Important role of muscle carnosine in rowing performance
Abstract
The role of the presence of carnosine (β-alanyl-L-histidine) in millimolar concentrations in human skeletal muscle is poorly understood. Chronic oral β-alanine supplementation is shown to elevate muscle carnosine content and improve anaerobic exercise performance during some laboratory tests, mainly in the untrained. It remains to be determined whether carnosine loading can improve single competition-like events in elite athletes. The aims of the present study were to investigate if performance is related to the muscle carnosine content and if β-alanine supplementation improves performance in highly trained rowers. Eighteen Belgian elite rowers were supplemented for 7 wk with either placebo or β-alanine (5 g/day). Before and following supplementation, muscle carnosine content in soleus and gastrocnemius medialis was measured by proton magnetic resonance spectroscopy ((1)H-MRS) and the performance was evaluated in a 2,000-m ergometer test. At baseline, there was a strong positive correlation between 100-, 500-, 2,000-, and 6,000-m speed and muscle carnosine content. After β-alanine supplementation, the carnosine content increased by 45.3% in soleus and 28.2% in gastrocnemius. Following supplementation, the β-alanine group was 4.3 s faster than the placebo group, whereas before supplementation they were 0.3 s slower (P = 0.07). Muscle carnosine elevation was positively correlated to 2,000-m performance enhancement (P = 0.042 and r = 0.498). It can be concluded that the positive correlation between baseline muscle carnosine levels and rowing performance and the positive correlation between changes in muscle carnosine and performance improvement suggest that muscle carnosine is a new determinant of rowing performance.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Many studies have observed mixed results on whether β-alanine supplementation can improve exercise performance, with the greatest effects in exercise lasting 1 to 4 min.
“Many studies have since investigated whether β-alanine supplementation can improve exercise performance and have observed mixed results [[212], [213], [214], [215]], with the greatest effects in exercise lasting 1 to 4 min [216].”
From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [214]
Cites
Physiology of Sport and Exercise
Wilmore, J. H., COSTILL, D. L., & Gleim, G. W. (1995) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199505000-00024 · Cited by 2,240 · see citing works
Diet, muscle glycogen and physical performance.
Bergström, J., Hermansen, L., Hultman, E., & Saltin, B. (1967) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1967.tb03720.x · Cited by 1,740 · cited 1× · see citing works
“However, glycogen is a rapidly fluctuating substrate as it is a fuel that declines with exercise and increases with carbohydrate ingestion (6).”
BackgroundElevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation
Harris, R. C., Söderlund, K., & Hultman, E. (1992) · Clinical Science · doi:10.1042/cs0830367 · Cited by 1,141 · cited 1× · see citing works
“Moreover, the present study found a positive correlation between the baseline muscle carnosine content and the increase in muscle carnosine after supplementation, whereas following creatine supplementation Harris and colleagues (20) found a negative correlation between baseline muscle creatine and the increase in musc…”
ResultAntioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain.
Kohen, R., Yamamoto, Y., Cundy, K. C., & Ames, B. N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.9.3175 · Cited by 794 · see citing works
Harris, R. C., Tallon, M. J., Dunnett, M., Boobis, L., Coakley, J., Kim, H. J., Fallowfield, J. L., Hill, C. A., Sale, C., & Wise, J. A. (2006) · Amino Acids · doi:10.1007/s00726-006-0299-9 · Cited by 534 · see citing works
Hill, C. A., Harris, R. C., Kim, H. J., Harris, B. D., Sale, C., Boobis, L. H., Kim, C. K., & Wise, J. A. (2007) · Amino Acids · doi:10.1007/s00726-006-0364-4 · Cited by 445 · see citing works
Derave, W., Özdemir, M. S., Harris, R. C., Pottier, A., Reyngoudt, H., Koppo, K., Wise, J. A., & Achten, E. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00397.2007 · Cited by 324 · see citing works
Self-citationMuscle Carnosine Metabolism and β-Alanine Supplementation in Relation to Exercise and Training
Derave, W., Everaert, I., Beeckman, S., & Baguet, A. (2010) · Sports Medicine · doi:10.2165/11530310-000000000-00000 · Cited by 245 · see citing works
Self-citationEffect of beta-alanine supplementation on muscle carnosine concentrations and exercise performance
Sale, C., Saunders, B., & Harris, R. C. (2009) · Amino Acids · doi:10.1007/s00726-009-0443-4 · Cited by 240 · see citing works
Enhancement of 2000-m rowing performance after caffeine ingestion.
