Cited by 124Bone Metabolism and DiseasesParathyroid Disorders and TreatmentsBone health and osteoporosis research

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Osteocytic osteolysis observed in rats to which parathyroid hormone was continuously administered

Tazawa, Kohei, Hoshi, Kazuto, Kawamoto, Shinichiro, Tanaka, Mikako, Ejiri, Sadakazu, Ozawa, Hidehiro·2004·Journal of Bone and Mineral Metabolism

DOI 10.1007/s00774-004-0519-x

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Abstract

In order to prove osteocytic osteolysis in vivo, human parathyroid hormone (hPTH (1-34), 749 ng/h), or only solvent of the same volume, was continuously administered to 8-month-old rats by an infusion pump for 4 weeks, and then structural changes in osteocytes in the cortical bones of the tibiae were analyzed morphometrically, histologically, and histochemically. Based on contact microradiography (CMR) observations, the osteocyte lacunae in the PTH group tended to be enlarged, compared with those of the control, while the average lacuna area was 137.0 microm2 in the PTH group versus 93.9 microm2 in the control, suggesting evidence of osteocytic osteolysis. Acid phosphatase enzyme histochemical localization was observed in some osteocytes in the PTH group; therefore, lysosome systems may participate in the osteolytic mechanisms. On histological samples stained with hematoxylin-eosin or toluidine blue, the lacunae of the controls were surrounded by narrow areas of matrices both positive for hematoxylin and metachromatic for toluidine blue, while belt-like areas positive for hematoxylin were observed around the PTH-group lacunae. These findings suggested that, after osteocytic osteolysis, regenerated bone matrices may be added to the walls of osteocytes that possess enlarged lacunae.

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Authors: Tazawa, K., Hoshi, K., Kawamoto, S., Tanaka, M., Ejiri, S., & Ozawa, H.
Affiliations: Niigata University (JP)
The University of Tokyo (JP)
Kagoshima University (JP)
Matsumoto Dental University (JP)
Corresponding author: Hoshi, Kazuto
ORCID: Hoshi, Kazuto
Tanaka, Mikako
Venue: Journal of Bone and Mineral Metabolism
Publisher: Springer Science and Business Media LLC
Published: 2004-11
Volume: 22
Issue: 6
Pages: 524-529
ISSN: 0914-8779 (ISSN-L)
1435-5604
DOI: 10.1007/s00774-004-0519-x
OpenAlex: W1997729832
Cited by: 124
References: 29
Citations by year: 2026: 2 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 8 · 2020: 6 · 2019: 10 · 2018: 9 · 2017: 11 · 2016: 8 · 2015: 9 · 2014: 3 · 2013: 10 · 2012: 7
FWCI: 0.59
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Bone and Mineral Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords: parathyroid hormone, human parathyroid hormone (1-34), osteocytes, osteocyte lacunae, cortical bone, tibia, acid phosphatase, lysosomes, bone matrix, bone remodeling, contact microradiography, rat model
MeSH terms: Animals, Fibula, Osteoclasts, Osteocytes, Osteolysis, Tibia, Infusion Pumps, Implantable, Rats, Wistar, Teriparatide, Rats

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Osteocytic osteolysis observed in rats to which parathyroid hormone was continuously administered

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