Angiogenesis during exercise and training.

Bloor, Colin M.

doi:10.1007/s10456-005-9013-x

Cited by 206Angiogenesis and VEGF in CancerCardiovascular and exercise physiologyExercise and Physiological Responses

Angiogenesis during exercise and training.

Bloor, Colin M.·2005·Angiogenesis

DOI 10.1007/s10456-005-9013-x

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Abstract

In this review the factors involved in angiogenesis are discussed in their various roles in initiating angiogenesis and inducing changes in the extracellular matrix to facilitate sprouting angiogenesis which is a major part of the angiogenesis seen in exercise and exercise training. A key role in angiogenesis is played by vascular endothelial growth factor (VEGF). The regulation of blood vessel growth to match the needs of the tissue depends on the control of VEGF production through changes in the stability of its mRNA and in its rate of transcription. The detailed studies describing its characteristics and its upregulation in acute exercise are presented along with a brief overview of the changes in the extracellular matrix that facilitate sprouting angiogenesis that occurs in response to exercise and training. Although the mechanisms involved in the growth and remodeling of arterioles and larger vessels are less detailed some recent studies have provided new insights. These are presented here to show a relationship between capillary development and arteriolar growth or remodeling in exercise training that raises questions to be addressed in future studies.

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Aerobic exercise is specifically associated with an increase in the density of small, rather than large-diameter blood vessels in both humans and animals.
“Interestingly, AE is specifically associated with an increase the density of small, rather than large-diameter blood vessels in both humans (Bullitt et al., 2009) and animals (Bloor, 2005; Van der Borght et al., 2009).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Bloor, 2005

