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Apolipoproteins E and C1 and brain morphology in memory impaired elders

Serra-Grabulosa, J. M., Salgado-Pineda, P., Junqué, C., Solé-Padullés, C., Moral, P., López-Alomar, A., López, T., López-Guillén, A., Bargalló, N., Mercader, J. M., Clemente, I. C., Bartrés-Faz, D.·2003·Neurogenetics
DOI 10.1007/s10048-002-0142-8
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Abstract

Previous research has shown that polymorphisms of the apolipoproteins E ( APOE) and APOC1 represent genetic risk factors for dementia and for cognitive impairment in the elderly. The brain mechanisms by which these genetic variations affect behavior or clinical severity are poorly understood. We studied the effect of APOE and APOC1 genes on magnetic resonance imaging measures in a sample of 50 subjects with age-associated memory impairment. The APOE E4 allele was associated with reduced left hippocampal volumes and APOE*E3 status was associated with greater frontal lobe white matter volumes. However, no APOE effects were observed when analyses accounted for other potential confounding variables. The effects of APOC1 on hippocampal volumes appeared to be more robust than those of the APOE polymorphism. However, no modulatory effects on brain morphology outside the medial temporal lobe region were observed when demographic variables, clinical status, and other anatomical brain measurements were taken into consideration. Our results suggest that the role of the APOC1 polymorphism in brain morphology of the cognitively impaired elderly should be examined in further studies.

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  • These results align with previous research highlighting the differential impacts of these genes on cortical atrophy and memory decline, particularly in the elderly with memory impairments.

    “These results align with previous research highlighting the differential impacts of these genes on cortical atrophy and memory decline, particularly in the elderly with memory impairments [25].”

    From Association of APOC1 with cortical atrophy during conversion to Alzheimer’s disease (2025) · cites this paper as [25]

  • APOC1 polymorphism influences hippocampal volume, which may have a significant effect on brain atrophy compared to APOE.

    “Moreover, APOC1 polymorphism influences HV, which may have a significant effect on brain atrophy compared to that of APOE [25].”

    From Association of APOC1 with cortical atrophy during conversion to Alzheimer’s disease (2025) · cites this paper as [25]

  • In a study involving elderly individuals with memory impairment, those carrying the APOC1 risk genotype exhibited smaller hippocampal volume compared to non-carriers, suggesting that APOC1 variants may contribute to AD-like neurodegeneration.

    “In a study involving elderly individuals with memory impairment, those carrying the APOC1 risk genotype exhibited smaller HV compared to non-carriers, suggesting that APOC1 variants may contribute to AD-like neurodegeneration [25].”

    From Association of APOC1 with cortical atrophy during conversion to Alzheimer’s disease (2025) · cites this paper as [25]

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Metadata

Authors
Serra-Grabulosa, J. M., Salgado-Pineda, P., Junqué, C., Solé-Padullés, C., Moral, P., López-Alomar, A., López, T., López-Guillén, A., Bargalló, N., Mercader, J. M., Clemente, I. C., & Bartrés-Faz, D.
Venue
Neurogenetics
Publisher
Springer Science and Business Media LLC
Published
2002-12-21
Volume
4
Issue
3
Pages
141-146
ISSN
  • 1364-6745
  • 1364-6753
DOI
10.1007/s10048-002-0142-8
Cited by
26
References
2
Language
en
Licence
www.springer.com/tdm (tdm)

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