Microbial lysate upregulates host oxytocin
Open accessAbstract
Neuropeptide hormone oxytocin has roles in social bonding, energy metabolism, and wound healing contributing to good physical, mental and social health. It was previously shown that feeding of a human commensal microbe Lactobacillus reuteri (L. reuteri) is sufficient to up-regulate endogenous oxytocin levels and improve wound healing capacity in mice. Here we show that oral L. reuteri-induced skin wound repair benefits extend to human subjects. Further, dietary supplementation with a sterile lysate of this microbe alone is sufficient to boost systemic oxytocin levels and improve wound repair capacity. Oxytocin-producing cells were found to be increased in the caudal paraventricular nucleus [PVN] of the hypothalamus after feeding of a sterile lysed preparation of L. reuteri, coincident with lowered blood levels of stress hormone corticosterone and more rapid epidermal closure, in mouse models. We conclude that microbe viability is not essential for regulating host oxytocin levels. The results suggest that a peptide or metabolite produced by bacteria may modulate host oxytocin secretion for potential public or personalized health goals.
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Effects of Lactobacillus on host plasma and hypothalamic oxytocin are dependent on vagal signaling.
“Interestingly, the effects observed above are dependent on vagal signaling, which blunted the effects of Lactobacillus on host plasma and hypothalamic oxytocin [132,133].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [133]
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- Authors
- Varian, B. J., Poutahidis, T., DiBenedictis, B. T., Levkovich, T., Ibrahim, Y., Didyk, E., Shikhman, L., Cheung, H. K., Hardas, A., Ricciardi, C. E., Kolandaivelu, K., Veenema, A. H., Alm, E. J., & Erdman, S. E.
- Affiliations
- Massachusetts Institute of Technology (US)
- Aristotle University of Thessaloniki (GR)
- Boston College (US)
- University of Massachusetts Chan Medical School (US)
- Broad Institute (US)
- Corresponding author
- Erdman, Susan E.
- ORCID
- Venue
- Brain Behavior and Immunity
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 61
- Pages
- 36-49
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC5431580
- OpenAlex
- W2547516517
- Cited by
- 153
- References
- 135
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 21 · 2023: 26 · 2022: 20 · 2021: 18 · 2020: 16 · 2019: 11 · 2018: 8 · 2017: 5 · 2016: 2
- FWCI
- 13.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- OpenBU (Boston University) (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (P30-ES002109, RO1CA108854, U01 CA164337)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, Lactobacillus reuteri, gut microbiota, wound healing, skin wound healing, corticosterone, stress hormones, dietary supplementation, host-microbe interactions, neuropeptide regulation
- MeSH terms
- Adult, Animals, Corticosterone, Female, Humans, Oxytocin, Skin, Skin Physiological Phenomena, Wound Healing, Up-Regulation, Mice, Knockout, Dietary Supplements, Probiotics, Mice, Limosilactobacillus reuteri, Young Adult
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