Repair of UVB-damaged skin by the antioxidant sulphated flavone glycoside thalassiolin B isolated from the marine plant Thalassia testudinum Banks ex Konig
Abstract
Daily topical application of the aqueous ethanolic extract of the marine sea grass, Thalassia testudinum, on mice skin exposed to UVB radiation resulted in a dose-dependent recovery of the skin macroscopic alterations over a 6-day period. Maximal effect (90%) occurred at a dose of 240 microg/cm(2), with no additional effects at higher doses. Bioassay-guided fractionation of the plant extract resulted in the isolation of thalassiolin B (1). Topical application of 1 (240 microg/cm(2)) markedly reduces skin UVB-induced damage. In addition, thalassiolin B scavenged 2,2-diphenyl-2-picrylhydrazyl radical with an EC(50) = 100 microg/ml. These results suggest that thalassiolin B is responsible for the skin-regenerating effects of the crude extract of T. testudinum.
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Thalassia testudinum has the ability to protect and repair photoinduced UVB damage due to the presence of thalassiolin B (55).
“the marine sea grass Thalassia testudinum. which demonstrated the ability to protect and repair the photoinduced UVB damage [125] due to the presence of a sulphated flavone glycoside thalassiolin B (55)”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [125]
Metabolite from ethanolic extract of plant Thalassia testudinum is thalassiolin B (55) and has antioxidant (DPPH) activity with IC50 = 100 μg/mL.
“| Metabolite from ethanolic extract of plant Thalassia testudinum | Thalassiolin B (55) | Antioxidant (DPPH) | IC50 = 100 μg/mL | [125] |”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [125]
Thalassiolin B (55) from ethanolic extract of Thalassia testudinum repairs acute UVB-damaged skin, suppressing skin damage by 90% at 240 μg/cm2.
“| Metabolite from ethanolic extract of plant Thalassia testudinum | Thalassiolin B (55) | Repair of Acute UVB-Damaged Skin | Skin damage suppression (with 55 at 240 μg/cm2) = 90% | [125] |”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [125]
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- Authors
- Regalado, E. L., Rodríguez, M., Menéndez, R., Concepción, Á. A., Nogueiras, C., Laguna, A., Rodríguez, A. A., Williams, D. E., Lorenzo-Luaces, P., Valdés, O., & Hernandez, Y.
- Affiliations
- University of Havana (CU)
- University of British Columbia (CA)
- Corresponding author
- Regalado, Erik L.
- ORCID
- Venue
- Marine Biotechnology
- Published
- 2008-07-08
- Volume
- 11
- Issue
- 1
- Pages
- 74-80
- ISSN
- 1436-2228 (ISSN-L)
- 1436-2236
- OpenAlex
- W2072453001
- Cited by
- 47
- References
- 31
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 3 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 4
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Marine Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- AquaDocs (United Nations Educational, Scientific and Cultural Organization) (submittedVersion)
- Funders
- Boehringer Ingelheim Fonds
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- Thalassia testudinum, UVB-induced skin damage, antioxidant activity, free radical scavenging, topical application, skin regeneration, bioassay-guided fractionation
- MeSH terms
- Animals, Antioxidants, Dose-Response Relationship, Drug, Flavonoids, Male, Mice, Inbred BALB C, Radiation Injuries, Experimental, Skin, Ultraviolet Rays, Molecular Structure, Hydrocharitaceae, Mice
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