Cited by 47Skin Protection and AgingSeaweed-derived Bioactive CompoundsPhytochemistry and Biological Activities

Repair of UVB-damaged skin by the antioxidant sulphated flavone glycoside thalassiolin B isolated from the marine plant Thalassia testudinum Banks ex Konig

Regalado, Erik L., Rodríguez, María, Menéndez, Roberto, Concepción, Ángel A., Nogueiras, Clara, Laguna, Abilio, Rodríguez, Armando A., Williams, David E. +3 more·2009·Marine Biotechnology

Abstract

Daily topical application of the aqueous ethanolic extract of the marine sea grass, Thalassia testudinum, on mice skin exposed to UVB radiation resulted in a dose-dependent recovery of the skin macroscopic alterations over a 6-day period. Maximal effect (90%) occurred at a dose of 240 microg/cm(2), with no additional effects at higher doses. Bioassay-guided fractionation of the plant extract resulted in the isolation of thalassiolin B (1). Topical application of 1 (240 microg/cm(2)) markedly reduces skin UVB-induced damage. In addition, thalassiolin B scavenged 2,2-diphenyl-2-picrylhydrazyl radical with an EC(50) = 100 microg/ml. These results suggest that thalassiolin B is responsible for the skin-regenerating effects of the crude extract of T. testudinum.

Integrity signals

Registry

Crossref · 10.1007/s10126-008-9123-8

Cites

31 of 31 references verified0 citation errors · 0 not checkable

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  • Thalassia testudinum has the ability to protect and repair photoinduced UVB damage due to the presence of thalassiolin B (55).

    “the marine sea grass Thalassia testudinum. which demonstrated the ability to protect and repair the photoinduced UVB damage [125] due to the presence of a sulphated flavone glycoside thalassiolin B (55)”

    From UV Filters: Challenges and Prospects (2022) · cites this paper as [125]

  • Metabolite from ethanolic extract of plant Thalassia testudinum is thalassiolin B (55) and has antioxidant (DPPH) activity with IC50 = 100 μg/mL.

    “| Metabolite from ethanolic extract of plant Thalassia testudinum | Thalassiolin B (55) | Antioxidant (DPPH) | IC50 = 100 μg/mL | [125] |”

    From UV Filters: Challenges and Prospects (2022) · cites this paper as [125]

  • Thalassiolin B (55) from ethanolic extract of Thalassia testudinum repairs acute UVB-damaged skin, suppressing skin damage by 90% at 240 μg/cm2.

    “| Metabolite from ethanolic extract of plant Thalassia testudinum | Thalassiolin B (55) | Repair of Acute UVB-Damaged Skin | Skin damage suppression (with 55 at 240 μg/cm2) = 90% | [125] |”

    From UV Filters: Challenges and Prospects (2022) · cites this paper as [125]

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Authors
Regalado, E. L., Rodríguez, M., Menéndez, R., Concepción, Á. A., Nogueiras, C., Laguna, A., Rodríguez, A. A., Williams, D. E., Lorenzo-Luaces, P., Valdés, O., & Hernandez, Y.
Affiliations
  • University of Havana (CU)
  • University of British Columbia (CA)
Corresponding author
Regalado, Erik L.
Venue
Marine Biotechnology
Published
2008-07-08
Volume
11
Issue
1
Pages
74-80
ISSN
  • 1436-2228 (ISSN-L)
  • 1436-2236
OpenAlex
W2072453001
Cited by
47
References
31
Citations by year
2025: 2 · 2023: 1 · 2022: 3 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 4
FWCI
4.30
Type
journal article
Language
en
Open access
closed
Locations
  • Marine Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
  • AquaDocs (United Nations Educational, Scientific and Cultural Organization) (submittedVersion)
Funders
Boehringer Ingelheim Fonds
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Keywords
Thalassia testudinum, UVB-induced skin damage, antioxidant activity, free radical scavenging, topical application, skin regeneration, bioassay-guided fractionation
MeSH terms
Animals, Antioxidants, Dose-Response Relationship, Drug, Flavonoids, Male, Mice, Inbred BALB C, Radiation Injuries, Experimental, Skin, Ultraviolet Rays, Molecular Structure, Hydrocharitaceae, Mice

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