A multilayered microfluidic blood vessel-like structure

Cell-laden microengineered gelatin methacrylate hydrogels

Nichol, J. W., Koshy, S. T., Bae, H., Hwang, C. M., Yamanlar, S., & Khademhosseini, A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.064 · Cited by 2,377

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

Miller, J. S., Stevens, K. R., Yang, M. T., Baker, B. M., Nguyen, D.-H. T., Cohen, D. M., Toro, E., Chen, A. A., Galie, P. A., Yu, X., et al. (2012) · Nature Materials · doi:10.1038/nmat3357 · Cited by 1,917

Structural and Rheological Properties of Methacrylamide Modified Gelatin Hydrogels

Van Den Bulcke, A. I., Bogdanov, B., De Rooze, N., Schacht, E. H., Cornelissen, M., & Berghmans, H. (2000) · Biomacromolecules · doi:10.1021/bm990017d · Cited by 1,536

Vascularization is the key challenge in tissue engineering

Novosel, E. C., Kleinhans, C., & Kluger, P. J. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.03.004 · Cited by 1,067

In vitro microvessels for the study of angiogenesis and thrombosis

Zheng, Y., Chen, J., Craven, M., Choi, N. W., Totorica, S., Diaz-Santana, A., Kermani, P., Hempstead, B., Fischbach-Teschl, C., López, J. A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201240109 · Cited by 894

Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels

Chen, Y., Lin, R., Qi, H., Yang, Y., Bae, H., Melero‐Martin, J. M., & Khademhosseini, A. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201101662 · Cited by 802

Electrospun scaffolds for tissue engineering of vascular grafts

Hasan, A., Memić, A., Annabi, N., Hossain, M., Paul, A., Dokmeci, M. R., Dehghani, F., & Khademhosseini, A. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.08.022 · Cited by 739

Formation of perfused, functional microvascular tubes in vitro

Chrobak, K. M., Potter, D. R., & Tien, J. (2006) · Microvascular Research · doi:10.1016/j.mvr.2006.02.005 · Cited by 555

Injectable Graphene Oxide/Hydrogel-Based Angiogenic Gene Delivery System for Vasculogenesis and Cardiac Repair

Paul, A., Hasan, A., Kindi, H. N. A., Gaharwar, A. K., Rao, V. T. S., Nikkhah, M., Shin, S. R., Krafft, D., Dokmeci, M. R., Shum‐Tim, D., et al. (2014) · ACS Nano · doi:10.1021/nn5020787 · Cited by 540

Cell migration into scaffolds under co-culture conditions in a microfluidic platform

Chung, S. H., Sudo, R., Mack, P. J., Wan, C.-R., Vickerman, V., & Kamm, R. D. (2008) · Lab on a Chip · doi:10.1039/b807585a · Cited by 530

Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1☆

Nakatsu, M. N., Sainson, R. C. A., Aoto, J. N., Taylor, K. L., Aitkenhead, M., Pérez‐del‐Pulgar, S., Carpenter, P. M., & Hughes, C. C. W. (2003) · Microvascular Research · doi:10.1016/s0026-2862(03)00045-1 · Cited by 451

Photocrosslinking of Gelatin Macromers to Synthesize Porous Hydrogels That Promote Valvular Interstitial Cell Function

Benton, J. A., DeForest, C. A., Vivekanandan, V., & Anseth, K. S. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0545 · Cited by 348

Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction

Hasan, A., Khattab, A., Islam, M. A., Hweij, K. A., Zeitouny, J., Waters, R., Sayegh, M., Hossain, M. M., & Paul, A. (2015) · Advanced Science · doi:10.1002/advs.201500122 · Cited by 330

Vascularization—The Conduit to Viable Engineered Tissues

Kaully, T., Kaufman‐Francis, K., Lesman, A., & Levenberg, S. (2009) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2008.0193 · Cited by 318

Use of Cardiac Procedures and Outcomes in Elderly Patients with Myocardial Infarction in the United States and Canada

Tu, J. V., Pashos, C. L., Naylor, C. D., Chen, E., Normand, S. T., Newhouse, J. P., & McNeil, B. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199705223362106 · Cited by 304

Tissue engineering of vascular grafts

Ratcliffe, A. (2000) · Matrix Biology · doi:10.1016/s0945-053x(00)00080-9 · Cited by 290

Microfluidic techniques for development of 3D vascularized tissue

Hasan, A., Paul, A., Vrana, N. E., Zhao, X., Memic, A., Hwang, Y.-S., Dokmeci, M. R., & Khademhosseini, A. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.04.091 · Cited by 282

