Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic hearts
Open accessAbstract
Wall shear stresses (WSS) exerted by blood flow on cardiac tissues modulate growth and development of the heart. To study the role of hemodynamic conditions on cardiac morphogenesis, here, we present a methodology that combines imaging and finite element modeling to quantify the in vivo blood flow dynamics and WSS in the cardiac outflow tract (OFT) of early chicken embryos (day 3 out of 21-day incubation period). We found a distinct blood flow field and heterogeneous distribution of WSS in the chicken embryonic heart OFT, which have physiological implications for OFT morphogenesis.
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Cells in the common ventricle and outflow tract of the embryonic heart are sensitive to wall and shear forces, and increases in these forces can lead to heart defects.
“Cells in the common ventricle and the outflow tract of the embryonic heart are sensitive to wall and shear forces (342, 442), and increases in these forces can lead to heart defects (135, 260, 379).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [342]
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- Authors
- Liu, A., Nickerson, A., Troyer, A., Yin, X., Cary, R., Thornburg, K., Wang, R., & Rugonyi, S.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Liu, Aiping
- Venue
- Computers & Structures
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 89
- Issue
- 11-12
- Pages
- 855-867
- ISSN
- 0045-7949 (ISSN-L)
- PMC
- PMC3091009
- OpenAlex
- W1966891540
- Cited by
- 44
- References
- 41
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 7 · 2015: 8 · 2014: 4 · 2013: 3 · 2012: 6
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Computers & Structures (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL094570)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- wall shear stress, blood flow, cardiac outflow tract, chick embryo heart, cardiac morphogenesis, hemodynamics, finite element analysis, early embryonic development
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