Environmental influences that affect attention deficit/hyperactivity disorder: Study of a genetic isolate
Abstract
Three independent complex segregation analyses found that the cause of Attention Deficit/Hyperactivity Disorder (ADHD) was the presence of major genes interacting with environmental influences. In order to identify potential environmental risk factors for ADHD in the Paisa community--a very well described, genetically isolated group--we randomly selected a sample of 486 children between 6 and 11 years of age. This group included 200 children with ADHD (149 males and 51 females) and 286 healthy controls (135 males and 151 females). The ADHD DSM-IV diagnosis was obtained using the DICA and BASC evaluation instruments, and the children's mothers or grandmothers filled out a questionnaire on each child's exposure to prenatal, neonatal, and early childhood risk factors. The data were analyzed using cross tabulation and stepwise logistic multiple-regression analyses. Cross tabulation associated ADHD with a variety of factors, including miscarriage symptoms, premature delivery symptoms, maternal respiratory viral infection, moderate to severe physical illness in the mother during gestation, prenatal cigarette and alcohol exposure, neonatal seizures, asphyxia or anoxia, severe neonatal illness, mild speech retardation, moderate brain injury, and febrile seizures (odds ratio >or= 2, P < 0.05). Stepwise logistic multiple-regression analysis also uncovered a block of variables, including male gender, maternal illnesses, prenatal alcohol exposure, mild speech retardation, febrile seizures, and moderate brain injury (odds ratio >or= 2.0, P < 0.05). Future studies on the risk of developing ADHD must include these environmental factors as covariates.
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Damage to the brain after birth due to traumatic brain injury has been considered a risk factor for ADHD.
“Damage to the brain after birth due to traumatic brain injury has also been considered as a risk factor for ADHD (Pineda et al., 2007; Adeyemo et al., 2014).”
From A Review of Heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD) (2019) · cites this paper as Pineda et al., 2007
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- Authors
- Pineda, D. A., Palacio, L. G., Puerta, I. C., Merchán, V., Arango, C. P., Galvis, A. Y., Gómez, M., Aguirre, D. C., Lopera, F., & Arcos-Burgos, M.
- Affiliations
- Universidad de San Buenaventura (CO)
- National Institutes of Health (US)
- Universidad de Antioquia (CO)
- Venue
- European Child & Adolescent Psychiatry
- Published
- 2007-05-08
- Volume
- 16
- Issue
- 5
- Pages
- 337-346
- ISSN
- 1018-8827 (ISSN-L)
- 1435-165X
- OpenAlex
- W1489207425
- Cited by
- 98
- References
- 78
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 4 · 2023: 1 · 2022: 6 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 5 · 2012: 11
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Repositorio Digital - Academia Colombiana de Ciencias Exactas, Fisicas y Naturales (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- attention deficit hyperactivity disorder, environmental risk factors, prenatal exposure, neonatal risk factors, maternal illness, prenatal alcohol exposure, febrile seizures, brain injury, speech delay, genetic isolation, complex segregation analysis
- MeSH terms
- Adult, Hypoxia, Asphyxia Neonatorum, Attention Deficit Disorder with Hyperactivity, Child, Cognition Disorders, Colombia, Environmental Exposure, Female, Health Status, Humans, Infant, Newborn, Male, Pregnancy, Pregnancy Complications, Risk Factors, Prevalence, Diagnostic and Statistical Manual of Mental Disorders
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