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Is rate of skin wound healing associated with aging or longevity phenotype?

Yanai, Hagai, Budovsky, Arie, Tacutu, Robi, Fraifeld, Vadim E.·2011·Biogerontology
DOI 10.1007/s10522-011-9343-6
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Abstract

Wound healing (WH) is a fundamental biological process. Is it associated with a longevity or aging phenotype? In an attempt to answer this question, we compared the established mouse models with genetically modified life span and also an altered rate of WH in the skin. Our analysis showed that the rate of skin WH in advanced ages (but not in the young animals) may be used as a marker for biological age, i.e., to be indicative of the longevity or aging phenotype. The ability to preserve the rate of skin WH up to an old age appears to be associated with a longevity phenotype, whereas a decline in WH-with an aging phenotype. In the young, this relationship is more complex and might even be inversed. While the aging process is likely to cause wounds to heal slowly, an altered WH rate in younger animals could indicate a different cellular proliferation and/or migration capacity, which is likely to affect other major processes such as the onset and progression of cancer. As a point for future studies on WH and longevity, using only young animals might yield confusing or misleading results, and therefore including older animals in the analysis is encouraged.

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Metadata

Authors
Yanai, H., Budovsky, A., Tacutu, R., & Fraifeld, V. E.
Venue
Biogerontology
Publisher
Springer Science and Business Media LLC
Published
2011-06-12
Volume
12
Issue
6
Pages
591-597
ISSN
  • 1389-5729
  • 1573-6768
DOI
10.1007/s10522-011-9343-6
Cited by
23
References
4
Language
en
Licence
www.springer.com/tdm (tdm)

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