Bruce, C., Anderson, M. E., Fraser, S., Stepto, N., Klein, R., Hopkins, W., & Hawley, J. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200011000-00021 · Cited by 232 · see citing works
Hipkiss, A. R., Michaelis, J., & Syrris, P. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00849-5 · Cited by 222 · see citing works
Physiological and Biomechanical Aspects of Rowing
Secher, N. H. (1993) · Sports Medicine · doi:10.2165/00007256-199315010-00004 · Cited by 220 · see citing works
Hagerman, F. C. (1984) · Sports Medicine · doi:10.2165/00007256-198401040-00005 · Cited by 220 · see citing works
The significance of carnosine and anserine in striated skeletal muscle
Davey, C. L. (1960) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(60)90059-x · Cited by 206 · see citing works
The buffering of muscle in rigor; protein, phosphate and carnosine
Smith, E. C. B. (1938) · The Journal of Physiology · doi:10.1113/jphysiol.1938.sp003605 · Cited by 205 · see citing works
Carnosine loading and washout in human skeletal muscles
Baguet, A., Reyngoudt, H., Pottier, A., Everaert, I., Callens, S., Achten, E., & Derave, W. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91357.2008 · Cited by 192 · see citing works
Self-citationStout, J. R., Cramer, J. T., Zoeller, R. F., Torok, D. J., Costa, P. B., Hoffman, J. R., Harris, R. C., & OʼKroy, J. A. (2006) · Amino Acids · doi:10.1007/s00726-006-0474-z · Cited by 186 · see citing works
Kendrick, I. P., Harris, R. C., Kim, H. J., Kim, C. K., Dang, V. H., Lam, T. Q., Bui, T. T., Smith, M., & Wise, J. A. (2008) · Amino Acids · doi:10.1007/s00726-007-0008-3 · Cited by 163 · see citing works
Muscle buffering capacity and dipeptide content in the Thoroughbred horse, Greyhound dog and man
Harris, R. C., Marlin, D., Dunnett, M., Snow, D. H., & Hultman, E. (1990) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(90)90180-z · Cited by 157 · see citing works
Beta-alanine improves sprint performance in endurance cycling.
van Thienen, R., van Proeyen, K., Eynde, B. V., Puype, J., Lefere, T., & Hespel, P. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31818db708 · Cited by 138 · see citing works
Anthropometric characteristics of elite male junior rowers
Bourgois, J., Claessens, A., Vrijens, J., Philippaerts, R. M., Renterghem, B. V., Thomis, M. A., Janssens, M., Loos, R. J. F., & Lefevre, J. (2000) · British Journal of Sports Medicine · doi:10.1136/bjsm.34.3.213 · Cited by 134 · see citing works
Self-citationBaguet, A., Koppo, K., Pottier, A., & Derave, W. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1225-0 · Cited by 123 · see citing works
Self-citationPoint:Counterpoint: Lactic acid accumulation is an advantage/disadvantage during muscle activity
Lamb, G. D., & Stephenson, D. G. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00023.2006 · Cited by 122 · see citing works
Kendrick, I. P., Kim, H. J., Harris, R. C., Kim, C. K., Dang, V. H., Lam, T. Q., Bui, T. T., & Wise, J. A. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-0998-5 · Cited by 112 · see citing works
Effect of Carnosine on Excitation–Contraction Coupling in Mechanically-Skinned Rat Skeletal Muscle
Dutka, T. L., & Lamb, G. (2004) · Journal of Muscle Research and Cell Motility · doi:10.1023/b:jure.0000038265.37022.c5 · Cited by 111 · see citing works
Antioxidative properties of histidine-containing dipeptides from skeletal muscles of vertebrates.
Boldyrev, A., Dupin, A., Pindel, E., & Severin, S. (1988) · Comparative biochemistry and physiology. B, Comparative biochemistry · doi:10.1016/0305-0491(88)90218-0 · Cited by 106 · see citing works
The effect of oral creatine supplementation on the 1000‐m performance of competitive rowers
Rossiter, H. B., Cannell, E. R., & Jakeman, P. M. (1996) · Journal of Sports Sciences · doi:10.1080/02640419608727699 · Cited by 96 · see citing works
Carnosine as a potential anti-senescence drug.
Gallant, S., SEMYONOVA, M. L., & Yuneva, M. O. (2000) · PubMed · Cited by 82 · see citing works
Vasodilatory actions of the dietary peptide carnosine
Ririe, D. G., Roberts, P. R., Shouse, M. N., & Zaloga, G. P. (2000) · Nutrition · doi:10.1016/s0899-9007(99)00268-3 · Cited by 81 · see citing works
Lamont, C., & Miller, D. J. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019271 · Cited by 80 · see citing works
Action of carnosine and beta-alanine on wound healing.
