Use of selective serotonin reuptake inhibitors (SSRIs) in women delivering liveborn infants and other women of child-bearing age within the U.S. Food and Drug Administration’s Mini-Sentinel program
Abstract
This study was conducted in order to assess the prevalence of use of selective serotonin reuptake inhibitors (SSRIs) among pregnant women delivering a liveborn infant in the USA. A retrospective study was conducted using the automated databases of 15 health-care systems participating in the Mini-Sentinel program. Diagnosis and procedure codes were used to identify women ages 10 to 54 years delivering a liveborn infant between April 2001 and December 2013. A comparison group of age- and date-matched women without live births was identified. The frequency of use of SSRIs was identified from outpatient dispensing data. Among the 1,895,519 liveborn deliveries, 113,689 women (6.0 %) were exposed to an SSRI during pregnancy during the period 2001-2013; 5.4 % were exposed to an SSRI during 2013. During the corresponding time period, 10.5 % of the age- and date-matched cohort of women without live births was exposed to an SSRI, with 10.1 % exposed to an SSRI during 2013. The most common agents dispensed during pregnancy were sertraline (n = 48,678), fluoxetine (n = 28,983), and citalopram (n = 20,591). Among those women exposed to an SSRI during pregnancy, 53.8 % had a diagnosis of depression and 37.3 % had a diagnosis of an anxiety disorder during pregnancy or within 180 days prior to pregnancy. Our finding that 6 % of women with live births were prescribed SSRIs during pregnancy highlights the importance of understanding the differential effects of these medications and other therapeutic options on the developing fetus and on the pregnant women.
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Maternal SSRI use in SEED matched other US estimates, which lessens worry about participation selection bias.
“Additionally, rates of maternal SSRI use in the SEED sample were comparable to other US estimates (5–7), mitigating concerns about selection bias in participation.”
From Maternal Psychiatric Conditions, Treatment With Selective Serotonin Reuptake Inhibitors, and Neurodevelopmental Disorders (2021) · cites this paper as [7]
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- Authors
- Andrade, S. E., Reichman, M. E., Mott, K., Pitts, M., Kieswetter, C., Dinatale, M., Stone, M. B., Popovic, J., Haffenreffer, K., & Toh, S.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- United States Food and Drug Administration (US)
- Harvard University (US)
- Corresponding author
- Andrade, Susan E.
- ORCID
- Venue
- Archives of Women's Mental Health
- Published
- 2016-05-13
- Volume
- 19
- Issue
- 6
- Pages
- 969-977
- ISSN
- 1434-1816 (ISSN-L)
- 1435-1102
- OpenAlex
- W2387774874
- Cited by
- 50
- References
- 22
- Citations by year
- 2025: 8 · 2024: 2 · 2023: 8 · 2022: 1 · 2021: 6 · 2020: 10 · 2019: 3 · 2018: 6 · 2017: 5 · 2016: 1
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Women s Mental Health (publishedVersion)
- PubMed (publishedVersion)
- eScholarship@UMassChan (submittedVersion)
- Funders
- U.S. Food and Drug Administration (HHSF223200910006I)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- selective serotonin reuptake inhibitors, antidepressant use in pregnancy, liveborn infants, sertraline, fluoxetine, citalopram, maternal depression, anxiety disorders in pregnancy, prenatal medication exposure, drug safety in pregnancy
- MeSH terms
- Adult, Depressive Disorder, Female, Humans, Pregnancy, Pregnancy Complications, United States, United States Food and Drug Administration, Prevalence, Selective Serotonin Reuptake Inhibitors, Sentinel Surveillance, Live Birth
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