Branched-Chain Amino Acid Supplementation Before Squat Exercise and Delayed-Onset Muscle Soreness

Shimomura, Yoshiharu; Inaguma, Asami; Watanabe, Satoko; Yamamoto, Yuko; Muramatsu, Yuji; Bajotto, Gustavo; Sato, Juichi; Shimomura, Noriko; Kobayashi, Hisamine; Mawatari, Kazunori

doi:10.1123/ijsnem.20.3.236

Cited by 166Exercise and Physiological ResponsesMuscle metabolism and nutritionCardiovascular and exercise physiology

Branched-Chain Amino Acid Supplementation Before Squat Exercise and Delayed-Onset Muscle Soreness

Shimomura, Yoshiharu, Inaguma, Asami, Watanabe, Satoko, Yamamoto, Yuko, Muramatsu, Yuji, Bajotto, Gustavo, Sato, Juichi, Shimomura, Noriko +2 more·2010·International Journal of Sport Nutrition and Exercise Metabolism

DOI 10.1123/ijsnem.20.3.236

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Abstract

The authors examined the effect of branched-chain amino acid (BCAA) supplementation on squat-exercise-induced delayed-onset muscle soreness (DOMS) using 12 young, healthy, untrained female participants. The experiment was conducted with a crossover double-blind design. In the morning on the exercise-session day, the participants ingested either BCAA (isoleucine:leucine:valine = 1:2.3:1.2) or dextrin at 100 mg/kg body weight before the squat exercise, which consisted of 7 sets of 20 squats/set with 3-min intervals between sets. DOMS showed a peak on Days 2 and 3 in both trials, but the level of soreness was significantly lower in the BCAA trial than in the placebo. Leg-muscle force during maximal voluntary isometric contractions was measured 2 d after exercise (Day 3), and the BCAA supplementation suppressed the muscle-force decrease (to ~80% of the value recorded under the control conditions) observed in the placebo trial. Plasma BCAA concentrations, which decreased after exercise in the placebo trial, were markedly elevated during the 2 hr postexercise in the BCAA trial. Serum myoglobin concentration was increased by exercise in the placebo but not in the BCAA trial. The concentration of plasma elastase as an index of neutrophil activation appeared to increase after the squat exercise in both trials, but the change in the elastase level was significant only in the placebo trial. These results suggest that muscle damage may be suppressed by BCAA supplementation.

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Oral ingestion of a BCAA supplement before or after exercise improved the recovery of damaged muscles by suppressing endogenous muscle-protein breakdown during exercise.
“Shimomoura et al. [12] found that oral ingestion of a BCAA supplement before or after exercise improved the recovery of damaged muscles by suppressing the endogenous muscle-protein breakdown during exercise [12].”
From In a single-blind, matched group design: Branched-chain amino acid supplementation and resistance training maintains lean body mass during a caloric restricted diet (2016) · cites this paper as [12]
Shimomoura et al. found that oral ingestion of a BCAA supplement before or after exercise improved the recovery of damaged muscles by suppressing endogenous muscle-protein breakdown during exercise.
“Shimomoura et al. [12] found that oral ingestion of a BCAA supplement before or after exercise improved the recovery of damaged muscles by suppressing the endogenous muscle-protein breakdown during exercise (decreasing the release of essential amino acids from exercising muscles) [12].”
From In a single-blind, matched group design: Branched-chain amino acid supplementation and resistance training maintains lean body mass during a caloric restricted diet (2016) · cites this paper as [12]

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RESEARCH ARTICLE Combined effect of branc t s
(2016)

Authors: Shimomura, Y., Inaguma, A., Watanabe, S., Yamamoto, Y., Muramatsu, Y., Bajotto, G., Sato, J., Shimomura, N., Kobayashi, H., & Mawatari, K.
Affiliations: Nagoya University (JP)
ORCID: Shimomura, Yoshiharu
Watanabe, Satoko
Yamamoto, Yuko
Sato, Juichi
Kobayashi, Hisamine
Venue: International Journal of Sport Nutrition and Exercise Metabolism
Publisher: Human Kinetics
Published: 2010-06
Volume: 20
Issue: 3
Pages: 236-244
ISSN: 1526-484X (ISSN-L)
1543-2742
DOI: 10.1123/ijsnem.20.3.236
OpenAlex: W2150326290
Cited by: 166
References: 45
Citations by year: 2026: 1 · 2025: 5 · 2024: 9 · 2023: 8 · 2022: 9 · 2021: 12 · 2020: 12 · 2019: 7 · 2018: 12 · 2017: 31 · 2016: 12 · 2015: 8 · 2014: 6 · 2013: 15 · 2012: 12
FWCI: 11.29
Type: journal article
Language: en
Open access: closed
Locations: International Journal of Sport Nutrition and Exercise Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: Uehara Memorial Foundation
Otsuka Pharmaceutical
Topics: Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: branched-chain amino acids, delayed onset muscle soreness, squatting, muscle damage, isoleucine, leucine, valine, muscle force, serum myoglobin, neutrophil activation, plasma elastase
MeSH terms: Adult, Amino Acids, Branched-Chain, Beverages, Female, Humans, Myoglobin, Pancreatic Elastase, Exercise, Neutrophil Activation, Muscle, Skeletal, Cross-Over Studies, Dietary Supplements, Young Adult

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Branched-Chain Amino Acid Supplementation Before Squat Exercise and Delayed-Onset Muscle Soreness

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