The development of the heart and microcirculation: role of shear stress
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The structural and morphological aspects of heart development have been well-described over the past years. Continuing research is performed on the genetic pathways, transcription factors and growth factors important for determination and specification of the various components and segments of the cardiovascular system during embryogenesis. It is necessary to realize that the intricate expression patterns and cellular and molecular interactions take place in a growing embryo with an increasing oxygen and fuel consumption. This is accompanied by an expanding cardiovascular system that is continuously adapting to the changing needs of the embryo. As the cardiovascular system is the first to function in an embryo we have to incorporate in our scientific thinking the forces generated by the heart with the local effects on the various components and segments as early as the heart is present. The cyclic activity of the heart generates both pressure and flow, both dampened and transmitted by the physico-chemical characteristics of the wall of the system and of the blood, incorporating their changing composition during development.
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Cells in the common ventricle and outflow tract of the embryonic heart are sensitive to wall and shear forces, and increases in these forces can lead to heart defects.
“Cells in the common ventricle and the outflow tract of the embryonic heart are sensitive to wall and shear forces (342, 442), and increases in these forces can lead to heart defects (135, 260, 379).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [442]
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Placental Origins of Chronic Disease
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- Authors
- Poelmann, R. E., Gittenberger-de Groot, A. C., & Hierck, B. P.
- Affiliations
- Leiden University Medical Center (NL)
- Corresponding author
- Poelmann, Robert E.
- Venue
- Medical & Biological Engineering & Computing
- Published
- 2008-01-29
- Volume
- 46
- Issue
- 5
- Pages
- 479-484
- ISSN
- 0140-0118 (ISSN-L)
- 1741-0444
- PMC
- PMC2329736
- OpenAlex
- W2027201913
- Cited by
- 62
- References
- 57
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 1 · 2016: 5 · 2015: 5 · 2014: 1 · 2013: 7 · 2012: 11
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Medical & Biological Engineering & Computing (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
- Keywords
- heart development, microcirculation, shear stress, hemodynamics, blood flow, blood pressure, growth factors, transcription factors, gene pathways
- MeSH terms
- Cardiovascular System, Coronary Circulation, Heart, Humans, Microcirculation, Models, Cardiovascular, Regional Blood Flow, Stress, Mechanical
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