Nagai, K., Suda, T., Kawasaki, K., & Mathuura, S. (1986) · PubMed · Cited by 80 · see citing works
Batrukova, M. A., & Rubtsov, A. M. (1997) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(96)00216-7 · Cited by 76 · see citing works
The Effect of β-Alanine Supplementation on Power Performance During Repeated Sprint Activity
Sweeney, K., WRIGHT, G. A., Brice, A. G., & Doberstein, S. T. (2010) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181c63bd5 · Cited by 73 · see citing works
Carnosine and Anserine Ingestion Enhances Contribution of Nonbicarbonate Buffering
Suzuki, Y., NAKAO, T., Maemura, H., Sato, M., Kamahara, K., Morimatsu, F., & Takamatsu, K. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000185108.63028.04 · Cited by 63 · see citing works
Carnosine and Oxidative Stress in Cells and Tissues
Болдырев, А. А. (2006) · Medical Entomology and Zoology · Cited by 53 · see citing works
Anthropometric and physiological profiles of rowers of varying ages and ranks
Mikulić, P. (2008) · University of Zagreb University Computing Centre (SRCE) · Cited by 52 · see citing works
Rowing, the ultimate challenge to the human body – implications for physiological variables
Volianitis, S., & Secher, N. H. (2009) · Clinical Physiology and Functional Imaging · doi:10.1111/j.1475-097x.2009.00867.x · Cited by 50 · see citing works
Morphological muscle characteristics in rowers.
Larsson, L., & Forsberg, A. (1980) · PubMed · Cited by 45 · see citing works
Day, A. (1985) · International Journal of Bank Marketing · doi:10.1108/eb010768 · Cited by 43 · see citing works
Seasonal variables among physiological variables in elite oarsmen.
Fc, H., & Staron, R. S. (1983) · PubMed · Cited by 40 · see citing works
In vivo 1D and 2D correlation MR spectroscopy of the soleus muscle at 7T
Ramadan, S. A., Ratai, E., Wald, L. L., & Mountford, C. E. (2010) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2010.02.008 · Cited by 38 · see citing works
Rubtsov, A. M. (2001) · Biochemistry (Moscow) · doi:10.1023/a:1012485030527 · Cited by 32 · see citing works
Mader, A., Hartmann, U., & Hollmann, W. (1988) · Springer eBooks · doi:10.1007/978-3-642-93375-2_10 · Cited by 10 · see citing works
Effects of Aging on the Renal Function after Physical Exercise
Suzuki, M., Imanishi, A., Otsuka, J., Shindou, D., Kimura, M., Shibasaki, T., & Tabata, I. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-200605001-01277 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Physiology and Pathophysiology of Carnosine
Болдырев, А. А., Aldini, G., & Derave, W. (2013) · Physiological Reviews · doi:10.1152/physrev.00039.2012 · Cited by 1,123 · see citing works
Self-citationIOC Consensus Statement: Dietary Supplements and the High-performance Athlete
Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., et al. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2018-099027 · Cited by 1,004 · see citing works
IOC Consensus Statement: Dietary Supplements and the High-Performance Athlete
Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., et al. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0020 · Cited by 540 · see citing works
Wu, G. (2020) · Amino Acids · doi:10.1007/s00726-020-02823-6 · Cited by 478 · see citing works
International society of sports nutrition position stand: Beta-Alanine
Trexler, E. T., Smith-Ryan, A. E., Stout, J. R., Hoffman, J. R., Wilborn, C. D., Sale, C., Kreider, R. B., Jäger, R., Earnest, C. P., Bannock, L., et al. (2015) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-015-0090-y · Cited by 315 · see citing works
Effects of β-alanine supplementation on exercise performance: a meta-analysis
Hobson, R. M., Saunders, B., Ball, G., Harris, R. C., & Sale, C. (2012) · Amino Acids · doi:10.1007/s00726-011-1200-z · Cited by 305 · see citing works
Saunders, B., Elliott-Sale, K., Artioli, G. G., Swinton, P. A., Dolan, E., Roschel, H., Sale, C., & Gualano, B. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-096396 · Cited by 302 · see citing works
Evidence-based supplements for the enhancement of athletic performance
Peeling, P., Binnie, M. J., Goods, P. S. R., Sim, M., & Burke, L. M. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2017-0343 · Cited by 225 · see citing works
31P magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations
Meyerspeer, M., Boesch, C., Cameron, D., Dezortová, M., Forbes, S. C., Heerschap, A., Jeneson, J. A. L., Kan, H. E., Kent, J. A., Layec, G., et al. (2020) · NMR in Biomedicine · doi:10.1002/nbm.4246 · Cited by 177 · see citing works
Lancha Junior, A. H., de Salles Painelli, V., Saunders, B., & Artioli, G. G. (2015) · Sports Medicine · doi:10.1007/s40279-015-0397-5 · Cited by 167 · see citing works
“Indeed, there is now a growing body of evidence to support the effective use of beta-alanine among the elite athletic populations; athletes involved in 100- and 200-m freestyle swimming [67], 2000-m rowing [68–70] and 800-m running [55].”
