Cited by 86Microbial Natural Products and BiosynthesisMarine Sponges and Natural ProductsBacterial biofilms and quorum sensing

Bioactive substances produced by marine isolates of Pseudomonas

Open access
Isnansetyo, Alim, Kamei, Yuto·2009·Journal of Industrial Microbiology & Biotechnology

Abstract

Pseudomonas is a genus of non-fermentative gram-negative Gammaproteobacteria found both on land and in the water. Many terrestrial isolates of this genus have been studied extensively. While many produce bioactive substances, enzymes, and biosurfactants, other Pseudomonas isolates are used for biological control of plant diseases and bioremediation. In contrast, only a few marine isolates of this genus have been described that produce novel bioactive substances. The chemical structures of the bioactive substances from marine Pseudomonas are diverse, including pyroles, pseudopeptide pyrrolidinedione, phloroglucinol, phenazine, benzaldehyde, quinoline, quinolone, phenanthren, phthalate, andrimid, moiramides, zafrin and bushrin. Some of these bioactive compounds are antimicrobial agents, and dibutyl phthalate and di-(2-ethylhexyl) phthalate have been reported to be cathepsin B inhibitors. In addition to being heterogeneous in terms of their structures, the antibacterial substances produced by Pseudomonas also have diverse mechanisms of action: some affect the bacterial cell membrane, causing bacterial cell lysis, whereas others act as acetyl-CoA carboxylase and nitrous oxide synthesis inhibitors. Marine Pseudomonas spp. have been isolated from a wide range of marine environments and are a potential untapped source for medically relevant bioactive substances.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s10295-009-0611-2

Cites

85 of 85 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Skrzydlewska E, Sulkowska M, Koda M, Sulkowski S (2005) Pro- teolytic-antiproteolytic balance and its regulation in carcinogene- sis. World J Gastroenterol 11:1251-1266 PMID: 15761961

Cited by

Sorted by citations

Authors
Isnansetyo, A., & Kamei, Y.
Affiliations
  • Universitas Gadjah Mada (ID)
  • Saga University (JP)
Corresponding author
Isnansetyo, Alim
Venue
Journal of Industrial Microbiology & Biotechnology
Published
2009-07-07
Volume
36
Issue
10
Pages
1239-1248
ISSN
  • 1367-5435 (ISSN-L)
  • 1476-5535
OpenAlex
W2052836701
Cited by
86
References
85
Citations by year
2026: 2 · 2025: 1 · 2024: 6 · 2023: 7 · 2022: 8 · 2021: 4 · 2020: 8 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 8
FWCI
0.52
Type
journal article
Language
en
Open access
Locations
  • Journal of Industrial Microbiology & Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords
bioactive compounds, marine natural products, antimicrobial agents, phenazine, phloroglucinol, pyrrolidinedione, quinolones, phthalate derivatives, cathepsin B inhibitors, dibutyl phthalate, DEHP, acetyl-CoA carboxylase inhibition, cell membrane damage
MeSH terms
Biological Products, Pseudomonas, Seawater

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review