Candida bloodstream infections in intensive care units: Analysis of the extended prevalence of infection in intensive care unit study*

Kett, Daniel H.; Azoulay, Elie; Echeverria, Pablo M.; Vincent, Jean-Louis

doi:10.1097/ccm.0b013e318206c1ca

Cited by 389Antifungal resistance and susceptibilityNosocomial Infections in ICUInfective Endocarditis Diagnosis and Management

Candida bloodstream infections in intensive care units: Analysis of the extended prevalence of infection in intensive care unit study*

Kett, Daniel H., Azoulay, Elie, Echeverria, Pablo M., Vincent, Jean-Louis·2011·Critical Care Medicine

DOI 10.1097/ccm.0b013e318206c1ca

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Abstract

Objectives To provide a global, up-to-date picture of the prevalence, treatment, and outcomes of Candida bloodstream infections in intensive care unit patients and compare Candida with bacterial bloodstream infection. Design A retrospective analysis of the Extended Prevalence of Infection in the ICU Study (EPIC II). Demographic, physiological, infection-related and therapeutic data were collected. Patients were grouped as having Candida, Gram-positive, Gram-negative, and combined Candida/bacterial bloodstream infection. Outcome data were assessed at intensive care unit and hospital discharge. Setting EPIC II included 1265 intensive care units in 76 countries. Patients Patients in participating intensive care units on study day. Interventions None. Measurement and main results Of the 14,414 patients in EPIC II, 99 patients had Candida bloodstream infections for a prevalence of 6.9 per 1000 patients. Sixty-one patients had candidemia alone and 38 patients had combined bloodstream infections. Candida albicans (n = 70) was the predominant species. Primary therapy included monotherapy with fluconazole (n = 39), caspofungin (n = 16), and a polyene-based product (n = 12). Combination therapy was infrequently used (n = 10). Compared with patients with Gram-positive (n = 420) and Gram-negative (n = 264) bloodstream infections, patients with candidemia were more likely to have solid tumors (p Conclusion Candidemia remains a significant problem in intensive care units patients. In the E…

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Authors: Kett, D. H., Azoulay, E., Echeverria, P. M., & Vincent, J.-L.
Affiliations: University of Miami (US)
Université Libre de Bruxelles (BE)
ORCID: Vincent, Jean-Louis
Venue: Critical Care Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2011-04
Volume: 39
Issue: 4
Pages: 665-670
ISSN: 0090-3493 (ISSN-L)
DOI: 10.1097/ccm.0b013e318206c1ca
OpenAlex: W2080363965
Cited by: 389
References: 16
Citations by year: 2026: 7 · 2025: 15 · 2024: 20 · 2023: 15 · 2022: 22 · 2021: 27 · 2020: 32 · 2019: 24 · 2018: 24 · 2017: 33 · 2016: 31 · 2015: 42 · 2014: 40 · 2013: 27 · 2012: 17
FWCI: 11.70
Type: journal article
Language: en
Open access: closed
Locations: Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion)
HAL (submittedVersion)
CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
DIAL (Catholic University of Leuven) (submittedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
IRIS (submittedVersion)
Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
ORBi (University of Liège) (submittedVersion)
RWTH Publications (RWTH Aachen) (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Research Publications (Maastricht University) (submittedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
Keywords: candidemia, intensive care unit, Candida albicans, antifungal therapy, fluconazole, caspofungin, polyene antibiotics, ICU mortality, length of hospital stay, gram-negative bacteremia, solid tumors, nosocomial infections
MeSH terms: Caspofungin, Aged, Antifungal Agents, Candida albicans, Candidiasis, Cross Infection, Female, Humans, Intensive Care Units, Male, Middle Aged, Retrospective Studies, Fluconazole, Prevalence, Sepsis, Echinocandins, Lipopeptides

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Candida bloodstream infections in intensive care units: Analysis of the extended prevalence of infection in intensive care unit study*

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