BackgroundCarnosine: from exercise performance to health
Sale, C., Artioli, G. G., Gualano, B., Saunders, B., Hobson, R. M., & Harris, R. C. (2013) · Amino Acids · doi:10.1007/s00726-013-1476-2 · Cited by 142 · see citing works
Favero, S. D., Roschel, H., Solis, M., Hayashi, A. P., Artioli, G., Otaduy, M., Benatti, F., Harris, R., Wise, J., Leite, C., et al. (2011) · Amino Acids · doi:10.1007/s00726-011-1190-x · Cited by 42 · see citing works
Use of Carnosine for Oxidative Stress Reduction in Different Pathologies
Prokopieva, V. D., Yarygina, E. G., Bokhan, N. A., & Ivanova, S. А. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2939087 · Cited by 129 · see citing works
Additive effects of beta-alanine and sodium bicarbonate on upper-body intermittent performance
Tobias, G., Benatti, F. B., de Salles Painelli, V., Roschel, H., Gualano, B., Sale, C., Harris, R. C., Lancha, A. H., & Artioli, G. G. (2013) · Amino Acids · doi:10.1007/s00726-013-1495-z · Cited by 129 · see citing works
Dutka, T. L., Lamboley, C., McKenna, M. J., Murphy, R. M., & Lamb, G. D. (2012) · Journal of applied physiology · doi:10.1152/japplphysiol.01331.2011 · Cited by 123 · see citing works
Effect of two β-alanine dosing protocols on muscle carnosine synthesis and washout
Stellingwerff, T., Anwander, H., Egger, A., Buehler, T., Kreis, R., Décombaz, J., & Boesch, C. (2011) · Amino Acids · doi:10.1007/s00726-011-1054-4 · Cited by 125 · see citing works
A New Method for Non-Invasive Estimation of Human Muscle Fiber Type Composition
Baguet, A., Everaert, I., Hespel, P., Petrović, M., Achten, E., & Derave, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021956 · Cited by 117 · see citing works
Self-citationPeeling, P., Castell, L. M., Derave, W., de Hon, O., & Burke, L. M. (2019) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0271 · Cited by 116 · see citing works
Self-citationEffect of slow-release β-alanine tablets on absorption kinetics and paresthesia
Décombaz, J., Beaumont, M., Vuichoud, J., Bouisset, F., & Stellingwerff, T. (2012) · Amino Acids · doi:10.1007/s00726-011-1169-7 · Cited by 122 · see citing works
Kong, G., Ellul, S., Narayana, V. K., Kanojia, K., Tran, H., Li, S., Renoir, T., Cao, K. L., & Hannan, A. J. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105199 · Cited by 110 · see citing works
Beta-alanine supplementation, muscle carnosine and exercise performance
Blancquaert, L., Everaert, I., & Derave, W. (2015) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000127 · Cited by 106 · see citing works
Self-citationDeterminants of muscle carnosine content
Harris, R. C., Wise, J. A., Price, K. A., Kim, H. J., Kim, C. K., & Sale, C. (2012) · Amino Acids · doi:10.1007/s00726-012-1233-y · Cited by 101 · see citing works
Proton magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations
Krššák, M., Lindeboom, L., Schrauwen‐Hinderling, V. B., Szczepaniak, L. S., Derave, W., Lundbom, J., Befroy, D. E., Schick, F., Machann, J., Kreis, R., et al. (2020) · NMR in Biomedicine · doi:10.1002/nbm.4266 · Cited by 86 · see citing works
Self-citationOptimizing human in vivo dosing and delivery of β-alanine supplements for muscle carnosine synthesis
Stellingwerff, T., Decombaz, J., Harris, R. C., & Boesch, C. (2012) · Amino Acids · doi:10.1007/s00726-012-1245-7 · Cited by 85 · see citing works
Krebs cycle: activators, inhibitors and their roles in the modulation of carcinogenesis
Gasmi, A., Peana, M., Arshad, M., Butnariu, M., Menzel, A., & Bjørklund, G. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-02974-9 · Cited by 82 · see citing works
Baguet, A., Everaert, I., Naeyer, H. D., Reyngoudt, H., Stegen, S., Beeckman, S., Achten, E., Vanhee, L., Volkaert, A., Petrović, M., et al. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1877-4 · Cited by 80 · see citing works
Self-citationPainelli, V. D. S., Roschel, H., de Jesus, F. D., Sale, C., Harris, R., Solis, M., Benatti, F., Gualano, B., Lancha, A., & Artioli, G. (2013) · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · doi:10.1139/apnm-2012-0286 · Cited by 78 · see citing works
Bex, T., Chung, W., Baguet, A., Stegen, S., Stautemas, J., Achten, E., & Derave, W. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01033.2013 · Cited by 77 · see citing works
Self-citationEffect of Combined β-Alanine and SodiumBicarbonate Supplementation on Cycling Performance
Bellinger, P., Howe, S., Shing, C. M., & Fell, J. W. (2012) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31824cc08d · Cited by 74 · see citing works
Effect of Beta-Alanine and Carnosine Supplementation on Muscle Contractility in Mice
Everaert, I., Stegen, S., Vanheel, B., Taes, Y., & Derave, W. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31826cdb68 · Cited by 73 · see citing works
Self-citationWang, Z., Qiu, B., Gao, J., & Del Coso, J. (2022) · Nutrients · doi:10.3390/nu15010148 · Cited by 72 · see citing works
