The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Osteocytic osteolysis observed in rats to which parathyroid hormone was continuously administered
Abstract
In order to prove osteocytic osteolysis in vivo, human parathyroid hormone (hPTH (1-34), 749 ng/h), or only solvent of the same volume, was continuously administered to 8-month-old rats by an infusion pump for 4 weeks, and then structural changes in osteocytes in the cortical bones of the tibiae were analyzed morphometrically, histologically, and histochemically. Based on contact microradiography (CMR) observations, the osteocyte lacunae in the PTH group tended to be enlarged, compared with those of the control, while the average lacuna area was 137.0 microm2 in the PTH group versus 93.9 microm2 in the control, suggesting evidence of osteocytic osteolysis. Acid phosphatase enzyme histochemical localization was observed in some osteocytes in the PTH group; therefore, lysosome systems may participate in the osteolytic mechanisms. On histological samples stained with hematoxylin-eosin or toluidine blue, the lacunae of the controls were surrounded by narrow areas of matrices both positive for hematoxylin and metachromatic for toluidine blue, while belt-like areas positive for hematoxylin were observed around the PTH-group lacunae. These findings suggested that, after osteocytic osteolysis, regenerated bone matrices may be added to the walls of osteocytes that possess enlarged lacunae.
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“The same outcome was observed in cases of excess PTH concentrations both in rats83 and humans84 and under PTH modulation after exercise.85”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [83]
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Demonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation
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Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482
Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption
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Metadata
- Authors
- Tazawa, K., Hoshi, K., Kawamoto, S., Tanaka, M., Ejiri, S., & Ozawa, H.
- Affiliations
- Niigata University (JP)
- The University of Tokyo (JP)
- Kagoshima University (JP)
- Matsumoto Dental University (JP)
- Corresponding author
- Hoshi, Kazuto
- Venue
- Journal of Bone and Mineral Metabolism
- Published
- 2004-11
- Volume
- 22
- Issue
- 6
- Pages
- 524-529
- ISSN
- 0914-8779 (ISSN-L)
- 1435-5604
- OpenAlex
- W1997729832
- Cited by
- 124
- References
- 29
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 8 · 2020: 6 · 2019: 10 · 2018: 9 · 2017: 11 · 2016: 8 · 2015: 9 · 2014: 3 · 2013: 10 · 2012: 7
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Bone and Mineral Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- parathyroid hormone, human parathyroid hormone (1-34), osteocytes, osteocyte lacunae, cortical bone, tibia, acid phosphatase, lysosomes, bone matrix, bone remodeling, contact microradiography, rat model
- MeSH terms
- Animals, Fibula, Osteoclasts, Osteocytes, Osteolysis, Tibia, Infusion Pumps, Implantable, Rats, Wistar, Teriparatide, Rats
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