Ramirez-Ruiz B Bargallo N Tolosa E Neuroanatomical substrate of visuospatial and visuoperceptual impairment in Parkinson’s disease Mov Disord Off J Mov Disord Soc 2009 24 8 1193 1199 19412935
  182. Petcharunpaisan S Ramalho J Castillo M Arterial spin labeling in neuroimaging World J Radiol 2010 2 10 384 398 21161024 PMC2999014
  183. Planetta PJ Ofori E Pasternak O Burciu RG Shukla P DeSimone JC Free-water imaging in Parkinson’s disease and atypical parkinsonism Brain J Neurol 2016 139 Pt 2 495 508 PMC5790142 26705348
  184. Poewe W The natural history of Parkinson’s disease J Neurol 2006 253 Suppl 7 VII2-6 17131223
  185. Poewe W Seppi K Tanner CM Halliday GM Brundin P Volkmann J Schrag AE Lang AE Parkinson disease Nat Rev Dis Prim 2017 28332488
  186. Postuma RB Berg D Adler CH Bloem BR Chan P Deuschl G The new definition and diagnostic criteria of Parkinson’s disease Lancet Neurol 2016 15 6 546 548 27302120
  187. Price S Paviour D Scahill R Stevens J Rossor M Lees A Voxel-based morphometry detects patterns of atrophy that help differentiate progressive supranuclear palsy and Parkinson’s disease Neuroimage 2004 23 2 663 669 15488416
  188. Prodoehl J Li H Planetta PJ Goetz CG Shannon KM Tangonan R Diffusion tensor imaging of Parkinson’s disease, atypical parkinsonism, and essential tremor Mov Disord Off J Mov Disord Soc 2013 28 13 1816 1822 PMC3748146 23674400
  189. Pyatigorskaya N Sharman M Corvol JC Valabregue R Yahia-Cherif L Poupon F High nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry Mov Disord Off J Mov Disord Soc 2015 30 8 1077 1084 26011561
  190. Quattrone A Nicoletti G Messina D Fera F Condino F Pugliese P MR imaging index for differentiation of progressive supranuclear palsy from Parkinson disease and the Parkinson variant of multiple system atrophy Radiology 2008 246 1 214 221 17991785
  191. Rademacher J Engelbrecht V Burgel U Freund H Zilles K Measuring in vivo myelination of human white matter fiber tracts with magnetization transfer MR Neuroimage 1999 9 4 393 406 10191168
  192. Rajput AH Rajput A Accuracy of Parkinson disease diagnosis unchanged in 2 decades Neurology 2014 83 5 386 387 24975858
  193. Rajput AH Rozdilsky B Rajput A Accuracy of clinical diagnosis in parkinsonism–a prospective study Can J Neurol Sci (Le journal canadien des sciences neurologiques) 1991 18 3 275 278 1913360
  194. Ramirez-Ruiz B Marti MJ Tolosa E Gimenez M Bargallo N Valldeoriola F Cerebral atrophy in Parkinson’s disease patients with visual hallucinations Eur J Neurol 2007 14 7 750 756 17594330
  195. Reimao S Pita Lobo P Neutel D Correia Guedes L Coelho M Rosa MM Substantia nigra neuromelanin magnetic resonance imaging in de novo Parkinson’s disease patients Eur J Neurol 2015 22 3 540 546 25534480
  196. Reimao S Pita Lobo P Neutel D Guedes LC Coelho M Rosa MM Quantitative analysis vs. visual assessment of neuromelanin MR imaging for the diagnosis of Parkinson’s disease J Parkinsons Dis 2015 5 3 561 567 26406136
  197. Reimao S Ferreira S Nunes RG Pita Lobo P Neutel D Abreu D Magnetic resonance correlation of iron content with neuromelanin in the substantia nigra of early-stage Parkinson’s disease Eur J Neurol 2016 23 2 368 374 26518135
  198. Reiter E Mueller C Pinter B Krismer F Scherfler C Esterhammer R Dorsolateral nigral hyperintensity on 3.0 T susceptibility-weighted imaging in neurodegenerative Parkinsonism Mov Disord Off J Mov Disord Soc 2015 30 8 1068 1076 25773707
  199. Ridgway GR Henley SM Rohrer JD Scahill RI Warren JD Fox NC Ten simple rules for reporting voxel-based morphometry studies Neuroimage 2008 40 4 1429 1435 18314353
  200. Righini A Antonini A Ferrarini M de Notaris R Canesi M Triulzi F Thin section MR study of the basal ganglia in the differential diagnosis between striatonigral degeneration and Parkinson disease J Comput Assist Tomogr 2002 26 2 266 271 11884785

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Authors
Heim, B., Krismer, F., De Marzi, R., & Seppi, K.
Affiliations
Innsbruck Medical University (AT)
Corresponding author
  • Krismer, Florian
  • Seppi, Klaus
ORCID
Venue
Journal of Neural Transmission
Publisher
Springer Science and Business Media LLC
Published
2017-04-04
Volume
124
Issue
8
Pages
915-964
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
DOI
10.1007/s00702-017-1717-8
PMC
PMC5514207
OpenAlex
W2604383919
Cited by
272
References
4
Citations by year
2026: 26 · 2025: 28 · 2024: 32 · 2023: 44 · 2022: 36 · 2021: 30 · 2020: 27 · 2019: 24 · 2018: 21 · 2017: 4
FWCI
2.76
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neural Transmission (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Medizinische Universität Innsbruck
  • Universität Innsbruck
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
Parkinson's disease, magnetic resonance imaging, differential diagnosis, parkinsonism, neurodegenerative parkinsonism, atypical parkinsonism, prodromal Parkinson's disease, early diagnosis, ultra-high field MRI, image analysis algorithms
MeSH terms
Brain, Humans, Magnetic Resonance Imaging, Parkinson Disease

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