Blancquaert, L., Baguet, A., Bex, T., Volkaert, A., Everaert, I., Delanghe, J., Petrović, M., Vervaet, C., Henauw, S. D., Constantin‐Teodosiu, D., et al. (2018) · British Journal Of Nutrition · doi:10.1017/s000711451800017x · Cited by 70 · see citing works
Self-citationEffects of β-Alanine Supplementation on Carnosine Elevation and Physiological Performance
Hoffman, J. R., Varanoske, A. N., & Stout, J. R. (2018) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2017.12.003 · Cited by 69 · see citing works
The Effects of Beta-Alanine Supplementation on Performance: A Systematic Review of the Literature
Quesnele, J. J., Laframboise, M. A., Wong, J. J., Kim, P., & Wells, G. D. (2014) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2013-0007 · Cited by 79 · see citing works
Ergogenic Effects of β-Alanine and Carnosine: Proposed Future Research to Quantify Their Efficacy
Caruso, J. F., Charles, J., Unruh, K., Giebel, R. M., Learmonth, L., & Potter, W. T. (2012) · Nutrients · doi:10.3390/nu4070585 · Cited by 64 · see citing works
Can the Skeletal Muscle Carnosine Response to Beta-Alanine Supplementation Be Optimized?
Perim, P., Marticorena, F., Ribeiro, F., Barreto, G., Gobbi, N., Kerksick, C., Dolan, E., & Saunders, B. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00135 · Cited by 54 · see citing works
Meal and Beta-Alanine Coingestion Enhances Muscle Carnosine Loading
Stegen, S., Blancquaert, L., Everaert, I., Bex, T., Taes, Y., Calders, P., Achten, E., & Derave, W. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31828ab073 · Cited by 61 · see citing works
Self-citationβ-Alanine Supplementation for Athletic Performance
Bellinger, P. (2013) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000000327 · Cited by 61 · see citing works
Effect of Beta Alanine and Sodium Bicarbonate Supplementation on Repeated-Sprint Performance
Ducker, K., Dawson, B., & Wallman, K. (2013) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31828fd310 · Cited by 59 · see citing works
Kresta, J. Y., Oliver, J. M., Jagim, A. R., Fluckey, J. D., Riechman, S. E., Kelly, K. A., Meininger, C. J., Mertens‐Talcott, S. U., Rasmussen, C. J., & Kreider, R. B. (2014) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-014-0055-6 · Cited by 55 · see citing works
The influence of sex, age and heritability on human skeletal muscle carnosine content
Baguet, A., Everaert, I., Achten, E., Thomis, M. A., & Derave, W. (2011) · Amino Acids · doi:10.1007/s00726-011-1197-3 · Cited by 53 · see citing works
Self-citationMcCormack, W. P., Stout, J. R., Emerson, N. S., Scanlon, T. C., Warren, A. M., Wells, A. J., Gonzalez, A. M., Mangine, G. T., Robinson, E. H., Fragala, M. S., et al. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.06.003 · Cited by 53 · see citing works
β-Alanine Dose for Maintaining Moderately Elevated Muscle Carnosine Levels
STEGEN, S., BEX, T., VERVAET, C., VANHEE, L., ACHTEN, E., & DERAVE, W. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000248 · Cited by 51 · see citing works
Self-citationComparison of Two β-Alanine Dosing Protocols on Muscle Carnosine Elevations
Church, D. D., Hoffman, J. R., Varanoske, A. N., Wang, R., Baker, K. M., La Monica, M. B., Beyer, K. S., Dodd, S. J., Oliveira, L. P., Harris, R. C., et al. (2017) · Journal of the American College of Nutrition · doi:10.1080/07315724.2017.1335250 · Cited by 48 · see citing works
Chung, W., Shaw, G., Anderson, M. E., Pyne, D., Saunders, P., Bishop, D., & Burke, L. (2012) · Nutrients · doi:10.3390/nu4101441 · Cited by 46 · see citing works
β-Alanine ingestion increases muscle carnosine content and combat specific performance in soldiers
Hoffman, J. R., Landau, G., Stout, J. R., Hoffman, M. W., Shavit, N., Rosen, P., Moran, D. S., Fukuda, D. H., Shelef, I., Carmom, E., et al. (2014) · Amino Acids · doi:10.1007/s00726-014-1896-7 · Cited by 48 · see citing works
Painelli, V. D. S., Saunders, B., Sale, C., Harris, R. C., Solis, M. Y., Roschel, H., Gualano, B., Artioli, G. G., & Lancha, A. H. (2014) · Amino Acids · doi:10.1007/s00726-014-1678-2 · Cited by 47 · see citing works
Gross, M., Boesch, C., Bolliger, C. S., Norman, B., Gustafsson, T. P., Hoppeler, H. H., & Vogt, M. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-013-2767-8 · Cited by 47 · see citing works
Chung, W., Baguet, A., Bex, T., Bishop, D., & Derave, W. (2014) · International Journal of Sport Nutrition & Exercise Metabolism · doi:10.1123/ijsnem.2013-0125 · Cited by 41 · see citing works
Self-citationNutritional Considerations for the Vegan Athlete
West, S., Monteyne, A. J., van der Heijden, I., Stephens, F. B., & Wall, B. T. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.04.012 · Cited by 42 · see citing works
Effect of beta-alanine supplementation on 2000-m rowing-ergometer performance.