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617 · see citing works
Angiogenesis.
Folkman, J., & Shing, Y. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49853-0 · Cited by 2,651 · see citing works
Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.
Waltenberger, J. L., Claesson, L., Siegbahn, A., Shibuya, M., & Heldin, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47116-5 · Cited by 1,656 · see citing works
Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension
Jiang, B. H., Semenza, G. L., Bauer, C., & Marti, H. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.4.c1172 · Cited by 1,213 · see citing works
Molecular mechanisms of blood vessel growth
Conway, E. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00281-9 · Cited by 1,030 · see citing works
VEGF-receptor signal transduction
Cross, M. J., Dixelius, J., Matsumoto, T., & Claesson, L. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00193-2 · Cited by 864 · see citing works
Exercise : regulation and integration of multiple systems
Rowell, L. B., & Shepherd, J. T. (1996) · Medical Entomology and Zoology · Cited by 810 · see citing works
Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular developmentPreprint
Gale, N. W., & Yancopoulos, G. D. (1999) · Genes & Development · doi:10.1101/gad.13.9.1055 · Cited by 776 · see citing works
Analysis of Biological Effects and Signaling Properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2)
Gille, H., Kowalski, J., Li, B., LeCouter, J. E., Moffat, B., Zioncheck, T. F., Pelletier, N., & Ferrara, N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m002016200 · Cited by 620 · see citing works
Angiogenesis in skeletal and cardiac muscle
HUDLICKÁ, O., Brown, M. D., & Egginton, S. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.2.369 · Cited by 615 · see citing works
What makes vessels grow with exercise training?
Prior, B. M., Yang, H. T., & Terjung, R. L. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00035.2004 · Cited by 511 · see citing works
VEGF Receptor Signal Transduction
Matsumoto, T., & Claesson, L. (2001) · Science s STKE · doi:10.1126/stke.2001.112.re21 · Cited by 506 · see citing works
Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels.
Goto, F., Goto, K., Weindel, K., & Folkman, J. (1993) · PubMed · Cited by 459 · see citing works
Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium
Morbidelli, L., Chang, C.-H., Douglas, J. G., Granger, H. J., Ledda, F., & Ziche, M. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.1.h411 · Cited by 417 · see citing works
Role of NO in Flow-Induced Remodeling of the Rabbit Common Carotid Artery
Tronc, F., Wassef, M., Esposito, B., Henrion, D., Glagov, S., & Tedgui, A. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.10.1256 · Cited by 372 · see citing works
Exercise-induced expression of angiogenesis-related transcription and growth factors in human skeletal muscle
Gustafsson, T. P., Puntschart, A., Kaijser, L., Jansson, E., & Sundberg, C. J. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.276.2.h679 · Cited by 362 · see citing works
Vascular remodeling by intussusceptive angiogenesis
Djonov, V., Baum, O., & Burri, P. H. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0784-3 · Cited by 327 · see citing works
Arteriogenesis The Development and Growth of Collateral Arteries
Helisch, A., & Schaper, W. K. A. (2003) · Microcirculation · doi:10.1038/sj.mn.7800173 · Cited by 312 · see citing works
Angiogenic growth factor mRNA responses in muscle to a single bout of exercise
Breen, E. C., Johnson, E. C., Wagner, H., Tseng, H. M., Sung, L. A., & Wagner, P. D. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.1.355 · Cited by 302 · cited 1× · see citing works
“Upregulation of VEGF occurs in rat skeletal muscle following chronic muscle stimulation [27, 42, 43] or with a single bout of moderately intense treadmill running [44].”
Background
Vascular Endothelial Growth Factor Effect on Endothelial Cell Proliferation, Migration, and Platelet-activating Factor Synthesis Is Flk-1-dependent
Bernatchez, P. N., Söker, S., & Sirois, M. G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.31047 · Cited by 300 · see citing works
Utilization of Distinct Signaling Pathways by Receptors for Vascular Endothelial Cell Growth Factor and Other Mitogens in the Induction of Endothelial Cell Proliferation
Wu, L., Mayo, L. D., Dunbar, J. D., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.5096 · Cited by 286 · see citing works
Unorthodox angiogenesis in skeletal muscle
Egginton, S. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00282-0 · Cited by 237 · see citing works
Evidence of O2 supply-dependentV˙ o 2 max in the exercise-trained human quadriceps
Richardson, R. S., Grassi, B., Gavin, T. P., Haseler, L. J., Tagore, K. S., Roca, J., & Wagner, P. D. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.3.1048 · Cited by 234 · see citing works
Coronary collateral development in swine after coronary artery occlusion.
White, F. C., Carroll, S. M., Magnet, A., & Bloor, C. M. (1992) · Circulation Research · doi:10.1161/01.res.71.6.1490 · Cited by 215 · see citing works
Self-citation
Matrix metalloproteinase activity is required for activity-induced angiogenesis in rat skeletal muscle
