The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood
Open accessAbstract
Detection of circulating tumor cells has emerged as a promising minimally invasive diagnostic and prognostic tool for patients with metastatic cancers. We report a novel three dimensional microfilter device that can enrich viable circulating tumor cells from blood. This device consists of two layers of parylene membrane with pores and gap precisely defined with photolithography. The positions of the pores are shifted between the top and bottom membranes. The bottom membrane supports captured cells and minimize the stress concentration on cell membrane and sustain cell viability during filtration. Viable cell capture on device was investigated with scanning electron microscopy, confocal microscopy, and immunofluorescent staining using model systems of cultured tumor cells spiked in blood or saline. The paper presents and validates this new 3D microfiltration concept for circulation tumor cell enrichment application. The device provides a highly valuable tool for assessing and characterizing viable enriched circulating tumor cells in both research and clinical settings.
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Cited by
Circulating Tumor Cells and Circulating Tumor DNA
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Liquid biopsy of cancer: a multimodal diagnostic tool in clinical oncology
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An integrated microfluidic chip for one-step isolation of circulating tumor cells
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Metadata
- Authors
- Zheng, S., Lin, H. K., Lu, B., Williams, A., Datar, R., Cote, R. J., & Tai, Y.-C.
- Venue
- Biomedical Microdevices
- Published
- 2010-10-27
- Volume
- 13
- Issue
- 1
- Pages
- 203-213
- ISSN
- 1387-2176 (ISSN-L)
- 1572-8781
- OpenAlex
- W1967625972
- Cited by
- 422
- References
- 47
- FWCI
- 17.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Zheng, S., Lin, H. K., Lu, B., Williams, A., Datar, R., Cote, R. J., & Tai, Y.-C. (2011). 3D microfilter device for viable circulating tumor cell (CTC) enrichment from blood. Biomedical Microdevices. https://doi.org/10.1007/s10544-010-9485-3
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