Ducker, K., Dawson, B., & Wallman, K. (2013) · International Journal of Sport Nutrition & Exercise Metabolism · doi:10.1123/ijsnem.23.4.336 · Cited by 40 · see citing works
Nutritional Strategies to Optimize Performance and Recovery in Rowing Athletes
Kim, J., & Kim, E.-K. (2020) · Nutrients · doi:10.3390/nu12061685 · Cited by 47 · see citing works
Varanoske, A. N., Hoffman, J. R., Church, D. D., Coker, N. A., Baker, K. M., Dodd, S. J., Oliveira, L. P., Dawson, V. L., Wang, R., Fukuda, D. H., et al. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.10.002 · Cited by 41 · see citing works
Qiu, J., Hauske, S. J., Zhang, S., Rodriguez-Niño, A., Albrecht, T., Pastene, D. O., van den Born, J., van Goor, H., Ruf, S. G., Kohlmann, M., et al. (2018) · Amino Acids · doi:10.1007/s00726-018-2601-z · Cited by 41 · see citing works
Lactic acidosis: implications for human exercise performance
Cairns, S. P., & Lindinger, M. I. (2025) · European Journal of Applied Physiology · doi:10.1007/s00421-025-05750-0 · Cited by 40 · see citing works
Rezende, N. S., Swinton, P. A., de Oliveira, L. F., da Silva, R. P., Silva, V. D. E., Nemezio, K., Yamaguchi, G. D. C., Artioli, G. G., Gualano, B., Saunders, B., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00913 · Cited by 40 · see citing works
Ojeda, Á. H., Cerda, C. T., Salvatierra, M. F. P., Barahona-Fuentes, G. D. F., & Aguilera, C. J. (2020) · Nutrients · doi:10.3390/nu12092490 · Cited by 40 · see citing works
Beta-Alanine Supplementation in High-Intensity Exercise
Harris, R. C., & Sale, C. (2012) · Medicine and sport science/Medicine and sport · doi:10.1159/000342372 · Cited by 38 · see citing works
Howe, S. T., Bellinger, P., Driller, M., Shing, C., & Fell, J. (2013) · International Journal of Sport Nutrition & Exercise Metabolism · doi:10.1123/ijsnem.23.6.562 · Cited by 37 · see citing works
Effect of Beta-Alanine Supplementation on 800-m Running Performance
Ducker, K. J., DAWSON, B. T., & Wallman, K. E. (2013) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.23.6.554 · Cited by 37 · see citing works
Influence of intermittent hypoxic training on muscle energetics and exercise tolerance
Holliss, B. A., Fulford, J., Vanhatalo, A., Pedlar, C. R., & JONES, A. M. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01331.2012 · Cited by 37 · see citing works
Zanella, P. B., Alves, F. D., & de Souza, C. G. (2017) · The Journal of Sports Medicine and Physical Fitness · doi:10.23736/s0022-4707.16.06582-8 · Cited by 35 · see citing works
The effect of β‐alanine supplementation on cycling time trials of different length
Bellinger, P., & MINAHAN, C. L. (2015) · European Journal of Sport Science · doi:10.1080/17461391.2015.1120782 · Cited by 34 · see citing works
Hoffman, J. R., Emerson, N. S., & Stout, J. R. (2012) · Current Sports Medicine Reports · doi:10.1249/jsr.0b013e3182604983 · Cited by 33 · see citing works
The Top 5 Can’t-Miss Sport Supplements
António, J., Pereira, F., Curtis, J., Rojas, J., & Evans, C. (2024) · Nutrients · doi:10.3390/nu16193247 · Cited by 37 · see citing works
Lievens, E., Vossel, K. V., de Casteele, F. V., Wezenbeek, E., Deprez, D. N., Matthys, S., Winne, B. D., McNally, S. J., Graaf, W. D., Murdoch, J. B., et al. (2021) · Sports Medicine · doi:10.1007/s40279-021-01538-2 · Cited by 32 · see citing works
Self-citationβ-Alanine supplementation and military performance
Hoffman, J. R., Stout, J. R., Harris, R. C., & Moran, D. S. (2015) · Amino Acids · doi:10.1007/s00726-015-2051-9 · Cited by 31 · see citing works
