The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Effects of β-alanine supplementation on exercise performance: a meta-analysis
Open accessAbstract
Due to the well-defined role of β-alanine as a substrate of carnosine (a major contributor to H+ buffering during high-intensity exercise), β-alanine is fast becoming a popular ergogenic aid to sports performance. There have been several recent qualitative review articles published on the topic, and here we present a preliminary quantitative review of the literature through a meta-analysis. A comprehensive search of the literature was employed to identify all studies suitable for inclusion in the analysis; strict exclusion criteria were also applied. Fifteen published manuscripts were included in the analysis, which reported the results of 57 measures within 23 exercise tests, using 18 supplementation regimes and a total of 360 participants [174, β-alanine supplementation group (BA) and 186, placebo supplementation group (Pla)]. BA improved (P=0.002) the outcome of exercise measures to a greater extent than Pla [median effect size (IQR): BA 0.374 (0.140-0.747), Pla 0.108 (-0.019 to 0.487)]. Some of that effect might be explained by the improvement (P=0.013) in exercise capacity with BA compared to Pla; no improvement was seen for exercise performance (P=0.204). In line with the purported mechanisms for an ergogenic effect of β-alanine supplementation, exercise lasting 60-240 s was improved (P=0.001) in BA compared to Pla, as was exercise of >240 s (P=0.046). In contrast, there was no benefit of β-alanine on exercise lasting <60 s (P=0.312). The median effect of β-alanine supplementation is a 2.85% (-0.37 to 10.49%) improvement in the outcome of an exercise measure, when a median total of 179 g of β-alanine is supplemented.
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Cites
Distribution Theory for Glass's Estimator of Effect Size and Related Estimators
Hedges, L. V. (1981) · Journal of Educational Statistics · doi:10.2307/1164588 · Cited by 5,695
Harris, R. C., Tallon, M. J., Dunnett, M., Boobis, L., Coakley, J., Kim, H. J., Fallowfield, J. L., Hill, C. A., Sale, C., & Wise, J. A. (2006) · Amino Acids · doi:10.1007/s00726-006-0299-9 · Cited by 534
Self-citationHill, C. A., Harris, R. C., Kim, H. J., Harris, B. D., Sale, C., Boobis, L. H., Kim, C. K., & Wise, J. A. (2007) · Amino Acids · doi:10.1007/s00726-006-0364-4 · Cited by 445
Self-citation(2004) · International Journal of Sports Medicine · doi:10.1055/s-2004-819955 · Cited by 344
Derave, W., Özdemir, M. S., Harris, R. C., Pottier, A., Reyngoudt, H., Koppo, K., Wise, J. A., & Achten, E. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00397.2007 · Cited by 324
Self-citationAcid-base balance after maximal exercise of short duration
Osnes, J. B., & Hermansen, L. (1972) · Journal of Applied Physiology · doi:10.1152/jappl.1972.32.1.59 · Cited by 204
Important role of muscle carnosine in rowing performance
Baguet, A., Bourgois, J., Vanhee, L., Achten, E., & Derave, W. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00141.2010 · Cited by 182
Hoffman, J., Ratamess, N., Kang, J., Mangine, G., Faigenbaum, A., & Stout, J. (2006) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.16.4.430 · Cited by 151
Hoffman, J. R., Ratamess, N. A., Faigenbaum, A. D., Ross, R., Kang, J., Stout, J. R., & Wise, J. A. (2008) · Nutrition Research · doi:10.1016/j.nutres.2007.11.004 · Cited by 135
Smith, A. E., Walter, A. A., Graef, J. L., Kendall, K. L., Moon, J. R., Lockwood, C. M., Fukuda, D. H., Beck, T. W., Cramer, J. T., & Stout, J. R. (2009) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-6-5 · Cited by 123
Cited by
IOC Consensus Statement: Dietary Supplements and the High-performance Athlete
Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., et al. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2018-099027 · Cited by 1,004
IOC Consensus Statement: Dietary Supplements and the High-Performance Athlete
Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., et al. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0020 · Cited by 540
International society of sports nutrition position stand: Beta-Alanine
Trexler, E. T., Smith-Ryan, A. E., Stout, J. R., Hoffman, J. R., Wilborn, C. D., Sale, C., Kreider, R. B., Jäger, R., Earnest, C. P., Bannock, L., et al. (2015) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-015-0090-y · Cited by 315
Self-citationSaunders, B., Elliott-Sale, K., Artioli, G. G., Swinton, P. A., Dolan, E., Roschel, H., Sale, C., & Gualano, B. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-096396 · Cited by 302
Self-citationChen, Y.-M., Wei, L., Chiu, Y.-S., Hsu, Y.-J., Tsai, T.-Y., Wang, M.-F., & Huang, C.-C. (2016) · Nutrients · doi:10.3390/nu8040205 · Cited by 297
Metadata
- Authors
- Hobson, R. M., Saunders, B., Ball, G., Harris, R. C., & Sale, C.
- Venue
- Amino Acids
- Published
- 2012-01-24
- Volume
- 43
- Issue
- 1
- Pages
- 25-37
- ISSN
- 0939-4451 (ISSN-L)
- 1438-2199
- OpenAlex
- W2113762370
- Cited by
- 303
- References
- 12
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
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