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Cited by 42Muscle metabolism and nutritionExercise and Physiological ResponsesSports Performance and Training

A 7-day oral supplementation with branched-chain amino acids was ineffective to prevent muscle damage during a marathon

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Areces, Francisco, Salinero, Juan Jose, Abian-Vicen, Javier, González-Millán, Cristina, Gallo-Salazar, Cesar, Ruiz-Vicente, Diana, Lara, Beatriz, Del Coso, Juan·2014·Amino Acids
DOI 10.1007/s00726-014-1677-3
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Abstract

The aim of this study was to determine the effectiveness of a 7-day oral supplementation with branched-chain amino acids (BCAA) to prevent muscle damage during a marathon. Forty-six experienced runners were randomly divided into two groups, one with BCAA supplementation (n = 25, supplemented with 5 g day(-1) of powdered 1:0.5:0.5 leucine:isoleucine:valine, during the 7 days prior to the competition) and the other as a control group (n = 21, supplemented with an isocaloric placebo). Before the marathon race and within 3 min of finishing, leg muscle power was measured with a maximal countermovement jump and a urine sample was obtained. During the race, running pace was measured by means of a time-chip. Myoglobin concentration was determined in the urine samples as an indirect marker of muscle damage. A visual analog scale (0-10 points) was used to assess leg muscle pain during the race. In the BCAA group, the mean running pace during the marathon was similar to the control group (3.3 ± 0.4 vs. 3.3 ± 0.5 m s(-1), respectively, 0.98). The pre- to post-race reduction in muscle power was similar in both BCAA and control groups (-23.0 ± 16.1 vs. -17.3 ± 13.8 %, P = 0.13). Post-race urine myoglobin concentration was similar in both BCAA and control groups (5.4 ± 7.5 vs. 4.5 ± 8.6 μg mL(-1), P = 0.70). Finally, there were no differences between groups in the perceived muscle pain during the race (6 ± 1 vs. 5 ± 1 points, P = 0.80). A 7-day supplementation of BCAA (5 g day(-1)) did not increase the running performance during a marathon. Furthermore, BCAA supplementation was ineffective to prevent muscle power loss, muscle damage or perceived muscle pain during a marathon race.

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Authors
Areces, F., Salinero, J. J., Abian-Vicen, J., González-Millán, C., Gallo-Salazar, C., Ruiz-Vicente, D., Lara, B., & Del Coso, J.
Affiliations
Camilo José Cela University (ES)
ORCID
Venue
Amino Acids
Publisher
Springer Science and Business Media LLC
Published
2014-01-30
Volume
46
Issue
5
Pages
1169-1176
ISSN
  • 0939-4451 (ISSN-L)
  • 1438-2199
DOI
10.1007/s00726-014-1677-3
OpenAlex
W1979084724
Cited by
42
References
37
Citations by year
2026: 4 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 5 · 2012: 1
FWCI
2.15
Type
journal article
Language
en
Open access
Licence
Locations
  • Amino Acids (publishedVersion)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
  • Depósito Digital e-UCJC (submittedVersion, cc-by-nc-nd)
  • RUIdeRA - Institutional University Repository (University of Castilla-La Mancha) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
branched-chain amino acids, leucine, isoleucine, valine, marathon running, exercise-induced muscle damage, muscle power, countermovement jump, running performance
MeSH terms
Adult, Amino Acids, Branched-Chain, Female, Humans, Male, Middle Aged, Myoglobin, Running, Muscle, Skeletal, Dietary Supplements, Athletes, Myalgia

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