Varanoske, A., Hoffman, J., Church, D., Wang, R., Baker, K., Dodd, S., Coker, N., Oliveira, L., Dawson, V., Fukuda, D., et al. (2017) · Nutrients · doi:10.3390/nu9090988 · Cited by 30 · see citing works
Ostfeld, I., Ben‐Zeev, T., Zamir, A., Levi, C., Gepner, Y., Springer, S., & Hoffman, J. R. (2023) · Nutrients · doi:10.3390/nu15040923 · Cited by 30 · see citing works
Cyclic movement frequency is associated with muscle typology in athletes
Bex, T., Baguet, A., Achten, E., Aerts, P., Clercq, D. D., & Derave, W. (2016) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12648 · Cited by 29 · see citing works
Self-citationCurrell, K., Derave, W., Everaert, I., McNaughton, L. R., Slater, G., Burke, L. M., Stear, S. J., & Castell, L. M. (2011) · British Journal of Sports Medicine · doi:10.1136/bjsports-2011-090020 · Cited by 30 · see citing works
Self-citationVaranoske, A. N., Hoffman, J. R., Church, D. D., Coker, N. A., Baker, K. M., Dodd, S. J., Harris, R. C., Oliveira, L., Dawson, V. L., Wang, R., et al. (2018) · Amino Acids · doi:10.1007/s00726-018-2609-4 · Cited by 29 · see citing works
A kinetic model of carnosine synthesis in human skeletal muscle
Spelnikov, D., & Harris, R. C. (2018) · Amino Acids · doi:10.1007/s00726-018-2646-z · Cited by 27 · see citing works
Muscle Typology of World-Class Cyclists across Various Disciplines and Events
Lievens, E., Bellinger, P., Vossel, K. V., Vancompernolle, J., Bex, T., MINAHAN, C. L., & Derave, W. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002518 · Cited by 27 · see citing works
Self-citationBlack, M. I., JONES, A. M., Morgan, P. T., Bailey, S. J., Fulford, J., & Vanhatalo, A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00111 · Cited by 24 · see citing works
Brisola, G. M. P., & Zagatto, A. M. (2018) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002925 · Cited by 22 · see citing works
Roveratti, M. C., Jacinto, J. L., Oliveira, D. B., da Silva, R. A., Andraus, R. A. C., de Oliveira, E. P., Ribeiro, A. S., & Aguiar, A. F. (2019) · Amino Acids · doi:10.1007/s00726-018-02686-y · Cited by 22 · see citing works
Analysis of Sport Supplement Consumption and Body Composition in Spanish Elite Rowers
Domínguez, R., López-Domínguez, R., López‐Samanes, Á., Gené, P., González-Jurado, J. A., & Sánchez-Oliver, A. J. (2020) · Nutrients · doi:10.3390/nu12123871 · Cited by 22 · see citing works
Lievens, E., Vossel, K. V., de Casteele, F. V., Krššák, M., Murdoch, J. B., Befroy, D. E., & Derave, W. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00056.2021 · Cited by 21 · see citing works
Self-citationBellinger, P., & MINAHAN, C. L. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0095 · Cited by 21 · see citing works
Georgiou, G. D., Antoniou, K., Antoniou, S., Michelekaki, E. A., Zare, R., Redha, A. A., Prokopidis, K., Christodoulides, E., & Clifford, T. (2024) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2024-0027 · Cited by 20 · see citing works
Wang, X., Salibi, N., Fayad, L. M., & Barker, P. B. (2014) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2014.03.010 · Cited by 20 · see citing works
Kim, J. (2019) · Exercise Science · doi:10.15857/ksep.2019.28.3.211 · Cited by 21 · see citing works
meeûs, C. D., Boshuizen, B., Oosterlinck, M., van de Winkel, D., Spiegelaere, W. D., de Bruijn, C. M., Goethals, K., Vanderperren, K., & Delesalle, C. J. G. (2021) · PLoS ONE · doi:10.1371/journal.pone.0249922 · Cited by 19 · see citing works
Amino acids and sport: a true love story?
