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Cited by 188Muscle metabolism and nutritionSports Performance and TrainingExercise and Physiological Responses

Ingestion of branched‐chain amino acids and tryptophan during sustained exercise in man: failure to affect performance.

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van Hall, G, Raaymakers, J S, Saris, W H, Wagenmakers, A J·1995·The Journal of Physiology
DOI 10.1113/jphysiol.1995.sp020854PMC PMC1156566
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Abstract

1. An increased uptake of tryptophan in the brain may increase serotoninergic activity and recently has been suggested to be a cause of fatigue during prolonged exercise. The present study, therefore, investigates whether ingestion of tryptophan or the competing branched‐chain amino acids (BCAAs) affect performance. Ten endurance‐trained male athletes were studied during cycle exercise at 70‐75% maximal power output, while ingesting, ad random and double‐blind, drinks that contained 6% sucrose (control) or 6% sucrose supplemented with (1) tryptophan (3 g l‐1), (2) a low dose of BCAA (6 g l‐1) or (3) a high dose of BCAA (18 g l‐1). 2. These treatments greatly increased the plasma concentration of the respective amino acids. Using the kinetic parameters of transport of human brain capillaries, BCAA supplements were estimated to reduce brain tryptophan uptake at exhaustion by 8‐12%, while tryptophan ingestion caused a 7‐ to 20‐fold increase. Exercise time to exhaustion was not different between treatments (122 +/‐ 3 min). 3. The data suggest that manipulation of tryptophan supply to the brain either has no additional effect upon serotoninergic activity during prolonged exhaustive exercise or that manipulation of serotoninergic activity functionally does not contribute to mechanisms of fatigue.

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Authors
van Hall, G., Raaymakers, J. S., Saris, W. H., & Wagenmakers, A. J.
Affiliations
Maastricht University (NL)
ORCID
Venue
The Journal of Physiology
Publisher
Wiley
Published
1995-08
Volume
486
Issue
3
Pages
789-794
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.1995.sp020854
PMC
PMC1156566
OpenAlex
W1973200548
Cited by
188
References
26
Citations by year
2026: 3 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 8 · 2015: 8 · 2014: 8 · 2013: 9 · 2012: 7
FWCI
1.89
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
branched-chain amino acids, tryptophan supplementation, exercise fatigue, serotonin, endurance exercise, time to exhaustion, amino acid kinetics, plasma amino acids, exercise performance
MeSH terms
Adult, Amino Acids, Branched-Chain, Ammonia, Blood-Brain Barrier, Dietary Carbohydrates, Double-Blind Method, Exercise Test, Humans, Kinetics, Male, Tryptophan, Exercise, Muscle Fatigue

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