Effect of Branched-Chain Amino Acid Supplementation on Recovery Following Acute Eccentric Exercise
Open accessAbstract
This study investigated the effect of branched-chain amino acid (BCAA) supplementation on recovery from eccentric exercise. Twenty males ingested either a BCAA supplement or placebo (PLCB) prior to and following eccentric exercise. Creatine kinase (CK), vertical jump (VJ), maximal voluntary isometric contraction (MVIC), jump squat (JS) and perceived soreness were assessed. No significant (p > 0.05) group by time interaction effects were observed for CK, soreness, MVIC, VJ, or JS. CK concentrations were elevated above baseline (p < 0.001) in both groups at 4, 24, 48 and 72 hr, while CK was lower (p = 0.02) in the BCAA group at 48 hr compared to PLCB. Soreness increased significantly from baseline (p < 0.01) in both groups at all time-points; however, BCAA supplemented individuals reported less soreness (p < 0.01) at the 48 and 72 hr time-points. MVIC force output returned to baseline levels (p > 0.05) at 24, 48 and 72 hr for BCAA individuals. No significant difference between groups (p > 0.05) was detected for VJ or JS. BCAA supplementation may mitigate muscle soreness following muscle-damaging exercise. However, when consumed with a diet consisting of ~1.2 g/kg/day protein, the attenuation of muscular performance decrements or corresponding plasma CK levels are likely negligible.
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In resistance-trained males consuming ~1.2 g·kg−1·day−1 of protein, the attenuation of muscular performance decrements and the observed decrease in plasma CK levels after BCAA supplementation is likely negligible.
“Notwithstanding, in resistance-trained males, the attenuation of muscular performance decrements and the observed decrease in plasma CK levels after BCAA supplementation is likely negligible when consumed with a diet consisting of ~1.2 g·kg−1·day−1 of protein [132].”
From The 4R’s Framework of Nutritional Strategies for Post-Exercise Recovery: A Review with Emphasis on New Generation of Carbohydrates (2020) · cites this paper as [132]
Two studies reported that BCAA supplementation attenuated decrements in performance.
“Two studies reported that the consumption of BCAA supplementation attenuated the decrements in performance [36,37].”
From Oral Branched-Chain Amino Acids Supplementation in Athletes: A Systematic Review (2022) · cites this paper as [37]
In studies including resistance participants, BCAAs attenuated muscle soreness after exercise.
“On the other hand, studies that included resistance participants showed that BCAAs attenuated muscle soreness after exercise, while in endurance sports the findings were inconsistent.”
From Oral Branched-Chain Amino Acids Supplementation in Athletes: A Systematic Review (2022) · cites this paper as [37]
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- Authors
- VanDusseldorp, T. A., Escobar, K. A., Johnson, K. E., Stratton, M. T., Moriarty, T., Cole, N., McCormick, J. J., Kerksick, C. M., Vaughan, R. A., Dokladny, K., Kravitz, L., & Mermier, C. M.
- Affiliations
- Kennesaw State University (US)
- California State University, Long Beach (US)
- Coastal Carolina University (US)
- University of New Mexico (US)
- Lindenwood University (US)
- High Point University (US)
- Department of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA
- Corresponding author
- VanDusseldorp, Trisha A.
- ORCID
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2018-10-01
- Volume
- 10
- Issue
- 10
- Pages
- 1389
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC6212987
- OpenAlex
- W2893668271
- Cited by
- 78
- References
- 55
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 12 · 2023: 12 · 2022: 14 · 2021: 13 · 2020: 11 · 2019: 5
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DigitalCommons - Kennesaw State University (Kennesaw State University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of New Mexico Research Allocations Committee (n/a)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- branched-chain amino acids, post-exercise recovery, eccentric exercise, muscle soreness, creatine kinase, muscle damage, vertical jump, isometric contraction, protein intake, dietary protein
- MeSH terms
- Amino Acids, Branched-Chain, Creatine Kinase, Double-Blind Method, Humans, Male, Muscle Contraction, Exercise, Muscle, Skeletal, Dietary Supplements, Resistance Training, Young Adult, Myalgia
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