Goron, A., & Moinard, C. (2018) · Amino Acids · doi:10.1007/s00726-018-2591-x · Cited by 29 · see citing works
Kim, K., Song, H., Yoon, D. H., Fukuda, D. H., Kim, S. H., & Park, D. (2018) · Journal of Exercise Rehabilitation · doi:10.12965/jer.1836462.231 · Cited by 19 · see citing works
Viallon, M., Leporq, B., Drinda, S., de Toledo, F. W., Galusca, B., Ratiney, H., & Croisille, P. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00005 · Cited by 19 · see citing works
Fu, T., Liu, H., Shi, C., Zhao, H., Liu, F., & Xia, Y. (2024) · Journal of Health Population and Nutrition · doi:10.1186/s41043-024-00638-9 · Cited by 20 · see citing works
Effect of β-Alanine Supplementation on High-Intensity Exercise Performance
Harris, R. C., & Stellingwerff, T. (2013) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000350258 · Cited by 17 · see citing works
Influence of l-carnosine on pro-antioxidant status in elite kayakers and canoeists
Słowińska-Lisowska, M. R., Zembroń-Łacny, A., Rynkiewicz, M., Rynkiewicz, T., & Kopeć, W. (2014) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.101.2014.008 · Cited by 16 · see citing works
Ko, R., Dog, T. L., Gorecki, D. K. J., Cantilena, L. R., Costello, R. B., Evans, W. J., Hardy, M. L., Jordan, S. A., Maughan, R. J., Rankin, J. W., et al. (2014) · Nutrition Reviews · doi:10.1111/nure.12087 · Cited by 16 · see citing works
Bex, T., Iannaccone, F., Stautemas, J., Baguet, A., Beule, M. D., Verhegghe, B., Aerts, P., Clercq, D. D., & Derave, W. (2016) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12649 · Cited by 16 · see citing works
Self-citationSamadi, M., Askarian, A., Shirvani, H., Shamsoddini, A., Shakibaee, A., Forbes, S. C., & Kaviani, M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19137992 · Cited by 15 · see citing works
Exercise Training and Beta-Alanine-Induced Muscle Carnosine Loading
Bex, T., Chung, W., Baguet, A., Achten, E., & Derave, W. (2015) · Frontiers in Nutrition · doi:10.3389/fnut.2015.00013 · Cited by 15 · see citing works
Self-citationKhumpeerawat, P., Duangjinda, M., & Phasuk, Y. (2021) · Animals · doi:10.3390/ani11071987 · Cited by 14 · see citing works
Turnes, T., Cruz, R. S. D. O., Caputo, F., & de Aguiar, R. A. (2019) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.2019-0247 · Cited by 14 · see citing works
Agreement of maximal lactate steady state with critical power and physiological thresholds in rowing
Possamai, L. T., Borszcz, F. K., de Aguiar, R. A., de Lucas, R. D., & Turnes, T. (2021) · European Journal of Sport Science · doi:10.1080/17461391.2021.1874541 · Cited by 12 · see citing works
Gatti, R., Andreatta, P., & Boschetti, S. (2013) · Journal of Chromatography A · doi:10.1016/j.chroma.2013.05.026 · Cited by 12 · see citing works
Effects of Acute Carnosine and β-Alanine on Isometric Force and Jumping Performance
Invernizzi, P. L., Limonta, E., Riboli, A., Bosio, A., Scurati, R., & Esposito, F. (2015) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.2014-0507 · Cited by 12 · see citing works
Held, S., Rappelt, L., & Donath, L. (2023) · Sports Medicine · doi:10.1007/s40279-023-01827-y · Cited by 14 · see citing works
- Authors
- Baguet, A., Bourgois, J., Vanhee, L., Achten, E., & Derave, W.
- Affiliations
- Ghent University (BE)
- Corresponding author
- Derave, Wim
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2010-10
- Volume
- 109
- Issue
- 4
- Pages
- 1096-1101
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2107354047
- Cited by
- 182
- References
- 44
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 13 · 2023: 10 · 2022: 9 · 2021: 10 · 2020: 9 · 2019: 9 · 2018: 17 · 2017: 8 · 2016: 8 · 2015: 11 · 2014: 14 · 2013: 25 · 2012: 11
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Flanders Marine Institute (Flanders Marine Institute) (submittedVersion)
- Funders
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering
- Topics
- Health Sciences › Medicine › Physiology › Biochemical effects in animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- muscle carnosine, beta-alanine supplementation, rowing performance, elite rowers, anaerobic exercise performance, skeletal muscle, soleus muscle, medial gastrocnemius, trained athletes
- MeSH terms
- Administration, Oral, Adult, Analysis of Variance, Carnosine, Cross-Sectional Studies, Double-Blind Method, Female, Humans, Male, Muscle Contraction, Magnetic Resonance Spectroscopy, Time Factors, beta-Alanine, Exercise, Up-Regulation, Muscle, Skeletal, Lactic Acid, Dietary Supplements, Young Adult, Performance-Enhancing Substances
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
