Exercise-induced oxidative stress: the effects of β-alanine supplementation in women
Abstract
The purpose of this study was to evaluate the effects of β-alanine supplementation on markers of oxidative stress. Twenty-four women (age: 21.7±2.1 years; VO2max: 2.6±0.3 l min(-1)) were randomly assigned, in a double-blind fashion, to a β-alanine (BA, 2×800 mg tablets, 3× daily; CarnoSyn®; n=13) or placebo (PL, 2×800 mg maltodextrin tablets, 3× daily; n=11) group. A graded oxygen consumption test (VO2max) was performed to evaluate VO2max, time to exhaustion, ventilatory threshold and establish peak velocity (PV). A 40-min treadmill run was used to induce oxidative stress. Total antioxidant capacity, superoxide dismutase, 8-isoprostane (8ISO) and reduced glutathione were measured. Heart rate and ratings of perceived exertion were recorded during the 40 min run. Separate three- [4×2×2; acute (base vs. IP vs. 2 vs. 4 h)×chronic (pre- vs. post-)×treatment (BA vs. PL)] and two- [2×2; time (pre-supplement vs. post-supplement)×treatment (BA vs. PL)] way ANOVAs were used for analyses. There was a significant increase in VO2max (p=0.009), independent of treatment, with no significant changes in TTE (p=0.074) or VT (p=0.344). Ratings of perceived exertion values were significantly improved from pre- to post-supplementation for the BA group only at 40 min (p=0.02). The ANOVA model demonstrated no significant treatment effects on oxidative stress. The chronic effects of BA supplementation demonstrated little antioxidant potential, in women, and little influence on aerobic performance assessments.
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Beta alanine (BA) has potential erogenicity by delaying the onset of both anaerobic and aerobic fatigue allowing for longer and/or more intense training sessions, which increases the potential for greater physiological adaptations and subsequent performance.
“The evidence for beta alanine (BA) determined potential erogenicity by delaying the onset of both anaerobic and aerobic fatigue allowing for longer and/or more intense training sessions, which increases the potential for greater physiological adaptations and subsequent performance [285,286].”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [285]
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International society of sports nutrition position stand: Beta-Alanine
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International society of sports nutrition position stand: nutritional concerns of the female athlete
Sims, S. T., Kerksick, C. M., Smith-Ryan, A. E., Janse de Jonge, X. A. K., Hirsch, K. R., Arent, S. M., Hewlings, S. J., Kleiner, S. M., Bustillo, E., Tartar, J. L., et al. (2023) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2023.2204066 · Cited by 91 · see citing works
“delaying the onset of both anaerobic and aerobic fatigue allowing for longer and/or more intense training sessions, which increases the potential for greater physiological adaptations and subsequent performance [285,286].”
BackgroundSelf-citationEffects of Acute Beta-Alanine Supplementation on Anaerobic Performance in Trained Female Cyclists
GLENN, J. M., SMITH, K., MOYEN, N. E., BINNS, A., & GRAY, M. (2015) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.61.161 · Cited by 41 · see citing works
- Authors
- Smith, A. E., Stout, J. R., Kendall, K. L., Fukuda, D. H., & Cramer, J. T.
- Affiliations
- University of Oklahoma (US)
- Oklahoma State University (US)
- Venue
- Amino Acids
- Published
- 2011-11-20
- Volume
- 43
- Issue
- 1
- Pages
- 77-90
- ISSN
- 0939-4451 (ISSN-L)
- 1438-2199
- OpenAlex
- W1967101801
- Cited by
- 62
- References
- 75
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 2 · 2018: 5 · 2016: 3 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 3
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Amino Acids (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Biochemical effects in animals
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- beta-alanine supplementation, exercise-induced oxidative stress, women, cardiorespiratory fitness, VO2max, time to exhaustion, ventilatory threshold, peak velocity, antioxidant capacity, superoxide dismutase, 8-isoprostane, reduced glutathione, treadmill running, perceived exertion, chronic supplementation
- MeSH terms
- Carnosine, Double-Blind Method, Exercise Test, Female, Glutathione, Heart Rate, Humans, Oxygen Consumption, Physical Endurance, Running, Superoxide Dismutase, beta-Alanine, Dinoprost, Reactive Oxygen Species, Oxidative Stress, Dietary Supplements, Young Adult
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