Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson’s disease

Sundaram, Saranya; Hughes, Rachel L.; Peterson, Eric; Müller-Oehring, Eva M.; Brontë-Stewart, Helen M.; Poston, Kathleen L.; Faerman, Afik; Bhowmick, Chloe; Schulte, Tilman

doi:10.1016/j.neubiorev.2019.05.016

Cited by 152Cerebrospinal fluid and hydrocephalusParkinson's Disease Mechanisms and TreatmentsSleep and Wakefulness Research

Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson’s disease

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Sundaram, Saranya, Hughes, Rachel L., Peterson, Eric, Müller-Oehring, Eva M., Brontë-Stewart, Helen M., Poston, Kathleen L., Faerman, Afik, Bhowmick, Chloe +1 more·2019·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2019.05.016PMC PMC6692229

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Abstract

Recent evidence has advanced our understanding of the function of sleep to include removal of neurotoxic protein aggregates via the glymphatic system. However, most research on the glymphatic system utilizes animal models, and the function of waste clearance processes in humans remains unclear. Understanding glymphatic function offers new insight into the development of neurodegenerative diseases that result from toxic protein inclusions, particularly those characterized by neuropathological sleep dysfunction, like Parkinson's disease (PD). In PD, we propose that glymphatic flow may be compromised due to the combined neurotoxic effects of alpha-synuclein protein aggregates and deteriorated dopaminergic neurons that are linked to altered REM sleep, circadian rhythms, and clock gene dysfunction. This review highlights the importance of understanding the functional role of glymphatic system disturbance in neurodegenerative disorders and the subsequent clinical and neuropathological effects on disease progression. Future research initiatives utilizing noninvasive brain imaging methods in human subjects with PD are warranted, as in vivo identification of functional biomarkers in glymphatic system functioning may improve clinical diagnosis and treatment of PD.

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The suppressive effects of age and amyloid-β overexpression on glymphatic flow extend to other rodent neurodegeneration models; traumatic brain injury and Parkinson's disease are linked to sustained reduction of glymphatic fluid transport.
“The suppressive effects of both age and amyloid-ß overexpression on glymphatic flow can be extended to other experimental rodent models of neurodegeneration; both traumatic brain injury and Parkinson’s disease are similarly linked to a sustained reduction of glymphatic fluid transport (56–58).”
From Glymphatic failure as a final common pathway to dementia (2020) · cites this paper as [58]

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Bush (1998) · doi:10.1002/(sici)1097-0193(1998)6:4

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Glymphatic failure as a final common pathway to dementia
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Authors: Sundaram, S., Hughes, R. L., Peterson, E., Müller-Oehring, E. M., Brontë-Stewart, H. M., Poston, K. L., Faerman, A., Bhowmick, C., & Schulte, T.
Affiliations: Palo Alto University (US)
SRI International (US)
Stanford Medicine (US)
Corresponding author: Schulte, Tilman
ORCID: Hughes, Rachel L.
Poston, Kathleen L.
Faerman, Afik
Schulte, Tilman
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2019-08
Volume: 103
Pages: 305-315
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2019.05.016
PMC: PMC6692229
OpenAlex: W2945136852
Cited by: 152
References: 175
Citations by year: 2026: 10 · 2025: 31 · 2024: 24 · 2023: 22 · 2022: 27 · 2021: 25 · 2020: 10 · 2019: 2 · 2018: 1
FWCI: 2.13
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 335 d)
Locations: Neuroscience & Biobehavioral Reviews (acceptedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism
National Institute of Neurological Disorders and Stroke
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: Parkinson's disease, glymphatic system, sleep, alpha-synuclein aggregates, REM sleep, circadian rhythm, clock genes, dopaminergic neurons, neurodegeneration, waste clearance, biomarkers
MeSH terms: Glymphatic System, Humans, Parkinson Disease, Sleep Wake Disorders, alpha-Synuclein, CLOCK Proteins

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Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson’s disease

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