Biomechanical properties of native and tissue engineered heart valve constructs

Hasan, A., Ragaert, K., Święszkowski, W., Selimović, Š., Paul, A., Camci‐Unal, G., Mofrad, M. R. K., & Khademhosseini, A. (2013) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2013.09.023 · Cited by 282

Cell Microenvironment Engineering and Monitoring for Tissue Engineering and Regenerative Medicine: The Recent Advances

Barthès, J., Özçelik, H., Hindié, M., Halili, A. N., Hasan, A., & Vrana, N. E. (2014) · BioMed Research International · doi:10.1155/2014/921905 · Cited by 238

Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays

Khademhosseini, A., Yeh, J., Eng, G. M., Karp, J. M., Kaji, H., Borenstein, J. T., Farokhzad, O. C., & Langer, R. (2005) · Lab on a Chip · doi:10.1039/b508096g · Cited by 238

TGFβ is required for the formation of capillary-like structures in three-dimensional cocultures of 10T1/2 and endothelial cells

Darland, D. C., & D'Amore, P. A. (2001) · Angiogenesis · doi:10.1023/a:1016611824696 · Cited by 211

Transport‐mediated angiogenesis in 3D epithelial coculture

Sudo, R., Chung, S. H., Zervantonakis, I. K., Vickerman, V., Toshimitsu, Y., Griffith, L. G., & Kamm, R. D. (2009) · The FASEB Journal · doi:10.1096/fj.08-122820 · Cited by 205

Molded polyethylene glycol microstructures for capturing cells within microfluidic channels

Khademhosseini, A., Yeh, J., Jon, S., Eng, G. M., Suh, K. Y., Burdick, J. A., & Langer, R. (2004) · Lab on a Chip · doi:10.1039/b404842c · Cited by 200

Recent Advances in Application of Biosensors in Tissue Engineering

Hasan, A., Nurunnabi, M., Morshed, M., Paul, A., Polini, A., Kuila, T., Hariri, M. A., Lee, Y.-K., & Jaffa, A. A. (2014) · BioMed Research International · doi:10.1155/2014/307519 · Cited by 200

Effect of mechanical factors on the function of engineered human blood microvessels in microfluidic collagen gels

Price, G. M., Wong, K. H. K., Truslow, J. G., Leung, A. D., Acharya, C., & Tien, J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.04.041 · Cited by 184

In vitro formation and characterization of a perfusable three-dimensional tubular capillary network in microfluidic devices

Yeon, J. H., Ryu, H. R., Chung, M., Hu, Q. P., & Jeon, N. L. (2012) · Lab on a Chip · doi:10.1039/c2lc40131b · Cited by 179

The promotion of microvasculature formation in poly(ethylene glycol) diacrylate hydrogels by an immobilized VEGF-mimetic peptide

Leslie-Barbick, J. E., Saik, J. E., Gould, D. J., Dickinson, M. E., & West, J. L. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.060 · Cited by 176

Covalently-Immobilized Vascular Endothelial Growth Factor Promotes Endothelial Cell Tubulogenesis in Poly(ethylene glycol) Diacrylate Hydrogels

Leslie-Barbick, J. E., Moon, J. J., & West, J. L. (2009) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856208x386381 · Cited by 173

Multilayer vascular grafts based on collagen-mimetic proteins

Browning, M. B., Dempsey, D. K., Güiza-Argüello, V. R., Becerra‐Bayona, S. M., Rivera, J. J., Russell, B. H., Höök, M., Clubb, F. J., Miller, M. W., Fossum, T. W., et al. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.11.015 · Cited by 151

Matrix density mediates polarization and lumen formation of endothelial sprouts in VEGF gradients

Shamloo, A., & Heilshorn, S. C. (2010) · Lab on a Chip · doi:10.1039/c005069e · Cited by 134

Integrated approach to designing growth factor delivery systems

Chen, R. R., Silva, E. A., Yuen, W. W., Brock, A. A., Fischbach, C., Lin, A., Guldberg, R. E., & Mooney, D. J. (2007) · The FASEB Journal · doi:10.1096/fj.06-7873com · Cited by 126

Microfluidics for Biological Applications

Finehout, E. J., & Tian, W. (2008) · Springer eBooks · doi:10.1007/978-0-387-09480-9 · Cited by 109

SAM-based cell transfer to photopatterned hydrogels for microengineering vascular-like structures