Haas, T. L., Milkiewicz, M., Davis, S. J., Zhou, A., Egginton, S., Brown, M. D., Madri, J. A., & HUDLICKÁ, O. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.4.h1540 · Cited by 207 · see citing works
Exercise adaptation attenuates VEGF gene expression in human skeletal muscle
Richardson, R. S., Wagner, H. E., Mudaliar, S. R. D., Saucedo, E., Henry, R. R., & Wagner, P. D. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.2.h772 · Cited by 205 · see citing works
Role of Nitric Oxide in the Angiogenic Response In Vitro to Basic Fibroblast Growth Factor
Babaei, S., Teichert-Kuliszewska, K., Monge, J. C., Mohamed, F., Bendeck, M. P., & Stewart, D. J. (1998) · Circulation Research · doi:10.1161/01.res.82.9.1007 · Cited by 205 · see citing works
Human VEGF gene expression in skeletal muscle: effect of acute normoxic and hypoxic exercise
Richardson, R. S., Wagner, H. E., Mudaliar, S. R. D., Henry, R. R., Noyszewski, E. A., & Wagner, P. D. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.6.h2247 · Cited by 202 · see citing works
Arteriogenesis The Development and Growth of Collateral Arteries
Helisch, A., & Schaper, W. K. A. (2003) · Microcirculation · doi:10.1080/mic.10.1.83.97 · Cited by 200 · see citing works
Capillary regression in vascular endothelial growth factor-deficient skeletal muscle
Tang, K., Breen, E. C., Gerber, H., Ferrara, N., & Wagner, P. D. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00023.2004 · Cited by 196 · see citing works
Control of Blood Flow to Cardiac and Skeletal Muscle During Exercise
Laughlin, M. H., Korthuis, R. J., Duncker, D. J., & Bache, R. J. (1996) · Comprehensive physiology · doi:10.1002/cphy.cp120116 · Cited by 189 · see citing works
Angiogenic growth factor expression in rat skeletal muscle in response to exercise training
Lloyd, P. G., Prior, B. M., Yang, H. T., & Terjung, R. L. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00743.2002 · Cited by 188 · see citing works
Circulating plasma VEGF response to exercise in sedentary and endurance-trained men
Kraus, R. M., Stallings, H. W., Yeager, R. C., & Gavin, T. P. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01031.2003 · Cited by 187 · see citing works
Modulation of physiological angiogenesis in skeletal muscle by mechanical forces: Involvement of VEGF and metalloproteinases
Brown, M. D., & HUDLICKÁ, O. (2003) · Angiogenesis · doi:10.1023/a:1025809808697 · Cited by 184 · see citing works
Differential involvement of MMP-2 and VEGF during muscle stretch- versus shear stress-induced angiogenesis
Rivilis, I., Milkiewicz, M., Boyd, P. J., Goldstein, J., Brown, M. D., Egginton, S., Hansen, F. M., HUDLICKÁ, O., & Haas, T. L. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00082.2002 · Cited by 183 · see citing works
Exercise training in swine promotes growth of arteriolar bed and capillary angiogenesis in heart
White, F. C., Bloor, C. M., McKirnan, M. D., & Carroll, S. M. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.3.1160 · Cited by 168 · see citing works
Self-citation
Angiotensin II and VEGF are involved in angiogenesis induced by short-term exercise training
Amaral, S. L., Papanek, P. E., & Greene, A. S. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.3.h1163 · Cited by 165 · see citing works
Muscle capillary supply and fiber type characteristics in weight and power lifters
Tesch, P. A., Thorsson, A., & Kaiser, P. K. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.56.1.35 · Cited by 164 · see citing works
Exercise training-induced coronary vascular adaptation
Laughlin, M. H., & McAllister, R. M. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.6.2209 · Cited by 149 · see citing works
Response of the coronary vasculature to myocardial hypertrophy
Tomanek, R. J. (1990) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(90)90620-5 · Cited by 148 · see citing works
Effects of age and exercise on the extent of the myocardial capillary bed
Tomanek, R. J. (1970) · The Anatomical Record · doi:10.1002/ar.1091670106 · Cited by 148 · see citing works
Exercise-induced angiogenesis-related growth and transcription factors in skeletal muscle and their modification in muscle pathology
Gustafsson, T. P. (2001) · Frontiers in bioscience · doi:10.2741/gustafss · Cited by 147 · see citing works
VEGF gene expression is upregulated in electrically stimulated rat skeletal muscle
Hang, J., Kong, L., Gu, J., & Adair, T. H. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.5.h1827 · Cited by 145 · see citing works
Size and blood flow of central and peripheral arteries in highly trained able-bodied and disabled athletes
Huonker, M., Schmid, A., Schmidt‐Trucksäss, A., Grathwohl, D., & Keul, J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00710.2001 · Cited by 144 · see citing works
Angiogenic growth factor response to acute systemic exercise in human skeletal muscle
Gavin, T. P., Robinson, C. B., Yeager, R. C., England, J. A., Nifong, L. W., & Hickner, R. C. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00748.2003 · Cited by 136 · see citing works
Angiogenesis Induced by Electrical Stimulation Is Mediated by Angiotensin II and VEGF
Amaral, S. L., Linderman, J. R., MORSE, M. M., & Greene, A. S. (2001) · Microcirculation · doi:10.1111/j.1549-8719.2001.tb00158.x · Cited by 133 · see citing works
