Cited by 269Antifungal resistance and susceptibilityFungal and yeast genetics researchYeasts and Rust Fungi Studies

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Candida glabrata: a review of its features and resistance

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Rodrigues, C. F., Silva, S., Henriques, M.·2014·European Journal of Clinical Microbiology & Infectious Diseases

DOI 10.1007/s10096-013-2009-3

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Abstract

Candida species belong to the normal microbiota of the oral cavity and gastrointestinal and vaginal tracts, and are responsible for several clinical manifestations, from mucocutaneous overgrowth to bloodstream infections. Once believed to be non-pathogenic, Candida glabrata was rapidly blamable for many human diseases. Year after year, these pathological circumstances are more recurrent and problematic to treat, especially when patients reveal any level of immunosuppression. These difficulties arise from the capacity of C. glabrata to form biofilms and also from its high resistance to traditional antifungal therapies. Thus, this review intends to present an excerpt of the biology, epidemiology, and pathology of C. glabrata, and detail an approach to its resistance mechanisms based on studies carried out up to the present.

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Authors: Rodrigues, C. F., Silva, S., & Henriques, M.
Affiliations: Institute for Biotechnology and Bioengineering (PT)
Corresponding author: Henriques, M.
ORCID: Rodrigues, C. F.
Silva, S.
Henriques, M.
Venue: European Journal of Clinical Microbiology & Infectious Diseases
Publisher: Springer Science and Business Media LLC
Published: 2013-11-19
Volume: 33
Issue: 5
Pages: 673-688
ISSN: 0934-9723 (ISSN-L)
1435-4373
DOI: 10.1007/s10096-013-2009-3
OpenAlex: W2099290964
Cited by: 268
References: 155
Citations by year: 2026: 11 · 2025: 10 · 2024: 23 · 2023: 17 · 2022: 25 · 2021: 28 · 2020: 27 · 2019: 24 · 2018: 34 · 2017: 24 · 2016: 19 · 2015: 16 · 2014: 10
FWCI: 1.95
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.springer.com/tdm (tdm)
Locations: European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
Keywords: Candida glabrata, antifungal resistance, biofilm, candidiasis, bloodstream infection, immunosuppression, fungal pathogenesis, yeast biology
MeSH terms: Antifungal Agents, Candidiasis, Humans, Drug Resistance, Fungal, Candida glabrata

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Candida glabrata: a review of its features and resistance

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