Sadr, N., Zhu, M., Osaki, T., Kakegawa, T., Yang, Y., Moretti, M., Fukuda, J., & Khademhosseini, A. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.06.034 · Cited by 107

Micron-Scale Spatially Patterned, Covalently Immobilized Vascular Endothelial Growth Factor on Hydrogels Accelerates Endothelial Tubulogenesis and Increases Cellular Angiogenic Responses

Leslie-Barbick, J. E., Shen, C. J., Chen, C. S., & West, J. L. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0202 · Cited by 100

The role of cyclic AMP in normalizing the function of engineered human blood microvessels in microfluidic collagen gels

Wong, K. H. K., Truslow, J. G., & Tien, J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.02.041 · Cited by 78

Promoting angiogenesis via manipulation of VEGF responsiveness with notch signaling

Cao, L., Arany, P. R., Wang, Y.-S., & Mooney, D. J. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.04.051 · Cited by 76

Mimicking nature by codelivery of stimulant and inhibitor to create temporally stable and spatially restricted angiogenic zones

Yuen, W. W., Du, N. R., Chan, C. H., Silva, E. A., & Mooney, D. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001192107 · Cited by 67

Multilayered Blood Capillary Analogs in Biodegradable Hydrogels for In Vitro Drug Permeability Assays

Yoshida, H., Matsusaki, M., & Akashi, M. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201201905 · Cited by 64

Mechanisms of Vascular Endothelial Growth Factor-Induced Pathfinding by Endothelial Sprouts in Biomaterials

Shamloo, A., Xu, H., & Heilshorn, S. C. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0323 · Cited by 58

Perivascular-Like Cells Contribute to the Stability of the Vascular Network of Osteogenic Tissue Formed from Cell Sheet-Based Constructs

Mendes, L. F., Pirraco, R. P., Szymczyk, W., Frias, A. M., Santos, T. C., Reis, R. L., & Marques, A. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041051 · Cited by 53

Biofunctional Materials for Directing Vascular Development

Saik, J. E., McHale, M. K., & West, J. L. (2012) · Current Vascular Pharmacology · doi:10.2174/157016112799959314 · Cited by 16

Organoids-on-a-chip

Park, S. E., Georgescu, A., & Huh, D. (2019) · Science · doi:10.1126/science.aaw7894 · Cited by 847

Nanoparticles in tissue engineering: applications, challenges and prospects

Hasan, A., Morshed, M., Memić, A., Hassan, S., Webster, T. J., & Marei, H. E. S. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s153758 · Cited by 498

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

Herland, A., van der Meer, A. D., Fitzgerald, E. A., Park, T., Sleeboom, J. J. F., & Ingber, D. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150360 · Cited by 496

Precise Tuning of Facile One-Pot Gelatin Methacryloyl (GelMA) Synthesis

Shirahama, H., Lee, B. H., Tan, L. P., & Cho, N. (2016) · Scientific Reports · doi:10.1038/srep31036 · Cited by 477

Multiscale bioprinting of vascularized models

Miri, A. K., Khalilpour, A., Çeçen, B., Maharjan, S., Shin, S. R., & Khademhosseini, A. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.08.006 · Cited by 277

On-Chip Construction of Multilayered Hydrogel Microtubes for Engineered Vascular-Like Microstructures

Yue, T., Liu, N., Liu, Y., Peng, Y., Xie, S., Luo, J., Huang, Q., Takeuchi, M., & Fukuda, T. (2019) · Micromachines · doi:10.3390/mi10120840 · Cited by 16

Microfabricated blood vessels undergo neoangiogenesis

DiVito, K. A., Daniele, M. A.-A., Roberts, S. A., Ligler, F. S., & Adams, A. A. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.05.012 · Cited by 46

Design and development of an in vitro vascular model using 3D printing-enabled hydrogel casting technique

Yang, L. (2016) · SURFACE: the Syracuse University Research Facility and Collaborative Environment (Syracuse University)

Fabrication of in vitro three-dimensional multilayered blood vessel model using human endothelial and smooth muscle cells and high-strength PEG hydrogel

Shinohara, S., Kihara, T., Sakai, S., Matsusaki, M., Akashi, M., Taya, M., & Miyake, J. (2013) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2013.02.013 · Cited by 40

An in vitro vascular chip using 3D printing-enabled hydrogel casting

Yang, L., Shridhar, S. V., Gerwitz, M., & Soman, P. (2016) · Biofabrication · doi:10.1088/1758-5090/8/3/035015 · Cited by 68