Increased expression of vascular endothelial growth factor in human skeletal muscle in response to short-term one-legged exercise training
Gustafsson, T. P., Knutsson, A., Puntschart, A., Kaijser, L., Nordqvist, S., Sundberg, C. J., & Jansson, E. (2002) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-002-0845-6 · Cited by 126 · see citing works
Internal division of capillaries in rat skeletal muscle in response to chronic vasodilator treatment with α 1 -antagonist prazosin
Zhou, A., Egginton, S., HUDLICKÁ, O., et al. (1998) · Cell and Tissue Research · doi:10.1007/s004410051121 · Cited by 126 · see citing works
Influence of Inflammatory Cytokines on Arteriogenesis
Buschmann, I. R., HEIL, M., JOST, M., & Schaper, W. K. A. (2003) · Microcirculation · doi:10.1038/sj.mn.7800199 · Cited by 123 · see citing works
Regional changes in capillary supply in skeletal muscle of high-intensity endurance-trained rats
Gute, D. C., Fraga, C., Laughlin, M. H., & Amann, J. F. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.2.619 · Cited by 121 · see citing works
Is Physiological Angiogenesis in Skeletal Muscle Regulated by Changes in Microcirculation?
HUDLICKÁ, O. (1998) · Microcirculation · doi:10.1111/j.1549-8719.1998.tb00048.x · Cited by 120 · see citing works
Physiological Society Symposium – the Athlete's Heart
Brown, M. D. (2003) · Experimental Physiology · doi:10.1113/eph8802618 · Cited by 117 · see citing works
Induction and maintenance of increased VEGF protein by chronic motor nerve stimulation in skeletal muscle
Annex, B. H., TORGAN, C. E., Lin, P. C., Taylor, D. A., Thompson, M. A., Peters, K. G., & Kraus, W. E. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.274.3.h860 · Cited by 114 · see citing works
In vivo angiogenesis in adult rat skeletal muscle: early changes in capillary network architecture and ultrastructure
Hansen‐Smith, F. M., HUDLICKÁ, O., & Egginton, S. (1996) · Cell and Tissue Research · doi:10.1007/s004410050681 · Cited by 110 · see citing works
Exercise but not Prostanoids Enhance Levels of Vascular Endothelial Growth Factor and other Proliferative Agents in Human Skeletal Muscle Interstitium
Höffner, L., Nielsen, J., Langberg, H., & Hellsten, Y. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.037051 · Cited by 108 · see citing works
Capillary growth in relation to blood flow and performance in overloaded rat skeletal muscle
Egginton, S., HUDLICKÁ, O., Brown, M. D., Walter, M. H., Weiss, J. B., & Bate, A. J. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.6.2025 · Cited by 107 · see citing works
Structural basis of muscle O2 diffusing capacity: evidence from muscle function in situ
Hepple, R. T., Hogan, M. C., Stary, C. M., Bebout, D. E., Mathieu-Costello, O. A., & Wagner, P. D. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.2.560 · Cited by 106 · see citing works
Microscopic observations on the extra‐endothelial cells of living mammalian blood vessels
Clark, E. R., & Clark, E. L. (1940) · American Journal of Anatomy · doi:10.1002/aja.1000660102 · Cited by 102 · see citing works
Effect of long-term exercise on regional myocardial function and coronary collateral development after gradual coronary artery occlusion in pigs.
Roth, D. M., White, F. C., Nichols, M. L., Dobbs, S. L., Longhurst, J. C., & Bloor, C. M. (1990) · Circulation · doi:10.1161/01.cir.82.5.1778 · Cited by 100 · see citing works
Self-citation
Increased expression of VEGF following exercise training in patients with heart failure
Gustafsson, T. P., Bodin, K., Sylvén, C., Gordon, A., Tyni‐Lenné, R., & Jansson, E. (2001) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2001.00816.x · Cited by 99 · see citing works
Interaction of age and exercise on the heart and its blood supply.
Bloor, C. M., & Leon, A. S. (1970) · PubMed · Cited by 93 · see citing works
Self-citation
Exercise training increases coronary transport reserve in miniature swine
Laughlin, M. H., Overholser, K. A., & Bhatte, M. J. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.67.3.1140 · Cited by 84 · see citing works
Fiber sizes and capillary to fiber ratios in skeletal muscle of exercised rats
Carrow, R. E., Brown, R. E., & Huss, W. D. V. (1967) · The Anatomical Record · doi:10.1002/ar.1091590106 · Cited by 82 · see citing works
Exercise-induced cardiac hypertrophy: a correlation of blood flow and microvasculature
Breisch, E. A., White, F. C., Nimmo, L. E., McKirnan, M. D., & Bloor, C. M. (1986) · Journal of Applied Physiology · doi:10.1152/jappl.1986.60.4.1259 · Cited by 81 · see citing works
Self-citation
Effect of short-term exercise training on angiogenic growth factor gene responses in rats
Gavin, T. P., & Wagner, P. D. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.4.1219 · Cited by 79 · see citing works
Vascular endothelial growth factor increases the migration and proliferation of smooth muscle cells through the mediation of growth factors released by endothelial cells
Cucina, A., Borrelli, V., Randone, B., et al. (2003) · Journal of Surgical Research · doi:10.1016/s0022-4804(02)00042-2 · Cited by 76 · see citing works
Regulation of nitric oxide production in limb and ventilatory muscles during chronic exercise training
Vassilakopoulos, T., Deckman, G., Kebbewar, M., Rallis, G., Harfouche, R., & Hussain, S. N. A. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00270.2002 · Cited by 75 · see citing works
Influence of Inflammatory Cytokines on Arteriogenesis
Buschmann, I. R., HEIL, M., JOST, M., & Schaper, W. K. A. (2003) · Microcirculation · doi:10.1080/mic.10.3-4.371.379 · Cited by 69 · see citing works
Vascular endothelial growth factor mRNA expression and arteriovenous balance in response to prolonged, submaximal exercise in humans
Hiscock, N. J., Fischer, C. P., Pilegaard, H., & Pedersen, B. K. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00150.2003 · Cited by 66 · see citing works
Increased peak oxygen consumption of trained muscle requires increased electron flux capacity
Robinson, D. M., Ogilvie, R. W., Tullson, P. C., & Terjung, R. L. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.4.1941 · Cited by 66 · see citing works
Differential expression of Flk-1 and Flt-1 in rat skeletal muscle in response to chronic ischaemia: favourable effect of muscle activity
Milkiewicz, M., HUDLICKÁ, O., Verhaeg, J. M., Egginton, S., & Brown, M. D. (2003) · Clinical Science · doi:10.1042/cs20030035 · Cited by 65 · see citing works
Comparative physiological responses to exercise stress
Hastings, A., White, F. C., Sanders, T. M., & Bloor, C. M. (1982) · Journal of Applied Physiology · doi:10.1152/jappl.1982.52.4.1077 · Cited by 63 · see citing works
Self-citation
Influence of training on blood flow to different skeletal muscle fiber types
MACKIE, B. G., & Terjung, R. L. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.4.1072 · Cited by 63 · see citing works
Myocardial capillarity and maximal capillary diffusion capacity in exercise-trained dogs
Laughlin, M. H., & Tomanek, R. J. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.63.4.1481 · Cited by 59 · see citing works
Growth of Arterioles Precedes That of Capillaries in Stretch-Induced Angiogenesis in Skeletal Muscle
Hansen‐Smith, F. M., Egginton, S., Zhou, A., et al. (2001) · Microvascular Research · doi:10.1006/mvre.2001.2308 · Cited by 56 · see citing works
Adaptation of the left ventricle to exercise-induced hypertrophy
White, F. C., McKirnan, M. D., Breisch, E. A., Guth, B. D., Liu, Y. M., & Bloor, C. M. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.62.3.1097 · Cited by 54 · see citing works
Self-citation
Physical conditioning modulates rat cardiac vascular endothelial growth factor gene expression in nitric oxide-deficient hypertension
Husain, K. M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.06.058 · Cited by 48 · see citing works
Hemodynamic Forces as a Stimulus for Arteriogenesis
Resnick, N., Einav, S., Chen‐Konak, L., et al. (2003) · Endothelium · doi:10.1080/10623320390246289 · Cited by 45 · see citing works
Placenta growth factor is not required for exercise-induced angiogenesis
Gigante, B., Tarsitano, M., Cimini, V., Falco, S. D., & Persico, M. G. (2004) · Angiogenesis · doi:10.1007/s10456-004-4179-1 · Cited by 42 · see citing works
Peripheral adaptations in trained aged rats with femoral artery stenosis.
Yang, H., Ogilvie, R. W., & Terjung, R. L. (1994) · Circulation Research · doi:10.1161/01.res.74.2.235 · Cited by 41 · see citing works
Exercise-induced coronary angiogenesis
Tomanek, R. J. (1994) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199410000-00011 · Cited by 35 · see citing works
Effect of captopril on skeletal muscle angiogenic growth factor responses to exercise
Gavin, T. P., Spector, D. A., Wagner, H. E., et al. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.5.1690 · Cited by 32 · see citing works
Coronary collateral reserve during exercise induced ischemia in swine
White, F. C., Roth, D. M., & Bloor, C. M. (1989) · Basic Research in Cardiology · doi:10.1007/bf01907002 · Cited by 32 · see citing works
Self-citation
Attenuation of the exercise‐induced increase in skeletal muscle Flt‐1 mRNA by nitric oxide synthase inhibition
Gavin, T. P., & Wagner, P. D. (2002) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2002.00987.x · Cited by 32 · see citing works
Effects of dislocations on threshold voltage of GaAs field-effect transistors
Suchet, P., Duseaux, M., Maluenda, J., & Martin, G. M. (1987) · Journal of Applied Physics · doi:10.1063/1.339715 · Cited by 30 · see citing works
Exercise stimulates neovascularization in occluded muscle without affecting bFGF content
Deschenes, M. R., & Ogilvie, R. W. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199911000-00016 · Cited by 21 · see citing works
The angiogenetic effect of intramuscular administration of VEGF on muscle. The influence of exercise on angiogenesis.
Efthimiadou, A., Asimakopoulos, B., Nikolettos, N., et al. (2005) · PubMed · Cited by 17 · see citing works
Proliferation of goblet cells and vacuolated cells in the rabbit distal colon
Grant, T. D., & Specian, R. D. (1998) · The Anatomical Record · doi:10.1002/(sici)1097-0185(199809)252:1 · Cited by 12 · see citing works
Related expression of vascular endothelial growth factor and hypoxia‐inducible factor‐1 mRNAs in human skeletal muscle
Gustafsson, T. P., PUNTSCHART, Sundberg, C. J., et al. (1999) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1999.00515.x · Cited by 10 · see citing works

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Voss, M. W., Vivar, C., Kramer, A. F., & van Praag, H. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.08.001 · Cited by 1,030 · see citing works
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Chinsomboon, J., Ruas, J., Gupta, R. K., Thom, R., Shoag, J., Rowe, G. C., Sawada, N., Raghuram, S., & Arany, Z. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909131106 · Cited by 379 · see citing works
Physical exercise, neuroplasticity, spatial learning and memory
Cassilhas, R. C., Tufik, S., & de Mello, M. T. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2102-0 · Cited by 340 · see citing works
The effects of aerobic activity on brain structure.
Thomas, A. G., Dennis, A., Bandettini, P. A., & Johansen-Berg, H. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00086 · Cited by 303 · see citing works
Physical exercise leads to rapid adaptations in hippocampal vasculature: temporal dynamics and relationship to cell proliferation and neurogenesis
Van der Borght, K., Kóbor‐Nyakas, D. É., Klauke, K., Eggen, B. J. L., Nyakas, C., Van der Zee, E. A., & Meerlo, P. (2009) · Hippocampus · doi:10.1002/hipo.20545 · Cited by 210 · see citing works
Exercise-induced ’browning’ of adipose tissues
Aldiss, P., Betts, J., Sale, C., Pope, M., Budge, H., & Symonds, M. E. (2018) · Metabolism · doi:10.1016/j.metabol.2017.11.009 · Cited by 175 · see citing works
Physical Activity and Cancer Prevention: Pathways and Targets for Intervention
Rogers, C. J., Colbert, L. H., Greiner, J. W., Perkins, S. N., & Hursting, S. D. (2008) · Sports Medicine · doi:10.2165/00007256-200838040-00002 · Cited by 170 · see citing works
Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment
Kandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00373 · Cited by 155 · see citing works
“Interestingly, AE is speciﬁcally associated with an increase the density of small, rather than large-diameter blood vessels in both humans (Bullitt et al., 2009) and animals (Bloor, 2005; Van der Borght et al., 2009).”
Influence of vitamin C and vitamin E on redox signaling: implications for exercise adaptations
Cobley, J. N., McHardy, H., Morton, J. P., Nikolaidis, M. G., & Close, G. L. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.018 · Cited by 118 · see citing works
Changes in fitness are associated with changes in hippocampal microstructure and hippocampal volume among older adults.
Kleemeyer, M. M., Kühn, S., Prindle, J., Bodammer, N. C., Brechtel, L., Garthe, A., Kempermann, G., Schaefer, S., & Lindenberger, U. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.026 · Cited by 98 · see citing works
Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21CIP1/WAF1 and p16INK4a in vascular endothelial cells.
Douville, J. M., Cheung, D. Y. C., Herbert, K. L., Moffatt, T., & Wigle, J. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029099 · Cited by 72 · see citing works
Targeting endothelial metabolism for anti-angiogenesis therapy: A pharmacological perspective
Missiaen, R., Morales-Rodriguez, F., Eelen, G., & Carmeliet, P. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.01.001 · Cited by 58 · see citing works
The role of exercise-induced myokines in promoting angiogenesis
Qi, C., Song, X., Wang, H., Yan, Y., & Liu, B. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.981577 · Cited by 63 · see citing works
Effect of weight loss and exercise on angiogenic factors in the circulation and in adipose tissue in obese subjects
Cullberg, K., Christiansen, T., Paulsen, S., Bruun, J., Pedersen, S., & Richelsen, B. (2013) · Obesity · doi:10.1002/oby.20060 · Cited by 58 · see citing works
An injectable thermosensitive hydrogel for dual delivery of diclofenac and avastin® to effectively suppress inflammatory corneal neovascularization
Shi, H., Zhu, Y., Xing, C., Li, S., Bao, Z., Lei, L., Lin, D., Wang, Y., Chen, H., & Xu, X. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122081 · Cited by 29 · see citing works

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Μπιτσάκου, Γ. (2013) · doi:10.12681/eadd/41000
Expression of total vascular endothelial growth factor (VEGF) and inhibitory isoforms of VEGF in head and neck squamous cell carcinoma
Wilkie, M. D., Santosh, S., Emmett, M. S., et al. (2012) · International Journal of Surgery · doi:10.1016/j.ijsu.2012.06.015
Serum vascular endothelial growth factor (VEGF), soluble VEGF receptor-1 (sVEGFR-1) and sVEGFR-2 in systemic sclerosis patients: Relation to clinical manifestations and capillaroscopy findings
Shenavandeh, S., Tarakemeh, T., Sarvestani, E. K., & Nazarinia, M. A. (2016) · The Egyptian Rheumatologist · doi:10.1016/j.ejr.2016.03.004 · Cited by 19 · see citing works
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Indrawati, N., Iswari, I. S., & Winarti, N. W. (2021) · Neurologico Spinale Medico Chirurgico · doi:10.36444/nsmc.v4i3.187 · Cited by 2 · see citing works
The Effect of VEGF (Vascular endothelial growth factor) on Endothelial Cells in Pathogenesis of Preeclampsia
Cho, Y.-K., & 이홍균 (2002) · Obstetrics & Gynecology Science

Authors: Bloor, C. M.
Affiliations: University of California San Diego (US)
Corresponding author: Bloor, Colin M.
Venue: Angiogenesis
Publisher: Springer Science and Business Media LLC
Published: 2005-11-19
Volume: 8
Issue: 3
Pages: 263-271
ISSN: 0969-6970 (ISSN-L)
1573-7209
DOI: 10.1007/s10456-005-9013-x
OpenAlex: W2028339124
Cited by: 206
References: 89
Citations by year: 2026: 4 · 2025: 7 · 2024: 6 · 2023: 14 · 2022: 9 · 2021: 11 · 2020: 15 · 2019: 9 · 2018: 9 · 2017: 15 · 2016: 7 · 2015: 14 · 2014: 13 · 2013: 16 · 2012: 12
FWCI: 0.35
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Angiogenesis (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords: exercise training, vascular endothelial growth factor, sprouting angiogenesis, extracellular matrix, VEGF transcription, arteriolar remodeling, capillary development, acute exercise
MeSH terms: Coronary Vessels, Extracellular Matrix, Gene Expression Regulation, Humans, Exercise, Muscle, Skeletal, Neovascularization, Physiologic, Vascular Endothelial Growth Factor A

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Angiogenesis during exercise and training.

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